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Randomized Trial: Adjuvant Chemotherapy in Upper Tract Urothelial Carcinoma

8 Mar, 2020 | 20:17h | UTC

Adjuvant chemotherapy in upper tract urothelial carcinoma (the POUT trial): a phase 3, open-label, randomised controlled trial – The Lancet (free)

NCCN Guideline: Bladder Cancer

8 Mar, 2020 | 20:18h | UTC

Bladder Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network (free)

Randomized Trial: Treatment of Advanced AIDS-associated Kaposi Sarcoma in Resource-limited Settings

8 Mar, 2020 | 20:16h | UTC

Treatment of advanced AIDS-associated Kaposi sarcoma in resource-limited settings: a three-arm, open-label, randomised, non-inferiority trial – The Lancet (free)

Coronavirus Disease 2019 (COVID-19): A Guide for UK GPs

6 Mar, 2020 | 10:27h | UTC

Coronavirus disease 2019 (covid-19): a guide for UK GPs – The BMJ (free)

See also: Latest Research on the COVID-19 Outbreak (free resources)

Related Commentary on Twitter

When should you suspect covid-19 infection and what should you do?

This #BMJEducation article offers a practical guide for GPs and others working in UK primary care on when to suspect covid-19 and how to respond https://t.co/yFwSYw267F #COVID19

— The BMJ (@bmj_latest) March 6, 2020

Guidelines on Point of Care Ultrasound (POCUS) for Critically Ill Neonates and Children

6 Mar, 2020 | 10:24h | UTC

International evidence-based guidelines on Point of Care Ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) – Critical Care (free)

8 Things to Know About E-cigarettes

6 Mar, 2020 | 10:25h | UTC

8 things to know about e-cigarettes – Public Health Matters (free)

FDA Safety Alert: Montelukast May Cause Serious Mental Health Side Effects

6 Mar, 2020 | 10:22h | UTC

FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis – U.S. Food & Drug Administration (free)

Commentary: Montelukast to Get Boxed Warning – NEJM Journal Watch (free)

Randomized Trial: Effect of a Workplace-Based Multicomponent Intervention on Hypertension Control

6 Mar, 2020 | 10:21h | UTC

Effect of a Workplace-Based Multicomponent Intervention on Hypertension Control: A Randomized Clinical Trial – JAMA Cardiology (free for a limited period)

Commentary: Blood pressure control achieved using workplace-based programs – News Medical (free)

Validation and Utility Testing of Clinical Prediction Models: Time to Change the Approach

6 Mar, 2020 | 10:18h | UTC

Validation and Utility Testing of Clinical Prediction Models: Time to Change the Approach – JAMA (free for a limited period)

Blood Pressure in Frail Older Adults: Associations with Cardiovascular Outcomes and All-cause Mortality

6 Mar, 2020 | 10:19h | UTC

Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality – Age and Ageing (free)

Commentary: Expert reaction to study looking at low blood pressure and mortality in older adults – Science Media Centre (free)

Related Commentary on Twitter

Important paper by Jane Masoli et al at Exeter. In over 75, BP <130/80 had higher mortality. In over 85s NO association high BP w mortality. Even BP>180!! https://t.co/F3KlOiRQxy pic.twitter.com/3168nRS2AX

— Lucy Pollock (@lucypgeridoc) March 5, 2020

Diet, Nutrition, and Cancer Risk: What Do We Know and What is The Way Forward?

6 Mar, 2020 | 10:16h | UTC

Diet, nutrition, and cancer risk: what do we know and what is the way forward? – The BMJ (free)

Study: Colorectal Cancer Burden Shifting to Younger Individuals

6 Mar, 2020 | 10:15h | UTC

News Release: Colorectal Cancer Burden Shifting to Younger Individuals – American Cancer Society (free)

Original Report: Colorectal cancer statistics, 2020 – CA: A Cancer Journal for Clinicians (free)

Commentary: Half of new colon and rectal cancer diagnoses are now in people age 66 and younger, report finds – CNN (free)

Joint International Consensus Statement for Ending Stigma of Obesity

5 Mar, 2020 | 10:32h | UTC

Joint international consensus statement for ending stigma of obesity – Nature Medicine (free)

Commentary: Scientific community pledges to end obesity stigma – King’s College London (free)

[Abstract Only] Randomized Trials: Monthly Injections Noninferior to Daily Oral Treatment for HIV

5 Mar, 2020 | 10:29h | UTC

Original Articles: Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection – New England Journal of Medicine (link to abstract – $ for full-text) AND Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Monthly Injections Noninferior to Daily Treatment for HIV – NEJM Journal Watch (free) AND A more convenient, monthly treatment for HIV cleared a key hurdle – ScienceNews (free)

Study: New 3-Drug Treatment Regimen Effective for Highly Drug-Resistant Pulmonary Tuberculosis

5 Mar, 2020 | 10:30h | UTC

Treatment of Highly Drug-Resistant Pulmonary Tuberculosis – New England Journal of Medicine (free)

Visual Abstract: Treatment of Highly Drug-Resistant Pulmonary TB (free)

Commentary: New TB drug regimen controls resistant disease in 9 of 10 cases: study – Reuters (free)

Systematic Review: Systemic Causes of In-Hospital Intravenous Medication Errors

5 Mar, 2020 | 10:26h | UTC

Systemic Causes of In-Hospital Intravenous Medication Errors: A Systematic Review – Journal of Patient Safety (free)

Source: PSNet

[Abstract Only] Study: MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis

5 Mar, 2020 | 10:27h | UTC

MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Adding MRI-targeted biopsy leads to more reliable diagnosis of aggressive prostate cancer – University of Maryland Medical Center (free) AND MRI-Targeted and Systematic Biopsy for Prostate Cancer Diagnosis – NEJM Journal Watch (free) AND Testing with combined biopsy method improves prostate cancer diagnosis in NIH study – NIH News Release (free)

Cohort Study: Comparing the 5-Year Diabetes Outcomes of Sleeve Gastrectomy and Gastric Bypass

5 Mar, 2020 | 10:24h | UTC

Comparing the 5-Year Diabetes Outcomes of Sleeve Gastrectomy and Gastric Bypass: The National Patient-Centered Clinical Research Network (PCORNet) Bariatric Study – JAMA Surgery (free)

Commentaries: Bariatric Surgery and Diabetes Treatment—Finding the Sweet Spot – JAMA Surgery (free) AND Gastric bypass may be best weight-loss surgery for diabetes remission – Reuters (free) AND Gastric bypass improves weight loss, type 2 diabetes, study finds – UPI (free)

Meta-Analysis: Watchful Waiting Strategy vs. Early Initiation of Renal Replacement Therapy in Critically Ill Patients with Acute Kidney Injury

5 Mar, 2020 | 10:25h | UTC

Comparison between watchful waiting strategy and early initiation of renal replacement therapy in the critically ill acute kidney injury population: an updated systematic review and meta-analysis – Annals of Intensive Care (free)

Meta-Analysis: Male and Female Physician Suicidality

5 Mar, 2020 | 10:20h | UTC

Male and Female Physician Suicidality: A Systematic Review and Meta-analysis – JAMA Psychiatry (free for a limited period)

Editorial: Physician Suicide—A Personal and Community Tragedy (free for a limited period)

Commentary: Meta-Analysis Spotlights Challenge of Physician Suicide – Psychiatric New Alert (free)

Another Egg Study. Three Large Prospective Cohort Studies, Systematic Review, and Updated Meta-analysis Suggest It Has a Neutral Effect on Risk of Cardiovascular Disease

5 Mar, 2020 | 10:19h | UTC

Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis – The BMJ (free)

Editorial: Egg consumption and cardiovascular disease (free)

Commentary: Study Finds No Link Between Moderate Egg Consumption and Overall Cvd Risk – MedicalResearch.com (free)

Study: Low Back and Neck Pain Tops U.S. Health Spending

4 Mar, 2020 | 08:32h | UTC

Low back and neck pain tops U.S. health spending – Institute for Health Metrics and Evaluation (free)

Original Study: US Health Care Spending by Payer and Health Condition, 1996-2016 – JAMA (free for a limited period)

Related Commentary on Twitter

The US #healthcare spending, by condition and payer, for the past 20 years, by @IHME_UW @JAMA_current
A noteworthy figure that sums up the 2016 story.
Musculoskeletal and #diabetes are the top 2 burdenshttps://t.co/6yWAbrKtxl pic.twitter.com/jfyTegCHuf

— Eric Topol (@EricTopol) March 3, 2020