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Practice Guideline: Neuromuscular blockade in patients with ARDS
27 Oct, 2020 | 09:28h | UTCNeuromuscular blockade in patients with ARDS: a rapid practice guideline – Intensive Care Medicine (free for a limited period)
Fauci says it might be time to mandate masks as Covid-19 surges across US
25 Oct, 2020 | 23:50h | UTCFauci says it might be time to mandate masks as Covid-19 surges across US – CNN
[Preprint] Randomized trial: Nitazoxanide does not improve symptoms in mild Covid-19 disease
25 Oct, 2020 | 23:46h | UTCEarly use of nitazoxanide in mild Covid-19 disease: randomized, placebo-controlled trial – medRxiv
Clinical Update: Virology, transmission, and pathogenesis of SARS-CoV-2
25 Oct, 2020 | 23:48h | UTCVirology, transmission, and pathogenesis of SARS-CoV-2 – The BMJ
Commentary on Twitter
https://twitter.com/bmj_latest/status/1320425173976256513
SARS-CoV-2 seroprevalence worldwide: a systematic review and meta-analysis
25 Oct, 2020 | 23:44h | UTC
Perspective: The race to make COVID antibody therapies cheaper and more potent
25 Oct, 2020 | 23:43h | UTCThe race to make COVID antibody therapies cheaper and more potent – Nature
Steroids boost survival of preterm babies in low-resource settings, new study finds
25 Oct, 2020 | 23:38h | UTCOriginal Study: Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries – New England Journal of Medicine
Commentary on Twitter (thread – click for more)
🆕 clinical trial shows that dexamethasone can boost survival of premature babies when given to pregnant women at risk of preterm birth in low-resource settings
👉 https://t.co/qKvDKMkrkd pic.twitter.com/hjmf01J4B1
— World Health Organization (WHO) (@WHO) October 23, 2020
[Abstract Only] Randomized trial: Effect of Finerenone on chronic kidney disease outcomes in Type 2 diabetes
25 Oct, 2020 | 23:34h | UTCEffect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Finerenone Linked to Reduced Cardiorenal Events for Chronic Kidney Disease – HCPLive
Commentary on Twitter (thread – click for more)
‼️Effect of Finerenone on CKD outcomes in T2DM
⚡️Finerenone decreased risk of CKD progression by 18%
⚡️Finerenone decreased CV morbidity & mortality by 14%
Published in @NEJM today https://t.co/XvshpZZCK4@ASNKidney #Kidneywk pic.twitter.com/FOkxnG1enz
— Aisha Shaikh (@aishaikh) October 23, 2020
Perspective: Why COVID outbreaks look set to worsen this winter
25 Oct, 2020 | 23:41h | UTCWhy COVID outbreaks look set to worsen this winter – Nature
Related: WHO warns of tough months ahead as COVID tops 42 million – CIDRAP
Perspective: COVID-19 can affect the heart
25 Oct, 2020 | 23:39h | UTCCOVID-19 can affect the heart – Science
Commentary from the author
https://twitter.com/EricTopol/status/1320427201351745536
Review: How to ventilate obese patients in the ICU
25 Oct, 2020 | 23:30h | UTCHow to ventilate obese patients in the ICU – Intensive Care Medicine (free for a limited period)
Commentary on Twitter
https://twitter.com/yourICM/status/1319623153283440640
Narrative systematic review: Benefits of medication charts provided at transitions of care
25 Oct, 2020 | 23:29h | UTC
The ‘Ten Commandments’ for the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
25 Oct, 2020 | 23:25h | UTCOriginal guideline and commentaries: 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
Randomized trial: Effects of regional citrate anticoagulation vs. systemic heparin anticoagulation on dialysis filter life span and mortality among critically ill patients with acute kidney injury
25 Oct, 2020 | 23:32h | UTC
Commentary on Twitter
In this RCT, anticoagulation with regional citrate, compared with systemic heparin, resulted in longer filter life span in patients with acute kidney injury receiving continuous kidney replacement therapy https://t.co/fmkawnqjmM #VisualAbstract
— JAMA (@JAMA_current) October 23, 2020
Systematic review: Laparoscopic surgery for pain and infertility associated with endometriosis
25 Oct, 2020 | 23:23h | UTCLaparoscopic surgery for pain and infertility associated with endometriosis – Cochrane Library
Original study: Laparoscopic surgery for endometriosis – Cochrane Library
Commentary on Twitter
Updated priority #Cochrane review published "Laparoscopic surgery for #endometriosis" Laparoscopic excision or ablation probably increases #pregnancy rate compared to diagnostic laparoscopy only. No data were reported on live birth. https://t.co/OaIduKN0B8 @JamesMNDuffy pic.twitter.com/C3EnffV4d3
— Cochrane Gynaecology & Fertility (@CochraneCGF) October 25, 2020
[Abstract only] Preliminary study suggests age-adjusted D-dimer can exclude left atrial thrombus in patients with atrial fibrillation
25 Oct, 2020 | 23:26h | UTCD-dimer blood concentrations to exclude left atrial thrombus in patients with atrial fibrillation – Heart (link to abstract – $ for full-text)
Commentary on Twitter
A nice study on the use of D-dimer for excluding left atrial thrombus.
Patients with D-dimer < (10 x patient's age) had 100% sensitivity and NPV for excluding LA thrombus.
This represented 60% of the population, who could in theory safely avoid TOE. https://t.co/OFUy9caWd0
— Mark Mills (@DrMarkMills) October 25, 2020
Down syndrome tied to 10 times the risk of COVID-19 death
23 Oct, 2020 | 09:13h | UTCDown syndrome tied to 10 times the risk of COVID-19 death – CIDRAP
Original study: COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study Of 8 Million Adults – Annals of Internal Medicine
Meta-analysis: Preventive malaria treatment among school-aged children in sub-Saharan Africa
25 Oct, 2020 | 23:22h | UTCCommentaries: Landmark Study Suggests Malaria-Preventive Drugs Dramatically Reduce Infections and Improve Health of School Children – University of Maryland AND Back to school for malaria prevention: a new tool in the era of malaria elimination? – The Lancet Global Health
Commentary on Twitter
Conclusion of a new systematic review and meta-analysis: "Preventive treatment of malaria among school-aged children reduces the burden of malaria in this age group and could be a key intervention to decrease P falciparum transmission…" https://t.co/UaNBdsKaze pic.twitter.com/82e1OMX7TF
— The Lancet Global Health (@LancetGH) October 23, 2020
Randomized trial: Convalescent plasma ineffective for patients hospitalized with Covid-19
23 Oct, 2020 | 09:15h | UTCEditorial: Convalescent plasma is ineffective for covid-19 – The BMJ
Commentary on Twitter
Just published @bmj_latest: A randomized trial of convalescent plasma for moderate covidhttps://t.co/dUvEMFSLHG
No benefit. It was underpowered to detect mortality reduction with 464 patients. A large RCT is needed to resolve the question, but these findings are not encouraging. pic.twitter.com/WGtz9IVSZe— Eric Topol (@EricTopol) October 23, 2020
A global survey of potential acceptance of a COVID-19 vaccine
23 Oct, 2020 | 09:11h | UTCA global survey of potential acceptance of a COVID-19 vaccine – Nature Medicine
Commentary: COVID Vaccine Hesitancy – Science-based Medicine
Pro/con debate: Therapeutic anticoagulation in hospitalized patients with Covid-19 without established thromboembolism
23 Oct, 2020 | 09:12h | UTCAnticoagulation in Hospitalized Patients with Covid-19 – New England Journal of Medicine
Related editorial: Anticoagulation in COVID-19: It Is Time for High-Quality Evidence – Journal of the American College of Cardiology
Coronavirus vaccine volunteer in Brazil’s AstraZeneca trial dies – but authorities say trial to continue
23 Oct, 2020 | 09:08h | UTCSee also: AstraZeneca COVID-19 vaccine trial Brazil volunteer dies, trial to continue – Reuters AND Expert reaction to media reports suggesting a person in Brazil who was taking part in the Brazil arm of the Oxford/AstraZeneca vaccine trial has died – Science Media Centre
Study: Low risk of SARS-CoV-2 transmission among coworkers in a surgical environment
23 Oct, 2020 | 09:05h | UTCRisk of SARS-CoV-2 Transmission Among Coworkers in a Surgical Environment – Mayo Clinic Proceedings
The false promise of herd immunity for COVID-19
23 Oct, 2020 | 09:03h | UTCThe false promise of herd immunity for COVID-19 – Nature
Study: COVID-19 is at least 5 times deadlier than flu for hospitalized patients
23 Oct, 2020 | 09:09h | UTCCOVID-19 is at least 5 times deadlier than flu for hospitalized patients – LiveScience
Commentary on Twitter
Patients hospitalized in @VeteransHealth facilities for #COVID19 were at higher risk for serious complications and death than those hospitalized for flu, a new MMWR report finds. Learn more: https://t.co/66ry7TJon4. pic.twitter.com/rCKMsVS03b
— CDC (@CDCgov) October 20, 2020