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ACR Guidance for pediatric patients with multisystem inflammatory syndrome in children associated with SARS‐CoV‐2
16 Dec, 2020 | 09:32h | UTC
Report: Lung transplantation for 3 patients with severe COVID-19
16 Dec, 2020 | 09:34h | UTCLung transplantation for patients with severe COVID-19 – Science Translational Medicine
Commentaries: COVID-19 can damage lungs so badly that ‘only hope’ is transplant – MedicalXpress
Commentary on Twitter
Case reports from 3 patients with severe #COVID19 who received lung transplants show the disease can cause extensive lung damage similar to that seen in pulmonary #fibrosis, and hints transplantation may be a viable treatment. @NUFeinbergMed @ScienceTM https://t.co/wXi0tx8gFg pic.twitter.com/vyerJLlJxi
— Science Magazine (@ScienceMagazine) November 30, 2020
Consensus Guideline: Defining and managing COVID-19-associated pulmonary aspergillosis
15 Dec, 2020 | 01:42h | UTC
Perspective: How Science Beat the Virus – And what it lost in the process
15 Dec, 2020 | 01:40h | UTCHow Science Beat the Virus – The Atlantic
Commentary from the author on Twitter (thread – click for more)
🚨I wrote the Atlantic’s next cover story on the COVIDization of science. No other disease has been scrutinized so intensely, by so much combined intellect, in so brief a time. This piece is about both the victories achieved & the weaknesses exposed. 1/ https://t.co/RbL9mVHhEv
— Ed Yong is not here (@edyong209) December 14, 2020
The coronavirus at 1: A year into the pandemic, what scientists know about how it spreads, infects, and sickens
15 Dec, 2020 | 01:42h | UTC
News Release: The Sputnik V vaccine’s efficacy is confirmed at 91.4% based on data analysis of the final control point of clinical trials
15 Dec, 2020 | 01:36h | UTC
[Preprint] RECOVERY trial: Azithromycin does not improve outcomes in hospitalized patients with COVID-19
15 Dec, 2020 | 01:44h | UTCNews release: RECOVERY trial finds no benefit from azithromycin in patients hospitalised with COVID-19
Commentary on Twitter
New RECOVERY result. In patients hospitalised with COVID-19, azithromycin did not provide any clinical benefit. 28 day mortality (19% vs 19%) (rate ratio 1·00; 95% confidence interval [CI] 0·90-1·12; p=0·99). No effect on secondary outcomes either.https://t.co/PTklz40WKr pic.twitter.com/NCzvRIND0S
— Peter Horby @peterhorby.bsky.social (@PeterHorby) December 14, 2020
Arab nations first to approve Chinese COVID vaccine — despite lack of public data
15 Dec, 2020 | 01:38h | UTCArab nations first to approve Chinese COVID vaccine — despite lack of public data – Nature
A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters
15 Dec, 2020 | 01:34h | UTCCommentary: Kids likely not driving household COVID-19 outbreaks – CIDRAP
Study: Children and adults equally susceptible to in-home COVID-19 spread, but children generally had less frequent and severe symptoms
15 Dec, 2020 | 01:36h | UTCCommentaries: Study: Kids, adults equally susceptible to in-home COVID-19 spread – CIDRAP AND COVID-19 in Children: Looking Forward, Not Back
WHO, UNICEF Report: Almost 2 billion people depend on health care facilities without basic water services
15 Dec, 2020 | 01:33h | UTC
Brazilian Cardio-oncology Guideline – 2020
15 Dec, 2020 | 01:31h | UTCBrazilian Cardio-oncology Guideline – 2020 – Arquivos Brasileiros de Cardiologia
Randomized trial: Among patients with advanced rectal cancer, short-course radiotherapy followed by chemotherapy before total mesorectal excision reduces disease-related treatment failure compared to standard treatment
15 Dec, 2020 | 01:29h | UTC
Commentary on Twitter
New online: phase 3 RAPIDO trial: Short-course #radiotherapy followed by #chemotherapy before total mesorectal excision (TME) vs standard of care in locally advanced #rectalcancer https://t.co/bTgUC6Lo39 #crcsm pic.twitter.com/Iu3HbQ1xjG
— The Lancet Oncology (@TheLancetOncol) December 8, 2020
AHA Scientific Statement: Menopause transition and cardiovascular disease risk
15 Dec, 2020 | 01:32h | UTCNews release: Heart disease risk in women increases leading up to menopause; early intervention is key – American Heart Association
Top Things to Know: Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention
Commentaries: Menopause Transition and Cardiovascular Health: Time Matters – American Heart Association AND Report on latest menopause science looks at heart risks – American Heart Association AND Menopause Transition and CVD Risk: AHA Scientific Statement – American College of Cardiology
Critical review: “I’m upset about the RELAX trial” (study showing a lower PEEP strategy is noninferior to a higher PEEP strategy in ICU patients without ARDS)
15 Dec, 2020 | 01:27h | UTCI’m upset about the RELAX trial – PulmCrit
Original study and commentaries: Randomized trial: Among patients in the ICU receiving invasive ventilation, a strategy with lower PEEP was noninferior to a strategy using higher PEEP
Commentary from the author on Twitter
RELAX trial
🧘♂️PEEP 8 cm vs. lowest possible PEEP (as low as zero!) among patients without ARDS
🧘♂️no difference in primary endpoints
🧘♂️low-PEEP caused lower PO2/FiO2 ratios, higher driving pressures, more need for rescue therapy 👎https://t.co/fGFiQyn3jY pic.twitter.com/yi2hN3yBZi— 𝙟𝙤𝙨𝙝 𝙛𝙖𝙧𝙠𝙖𝙨 💊 (@PulmCrit) December 14, 2020
Randomized trial: In acutely ill children, the risk of electrolyte disorders is markedly increased with plasmalike isotonic fluid therapy compared with moderately hypotonic fluid therapy containing 20 mmol/L of potassium
15 Dec, 2020 | 01:25h | UTCRisk of Electrolyte Disorders in Acutely Ill Children Receiving Commercially Available Plasmalike Isotonic Fluids: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)
Commentary: Isotonic Fluids Without Potassium Could Be Harmful for Some Acutely Ill Kids – Medscape (free registration required)
Commentary on Twitter
A randomized pragmatic clinical trial shows a high risk of #hypokalemia and a small risk of #hypernatremia in acutely ill children receiving plasma-like fluid therapy https://t.co/FOoJeaSSes @TerhiTapiainen
— JAMA Pediatrics (@JAMAPediatrics) October 27, 2020
Randomized trial: Among women with urinary incontinence, biofeedback-mediated intensive pelvic floor training does not provide additional benefit to basic pelvic floor muscle training
15 Dec, 2020 | 01:23h | UTC
Meta-analysis: Induction of labor at 41 weeks improves perinatal outcomes compared with expectant management until 42 weeks, without increasing the cesarean delivery rate
15 Dec, 2020 | 01:21h | UTC
Randomized trial: Baricitinib plus remdesivir reduce recovery time in patients with COVID-19
13 Dec, 2020 | 23:31h | UTCBaricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine
Commentary: Baricitinib plus remdesivir shows promise for treating COVID-19 – NIH News Releases
Commentary on Twitter
Not sure how to interpret a trial for a drug plus Remdesivir vs Remdesivir alone when you don't know if Remdesivir works. @NEJM today for this combo, which has already received FDA EUAhttps://t.co/tpmHPFPJX1 pic.twitter.com/Tmue99oJnV
— Eric Topol (@EricTopol) December 11, 2020
Podcast: Management of Cellulitis
15 Dec, 2020 | 01:20h | UTC
Call for action: Managing the infodemic – A global movement to promote access to health information and mitigate harm from health misinformation among online and offline communities
13 Dec, 2020 | 23:34h | UTCCall for Action: Managing the Infodemic – World Health Organization
See also: Infodemic Management – World Health Organization AND Tips for professional reporting on COVID-19 vaccines – World Health Organization
Meta-analysis: Efficacy and harms of remdesivir for the treatment of COVID-19. “Until stronger evidence emerges, we cannot conclude that remdesivir is efficacious for treating COVID-19”.
13 Dec, 2020 | 23:27h | UTC
Video: Coronavirus vaccine update with Anthony Fauci
13 Dec, 2020 | 23:25h | UTCCoronavirus Vaccine Update With Anthony Fauci – JAMA
A systematic review of corticosteroid treatment for noncritically ill patients with COVID-19 – corticosteroid treatment is not recommended for patients with mild or moderate COVID-19
13 Dec, 2020 | 23:26h | UTC
Fauci says herd immunity possible by fall, ‘normality’ by end of 2021
13 Dec, 2020 | 23:23h | UTCFauci says herd immunity possible by fall, ‘normality’ by end of 2021 – The Harvard Gazette