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Loss of smell in mild Covid-19 cases occurs 86% of the time, study says
13 Jan, 2021 | 02:20h | UTCLoss of smell in mild Covid-19 cases occurs 86% of the time, study says – CNN
Original study: Prevalence and 6‐month recovery of olfactory dysfunction: a multicentre study of 1363 COVID‐19 patients – Journal of Internal Medicine
Pregnant women & vaccines against emerging epidemic threats: Ethics guidance for preparedness, research, and response
13 Jan, 2021 | 02:10h | UTC
Commentaries on Twitter
New paper via our PREVENT Group w 22 concrete recs that provide a roadmap for the ethically responsible, socially just, & respectful inclusion of the interests of pregnant women in the development & deployment of vaccines against emerging pathogens. https://t.co/tp6gt20dh0
— Ruth Faden (@fadenethx) May 6, 2019
Infectious disease outbreaks can severely affect the health interests of pregnant women and their babies. PREVENT's guidance promotes the inclusion of pregnant women in the development and deployment of vaccines against emerging pathogens ➡️ https://t.co/P8IKXCU8tI pic.twitter.com/LYDHfQ2f9y
— CEPI (@CEPIvaccines) May 13, 2019
Randomized trial: Stable supportive shoes improve knee osteoarthritis symptoms when compared to flat flexible shoes
13 Jan, 2021 | 02:08h | UTCThe Effect of Flat Flexible Versus Stable Supportive Shoes on Knee Osteoarthritis Symptoms: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Summary for Patients: The Effect of Flat Flexible Versus Stable Supportive Shoes on Knee Osteoarthritis Symptoms
Commentary: Stable, Supportive Shoes Better for Knee Osteoarthritis Pain – NEJM Journal Watch
Inferring the effectiveness of government interventions against COVID-19
13 Jan, 2021 | 02:17h | UTCInferring the effectiveness of government interventions against COVID-19 – Science
Commentary on Twitter
Do we really need #StayAtHome orders?
New @ScienceMagazine modeling explores what really works around the globe.
TL;DR: the answer is no. Targeted efforts work; the effect of stay at home is small👍https://t.co/Km7kfWyVUJ by @JanMBrauner @jankulveitb @OATML_Oxford @fhioxford pic.twitter.com/Uo0lhZD5WR— Eric Topol (@EricTopol) December 15, 2020
ACP Policy Paper: A comprehensive policy framework to understand and address disparities and discrimination in health and health care
13 Jan, 2021 | 02:07h | UTCCommentary: ACP releases policy to address disparities, discrimination in health care – ACP Internist
Covid-19: Breastfeeding women can have vaccine after guidance turnaround
13 Jan, 2021 | 02:11h | UTCCovid-19: Breastfeeding women can have vaccine after guidance turnaround – The BMJ
Related opinion: Why were breastfeeding women denied the covid-19 vaccine? – The BMJ
2021 ACC Expert consensus decision pathway for optimization of heart failure treatment
13 Jan, 2021 | 02:01h | UTCCommentary: ACC Issues Updated Guidance For Managing Patients With HFrEF – American College of Cardiology
2021 ACC Expert Consensus: Same-day discharge after percutaneous coronary intervention
13 Jan, 2021 | 02:05h | UTCCommentaries: 2021 ACC Expert Decision Pathway on Same-Day Discharge After PCI – American College of Cardiology AND Checklist for Same-Day Discharge PCI Stresses Buy-In, and a Plan – TCTMD AND Same-Day Discharge After PCI: ACC Expert Consensus Decision Pathway – Cardiology Advisor AND Ticking all the right boxes for same-day discharge PCI – MDedge Cardiology
Case series: Safety of same‐day discharge after uncomplicated, minimalist transcatheter aortic valve replacement in the COVID‐19 era
13 Jan, 2021 | 02:03h | UTCCommentary: Pandemic Prompts Closer Look at Same-Day Discharge After TAVI – TCTMD
Commentary on Twitter
With dwindling hospital capacity from #COVID19, study of safety of same‐day discharge after #TAVR @emoryhealthcare available via @CCIJournal. SDD after uncomplicated #TAVR in selected patients may open beds & prevent unnecessary CV morbidity. https://t.co/fuTdVUrFu5
— Chandan Devireddy (@drdevireddy) December 31, 2020
HEAR or HEART Pathway – Can We Drop Troponin?
13 Jan, 2021 | 01:59h | UTCHEAR or HEART Pathway – Can We Drop Troponin? – Journal Feed
Original Study: Identification of very low-risk acute chest pain patients without troponin testing – Emergency Medicine Journal
Systematic review: Acute treatments for episodic migraine
13 Jan, 2021 | 01:56h | UTCAcute Treatments for Episodic Migraine – Agency for Healthcare Research and Quality
Full text: Acute Treatments for Episodic Migraine
Evidence summary: Acute Treatments for Episodic Migraine
The Pharmacologic Treatment of Schizophrenia—2021
13 Jan, 2021 | 01:53h | UTCThe Pharmacologic Treatment of Schizophrenia—2021 – JAMA (free for a limited period)
Commentary on Twitter
Available treatments have transformed lives of people with schizophrenia, allowing many to live in the community & function independently. However, considerable unmet needs remain due to symptoms refractory to treatment, and adverse effects. @nyulangone https://t.co/tRh1fG6DMD
— JAMA Psychiatry (@JAMAPsych) January 9, 2021
Systematic review: Treatments for acute pain
13 Jan, 2021 | 01:55h | UTCTreatments for Acute Pain: A Systematic Review – Agency for Healthcare Research and Quality
Full text: Treatments for Acute Pain
Evidence summary: Treatments for Acute Pain
Systematic review: There is no evidence that Souvenaid is useful for preventing dementia or provide benefit for patients with Alzheimer’s disease
13 Jan, 2021 | 01:47h | UTCSouvenaid for Alzheimer’s disease – Cochrane Library
Randomized trial: Effect of therapeutic suggestions during general anesthesia on postoperative pain and opioid use
13 Jan, 2021 | 01:51h | UTCCommentaries: Can we sooth the subconscious during general anaesthesia? – The BMJ AND Ernil Hansen: Soothing words and music during surgery might reduce postoperative pain – The BMJ Opinion AND Soothing words and music during surgery might reduce postoperative pain – The BMJ
Commentary on Twitter
Therapeutic suggestions played through earphones during general anaesthesia could provide a safe, feasible, inexpensive, and non-drug technique to reduce postoperative pain and opioid use, suggests new research https://t.co/LpTBnBbcT9
— The BMJ (@bmj_latest) December 13, 2020
AASM Guideline: Behavioral and psychological treatments for chronic insomnia disorder in adults
13 Jan, 2021 | 01:58h | UTCCommentary: New guideline encourages use of cognitive behavioral therapy for insomnia in adults – ACP Internist
Observational study: Surgical decompression within 24 h of acute spinal cord injury is associated with improved sensorimotor recovery
13 Jan, 2021 | 01:49h | UTCThe influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data – The Lancet Neurology (link to abstract – $ for full-text)
Commentary on Twitter
.@TheLancetNeuro Surgical decompression within one day of acute #spinalcordinjury is linked with improved sensorimotor recovery. The first 24-36 hours following injury seem to represent a crucial time frame to reach optimal #neurological recovery. @UofT https://t.co/Fi53K2YKBk pic.twitter.com/RDESblOgoM
— Neurology Today (@NeurologyToday) December 28, 2020
USPSTF recommends screening for Hepatitis B Virus infection in adolescents and adults
13 Jan, 2021 | 01:43h | UTCAuthor Interview: USPSTF Recommendation: Screening for Hepatitis B Virus Infection in Adolescents and Adults
Patient Page: Screening for Hepatitis B in Nonpregnant Adolescents and Adults – JAMA
Systematic review: Treatment with antenatal corticosteroids in women at risk of preterm birth reduces the risk of perinatal death, neonatal death, respiratory distress syndrome, and the risk of intraventricular hemorrhage
13 Jan, 2021 | 01:46h | UTC
Podcast: Nephrotic Syndrome vs. Glomerulonephritis
13 Jan, 2021 | 01:44h | UTC
Randomized trial: Adjuvant capecitabine in triple-negative breast cancer
13 Jan, 2021 | 01:40h | UTCCommentaries: Capecitabine maintenance may improve TNBC outcomes – medwire News
Commentary on Twitter
In this RCT, low-dose #capecitabine maintenance therapy for 1y resulted in improved 5-y disease-free survival vs observation among women with early-stage triple-negative breast cancer who received standard adjuvant treatment https://t.co/sIgxUSjaYe #BCSM #SABCS20 #VisualAbstract
— JAMA (@JAMA_current) January 6, 2021
Systematic review: Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy
13 Jan, 2021 | 01:37h | UTC
Cohort study: Concomitant use of gabapentinoids with opioids linked to increased risk of opioid overdose and other opioid-related adverse events
13 Jan, 2021 | 01:42h | UTCCommentaries: Exploring the Combination of Gabapentinoids and Opioids for Postoperative Analgesia – JAMA Network Open AND Gabapentinoids Plus Opioids Up Overdose Risk After Surgery – MedPage Today
Commentary on Twitter
🆕 Postop concomitant use of #gabapentinoids with #opioids was associated with
👉🏼⬆️ risk of opioid overdose
👉🏼⬆️ opioid-related adverse events
🎯The absolute risk of adverse events was low.@JAMA_current @JAMASurgery
@amit_pawa @KalagaraHari @Ropivacainehttps://t.co/aw3cig2Rp8— Samer Narouze,MD,PhD,MMM (@NarouzeMD) December 30, 2020
Blood plasma treatment has limited effect for sickest COVID-19 patients
12 Jan, 2021 | 02:07h | UTCBlood plasma treatment has limited effect for sickest COVID-19 patients – Imperial College London
See also: Expert reaction to REMAP-CAP recruitment of severely ill COVID-19 patients into convalescent plasma trial being paused after initial analysis suggested it did not improve outcomes – Science Media Centre AND Trial of COVID-19 blood plasma finds no benefit in severely ill patients – Reuters
Randomized trial: Plasma therapy administered early is beneficial in high-risk elderly patients
12 Jan, 2021 | 02:05h | UTCCommentaries: Early convalescent plasma may lower risk of severe COVID in seniors – CIDRAP AND Covid-19: Early Plasma Treatment Improved Outcomes in Older Patients – Physician’s Weekly
Commentaries on Twitter
Just published @NEJM: A small, placebo-controlled randomized trial (N=160) of high IgG titer convalescent plasma administered early (within 72 hrs) for mild covid-19 to older adults (median age >70) shows benefit https://t.co/dhyFH4OwpH pic.twitter.com/14lMBBofUh
— Eric Topol (@EricTopol) January 6, 2021
Early convalescent plasma may lower risk of severe COVID in seniors@NEJM study finds that 16% of those treated with high-titer convalescent therapy developed severe #COVID19, compared with 31% in the placebo grouphttps://t.co/7hqCXsNHDM pic.twitter.com/dZDUwcjxUh
— CIDRAP (@CIDRAP) January 6, 2021