All Posts
ESMO Guideline | Prognostic evaluation in patients with advanced cancer in the last months of life
26 Apr, 2023 | 14:07h | UTC
Cohort Study | Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer
26 Apr, 2023 | 14:05h | UTCNews Release: Previous cancer linked to long term heightened risk of CVD – BMJ Newsroom
Perspective | N-of-1 trials in cancer drug development
26 Apr, 2023 | 14:06h | UTCN-of-1 Trials in Cancer Drug Development – Cancer Discovery
Commentary on Twitter
⭐️Just published in @AACR 's highest impact journal Cancer Discovery this week for your #FridayMotivation –> "N-of-1 Trials in Cancer Drug Development"
We propose N-of-1 trials as a departure from the traditional “drug-centric” model to a “patient-centric” model.
N-of-1 trials… pic.twitter.com/Set2jTpTBO— Vivek Subbiah, MD (@VivekSubbiah) April 21, 2023
PEEP-test study | The increase in cardiac output induced by a decrease in PEEP reliably detects volume responsiveness
26 Apr, 2023 | 14:03h | UTC
RCT | The effectiveness of early surgical stabilization for multiple rib fractures
26 Apr, 2023 | 14:01h | UTCRelated:
RCT | Operative vs. nonoperative treatment of acute unstable chest wall injuries.
RCT | Rib fixation is not beneficial for non–ventilator-dependent chest wall injuries.
M-A | Prevalence of atypical pathogens in patients with severe pneumonia
26 Apr, 2023 | 14:02h | UTC
Review | What the clinician needs to know about medical nutrition therapy in critically ill patients in 2023
26 Apr, 2023 | 13:59h | UTC
RCT | Trastuzumab deruxtecan versus treatment of physician’s choice in patients with HER2-positive metastatic breast cancer
26 Apr, 2023 | 13:57h | UTCTrastuzumab deruxtecan versus treatment of physician’s choice in patients with HER2-positive metastatic breast cancer (DESTINY-Breast02): a randomised, open-label, multicentre, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT | Anti-TNF in combination with low dose methotrexate vs anti-TNF monotherapy in pediatric Crohn’s disease
26 Apr, 2023 | 13:55h | UTCComparative Effectiveness of Anti-TNF in Combination with Low Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn’s Disease: a Pragmatic Randomized Trial – Gastroenterology (link to abstract – $ for full-text)
M-A | Efficacy of erector spinae plane block for postoperative analgesia lumbar surgery
26 Apr, 2023 | 13:53h | UTC
RCT | Endosonography with or without confirmatory mediastinoscopy for resectable lung cancer
26 Apr, 2023 | 13:56h | UTC
AGA Practical Guidance | Diagnosis and management of extraesophageal gastroesophageal reflux disease
25 Apr, 2023 | 14:50h | UTCCommentary: Guidance offered on management of extraesophageal GERD – ACP Gastroenterology
Commentary on Twitter (thread – click for more)
Looking for guidance on management of extraesophageal reflux?? Check out our Best Practice Advice in the latest AGA Clinical Practice Update on Management of EER @AGA_CGH. @AmerGastroAssn
Read the article➡️:https://t.co/S6WYsQUoTj pic.twitter.com/UqjDR2JXP8
— Joan Chen, MD MS (@joanwchen) April 19, 2023
Review | New treatment paradigms in primary biliary cholangitis
26 Apr, 2023 | 13:49h | UTCNew Treatment Paradigms in Primary Biliary Cholangitis – Clinical Gastroenterology and Hepatology
ASCO Guideline Update | Venous thromboembolism prophylaxis and treatment in patients with cancer
25 Apr, 2023 | 14:49h | UTC
RCT | Effectiveness of an over-the-counter self-fitting hearing aid compared with an audiologist-fitted hearing aid
25 Apr, 2023 | 14:47h | UTCAuthor Interview: Effectiveness of Self-fitting vs Audiologist-Fitted Hearing Aids – JAMA
Commentaries:
Self-Fitting, Over-the-Counter Hearing Aids Beneficial – HealthDay
How Do Over-the-Counter Hearing Aids Compare with Those Fitted by Audiologists? – NEJM Journal Watch (free for a limited period)
Commentary on Twitter
Findings suggest that a self-fitting OTC hearing aid may be an effective intervention option for individuals with mild to moderate #hearingloss and produce self-perceived and clinical outcomes similar to those of an audiologist-fitted #hearingaid. https://t.co/Zbc8URj2uA
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) April 13, 2023
RCT | Cerebral oximetry monitoring fails to reduce death or severe brain injury in extremely preterm infants
25 Apr, 2023 | 14:45h | UTCCerebral Oximetry Monitoring in Extremely Preterm Infants – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In extremely preterm infants, the use of cerebral oximetry monitoring to guide treatment for the first 72 hours after birth did not reduce the risk of death or severe brain injury at 36 weeks’ postmenstrual age. Full study: https://t.co/JX7Ra3OpjM pic.twitter.com/VACbUUAq3i
— NEJM (@NEJM) April 19, 2023
Cohort Study | Impact of work schedules of senior resident physicians on patient and resident physician safety
25 Apr, 2023 | 14:43h | UTCNews Release: National Study of Resident Physicians Suggests Need for Federal Work Hour Guideline Changes – Brigham and Women’s Hospital
Commentaries:
Resident Doctors’ Long Work Shifts Could Bring Peril to Patients – HealthDay
SR | Cranberries can prevent recurrent urinary tract infections in selected patients
25 Apr, 2023 | 14:41h | UTCCranberries for preventing urinary tract infections – Cochrane Library
Summary: Cranberries for preventing urinary tract infections – Cochrane Library
Commentaries:
Cranberry juice can prevent recurrent UTIs, but only for some people – The Conversation
Review confirms that cranberry products help prevent urinary tract infections – News Medical
Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary
25 Apr, 2023 | 14:42h | UTCSummary: 2023 GOLD Guidelines for Chronic Obstructive Pulmonary Disease – NEJM Journal Watch (free for a limited period)
Original Guidance: 2023 GOLD REPORT: global strategy for prevention, diagnosis and management of COPD: 2023 Report – Global Initiative for Chronic Obstructive Lung Disease
M-A | Surgical versus non-surgical treatment for sciatica
25 Apr, 2023 | 14:39h | UTCEditorial: Early surgery for sciatica – The BMJ
News Release: Surgery for sciatica reduces leg pain and disability, but benefits are short-lived – University of Oxford
Commentary on Twitter
Very low to low certainty evidence suggests that discectomy was superior to non-surgical treatment or epidural steroid injections in reducing leg pain and disability in people with sciatica with a surgical indication, but the benefits reduced over timehttps://t.co/kHL2HBNscF
— The BMJ (@bmj_latest) April 19, 2023
Antiplatelet strategies following PCI: a review of trials informing current and future therapies
25 Apr, 2023 | 14:38h | UTC
Review | Risk stratification of low-risk prostate cancer: individualizing care in the era of active surveillance
25 Apr, 2023 | 14:35h | UTCRisk Stratification of Low-Risk Prostate Cancer: Individualizing Care in the Era of Active Surveillance – Journal of Urology (free PDF for a limited period)
Related:
Low-Value Prostate-Specific Antigen Screening in Older Males – JAMA Network Open
RCT | Patient-reported outcomes 12 years after different treatments for localized prostate cancer
RCT | Localized prostate cancer treatment options have similar 15-year survival outcomes
Perspective | Liver transplantation for patients with severe acute on chronic liver failure: it is time to change paradigms
25 Apr, 2023 | 14:37h | UTC
Commentary on Twitter
Liver #Tx in severe acute on chronic failure
➡️ #ICU care crucial in ACLF-3
➡️ improve referrals to LT centers & pre-LT workup
➡️ to decide to put pt on waitlist consider donor shortage/collective utility of LT
➡️ identifying transplantability window
?️ https://t.co/VZxDyZ1k74 pic.twitter.com/6YOcd5rzMu— Intensive Care Medicine (@yourICM) April 19, 2023
Cardiovascular disease in testicular cancer survivors: Identification of risk factors and impact on quality of life
25 Apr, 2023 | 14:34h | UTC
Burden of typhoid and paratyphoid fever in India
25 Apr, 2023 | 14:32h | UTCBurden of Typhoid and Paratyphoid Fever in India – New England Journal of Medicine
Commentary on Twitter
From 2017 through 2020 in India, weekly surveillance for blood-confirmed typhoid and paratyphoid among children showed an incidence of 576 to 1173 cases of typhoid fever per 100,000 child-years in urban sites. Full NSSEFI study: https://t.co/BbweY5hVcQ#InfectiousDisease pic.twitter.com/S2D3bM29f5
— NEJM (@NEJM) April 19, 2023