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Editorial: The world needs a single naming system for coronavirus variants (geographic associations risk stigma)

27 Jan, 2021 | 01:24h | UTC

The world needs a single naming system for coronavirus variants – Nature

 

Opinion: Monoclonal antibodies yet to show important clinical benefit in patients with Covid-19

27 Jan, 2021 | 01:23h | UTC

Monoclonal Antibodies Yet To Show Important Clinical Benefit In Patients With Covid-19. A Review Of What We Know, Including The Latest Clinical Trial Data – Brief19

See also: PulmCrit Wee – Follow-up Bamlanivimab study unmasks statistical chicanery

 

[Press release – not published yet] Neutralizing antibodies bamlanivimab and etesevimab together reduced risk of COVID-19 hospitalizations and death by 70 percent

27 Jan, 2021 | 01:22h | UTC

New data show treatment with Lilly’s neutralizing antibodies bamlanivimab (LY-CoV555) and etesevimab (LY-CoV016) together reduced risk of COVID-19 hospitalizations and death by 70 percent – Lilly

Commentary: Lilly antibody combo therapy cuts risk of COVID-19 deaths – Reuters

 

Commentary on Twitter

 

WHO Updated Guideline: COVID-19 clinical management

27 Jan, 2021 | 01:26h | UTC

COVID-19 Clinical management: living guidance – World Health Organization

News release: WHO recommends follow-up care, low-dose anticoagulants for COVID-19 patients

Commentary: WHO issues new clinical advice on treating COVID-19 patients – Reuters

 

[Press release – not published yet] REGENERON reports positive interim data with antibody cocktail used as passive vaccine to prevent COVID-19

27 Jan, 2021 | 01:21h | UTC

REGENERON REPORTS POSITIVE INTERIM DATA WITH REGEN-COV™ ANTIBODY COCKTAIL USED AS PASSIVE VACCINE TO PREVENT COVID-19

Commentaries: Regeneron’s antibody cocktail effective in preventing COVID-19 infection: study – Reuters AND Regeneron says monoclonal antibodies prevent Covid-19 in study – STAT AND Expert reaction to press release from Regeneron giving interim data from its REGEN-COV™ antibody cocktail trial for the prevention of COVID-19 in people at high risk of infection – Science Media Centre

 

Systematic review: Cardiopulmonary resuscitation in the prone position in the operating room or in the intensive care unit

27 Jan, 2021 | 01:14h | UTC

Cardiopulmonary Resuscitation in the Prone Position in the Operating Room or in the Intensive Care Unit: A Systematic Review – Anesthesia & Analgesia

 

Commentary on Twitter (thread – click for more)

https://twitter.com/IARS_Journals/status/1350827861016535043

 

Early warnings of COVID-19 outbreaks across Europe from social media

27 Jan, 2021 | 01:17h | UTC

Early warnings of COVID-19 outbreaks across Europe from social media – Scientific Reports

Commentary: COVID-19 warnings were on Twitter well before the outbreak of the pandemic – IMT School for Advanced Studies Lucca

 

Commentary on Twitter

 

Randomized trial: Remote, online support for blood pressure management at home is effective and low-cost

26 Jan, 2021 | 00:46h | UTC

Remote, online support for blood pressure management at home is effective and low-cost – University of Bristol

Original study: Home and Online Management and Evaluation of Blood Pressure (HOME BP) using a digital intervention in poorly controlled hypertension: randomised controlled trial – The BMJ

 

Commentary on Twitter

 

Israel sees 60% drop in hospitalizations for age 60-plus 3 weeks after 1st shot

27 Jan, 2021 | 01:19h | UTC

Israel sees 60% drop in hospitalizations for age 60-plus 3 weeks after 1st shot – The Times of Israel

Related: No serious COVID-19 cases among Israelis given Pfizer shot, minister says – Reuters

 

In a major setback, Merck to stop developing its two Covid-19 vaccines and focus on therapies

27 Jan, 2021 | 01:18h | UTC

In a major setback, Merck to stop developing its two Covid-19 vaccines and focus on therapies – STAT

 

10-year follow up of a randomized trial shows metabolic surgery is more effective than conventional medical therapy for the control of type 2 diabetes

26 Jan, 2021 | 00:44h | UTC

Metabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Gastrointestinal surgery can be a ‘cure’ for type 2 diabetes finds new long-term study – King’s College London

 

Podcast: Smoking Cessation Unfiltered

26 Jan, 2021 | 00:41h | UTC

#252 Smoking Cessation Unfiltered: Breaking the Chain with Medications and Behavioral Interventions – The Curbsiders Internal Medicine Podcast

 

Nurse Home Visiting and Maternal Mental Health: 3-Year Follow-Up of a Randomized Trial

26 Jan, 2021 | 00:42h | UTC

Nurse Home Visiting and Maternal Mental Health: 3-Year Follow-Up of a Randomized Trial – Pediatrics (link to abstract – $ for full-text)

 

Cohort study: Association of maternal autoimmune disease with Attention-Deficit/Hyperactivity Disorder in children

26 Jan, 2021 | 00:40h | UTC

Association of Maternal Autoimmune Disease With Attention-Deficit/Hyperactivity Disorder in Children – JAMA Pediatrics (free for a limited period)

Editorial: More Evidence Linking Autoimmune Diseases to Attention-Deficit/Hyperactivity Disorder (free for a limited period)

Commentary: Risk of ADHD may increase if expectant mother has autoimmune disorder, study says – CNN AND Study Suggests Maternal Autoimmune Disease Linked to ADHD in Children – Physician’s Weekly AND Maternal Autoimmune Diseases Linked to ADHD in Children – NEJM Journal Watch

 

Commentary on Twitter

 

Randomized trial: Clozapine vs. Olanzapine vs. Haloperidol in the treatment of violence in schizophrenia

26 Jan, 2021 | 00:33h | UTC

The Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Clozapine Found Most Effective to Reduce Aggression in Patients With Schizophrenia and Conduct Disorder – Psychiatric News Alert

 

Commentary on Twitter (thread – Click for more)

 

Cohort study: Association of potent and very potent topical corticosteroids and the risk of osteoporosis and major osteoporotic fractures

26 Jan, 2021 | 00:38h | UTC

Association of Potent and Very Potent Topical Corticosteroids and the Risk of Osteoporosis and Major Osteoporotic Fractures – JAMA Dermatology

Editorial: Topical Corticosteroids and Glucocorticoid-Induced Osteoporosis—Cumulative Dose and Duration Matter

Commentaries: Prolonged Use of Topical Steroids Associated with Increased Risk of Osteoporosis – Physician’s Weekly AND Potent Topical Corticosteroids Tied to Increased Fracture Risk – NEJM Journal Watch

Author Interview: Association of Topical Corticosteroids and Risk of Osteoporosis and Major Osteoporotic Fractures – JAMA

 

Commentary on Twitter

 

Preliminary study shows sitagliptin may prevent acute Graft-versus-Host Disease

26 Jan, 2021 | 00:35h | UTC

Dipeptidyl Peptidase 4 Inhibition for Prophylaxis of Acute Graft-versus-Host Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Sitagliptin promising addition for preventing acute GVHD – HealthDay

 

Cohort study: Aspirin linked to reduced risk of colon cancer if you start it before age 70

26 Jan, 2021 | 00:37h | UTC

Aspirin Use and Risk of Colorectal Cancer Among Older Adults – JAMA Oncology (free for a limited period)

Commentaries: Does aspirin lower colorectal cancer risk in older adults? It depends on when they start – Massachusetts General Hospital AND Aspirin Use Cuts CRC Risk in Those Initiating Use Before Age 70 – Physician’s Weekly

 

Randomized trial: In patients with colorectal peritoneal metastases, adding hyperthermic intraperitoneal chemotherapy to cytoreductive surgery does not improve survival and causes more frequent late complications

26 Jan, 2021 | 00:34h | UTC

Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

 

Commentary on Twitter

https://twitter.com/TheLancetOncol/status/1351469448264351752

 

Covid-19 vaccine tracker: The global race to vaccinate

26 Jan, 2021 | 00:59h | UTC

Covid-19 vaccine tracker: the global race to vaccinate – Financial Times

See also: Coronavirus (COVID-19) Vaccinations – Our World in Data

 

Commentary on Twitter

 

Report: UK variant of Coronavirus possibly more deadly

26 Jan, 2021 | 00:58h | UTC

NERVTAG paper on COVID-19 variant of concern B.1.1.7

Commentaries: Coronavirus: UK variant ‘may be more deadly’ – BBC AND CDC reviewing new data that suggests coronavirus variant identified in UK could be more deadly – CNN

 

Why scientists are more worried about the Covid-19 variant discovered in South Africa

26 Jan, 2021 | 00:56h | UTC

Why scientists are more worried about the Covid-19 variant discovered in South Africa – Vox

Original study (preprint and commentaries): South African COVID-19 variant escapes neutralization by antibodies in COVID-19 convalescent plasma

See also: Fast-spreading COVID variant can elude immune responses – Nature

 

Commentary on Twitter

 

[Press release – not published yet] Azithromycin and doxycycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial

26 Jan, 2021 | 01:03h | UTC

Azithromycin and doxcycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial – University of Oxford

See also: PRINCIPLE trial finds no benefit from antibiotics, azithromycin and doxycycline for COVID-19 patients – National Institute for Health Research

 

NCCN shares new guidance principles for vaccinating people with cancer against COVID-19

26 Jan, 2021 | 00:47h | UTC

NCCN Shares New Guidance Principles for Vaccinating People with Cancer Against COVID-19 – National Comprehensive Cancer Network

Original guideline: Preliminary Recommendations of the NCCN COVID-19 Vaccination Advisory Committee

Commentary: NCCN Shares New Recommendations for Vaccinating Patients With Cancer Against COVID-19 – The ASCO Post

 

Moderna COVID-19 vaccine may be less effective against variant found in South Africa

26 Jan, 2021 | 00:54h | UTC

Moderna Finds COVID-19 Vaccine Less Effective Against Variant Found In South Africa – NPR

Moderna Press release: Moderna COVID-19 Vaccine Retains Neutralizing Activity Against Emerging Variants First Identified in the U.K. and the Republic of South Africa

Preprint: mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants – bioRxiv

See also: Expert reaction to preprint from Moderna about neutralising activity of their vaccine against new variants and announcement of plans to trial a variant booster jab targeting the South African (B.1.351) variant – Science Media Centre AND Moderna Launches Trial For Covid-19 Vaccine Booster To Tackle South African Strain – Forbes

 

Commentary on Twitter

 

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