All Posts
RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19
12 Feb, 2021 | 02:25h | UTCNews release: Tocilizumab reduces deaths in patients hospitalised with COVID-19 – University of Oxford
Commentary: Tocilizumab cuts death rate in severe COVID-19, study finds – CIDRAP
Commentary on Twitter
👇RECOVERY pre-print:
Tocilizumab
– reduces mortality
– shortens hospital stay
– reduces progression to invasive mechanical ventilationClear benefits on top of corticosteroids
Good news!https://t.co/dal17tQG5b
— Martin Landray (@MartinLandray) February 11, 2021
Study: New B.1.1.7 variant does not result in more severe disease in children compared to the original strain
12 Feb, 2021 | 02:23h | UTC
Commentary on Twitter
There were recent concerns and media reports that B.1.1.7 has more effects in children and young adults than the ancestral strain. Here are new data to provide reassurance that's not the case @LancetChildAdol https://t.co/85Dj4tl2qq pic.twitter.com/YmNOeOhpTB
— Eric Topol (@EricTopol) February 11, 2021
Podcast: Does vaccination mean the end of masking and social distancing?
12 Feb, 2021 | 02:22h | UTCDoes Vaccination Mean the End of Masking and Social Distancing? – New England Journal of Medicine
Fully vaccinated people can skip Covid quarantines, CDC says
12 Feb, 2021 | 02:21h | UTCFully vaccinated people can skip Covid quarantines, CDC says – CNN
Video (6 min): A visual guide to the new coronavirus variants
12 Feb, 2021 | 02:20h | UTCA Visual Guide to the New Coronavirus Variants – Scientific American
Opinion: It’s time to consider vaccine mandates in high-risk settings
12 Feb, 2021 | 02:19h | UTCIt’s Time to Consider Vaccine Mandates in High-Risk Settings – Scientific American
Commentary on Twitter
It's Time to Consider #Vaccine Mandates in High-Risk Settings
"Leaving vaccination to individual choice is unacceptably high in places like #NursingHomes, #LongTermCare facilities and #Prisons"
Professors @doritmi @ArthurCaplan in @sciam https://t.co/km2PZPM5bK
— Paul Belcher *ON BLUESKY – DORMANT ON X* (@PaulJBelcher) January 28, 2021
Editorial: Covid-19 has amplified moral distress in medicine
12 Feb, 2021 | 02:16h | UTCCovid-19 has amplified moral distress in medicine – The BMJ
Related: Physicians aren’t ‘burning out.’ They’re suffering from moral injury – STAT
[Preprint] Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19
12 Feb, 2021 | 02:14h | UTCSix-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19 – medRxiv
Commentary: Covid linked to risk of mental illness and brain disorder, study suggests – The Guardian
Perspective: Mandating COVID-19 Vaccines—Ethical and Legal Considerations
12 Feb, 2021 | 02:18h | UTCMandating COVID-19 Vaccines – JAMA
Commentary on Twitter
Mandatory #COVID #vaccines are of intense interest. Now, in @JAMA_current, Dan Salmon @JohnsHopkinsSPH, @ProfHeidiLarson & I examine whether it's lawful & ethical. We cover mandates ordered by states, employers, schools, unis & as a condition of service. https://t.co/n9MQN3p1Wi pic.twitter.com/GmacRB5KKZ
— Lawrence Gostin (@LawrenceGostin) December 29, 2020
Pediatric eye injuries by hydroalcoholic gel in the context of the Covid-19 Pandemic
12 Feb, 2021 | 02:12h | UTCCase series: Hand Sanitizer–Induced Ocular Injury: A COVID-19 Hazard in Children – JAMA Ophthalmology
Invited commentary: Unintended Consequences of Hand Sanitizer Use in the Coronavirus Disease 2019 Pandemic – JAMA Ophthalmology
Do you need a checklist? There’s limited evidence but apparent potential for these tools in hospital medicine
12 Feb, 2021 | 01:59h | UTCDo you need a checklist? – ACP Hospitalist
Cohort study: First trimester prescription opioid use not associated with a substantial increase in risk for major congenital malformations
12 Feb, 2021 | 02:03h | UTC
SR: How accurate are tests (Xpert Ultra and Xpert MTB/RIF) for diagnosing extrapulmonary tuberculosis and rifampicin resistance?
12 Feb, 2021 | 01:55h | UTC
Commentary on Twitter
How accurate are tests for diagnosing #tuberculosis #TB outside the lungs and rifampicin resistance? This @Cochrane_IDG systematic review found that Xpert Ultra and Xpert MTB/RIF may be helpful in diagnosing extrapulmonary tuberculosis. https://t.co/H79gK5CcR0 pic.twitter.com/bVy88zNpqQ
— The Cochrane Library (@CochraneLibrary) February 5, 2021
Short-term exposure to ambient air pollution is associated with increased risk of myocardial infarction mortality
12 Feb, 2021 | 01:51h | UTCCommentaries: Acute Exposure to Air Pollution Can Trigger MI-Related Death – TCTMD AND Does Short-Term Air-Pollution Exposure Increase MI Mortality? – American College of Cardiology
SR: Plasma and cerebrospinal fluid ABeta42 for the differential diagnosis of Alzheimer’s disease dementia
12 Feb, 2021 | 01:53h | UTC
RCT: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults
11 Feb, 2021 | 02:09h | UTCOnce-Weekly Semaglutide in Adults with Overweight or Obesity – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Semaglutide Plus Lifestyle Change Shown Effective for Obesity – NEJM Journal Watch
Commentary on Twitter
This double-blind study randomly assigned adults with obesity without diabetes to 68 weeks of once-weekly subcutaneous semaglutide or placebo, plus lifestyle intervention. Semaglutide therapy was associated with sustained, clinically relevant weight reduction.
— NEJM (@NEJM) February 10, 2021
Randomized, cross-over trial: Compared to Mediterranean diet, a Low-fat vegan diet is better at improving body weight, lipid concentrations, and insulin sensitivity
11 Feb, 2021 | 01:56h | UTC
Commentary on Twitter
36-week randomized cross-over trial:
💥Low-fat plant-based diet reduced body weight, fat mass, and visceral fat, increased insulin sensitivity, and improved blood lipids, compared with a Mediterranean diet.https://t.co/ROJX9WYcix
— Danielle Belardo, MD (@DBelardoMD) February 6, 2021
ERS guidelines for the management of children and adolescents with bronchiectasis
11 Feb, 2021 | 02:05h | UTC
Near-equivalence in oncology: Generating evidence to support alternative cost-effective treatments
11 Feb, 2021 | 02:02h | UTC
Commentary on Twitter
Thoughtful piece with real implications for decreasing costs and improving access to cancer care – with particular relevance in low- and middle-resource settings although applicable in all settings. https://t.co/MkQx6Gzte4
— Julie Gralow (@jrgralow) February 10, 2021
RCT: The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults
11 Feb, 2021 | 01:58h | UTCThe effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults: A randomized controlled trial – The American Journal of Clinical Nutrition (link to abstract – $ for full-text)
Commentary on Twitter
Daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults: A randomized controlled trial https://t.co/sT81S8JfNs
No effect of protein supplementation in older persons, but lifting is good!
— Stuart Phillips (he/him) (@mackinprof) February 10, 2021
Meta-analysis: Chlorthalidone vs. hydrochlorothiazide
11 Feb, 2021 | 02:00h | UTCChlorthalidone versus hydrochlorothiazide: major cardiovascular events, blood pressure, left ventricular mass, and adverse effects – Journal of Hypertension (link to abstract – $ for full-text)
Commentary: Chlorthalidone Compared With HCTZ for MACE Reduction – Renal & Urology News
Red Yeast Rice for Hypercholesterolemia: JACC Focus Seminar
11 Feb, 2021 | 01:54h | UTC
Guidelines for extracorporeal cardiopulmonary resuscitation in children and adults
11 Feb, 2021 | 01:48h | UTCSee also: Pediatric Extracorporeal Cardiopulmonary Resuscitation ELSO Guidelines – ASAIO Journal
Commentary on Twitter
#ECPR in adults @ELSOOrg guidelines
🔸pt selection, timing & location
🔸rationale for VA #ECPR
🔸cannula/cannulation
🔸#ACLS modifications
🔸establishing #ECMO & specific post CA care
🔸coronary angiography/PCI & imaging
🔸weaning@asaiojournal #FOAMecmo https://t.co/uDrPuSTTpg pic.twitter.com/A1ri9mn56s— M Velia Antonini (@FOAMecmo) February 1, 2021
Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis
11 Feb, 2021 | 01:50h | UTCRelated: Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases AND Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text) AND Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text) AND Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients – Critical Care
Commentary on Twitter
🚨 New paper from our team @HopitalCochin ⤵️
New data supporting a drug-drug interaction between vancomycin and piperacillin ⚠️ increased risk of acute kidney injury | Great collab with @AdrienContejean
@KerneisSolen
Read more in @BSACandJAC ⤵️https://t.co/eQW5s52fOY@ABsteward— Laurent Chouchana (@LChouchana) February 1, 2021
RCT: Among patients undergoing transurethral resection of the prostate, it is safe to withhold antimicrobial prophylaxis for those without pre-operative pyuria or a pre-operative, indwelling catheter
11 Feb, 2021 | 01:52h | UTC