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Consensus guidelines on perioperative management of suspected malignant hyperthermia or susceptible patients

15 Feb, 2021 | 00:56h | UTC

Consensus guidelines on perioperative management of malignant hyperthermia suspected or susceptible patients from the European Malignant Hyperthermia Group – British Journal of Anaesthesia

 

Randomized trial: Procalcitonin to reduce long-term infection-associated adverse events in sepsis

15 Feb, 2021 | 00:43h | UTC

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial – American Journal of Respiratory and Critical Care Medicine

 

For patients with schizophrenia, five variables associated with everyday functioning

15 Feb, 2021 | 00:41h | UTC

For Patients With Schizophrenia, Five Variables Associated With Everyday Functioning – Psychiatric News Alert

Original study: Factors Associated With Real-Life Functioning in Persons With Schizophrenia in a 4-Year Follow-up Study of the Italian Network for Research on Psychoses – JAMA Psychiatry

 

Commentary on Twitter

 

CT angiography and MRI of hand vascular lesions: technical considerations and spectrum of imaging findings

15 Feb, 2021 | 00:38h | UTC

CT angiography and MRI of hand vascular lesions: technical considerations and spectrum of imaging findings – Insights into Imaging

 

6 Red Flags: Avoid becoming invisible in the dark reading room

15 Feb, 2021 | 00:40h | UTC

6 Red Flags: Avoid Becoming Invisible in the Dark Reading Room – Diagnostic Imaging

 

Cohort study: Early initiation of prophylactic anticoagulation linked to reduced mortality in patients admitted to hospital with Covid-19

15 Feb, 2021 | 01:18h | UTC

Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study – The BMJ

Commentaries: Preventive blood thinning drugs could reduce COVID hospital deaths – London School of Hygiene & Tropical Medicine AND Preventive blood thinning drugs linked to reduced risk of death in COVID-19 patients – The BMJ AND Expert reaction to a study looking at prophylactic anticoagulants as a treatment for hospitalised patients with COVID-19 – Science Media Centre AND

 

Commentary on Twitter

 

Take whatever COVID vaccine you can get. All of them stop death and hospitalization

15 Feb, 2021 | 01:17h | UTC

Take whatever COVID vaccine you can get. All of them stop death and hospitalization – USA Today

“All seven COVID-19 vaccines that have completed large efficacy trials — Pfizer, Moderna, Johnson & Johnson, Novavax, AstraZeneca, Sputnik V and Sinovac — appear to be 100% effective for serious complications. Not one vaccinated person has gotten sick enough to require hospitalization. Not a single vaccinated person has died of COVID-19.”

 

Small RCT: No effect from Zinc and Vitamin C supplementation among ambulatory patients with SARS-CoV-2 infection

15 Feb, 2021 | 01:20h | UTC

Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial – JAMA Network Open

Commentaries: Vitamin C, zinc don’t lessen Covid-19 symptoms, study finds – CNN AND Supplements for the Treatment of Mild COVID-19—Challenging Health Beliefs With Science From A to Z – JAMA Network Open AND Zinc, vitamin C show no effect for COVID-19 in small study – CIDRAP AND Expert reaction to a study looking at prophylactic anticoagulants as a treatment for hospitalised patients with COVID-19 – Science Media Centre

 

Commentary on Twitter

 

Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation, and deployment

15 Feb, 2021 | 01:14h | UTC

Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation, and deployment – The Lancet

Commentary: COVID vaccination potential will not be achieved without increased production, affordable pricing, global availability – The Lancet

 

Commentaries on Twitter

 

Limited transmission of COVID-19 from open schools but teachers were affected: Swedish study

15 Feb, 2021 | 01:11h | UTC

Limited transmission of COVID-19 from open schools but teachers were affected: Swedish study – Uppsala University

Original Study: The effects of school closures on SARS-CoV-2 among parents and teachers – Proceedings of the National Academy of Sciences

 

Commentary on Twitter

 

Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US

15 Feb, 2021 | 01:13h | UTC

Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021 – JAMA

Author interview: COVID-19 Vaccine Safety–Anaphylaxis and Allergic Reactions – JAMA

 

Commentary on Twitter

 

CDC says it’s safe to reopen schools — with proper precautions

15 Feb, 2021 | 01:09h | UTC

CDC says it’s safe to reopen schools — with proper precautions – Vox

See also: CDC Offers Clearest Guidance Yet For Reopening Schools – NPR

Guideline: Schools and Child Care Programs​ – Centers for Disease Control and Prevention

 

[Preprint] Covid-19 vaccination associated with reduced viral load, may reduce transmission

15 Feb, 2021 | 01:07h | UTC

Decreased SARS-CoV-2 viral load following vaccination – medRxiv

Commentary: COVID-19 vaccination associated with 3- to 5-fold reduction in viral load – News Medical

 

Increase aerosol transmission of Covid-19 with increased age and obesity

15 Feb, 2021 | 01:03h | UTC

Exhaled aerosol increases with COVID-19 infection, age, and obesity – Proceedings of the National Academy of Sciences

Commentary: Older, heavier adults possible ‘superspreaders’ of COVID-19, study finds – UPI AND Researchers unravel what makes someone a COVID-19 super-spreader – Tulane University

 

France’s health authority recommends single vaccine shot for people who have had COVID-19

15 Feb, 2021 | 01:02h | UTC

France’s health authority recommends single vaccine shot for people who have had COVID-19 – Euronews

See also: Covid: France says just one jab needed for previously infected – BBC

Related: Covid-19: People who have had infection might only need one dose of mRNA vaccine – The BMJ AND You’ve had COVID: maybe one dose of vaccine is enough, studies suggest – MedicalXpress

 

RCT: Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma

15 Feb, 2021 | 00:36h | UTC

Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Immunotherapy – targeted drug combination improves survival in advanced kidney cancer – Dana-Farber Cancer Institute

 

Commentary on Twitter

 

RCT: Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma

15 Feb, 2021 | 00:34h | UTC

Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: 2021 Genitourinary Cancers Symposium: Enfortumab Vedotin-ejfv Prolongs Survival in Patients With Metastatic Urothelial Carcinoma – The ASCO Post

 

RCT: A comparison of sunitinib with cabozantinib, crizotinib, and savolitinib for treatment of advanced papillary renal cell carcinoma

15 Feb, 2021 | 00:32h | UTC

A comparison of sunitinib with cabozantinib, crizotinib, and savolitinib for treatment of advanced papillary renal cell carcinoma: a randomised, open-label, phase 2 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Cabozantinib most effective treatment for metastatic papillary kidney cancer – MedicalXpress

 

RCT: Radiopharmaceutical therapy vs. cabazitaxel in patients with metastatic castration-resistant prostate cancer

15 Feb, 2021 | 00:29h | UTC

[177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Radionuclide Tx Wins in Third-Line Metastatic CRPC – MedPage Today

 

Updated U.S. Recommended Adult Immunization Schedule

12 Feb, 2021 | 02:07h | UTC

Recommended Adult Immunization Schedule, United States, 2021 – Annals of Internal Medicine

Summary: Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older — United States, 2021 – Centers for Disease Control and Prevention

 

Long-term data: No difference in cardiovascular mortality or morbidity with transdermal estradiol vs. LHRH agonists for androgen suppression in prostate cancer

15 Feb, 2021 | 00:31h | UTC

Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme – The Lancet (link to abstract – $ for full-text)

 

M-A: No link between blood pressure drugs and falls

12 Feb, 2021 | 02:05h | UTC

No link between blood pressure drugs and falls, finds study – University of Oxford

Original study: Association between antihypertensive treatment and adverse events: systematic review and meta-analysis – The BMJ

 

Commentary on Twitter (thread – click for more)

 

M-A: As consumer products, E-Cigarettes are not associated with increased smoking cessation, but may improve smoking cessation rates as a prescription therapy intervention

12 Feb, 2021 | 01:52h | UTC

E-Cigarette Use and Adult Cigarette Smoking Cessation: A Meta-Analysis – American Journal of Public Health

Invited Commentaries: E-Cigarettes: A Public Health Threat, Not a Population Health Intervention – American Journal of Public Health AND Reporting Certainty of Evidence on E-Cigarette Use for Adult Smoking Cessation – American Journal of Public Health AND Is Good Enough Good Enough? E-Cigarettes, Evidence, and Policy – American Journal of Public Health AND Should E-Cigarette Regulation Be Based on Randomized Trials or Observational Studies? – American Journal of Public Health AND

Commentary: E-cigarettes, as consumer products, do not help people quit smoking, study finds – University of California – San Francisco

Related: Updated Cochrane Review shows electronic cigarettes can help people quit smoking – Cochrane Library

 

RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections

12 Feb, 2021 | 02:02h | UTC

Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP

 

Cohort study: The use of macrolide antibiotics in pregnancy is not associated with an increased risk of major congenital malformations

12 Feb, 2021 | 02:04h | UTC

Association between use of macrolides in pregnancy and risk of major birth defects: nationwide, register based cohort study – The BMJ

 

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