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SARS-CoV-2 variants B.1.351 and P.1 can escape from therapeutic antibodies and evade antibodies induced by infection or mRNA vaccination

21 Mar, 2021 | 22:02h | UTC

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies – Cell

CDC Guidance for schools says students can now stay 3 feet apart, rather than 6

21 Mar, 2021 | 22:07h | UTC

CDC Guidance: CDC Updates Operational Strategy for K-12 Schools to Reflect New Evidence on Physical Distance in Classrooms – Centers for Disease Control and Prevention

Commentaries: CDC Says Schools Can Now Space Students 3 Feet Apart, Rather Than 6 – NPR AND CDC updates COVID school guidance, OKs 3-feet distancing – CIDRAP

Commentaries on Twitter

CDC: Children in elementary schools don't need to be kept 6-feet apart. In a major policy revision, federal health officials said only 3 feet of distance is required between young children in classrooms https://t.co/UBvES1T6ps

— delthia ricks 🔬 (@DelthiaRicks) March 19, 2021

Very happy CDC now recommending 3 feet spacing in schools: "The change is momentous .because many schools.. operate on part-time or hybrid schedules in order to reduce class sizes. A 3-foot rule would allow many more schools to open in person, full time."https://t.co/wR88jdUBgM

— Monica Gandhi MD, MPH (@MonicaGandhi9) March 19, 2021

[Preprint] Oxford/AstraZeneca and Pfizer/BioNTech vaccines probably can still neutralize P.1 strain of SARS-CoV-2, but at lower levels

21 Mar, 2021 | 21:55h | UTC

Antibody evasion by the Brazilian P.1 strain of SARS-CoV-2 – bioRxiv

Commentary: Existing COVID vaccines may protect against Brazilian variant – Oxford study – Reuters

B.1.351 strain of SARS-CoV-2 neutralization titer reduced 8- to 9-fold for Pfizer and AstraZeneca vaccinees. Convalescent plasma and therapeutic antibodies were less effective against this variant as well.

21 Mar, 2021 | 21:52h | UTC

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera – Cell

Bioethics | “Europe’s Vaccine Ethics Call: Do No Harm and Let More Die?”

21 Mar, 2021 | 21:50h | UTC

Europe’s Vaccine Ethics Call: Do No Harm and Let More Die? – The New York Times (free registration may be required)

Commentary on Twitter

Many bioethicists have a problem with how Europe halted use of the AstraZeneca vaccine. Keeping the vaccine available would have allowed people “to consensually protect themselves from a big risk by taking a very small one.” https://t.co/qctELhfFGI

— NYT Health (@NYTHealth) March 20, 2021

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review

21 Mar, 2021 | 21:49h | UTC

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review – Journal of the American College of Cardiologyv

Commentary on Twitter

@JACCJournals: We share a systematic summary of #anticcogulation,#antiplatelet, and #fibrinolysis #RCTs in #COVID19. Amazing work by @AzitaTalasaz and a stellar multidisciplinary team! Figs illustrate areas where we’ll have evidence, & the gaps. Link: https://t.co/t4ksxwjAze pic.twitter.com/0Th3OZBXOY

— Behnood Bikdeli (@bbikdeli) March 16, 2021

Modeling Study: Vaccination alone is unlikely to contain COVID-19 infections in UK

21 Mar, 2021 | 21:46h | UTC

Vaccination and non-pharmaceutical interventions for COVID-19: a mathematical modelling study – The Lancet Infectious Diseases

Commentaries: Risking further COVID-19 waves despite vaccination – The Lancet Infectious Diseases AND Vaccination alone is unlikely to contain COVID-19 infections in UK – The Lancet

Commentary on Twitter

Vaccination alone is unlikely to contain #COVID19 infections in UK, suggests modelling study in @TheLancetInfDis—gradual release of control measures, high vaccine uptake, and high efficacy vaccine essential to minimise future waves. https://t.co/zpbPsYVHS2 pic.twitter.com/v47v6ux4r6

— The Lancet (@TheLancet) March 19, 2021

Clinician Guide to COVID-19 diagnostics in children

21 Mar, 2021 | 21:48h | UTC

Clinician guide to COVID-19 diagnostics – ADC Education & Practice

RCT: A brief home-based parenting intervention to reduce behavior problems in young children

19 Mar, 2021 | 08:02h | UTC

A Brief Home-Based Parenting Intervention to Reduce Behavior Problems in Young Children: A Pragmatic Randomized Clinical Trial – JAMA Pediatrics

Diagnosing and treating brain tumors: reflections on the latest Cochrane evidence

19 Mar, 2021 | 08:06h | UTC

Diagnosing and treating brain tumours: reflections on the latest Cochrane evidence – Evidently Cochrane

Assessment of concordance and discordance among clinical studies posted as preprints and subsequently published in high-impact journals

19 Mar, 2021 | 08:08h | UTC

Assessment of Concordance and Discordance Among Clinical Studies Posted as Preprints and Subsequently Published in High-Impact Journals – JAMA Network Open

Cohort study: Fish consumption linked to reduced risk of major cardiovascular complications among patients with prior cardiovascular disease, but not in the general population

19 Mar, 2021 | 08:03h | UTC

Associations of Fish Consumption With Risk of Cardiovascular Disease and Mortality Among Individuals With or Without Vascular Disease From 58 Countries – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Study finds two servings of fish per week can help prevent recurrent heart disease – McMaster University

Author interview: Fish Consumption and Risk of Cardiovascular Disease or Mortality With or Without Vascular Disease

Fish intake of up to 175 grams (about 2 servings) weekly is associated with a lower risk of major cardiovascular events and overall mortality in high-risk individuals or patients with existing vascular disease, but not in the general population https://t.co/Jz9RTYtgSa

— JAMA Internal Medicine (@JAMAInternalMed) March 8, 2021

Cover Story | Interventional Management in Acute Type B and Type A Aortic Dissection

19 Mar, 2021 | 08:04h | UTC

Cover Story | Interventional Management in Acute Type B and Type A Aortic Dissection – Cardiology Magazine / American College of Cardiology

Podcast | Acute Otitis Media: Q-tips and Tricks

19 Mar, 2021 | 07:57h | UTC

Acute Otitis Media: Q-tips and Tricks – The Cribsiders Pediatric Medicine

Podcast | Addiction Medicine Triple Distilled

19 Mar, 2021 | 08:00h | UTC

#259 Addiction Medicine Triple Distilled – The Curbsiders

M-A: Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments

19 Mar, 2021 | 07:52h | UTC

Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments: a network meta‐analysis – Cochrane Library

Systematic Review: Umbilical vein injection for management of retained placenta

19 Mar, 2021 | 07:53h | UTC

Umbilical vein injection for management of retained placenta – Cochrane Library

Summary: Umbilical vein injection after childbirth for management of retained placenta – Cochrane Library

RCT: Intermediate-dose enoxaparin (1 mg/kg/d) not better than standard-dose prophylactic anticoagulation in patients with Covid-19 admitted to the intensive care unit

19 Mar, 2021 | 08:42h | UTC

Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial – JAMA

Editorial: Finding the Optimal Thromboprophylaxis Dose in Patients With COVID-19 – JAMA

Commentary on Twitter

Intermediate-dose prophylactic enoxaparin (1 mg/kg/d) had no effect on a primary composite outcome of adjudicated venous or arterial thrombosis, ECMO, or 30-d mortality vs standard dose enoxaparin among ICU patients w #COVID19 https://t.co/L6UdB31J7V

— JAMA (@JAMA_current) March 18, 2021