All Posts
RCT: Fixed (40 mg twice daily) or variable (0.5 mg/kg twice daily) dosing of prophylactic enoxaparin after surgical procedures
26 Mar, 2021 | 08:23h | UTCOptimal Dosing of Prophylactic Enoxaparin after Surgical Procedures: Results of the Double-Blind, Randomized, Controlled FIxed or Variable Enoxaparin (FIVE) Trial – Plastic and Reconstructive Surgery (link to abstract – $ for full-text)
RCT: Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc
25 Mar, 2021 | 08:12h | UTC
Commentary on Twitter
NEW RESEARCH—Surgical microdiscectomy and
transforaminal epidural steroid injection are similarly effective at reducing #pain and disability from #sciatica secondary to herniated lumbar disc https://t.co/xXOr1aOX8K #LancetRheumatology #OpenAccess pic.twitter.com/2CHh1YD2gm— The Lancet Rheumatology (@TheLancetRheum) March 19, 2021
Pushing back against U.S. health officials, AstraZeneca says new analysis confirms efficacy of its Covid-19 vaccine
26 Mar, 2021 | 09:01h | UTCNews release: AZD1222 US Phase III primary analysis confirms safety and efficacy – AstraZeneca
See also: Latest results put Oxford–AstraZeneca COVID vaccine back on track – Nature AND AstraZeneca’s absurd and unprecedented dispute with regulators, explained – Vox AND Expert reaction to press release from AstraZeneca announcing primary data on safety and efficacy from the US trial of the Oxford-AstraZeneca COVID-19 vaccine – Science Media Centre AND AstraZeneca says COVID-19 vaccine 76% effective in new analysis, to seek U.S. approval – Reuters AND AstraZeneca’s new data showing Covid vaccine slightly less effective than suggested doesn’t worry experts – The Guardian AND Latest AstraZeneca Report Supports Effectiveness Of COVID Vaccine – NPR
Practice Pointer: Remote management of Covid-19 using home pulse oximetry and virtual ward support
26 Mar, 2021 | 09:05h | UTCRemote management of covid-19 using home pulse oximetry and virtual ward support – The BMJ
Related: Virtual clinics are reassuring but sometimes daunting – The BMJ
Commentary on Twitter
https://twitter.com/trishgreenhalgh/status/1375110854094520322
Experts: 3-foot rule in schools problematic in light of COVID variants
26 Mar, 2021 | 08:56h | UTCExperts: 3-foot rule in schools problematic in light of COVID variants – CIDRAP
Related: CDC Guidance for schools says students can now stay 3 feet apart, rather than 6
RCT: Similar number of days free of respiratory support with helmet noninvasive ventilation vs. high-flow nasal oxygen in patients with COVID-19 and moderate to severe hypoxemic respiratory failure
26 Mar, 2021 | 09:02h | UTCEffect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Respiratory Support During the COVID-19 Pandemic: Is It Time to Consider Using a Helmet?
Video: Helmet Noninvasive Ventilation of COVID-19 Patients
Variant-proof vaccines — invest now for the next pandemic
26 Mar, 2021 | 08:48h | UTCVariant-proof vaccines — invest now for the next pandemic – Nature
Another study shows increased transmissibility of SARS-CoV-2 lineage B.1.1.7 with a 50% to 100% higher reproduction number
26 Mar, 2021 | 08:57h | UTCAssessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England – Nature
Related: Study confirms higher transmissibility of SARS-CoV-2 lineage B.1.1.7 (study and commentary)
Commentary on Twitter
Just published @nature: Transmissibility of the B.1.1.7 (UK) variant https://t.co/dsMge8bB83 "A substantial transmission advantage with a 50 to 100% higher reproduction number"
Secondary attack rates were 30-40% higher than ancestral strain (non-VOC); no age gradient by modeling pic.twitter.com/870A3PojyF— Eric Topol (@EricTopol) March 25, 2021
The first and second waves of the COVID-19 pandemic in Africa: a cross-sectional study
26 Mar, 2021 | 08:44h | UTCThe first and second waves of the COVID-19 pandemic in Africa: a cross-sectional study – The Lancet
Commentary: Africa needs local solutions to face the COVID-19 pandemic – The Lancet
Commentary on Twitter (thread – click for more)
NEW—Continent-wide analysis suggests 30% increase in daily #COVID19 infections during rise of Africa's second wave compared with peak of the first. Authors urge improved data reporting, testing capacity, and renewed adherence to public health measures. https://t.co/bQq2F1Zrg0 pic.twitter.com/5TTSW7mkzF
— The Lancet (@TheLancet) March 25, 2021
Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)
26 Mar, 2021 | 08:53h | UTCCovid: The London bus trip that saved maybe a million lives – BBC
Related: Covid-19: The Inside Story of the RECOVERY Trial
Commentary on Twitter
Very cool story by @JamesTGallagher about a convo on a London bus that led to the creation of the RECOVERY trial, which has been a shining (& too rare) example of how to do critical research in a pandemic. Bravo @PeterHorby & @MartinLandray h/t @hildabast https://t.co/BRSJLSFXdc
— Helen Branswell 🇨🇦 (@HelenBranswell) March 25, 2021
Perspective | The emerging plasticity of SARS-CoV-2
26 Mar, 2021 | 08:47h | UTCThe emerging plasticity of SARS-CoV-2 – Science
M-A: Incidence and prevalence of tuberculosis in incarcerated populations
25 Mar, 2021 | 08:09h | UTCCommentary: Tuberculosis in prisons: an unintended sentence? – The Lancet Public Health
Commentary on Twitter (thread – click for more)
https://twitter.com/LeoMarti_EpiTB/status/1374073141195014145
[Press release – not published yet] Trial of multi drug-resistant TB treatment ends enrolment early after independent board indicates new regimen is superior
25 Mar, 2021 | 08:10h | UTC
Commentary on Twitter
Promising news improving treatment #MDR #TB https://t.co/Lxjb7LBofy Translating findings to available drugs & diagnostics back it up will be key pic.twitter.com/YGp8d9ixww
— Michael Marks (@dr_michaelmarks) March 24, 2021
Modeling study suggest patients should receive COVID-19 vaccine before surgery to reduce the risk of death
26 Mar, 2021 | 08:43h | UTCSee also: Infographic and Video
Commentary on Twitter
New from @CovidSurg–@GlobalSurg
🔸Vaccination significantly reduces death after elective surgery
🔸Fewer surgical patients need to be vaccinated than people in general population to save one life
▶️Prioritise elective surgery patients for vaccination
🆓https://t.co/iOUSixD6Cr pic.twitter.com/PTbOMoVPFl
— Dmitri Nepogodiev (@dnepo) March 25, 2021
M-A: Outpatient Cervical Ripening
25 Mar, 2021 | 08:07h | UTCOutpatient Cervical Ripening: A Systematic Review and Meta-analysis – Obstetrics & Gynecology
RCT: Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures
25 Mar, 2021 | 08:04h | UTCEffect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Viewpoint | Precision Dosing: A Clinical and Public Health Imperative
25 Mar, 2021 | 07:40h | UTCPrecision Dosing: A Clinical and Public Health Imperative – JAMA
Author interview: Precision Dosing—A Clinical and Public Health Imperative
USPSTF Statement: Current evidence is insufficient to recommend screening for hearing loss in older adults
24 Mar, 2021 | 08:12h | UTCScreening for Hearing Loss in Older Adults – U.S. Preventive Services Task Force
Editorial: Screening for Hearing Loss in Older Adults: Insufficient Evidence Does Not Mean Insufficient Benefit – JAMA AND United States Preventive Services Task Force Recommendation for Hearing-Loss Screening Among Older Adults: An Opportunity in Insufficient Evidence – AMA Otolaryngology-Head & Neck Surgery AND USPSTF Recommendations for Hearing Loss Screening in Asymptomatic Older Adults—A Case of Missing Evidence and Missing Treatment Options – JAMA Network Open
Evidence Report: Screening for Hearing Loss in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA
Author interview: USPSTF Recommendation: Screening for Hearing Loss in Older Adults – JAMA
JAMA Patient Page: Screening for Hearing Loss in Older Adults
Review: Use of urine electrolytes and urine osmolality in the clinical diagnosis of fluid, electrolytes, and acid-base disorders
25 Mar, 2021 | 08:06h | UTC
Commentary on Twitter
Do people use Urine K/crt ratio? for K disorders? What about FeK? TTKG is out! @askrenal –this flow chart makes sense to me https://t.co/8o8a7VYTMQ pic.twitter.com/UVZiFPo4vK
— Kenar Jhaveri (@kdjhaveri) February 20, 2021
RCT: Aspirin NOT noninferior to vitamin K antagonists in the treatment of cervical artery dissection
24 Mar, 2021 | 08:09h | UTCAspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial – The Lancet Neurology (link to abstract – $ for full-text)
International study describes peri-intubation incidence of adverse events in critically ill patients
24 Mar, 2021 | 08:08h | UTCIntubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries – JAMA (free for a limited period)
Editorial: International Variation in Intubation and Extubation Practices and Adverse Events Among Critically Ill Patients Receiving Mechanical Ventilation – JAMA (free for a limited period)
Observational study of invasive mechanical ventilation discontinuation showed weaning practices varied internationally
24 Mar, 2021 | 08:06h | UTCVentilator Weaning and Discontinuation Practices for Critically Ill Patients – JAMA (free for a limited period)
Editorial: International Variation in Intubation and Extubation Practices and Adverse Events Among Critically Ill Patients Receiving Mechanical Ventilation – JAMA (free for a limited period)
WHO Campaign | World Tuberculosis Day 2021: The Clock Is Ticking
24 Mar, 2021 | 08:16h | UTCWorld Tuberculosis Day 2021: The Clock Is Ticking – World Health Organization
Perspective | Leveraging Open Science to Accelerate Research
25 Mar, 2021 | 08:37h | UTCLeveraging Open Science to Accelerate Research – New England Journal of Medicine
Audio Interview: What earlier epidemics teach us about Covid-19
25 Mar, 2021 | 08:33h | UTCAudio Interview: What Earlier Epidemics Teach Us about Covid-19 – New England Journal of Medicine