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NICE Guideline Update: Cannabis-based medicinal products
28 Mar, 2021 | 22:24h | UTCCannabis-based medicinal products – National Institute for Health and Care Excellence
Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination
28 Mar, 2021 | 22:53h | UTC
Commentaries on Twitter
Now a peer-reviewed pub in a top journal, this elegant study clearly shows that variant B.1.351 isn't stopped by antibodies from prior infection or the Pfizer vax. We'll have revised vaccines, but we don't yet. Please behave accordingly. https://t.co/w8GHPDB7aL
— EQV Analytics 🇺🇦😷🔬🪷 (@AnalyticsEqv) March 27, 2021
New @NatureMedicine, further data on immune response after vaccination to 2 variants, B.1.1.7 (UK) and B.1.351 (SA). Reinforcing recent reports, the latter is more of an immune evader, and may pose vulnerability for reinfection post-vaccinehttps://t.co/w8xFc3fkh5 pic.twitter.com/i7DAnjSZwE
— Eric Topol (@EricTopol) March 26, 2021
Choosing Wisely: Five things clinicians and patients should question in Neurological Surgery in Children
28 Mar, 2021 | 22:04h | UTCAmerican Academy of Pediatrics – Section on Neurological Surgery – Choosing Wisely
Commentary: Choosing Wisely: 5 Things to Avoid in Pediatric Neurologic Surgery – NEJM Journal Watch
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Editorial | Remote by default general practice: must we, should we, dare we?
28 Mar, 2021 | 22:18h | UTC
https://twitter.com/trishgreenhalgh/status/1375408196303650818
Opinion | Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum
28 Mar, 2021 | 22:16h | UTC
Commentaries on Twitter
Excellent 2-pager on prioritising understanding of results over critical appraisal in EBM training. (Note: I want both, but understanding results should be first). @LoaiAlbarqouni @Tammy_Hoffmann have experimented with that. https://t.co/Fd88xaqgOu pic.twitter.com/0LYnmUmD4K
— Paul Glasziou (@PaulGlasziou) March 18, 2021
We argue (with Gordon Guyatt) that evidence based medicine educators should spend much more time & emphasis on understanding of magnitude of effect & applicability of results; less time & emphasis to risk of bias in primary studies. Open access at https://t.co/E7NjzJwFxP #EBM pic.twitter.com/nMXp8hVzHb
— Kari Tikkinen (@KariTikkinen) March 18, 2021
Just published, exhorting the #EBM community to wake up to the fact that our teaching should focus on helping clinicians understand research results, not on conducting critical appraisal. @KariTikkinen https://t.co/07Hm8aSnAI pic.twitter.com/m2RWrBvCVT
— Gordon H. Guyatt (@GuyattGH) March 22, 2021
Really interesting article in BMJ EBM. Are we prioritising the wrong things in critical appraisal training? "Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum" https://t.co/gXk1zLVUX8
— MPFT Library (@library_mpft) March 23, 2021
Junior doctors *usually* rely on guidelines/evidence summaries, NOT primary research studies.
"….notion that most clinicians emerging from professional training will regularly evaluate the risk of bias in methods and results of primary studies is deluded."
Seems fair enough… https://t.co/prv2ZuZ6Yp— David Henshall (@DavidHenshall_) March 22, 2021
Integrating Transwomen and Female Athletes with Differences of Sex Development (DSD) into Elite Competition: The FIMS 2021 Consensus Statement
28 Mar, 2021 | 22:06h | UTC
Cohort study: Even small amounts of Caffeine consumption in pregnancy were linked to smaller neonatal birth size
28 Mar, 2021 | 22:14h | UTCCommentaries: Even a Little Coffee in Pregnancy Could Impact Newborn’s Weight: Study – HealthDay AND Moderate daily caffeine intake during pregnancy may lead to smaller birth size – NIH News Releases
Commentary on Twitter
Cohort study finds even small amounts of caffeine consumption in pregnancy were associated with smaller birthweight and lean tissue measures, consistent for measured plasma caffeine/paraxanthine, and self-reported caffeine consumption. @NIH https://t.co/YzDVU6ejYO
— JAMA Network Open (@JAMANetworkOpen) March 25, 2021
Quadrivalent influenza nanoparticle vaccines induce broad protection against a wide variety of seasonal and pandemic influenza strains in animal models
28 Mar, 2021 | 22:01h | UTCQuadrivalent influenza nanoparticle vaccines induce broad protection – Nature
Commentary: Nanoparticle flu vaccine blocks seasonal and pandemic strains – University of Washington School of Medicine
RCT: Using low-pressure pneumoperitoneum in laparoscopic colonic resection improves postoperative recovery compared to standard pressure pneumoperitoneum
28 Mar, 2021 | 22:11h | UTC
Commentary on Twitter
Low-pressure in colorectal lap surgery impacts pain / LOHS Our randomized trial just published in @BJSurgery @CHUBordeaux @univbordeaux Low-pressure versus standard pressure laparoscopic colorectal surgery (PAROS trial): a phase III randomized control… https://t.co/VWvT76ibey pic.twitter.com/rufjLPAsDa
— Quentin Denost (@QDenost) March 24, 2021
Covid-19: Middle aged women face greater risk of debilitating long term symptoms
28 Mar, 2021 | 22:49h | UTCCovid-19: Middle aged women face greater risk of debilitating long term symptoms – The BMJ
Linked Opinion: The stigma is real for people living with long covid – The BMJ Opinion
How COVID-19 Affects the Brain
28 Mar, 2021 | 22:51h | UTCHow COVID-19 Affects the Brain – JAMA Psychiatry
Commentary on Twitter
#COVID19 brain symptoms are a rising concern. Mechanisms of brain damage by the virus include lasting neuroinflammation, thrombotic events and alteration of neurotransmitters release. Consequently, people suffer cognitive, emotional and behavioral symptoms https://t.co/pTzJo6DLV8
— JAMA Psychiatry (@JAMAPsych) March 26, 2021
Opinion | The Coronavirus Variants Don’t Seem to Be Highly Variable So Far
28 Mar, 2021 | 22:46h | UTCThe Coronavirus Variants Don’t Seem to Be Highly Variable So Far – Scientific American
Routine asymptomatic testing strategies for airline travel during the COVID-19 pandemic: a simulation study
28 Mar, 2021 | 22:34h | UTC
Commentary on Twitter (thread – click for more)
1/N Our new study published in @TheLancetInfDis on #COVID19 testing strategies for safer airline travel. Getting tested before and after air travel can prevent the spread of #COVID19 and make flying safer. Collab led by the singular Dr. @mathewkiang. https://t.co/mO3JrMIhOp pic.twitter.com/0yBhux4eKb
— Nathan Lo (@NathanLo3579) March 22, 2021
Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”
28 Mar, 2021 | 22:48h | UTCCommentary: 85% of COVID-19 long-haulers have multiple brain-related symptoms – LiveScience AND ‘Brain fog’ and other neurologic symptoms can last for months after Covid – NBC News AND Neurologic Symptoms Persistent for Many COVID-19 ‘Long-Haulers’ – Health Day
Interleukin‐6 blocking agents for treating COVID‐19: a living systematic review
28 Mar, 2021 | 22:40h | UTCInterleukin‐6 blocking agents for treating COVID‐19: a living systematic review – Cochrane Library
Commentary on Twitter
https://twitter.com/CochraneUK/status/1375456773486874628
Opinion | COVID-19 Is Different Now: The coronavirus is changing. So is the disease it causes.
28 Mar, 2021 | 22:44h | UTCCOVID-19 Is Different Now – The Atlantic
International travel‐related control measures to contain the COVID‐19 pandemic: a rapid review
28 Mar, 2021 | 22:38h | UTC
Commentary on Twitter
Can international travel‐related control measures contain the spread of the #COVIV19 #pandemic? https://t.co/9AC4OVJL83 Updated @CochranePH rapid review looks at evidence around closing borders, restricting travel, screening/testing, & quarantining newly‐arrived. pic.twitter.com/LKeXoEGPGp
— The Cochrane Library (@CochraneLibrary) March 26, 2021
Evolution of the randomized clinical trial in the era of precision oncology
26 Mar, 2021 | 08:35h | UTCEvolution of the Randomized Clinical Trial in the Era of Precision Oncology – JAMA Oncology
Commentary on Twitter
Food for thoughts: randomized clinical trials in the era of precision oncology
➡️PFS, not OS predominant endpoint
➡️Modest median survival gains
➡️Almost all industry funded
➡️Substantial increase in use of professional medical writers#radonchttps://t.co/k92MEs1eWR— Matthias Guckenberger (@Mat_Guc) March 25, 2021
ERC and ESICM Guidelines: Post-resuscitation Care
26 Mar, 2021 | 08:41h | UTC
Commentary on Twitter
Post #resuscitation @ERC_resus @ESICM guidelines #resus21
🫀diagnosis & reperfusion
🫀post CA syndrome
🫀hemodynamics
🫁oxygenation/ventilation
🧠general #ICU approach
🧠seizures control
🌡️TTM
🧠prognosis & outcome
💪#ICUrehab
🫁organ donation
🏥CA centershttps://t.co/BrPJtKw8vo pic.twitter.com/xS0FKFSK6F— Intensive Care Medicine (@yourICM) March 25, 2021
FDA approval standards for anticancer agents — lessons from two recent approvals in breast cancer
26 Mar, 2021 | 08:30h | UTC
Commentary on Twitter
Our paper published today in @NatRevClinOncol discussing the dropping of bar for approval of cancer drugs. These two examples highlight why we all should seriously be concerned about this low bar. https://t.co/T27QI00dj2 pic.twitter.com/26Df3fJsoD
— Bishal Gyawali, MD, PhD, FASCO (@oncology_bg) March 25, 2021
RCT: Abrocitinib vs. Placebo or Dupilumab for Atopic Dermatitis
26 Mar, 2021 | 08:27h | UTCAbrocitinib versus Placebo or Dupilumab for Atopic Dermatitis – New England Journal of Medicine
RCT: Metoclopramide + diphenhydramine more efficacious than placebo for acute post-traumatic headache in the ED
26 Mar, 2021 | 08:24h | UTCRandomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache – Neurology (link to abstract – $ for full-text)
Commentary: Drug Combo Superior to Placebo for Posttraumatic Headache – HealthDay
M-A: Fracture risk is lower in patients anticoagulated with NOACs compared to patients treated with warfarin
26 Mar, 2021 | 08:26h | UTCCommentary: NOACs associated with a 16% lower risk of bone fractures than warfarin – Cardiovascular Business
Systematic review: Lens extraction for chronic angle‐closure glaucoma
26 Mar, 2021 | 08:22h | UTCLens extraction for chronic angle‐closure glaucoma – Cochrane Library
State of the Art Review | Management of colonic diverticulitis
25 Mar, 2021 | 08:14h | UTCManagement of colonic diverticulitis – The BMJ
Commentary on Twitter
NEW 🔥💥State of the Art Clinical Review @bmj_latest
Management of colonic diverticulitis #IDTwitter https://t.co/aUOGYZ8I4n pic.twitter.com/vYjzQ50LY1— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) March 24, 2021