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RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19
13 Apr, 2021 | 05:30h | UTCOriginal study (preprint): Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial – medRxiv
Commentary: Covid: Asthma drug ‘speeds up recovery at home’ – BBC
Related study: Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19 (study and commentaries)
Characteristics and Disease Severity of US Children and Adolescents Diagnosed With COVID-19
14 Apr, 2021 | 01:59h | UTCCommentary: CDC: 1 in 3 children hospitalized with COVID-19 requires treatment in ICU – UPI AND 12% of Children with COVID Are Hospitalized: Study – WebMD
Commentary on Twitter
Of 2430 pediatric patients who were hospitalized with COVID-19, 756 (31.1%) experienced severe COVID-19. Severe disease was more common in patients with chronic conditions, in male patients, and in children aged 2-11 years vs children aged 12-18 years. https://t.co/3fmlCFsmo8
— COVID Reference (@CovidReference) April 10, 2021
Tobacco Taxes Are Most Effective Yet Least Implemented Tactics, Says WHO
13 Apr, 2021 | 05:06h | UTCTobacco Taxes Are Most Effective Yet Least Implemented Tactics, Says WHO – Health Policy Watch
Guidance: WHO technical manual on tobacco tax administration – World Health Organization
Infectivity of severe acute respiratory syndrome coronavirus 2 in children compared with adults
13 Apr, 2021 | 05:27h | UTCCommentary: Children may be less infectious in spreading SARS-CoV-2 to others – News Medical
RCT: Comparison of Levetiracetam vs. Zonisamide vs. Lamotrigine for newly diagnosed focal epilepsy shows Lamotrigine should remain the first-line treatment option
12 Apr, 2021 | 00:51h | UTCCommentary: Clinical trials assess best first-line drugs for epilepsy – University of Liverpool
Cohort Study: Effects of fluoroquinolones on outcomes of patients with aortic dissection or aneurysm
13 Apr, 2021 | 05:05h | UTCRelated: Another study suggests fluoroquinolone use may increase the risk of development of aortic aneurysms (study and commentaries) AND Link between fluoroquinolones, aorta problems may not be as strong as thought AND Study: Oral Fluoroquinolones and Risk of Mitral and Aortic Regurgitation AND FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones AND Meta-analysis: Fluoroquinolones and the Risk of Aortopathy AND Study: Oral Fluoroquinolone and the Risk of Aortic Dissection AND Research: Fluoroquinolone use and risk of aortic aneurysm and dissection
Clinical Review: Screening and management of atrial fibrillation in primary care
13 Apr, 2021 | 05:09h | UTCScreening and management of atrial fibrillation in primary care – The BMJ
M-A: Post-extubation oxygenation strategies in acute respiratory failure – NPPV or HFNC may reduce the risk of endotracheal reintubation but not mortality
12 Apr, 2021 | 00:42h | UTC
RCT: Comparison of Valproate vs. Levetiracetam for newly diagnosed generalized and unclassifiable epilepsy shows Valproate should remain the first-line treatment option
12 Apr, 2021 | 00:52h | UTCCommentary: Clinical trials assess best first-line drugs for epilepsy – University of Liverpool
AHA/ASA Scientific Statement: Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery
12 Apr, 2021 | 00:50h | UTC
Commentary on Twitter
NEW GUIDELINE – now codifies what has been discussed for a while "If history of stroke exists, consider delaying elective surgery at least 6 mo
and preferably 9 mo from time of incident stroke." @SPAQIedu @LeeAFleisher @preopconsult @afedwardMD https://t.co/0ewdlPGVlj— Kurt Pfeifer (@KurtPfeifer) April 9, 2021
China considers mixing COVID-19 vaccines to boost protection rate
13 Apr, 2021 | 05:24h | UTCChina considers mixing COVID-19 vaccines to boost protection rate – Reuters
Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19
13 Apr, 2021 | 05:21h | UTCRelated: Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery AND Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk
[Press release – not published yet] Phase 3 prevention trial showed 81% reduced risk of symptomatic SARS-CoV-2 infections with subcutaneous administration of monoclonal antibodies
13 Apr, 2021 | 05:26h | UTCCommentaries: Regeneron says antibody cocktail prevented Covid when given as simple injection, not an IV – STAT AND Regeneron’s Covid mAb as a prophylactic injection: Reduced risk of symptomatic infection by 81% – Endpoint News
Cohort study: SARS-CoV-2 infection rates of antibody-positive vs. antibody-negative health-care workers – previous infection was associated with 84% lower risk of (re)infection
12 Apr, 2021 | 01:30h | UTCCommentary: Correlates of protection from SARS-CoV-2 infection – The Lancet
Commentary on Twitter
💥SIREN STUDY💥 @TheLancet
Previous SARS-CoV-2 infection
provides protection similar to or even better than currently used vaccines
📌84% risk reduction(RR) for reinfection
📌93% RR for those w symptomatic infections
📌B.1.1.7 circulate during the studyhttps://t.co/uQ3M9yahAv pic.twitter.com/leQCNbmHQO— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 10, 2021
Perspective | They Tested Negative for Covid. Still, They Have Long Covid Symptoms.
13 Apr, 2021 | 05:23h | UTCThey Tested Negative for Covid. Still, They Have Long Covid Symptoms. – Kaiser Health News
Commentary on Twitter
Scary: Many people have tested negative for SARSCoV2, yet they developed Long Covid. What's to blame? Haphazard testing protocols, delays & difficulties accessing tests & poor quality of many of the tests on the market. All have have left people without proof of infection. https://t.co/KH3QYkbbKW pic.twitter.com/MVuRhWoHle
— delthia ricks 🔬 (@DelthiaRicks) April 12, 2021
Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients
12 Apr, 2021 | 01:23h | UTC
Commentary on Twitter
Prone position in #COVID19, use & effect:
➡️PP widely adopted, the more severe the respiratory failure, the more frequent the use
➡️PP improved oxygenation in most (better V/Q matching?)
➡️mortality of O2-Non-Responders significantly higher@Crit_Care https://t.co/Q2Z15a8Pvr pic.twitter.com/CZqshIfJrg— M Velia Antonini (@FOAMecmo) April 7, 2021
[Preprint] Pfizer vaccine less effective for SARS-CoV-2 variant B.1.351
12 Apr, 2021 | 01:26h | UTCCommentaries: South African variant may evade protection from Pfizer vaccine, Israeli study says – Reuters AND Israeli data shows South African variant able to ‘break through’ Pfizer vaccine – The Times of Israel
Related: Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination AND SARS-CoV-2 variants B.1.351 and P.1 can escape from therapeutic antibodies and evade antibodies induced by infection or mRNA vaccination AND B.1.351 strain of SARS-CoV-2 neutralization titer reduced 8- to 9-fold for Pfizer and AstraZeneca vaccinees. Convalescent plasma and therapeutic antibodies were less effective against this variant as well.
Another study shows intravenous radiocontrast use is not associated with reduced kidney function
12 Apr, 2021 | 00:44h | UTCCommentaries: Radiocontrast Exposure Safe for Kidney Function – HCP Live AND Exposure to contrast on CTPA doesn’t cause long-term kidney injury – AuntMinnie
Related: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (Guideline and commentaries)
Commentary on Twitter (thread – click for more)
Our new paper in @JAMAInternalMed: is IV contrast nephrotoxic? Lots of studies say no, but have ⬆️risk of confounding: people who get contrast ≠ people who don't get it. We used a natural experiment to try to overcome this bias https://t.co/XWEEohAvK0 1/5
— Robert Goulden (@EMrobg) April 5, 2021
AHA Policy Statement: Reducing Nontraumatic Lower-Extremity Amputations by 20% by 2030
12 Apr, 2021 | 00:48h | UTCCommentary: AHA issues policy statement on reducing lower-extremity amputations – ACP Diabetes AND AHA Seeks to Drive Down Amputations 20% by 2030 – TCTMD
M-A: Treatment for bleeding esophageal varices in people with decompensated liver cirrhosis
12 Apr, 2021 | 00:39h | UTCRelated Cochrane Reviews: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis AND Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta‐analysis – Cochrane Library
Concussion in para sport: the first position statement of the Concussion in Para Sport (CIPS) Group
12 Apr, 2021 | 00:37h | UTC
Commentary on Twitter
The ink is still wet .. fresh out in @BJSM_BMJ. Para athletes suffer concussions too, but specific guidelines for care did not exist .. until now ‼️ Open access ➡️ https://t.co/ld1BENeoho pic.twitter.com/lkwsa8HsKd
— Evert Verhagen (@EvertVerhagen) April 10, 2021
[Preprint] Efficacy and safety of CoronaVac in healthcare professionals in Brazil
12 Apr, 2021 | 01:17h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/hildabast/status/1381366467665391619
Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents
12 Apr, 2021 | 00:36h | UTC
Commentary onTwitter
NIH study found evidence that a ketogenic diet (high fat, low carbohydrate and protein) can have beneficial effects on inpatients managing alcohol withdrawal and on reducing alcohol drinking in those with an alcohol use disorder.https://t.co/IBiQ6hZY5i#NIDAscience @NIAAAnews
— NIDAnews (@NIDAnews) April 9, 2021
RCT: Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
9 Apr, 2021 | 03:18h | UTCAuthor Interview: Effect of High-Frequency (10 kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
Commentary on Twitter
Thrilled to see our publication out today in @JAMANeuro using #SCS to treat #diabetic #pain. 86% of patients with over 50% pain relief at 6 months with better sleep and walking! #progress #needherscience #neuromodulation @UAMSneurosurg @UAMSPain @uamshealth https://t.co/TJQPHsHvSa
— Dr. Erika Petersen (@ErikaPetersenMD) April 5, 2021
Consensus Document: Management of ureteric and bladder injury
12 Apr, 2021 | 00:29h | UTC