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Guideline Synopsis: Management of Acute Coronary Syndromes in Patients Without Persistent ST-Segment Elevation
21 Apr, 2021 | 06:41h | UTCManagement of Acute Coronary Syndromes in Patients Without Persistent ST-Segment Elevation – JAMA (free for a limited period)
Original guideline: #ESCCongress – 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation AND Summary: The ‘Ten Commandments’ for the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation – European Heart Journal
Another study shows SARS-CoV-2 variant B.1.1.7 is more transmissible than the original virus
21 Apr, 2021 | 06:58h | UTCCommentary: The British variant is 45% more contagious than the original virus – Tel Aviv University
Related: New studies suggest SARS-CoV-2 variant B.1.1.7 is not more deadly, just more transmissible AND Study confirms higher transmissibility of SARS-CoV-2 lineage B.1.1.7
Large clinical trial to study repurposed drugs to treat COVID-19 symptoms
21 Apr, 2021 | 06:59h | UTCLarge clinical trial to study repurposed drugs to treat COVID-19 symptoms – NIH News Releases
Review: Perioperative Management of the Patient With Obstructive Sleep Apnea
21 Apr, 2021 | 06:18h | UTC
M-A: Progestogens for preventing miscarriage
21 Apr, 2021 | 06:22h | UTCProgestogens for preventing miscarriage: a network meta‐analysis – Cochrane Library
Summary: Are progestogen treatments effective in preventing miscarriage? – Cochrane Library
Related Meta-analysis: Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials – The Lancet (link to abstract – $ for full-text)
Chlamydia and gonorrhea: new recommendation to screen sexually active patients under 30
20 Apr, 2021 | 05:42h | UTCRelated USPSTF Draft Statement: Screening for Chlamydia and Gonorrhea – U.S. Preventive Services Task Force
M-A: Portal venous system thrombosis after bariatric surgery
21 Apr, 2021 | 06:16h | UTCPortal venous system thrombosis after bariatric surgery: A systematic review and meta-analysis – Surgery (link to abstract – $ for full-text)
RCT: Effect of infusion set replacement intervals on catheter-related bloodstream infections – “Infusion set use can be safely extended to 7 days with resultant cost and workload reductions”
20 Apr, 2021 | 05:37h | UTCEffect of infusion set replacement intervals on catheter-related bloodstream infections (RSVP): a randomised, controlled, equivalence (central venous access device)–non-inferiority (peripheral arterial catheter) trial – The Lancet (link to abstract – $ for full-text)
Commentaries on Twitter
If you're an #RN👩⚕️or #infection preventer & it makes you crazy🤯that different hospitals🏥use infusion sets for different durations⏰- READ this massive #RCT in @TheLancet from @AVATAR_grp @UQHealth @UQMedicine @MetroNorthHHS @MenziesHealth & large team https://t.co/lpz1C6ceM2
— Prof Claire Rickard (@Claire_AVATAR) April 18, 2021
Use for 7 vs. 4 days = similar outcomes. Effect of infusion set replacement intervals on catheter-related bloodstream infections (RSVP): a randomised, controlled, equivalence (CV access device)–non-inferiority (peripheral arterial catheter) trial https://t.co/6qaJczu1Cr
— Skeptical Scalpel (@Skepticscalpel) April 16, 2021
Catheter-related bloodstream infections (CRBSIs) account for around 70% of all health care associated bloodstream infections. New trial indicates that 7-day replacement of infusion sets is safe, with resultant cost and workload reductions. https://t.co/ua633FkA3K pic.twitter.com/LfaC6lZYMv
— The Lancet (@TheLancet) April 19, 2021
M-A: Guided versus standard antiplatelet therapy in patients undergoing percutaneous coronary intervention
20 Apr, 2021 | 05:40h | UTC
Commentary on Twitter
Great paper on guided vs standard DAPT.
Interestingly outcomes were found to vary according to the strategy used:
ESCALATION was associated with⬇️ISCHEMIC EVENTS (without⬆️bleedings)
DE-ESCALATION was associated with⬇️ BLEEDINGS (without ⬆️ischemic events). https://t.co/y4ys6tvktw— Gregory A. Sgueglia (@GregorySgueglia) April 16, 2021
RCT: Atenolol has similar efficacy as propranolol with fewer adverse events in the treatment of problematic infantile hemangiomas
20 Apr, 2021 | 05:32h | UTCEfficacy and Safety of Propranolol vs Atenolol in Infants With Problematic Infantile Hemangiomas: A Randomized Clinical Trial – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – $ for full-text)
Perspective | The Confident Generalist: Putting The Primary Care Physician Back At The Center
20 Apr, 2021 | 05:35h | UTCThe Confident Generalist: Putting The Primary Care Physician Back At The Center – Health Affairs
Podcast: Management of Obesity Hypoventilation Syndrome
20 Apr, 2021 | 05:23h | UTC#269 Obesity Hypoventilation Syndrome (OHS) and the Didgeridoo with Dr Aneesa Das – The Curbsiders
Podcast: Dementia Made Simple
20 Apr, 2021 | 05:21h | UTC#268 Dementia Made Simple with Dr. Josh Uy – The Curbsiders
Outcome of acute kidney injury: how to make a difference?
20 Apr, 2021 | 05:26h | UTCOutcome of acute kidney injury: how to make a difference? – Annals of Intensive Care
[News release – not published yet] Sputnik V demonstrates 97.6% efficacy according to the analysis of data of 3.8 million vaccinated persons in Russia
20 Apr, 2021 | 06:08h | UTC
Commentary on Twitter
https://twitter.com/hildabast/status/1384270692946878471
Large cohort finds low risk of SARS-CoV-2 cardiac involvement in young competitive athletes
20 Apr, 2021 | 06:04h | UTCSARS-CoV-2 Cardiac Involvement in Young Competitive Athletes – Circulation
News Release: Study: Heart setbacks from COVID-19 unlikely in athletes – UW Medicine
M-A: Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing
20 Apr, 2021 | 06:09h | UTCCommentary: Beyond COVID-19—will self-sampling and testing become the norm? – The Lancet Infectious Diseases
Related Meta-analysis: Saliva and nasopharyngeal swab nucleic acid amplification have similar diagnostic accuracy for the detection of SARS-CoV-2 AND Saliva vs. nasopharyngeal swabs equally sensitive for Covid-19 diagnosis
COVID-19 dynamics after a national immunization program in Israel
20 Apr, 2021 | 06:06h | UTCCOVID-19 dynamics after a national immunization program in Israel – Nature Medicine
Commentary on Twitter
https://twitter.com/segal_eran/status/1384134124244406280
M-A: Prevalence of depression, anxiety and post-traumatic stress disorder in health care workers during the COVID-19 pandemic
20 Apr, 2021 | 06:00h | UTC
Pfizer CEO says third Covid vaccine dose likely needed within 12 months
20 Apr, 2021 | 06:02h | UTCPfizer CEO says third Covid vaccine dose likely needed within 12 months – CNBC
Commentary: Fully Vaccinated? Get Ready For Your Third Dose – Forbes
UK researchers will deliberately reinfect people with COVID-19 in new ‘challenge study’
20 Apr, 2021 | 06:03h | UTCSee also: Young people to be reinfected with Covid for study – BBC
Ten scientific reasons in support of airborne transmission of SARS-CoV-2
18 Apr, 2021 | 21:51h | UTCTen scientific reasons in support of airborne transmission of SARS-CoV-2 – The Lancet
Animated Videos: Aerosols and making spaces safe – University of Oxford
Commentary on Twitter (thread – click for more)
Just out in @TheLancet what experts have said for a year
SARS-CoV2 spreads PRIMARILY via airborne route
Failure to act on this has hampered efforts to prevent spread of COVID
Thank you @trishgreenhalgh @linseymarr @kprather88 @j_g_allen, others who stuck to the evidence https://t.co/uuJcUIKWHE
— Ashish K. Jha, MD, MPH (@ashishkjha) April 16, 2021
Clinical trial completion rates decline during COVID-19 pandemic
20 Apr, 2021 | 05:59h | UTCClinical trial completion rates decline during COVID-19 pandemic – Penn State
Original study: Assessing the Impact of COVID‐19 on Registered Interventional Clinical Trials – Clinical and Translational Science
M-A: Intravenous tranexamic acid in surgical patients is not associated with increased risk of thromboembolic events and mortality
20 Apr, 2021 | 05:28h | UTCAssociation of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression – JAMA Surgery (free for a limited period)
Invited commentary: Tranexamic Acid and Safety in the Right Patient – JAMA Surgery (free for a limited period)
Commentary on Twitter
https://twitter.com/lucasmorin_eolc/status/1383896490779635714
Update on Corneal Transplant in 2021
20 Apr, 2021 | 05:33h | UTCUpdate on Corneal Transplant in 2021 – JAMA (free for a limited period)