All Posts
Recommendations to address patients fear of adverse effects and COVID-19 vaccine hesitancy
25 Apr, 2021 | 21:58h | UTC
WHO: COVID-19 continues to disrupt essential health services in 90% of countries
25 Apr, 2021 | 22:12h | UTC
Commentary on Twitter (thread – click for more)
Over one year into the #COVID19 pandemic, about 9⃣0⃣% of countries surveyed still report one or more disruptions to essential health services. Major efforts are required to restore and strengthen services in all countries.
👉 https://t.co/P34xPKY1Io pic.twitter.com/UYDQPX67Vw
— World Health Organization (WHO) (@WHO) April 23, 2021
U.S. lifts pause on use of J&J’s Covid-19 vaccine
25 Apr, 2021 | 21:57h | UTCU.S. lifts pause on use of J&J’s Covid-19 vaccine – STAT
See also: CDC, FDA lift pause on using J&J’s coronavirus vaccine, add safety warning – CNN AND ACIP opts to lift pause on Johnson & Johnson vaccine – CIDRAP
One million coronavirus sequences: popular genome site hits mega milestone
25 Apr, 2021 | 21:59h | UTCOne million coronavirus sequences: popular genome site hits mega milestone – Nature
Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal
25 Apr, 2021 | 21:17h | UTCNews release: Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal – University of Oxford
Original study (preprint): High Efficacy of a Low Dose Candidate Malaria Vaccine, R21 in 1 Adjuvant Matrix-M™, with Seasonal Administration to Children in Burkina Faso – The Lancet
Commentaries: Malaria vaccine hailed as potential breakthrough – BBC AND Oxford Malaria vaccine proves highly effective in Burkina Faso trial – The Guardian
Commentary on Twitter (thread – click for more)
💡AMAZING—First high >75% efficacy vaccine for a disease with 229 million cases & 409,000 deaths worldwide in 2019 —#Malaria!
Created by Oxford, produced by Serum Institute of India, & supporting adjuvant by Novavax, SII expects to make 200 mil doses a year!
Science! #vaccine pic.twitter.com/gnPMvXxww6
— Eric Feigl-Ding (@DrEricDing) April 23, 2021
Resurgence of SARS-CoV-2: detection by community viral surveillance
25 Apr, 2021 | 21:55h | UTCResurgence of SARS-CoV-2: detection by community viral surveillance – Science
Commentary on Twitter
A #SARSCoV2 surveillance program tested in England in 2020 successfully detected a resurgence of virus infection at low prevalence, @imperialcollege researchers say. Such programs can augment routine surveillance to inform public health interventions. https://t.co/veilAJ8YX4 pic.twitter.com/9YFQbvtqbw
— Science Magazine (@ScienceMagazine) April 23, 2021
RCT: Intracytoplasmic sperm injection vs. conventional in-vitro fertilization in couples with infertility in whom the male partner has normal total sperm count and motility – no difference in livebirth rates between the strategies
25 Apr, 2021 | 21:14h | UTCIntracytoplasmic sperm injection versus conventional in-vitro fertilisation in couples with infertility in whom the male partner has normal total sperm count and motility: an open-label, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
🔴New RCT in @TheLancet
⭐In couples with infertility + normal total sperm count and motility ➡️ ICSI did not improve the livebirth rate compared with conventional IVF.
No excuses left to do ICSI for all.
Full text ⬇️https://t.co/6FYX7TeDRN— Rita Vassena (@RitaVassena) April 23, 2021
RCT: Promising results with vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischemic stroke
25 Apr, 2021 | 21:10h | UTCCommentary: Vagus nerve stimulation: a potential new treatment for ischaemic stroke – The Lancet
Commentary on Twitter
Very important @TheLancet study showing #vagus nerve stimulation improves rehabilitation ischemic #stroke.
Kudos Prof Jesse Dawson @UofGlasgow at colleagues!https://t.co/DsIH3wMuAp pic.twitter.com/QtzBBDVnso
— Prof. Kevin J. Tracey, MD (@KevinJTraceyMD) April 23, 2021
Opinion | What it Means to be a Medical Conservative
25 Apr, 2021 | 21:06h | UTCWhat it Means to be a Medical Conservative – Stop and Think
New studies in patients with moderate-to-severe psoriasis show greater skin clearance with Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits both interleukin-17A and interleukin-17F
25 Apr, 2021 | 21:08h | UTCStudy 1: Bimekizumab versus Secukinumab in Plaque Psoriasis – New England Journal of Medicine
Study 2: Bimekizumab versus Adalimumab in Plaque Psoriasis – New England Journal of Medicine
Related studies: Bimekizumab efficacy and safety in moderate to severe plaque psoriasis (BE READY): a multicentre, double-blind, placebo-controlled, randomised withdrawal phase trial – The Lancet AND Bimekizumab versus ustekinumab for the treatment of moderate to severe plaque psoriasis (BE VIVID): efficacy and safety from a 52-week, multicentre, double-blind, active comparator and placebo controlled phase 3 trial – The Lancet
Analysis of 1060 Cases of Drug-Induced Acute Pancreatitis – a large proportion of cases were caused by antineoplastic (16.89%), antibiotic (12.08%), and anticonvulsant (9.72%) drugs
25 Apr, 2021 | 20:55h | UTCAnalysis of 1060 Cases of Drug-Induced Acute Pancreatitis – Gastroenterology
RCT: Metformin vs. insulin in gestational diabetes – metformin was associated better glycemic control, lower risk of hypoglycemia, and less maternal weight gain
25 Apr, 2021 | 21:03h | UTCMeDiGes Study. Metformin versus insulin in gestational diabetes: Glycemic control, and obstetrical and perinatal outcomes. Randomized prospective trial. – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Related: Randomized trial tests metformin in women with type 2 diabetes in pregnancy AND Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis – PLOS Medicine AND Case-Control Study: Metformin Exposure in First Trimester of Pregnancy is Not Associated with Congenital Anomalies
RCT: Induction of Labor at Term with Vaginal Misoprostol or a PGE2 Pessary – little difference in outcomes, the clinical risk-benefit ratio justifies the use of both drugs
25 Apr, 2021 | 20:59h | UTCInduction of Labor at Term With Vaginal Misoprostol or a PGE2 Pessary: a Noninferiority RCT – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Guideline: Prevention of Positioning Injuries During Gynecologic Surgery
25 Apr, 2021 | 20:50h | UTC
Guide to Enhanced Recovery for Cancer Patients Undergoing Liver Surgery
25 Apr, 2021 | 20:53h | UTCSee also: Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations – World Journal of Surgery AND Enhanced Recovery After Surgery (ERAS) Society Guidelines
RCT: No benefit from immune checkpoint inhibitors in newly diagnosed stage III or IV ovarian cancer
25 Apr, 2021 | 20:57h | UTC
Long Covid: Largest post-acute COVID-19 study to date examined the health outcomes in more than 73,000 people who’d had COVID-19 and were not hospitalized
23 Apr, 2021 | 08:48h | UTCHigh-dimensional characterization of post-acute sequalae of COVID-19 – Nature
Commentary on Twitter (thread – click for more)
Happy to share the latest paper from our team in @nature
A comprehensive characterization of post acute sequelae of COVID-19#longcovid #PASChttps://t.co/AGLnYCamWe@VAResearch @vahsrd @WUSTL @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL @Biostayan @BCBowe
— Ziyad Al-Aly, MD (@zalaly) April 22, 2021
Guideline: Diagnosis and Treatment of Endometriosis
25 Apr, 2021 | 20:46h | UTC
Recommendations on the Management of Maternal Hepatitis B, C and D Infection in Pregnancy
25 Apr, 2021 | 20:44h | UTC
Guideline: Vulvovaginal Candidosis (Excluding Mucocutaneous Candidosis)
25 Apr, 2021 | 20:47h | UTC
NIH Updates COVID-19 Treatment Guidelines – adds recommendations on colchicine, fluvoxamine, and monoclonal antibodies
23 Apr, 2021 | 08:46h | UTCNIH Coronavirus Disease 2019 (COVID-19)
Treatment Guidelines – National Institutes of Health
RCT: COVID outpatients don’t benefit from hydroxychloroquine, lopinavir-ritonavir
23 Apr, 2021 | 08:42h | UTCCOVID outpatients don’t benefit from hydroxychloroquine, lopinavir-ritonavir – CIDRAP
Commentary on Twitter (thread – Click for more)
1/ No benefit from Hydroxychloroquine or Lopinavir-Ritonavir on Hospitalization/Viral clearance for COVID-19 https://t.co/yhXxv26418 via @JAMANetworkOpen part of @JAMANetwork
— Priya Sampathkumar (@PSampathkumarMD) April 22, 2021
Case series of 18 male adults aged 50 years or younger with acute ischemic stroke during the convalescent phase of asymptomatic Covid-19
23 Apr, 2021 | 08:39h | UTC
Commentary on Twitter
A 💥🆕 case series highlights that adults 50 years or younger with asymptomatic COVID-19 infection diagnosed by positive SARS-CoV-2 serological test result may present with ischemic stroke during the convalescent phase of the infection
https://t.co/BVlo7Z1hgn @JAMANetworkOpen— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 22, 2021
Covid-19: More data on the increased risks to pregnant women and their newborn infants
23 Apr, 2021 | 08:44h | UTCEditorial: COVID-19 in Pregnant Women and Their Newborn Infants
Commentaries: Pregnant women with COVID-19 face high mortality rate – University of Washington School of Medicine AND Covid-19 raises risks for expectant mothers and babies, study says – CNN
Commentary on Twitter
18 country study in >2000 pregnant women with and without #COVID19 shows higher complication and death rates in symptomatic, but not asymptomatic, women with COVID-19. Their babies were at greater risk of neonatal complications, mainly due to preterm birth https://t.co/mRl8OOIMsz
— JAMA Pediatrics (@JAMAPediatrics) April 22, 2021
RCT: Single-Dose Johnson & Johnson Vaccine has 85% efficacy against severe/critical Covid-19 and maintains efficacy against variant B.1.351
22 Apr, 2021 | 08:50h | UTC