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RCT: Prophylactic closed incision negative pressure wound therapy reduces (difference close to statistical significance; P=0.06) the risk of surgical site infection in obese women undergoing cesarean section.
7 May, 2021 | 08:24h | UTC
Review: Hyperthermic intraperitoneal chemotherapy for ovarian and colorectal cancer
7 May, 2021 | 08:23h | UTCHyperthermic Intraperitoneal Chemotherapy for Ovarian and Colorectal Cancer: A Review – JAMA Oncology (free for a limited period)
Perspective | The weird science of the placebo effect keeps getting more interesting
7 May, 2021 | 08:17h | UTCThe weird science of the placebo effect keeps getting more interesting – Vox
Cohort study: Sugar-sweetened beverage intake in adulthood and adolescence linked to increased risk of early-onset colorectal cancer among women
7 May, 2021 | 08:22h | UTCCommentaries: Daily intake of two or more sugar-sweetened drinks associated with higher bowel cancer risk – BMJ AND Expert reaction to study looking at sugary drinks intake and incidence of early-onset colorectal cancer among women – Science Media Centre
In shock move, US backs waiving patents on COVID vaccines. “The development from the Biden administration draws cheers from public health researchers and ire from drugmakers.”
6 May, 2021 | 09:10h | UTCIn shock move, US backs waiving patents on COVID vaccines – Nature
See also: U.S. will back proposal to waive intellectual property rights and boost Covid-19 vaccine production – STAT AND Statement from the Executive Director of UNAIDS, Winnie Byanyima on the decision by the United States of America to support the TRIPS waiver for COVID-19 vaccines – UNAIDS AND WHO Director-General commends United States decision to support temporary waiver on intellectual property rights for COVID-19 vaccines – World Health Organization
Commentary on Twitter
These extraordinary times and circumstances of call for extraordinary measures.
The US supports the waiver of IP protections on COVID-19 vaccines to help end the pandemic and we’ll actively participate in @WTO negotiations to make that happen. pic.twitter.com/96ERlboZS8
— Ambassador Katherine Tai (@AmbassadorTai) May 5, 2021
Cohort study shows inadequate antibody response to mRNA SARS-CoV-2 vaccine among kidney transplant recipients.
6 May, 2021 | 09:01h | UTC
Commentary on Twitter
https://twitter.com/hildabast/status/1390097665451462656
Observational study in Israel: Pfizer-BioNTech is 95.3% effective against SARS-CoV-2 infection.
6 May, 2021 | 09:04h | UTCCommentaries: Expert reaction to Israel nation-wide study looking at Pfizer vaccine effectiveness – Science Media Centre AND Covid-19: Two doses of Pfizer vaccine are “highly effective” against infection, hospital admission, and death, study finds – The BMJ
Short review: How to diagnose and manage QT prolongation in cancer patients
7 May, 2021 | 08:18h | UTCHow to Diagnose and Manage QT Prolongation in Cancer Patients – JACC: CardioOncology
Commentary on Twitter (thread – click for more)
1/3 #JACCCardioOnc Just out 🔥 in @JACCJournals , our perspective on Management of QT prolongation in patients with cancer 👉🏼 https://t.co/s2Fo6lSIFc pic.twitter.com/FamiE0huCh
— Juan Lopez-Mattei, MD (@onco_cardiology) March 16, 2021
Observational study in Qatar: Pfizer–BioNTech Covid vaccine is 89.5% effective against B.1.1.7 variant and 75.0% effective against B.1.351 variant. Vaccine effectiveness against severe, critical, or fatal disease with any SARS-CoV-2 variant was very high, at 97.4%.
6 May, 2021 | 09:06h | UTC
Commentary on Twitter
https://twitter.com/DrEricDing/status/1390107362485211136
RCT: Novavax vaccine is 49.4% effective against B.1.351 SARS-CoV-2 variant.
6 May, 2021 | 09:08h | UTC
Organ transplant recipients remain vulnerable to Covid-19 even after second vaccine dose.
6 May, 2021 | 09:03h | UTCOriginal Study: Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients – JAMA
[Press release – not published yet] Moderna announces positive initial booster data against SARS-CoV-2 variants of concern.
6 May, 2021 | 08:57h | UTCModerna Announces Positive Initial Booster Data Against SARS-CoV-2 Variants of Concern – Moderna
Commentary: We just got our first evidence that Moderna’s coronavirus booster shot works to fight variants – Insider
Commentaries on Twitter
Moderna announces that a single dose of their #COVID19 booster shot provides a strong immunologic response to the variant first identified in South Africa (B.1.351) & Brazil (P.1).
This was also well tolerated.
Press release: https://t.co/q46Wx27BzI pic.twitter.com/16JpxrM4Vq
— Isaac Bogoch (@BogochIsaac) May 5, 2021
Great news
💥Single booster dose of 50 µg of mRNA-1273 or mRNA-1273.351 increased neutralizing titers against SARS-CoV-2 and two variants of concern (B.1.351, P.1)in previously vaccinated clinical trial participants💥 https://t.co/rzhDsgxEDh— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 6, 2021
Perspective | How many COVID deaths are acceptable in a post-pandemic world? “Even after mass vaccinations, some hospitalizations and deaths from the coronavirus are inevitable — but opinions differ on how many is too many for a return to relative normality.”
6 May, 2021 | 08:59h | UTCHow many COVID deaths are acceptable in a post-pandemic world? – Nature
RCT: Perioperative dexamethasone reduces postoperative nausea and vomiting and is not associated with increased risk of surgical-site infections, even among diabetic patients.
6 May, 2021 | 08:54h | UTCDexamethasone and Surgical-Site Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Dexamethasone treatment safe in surgery – Monash University
Practice changing | A four-month rifapentine regiment with moxifloxacin is noninferior to the standard 6-month regimen in the treatment of tuberculosis.
6 May, 2021 | 08:56h | UTCCommentary: Four-month TB treatment matches six-month standard of care – Aidsmap
RCT: The combination of liraglutide + exercise improves weight loss maintenance more than either treatment alone.
6 May, 2021 | 08:52h | UTCCommentary: Liraglutide beneficial for post-diet weight loss maintenance – Medwire News
Review: Diagnosis and management of stable angina.
6 May, 2021 | 08:49h | UTCDiagnosis and Management of Stable Angina: A Review – JAMA (free for a limited period)
Podcast: Chronic Stable Angina—Diagnosis and Treatment – JAMA
Guideline: Diagnosis and treatment of neurogenic dysphagia.
6 May, 2021 | 08:51h | UTC
New WHO benchmarks help countries reduce salt intake and save lives.
6 May, 2021 | 08:47h | UTCNew WHO benchmarks help countries reduce salt intake and save lives – World Health Organization
Publication: WHO global sodium benchmarks for different food categories – World Health Organization
[Preprint] SARS-CoV-2 antibodies remain detectable 12 months after infection and antibody magnitude is associated with age and COVID-19 severity
5 May, 2021 | 08:40h | UTCCommentary: SARS-CoV-2 antibodies are detectable up to a year after infection, finds study – News Medical
Commentary on Twitter
https://twitter.com/hildabast/status/1388963453134532609
WHO: New report sounds the alarm on global shortage of 900 000 midwives.
6 May, 2021 | 08:45h | UTCNew report sounds the alarm on global shortage of 900 000 midwives – World Health Organization
Report: The State of the World’s Midwifery 2021 – UN sexual and reproductive health agency
Commentary on Twitter (thread – click for more)
9⃣3⃣% of #midwives are women. But too many face persistent gender discrimination that prevents them from thriving professionally.
Gender transformative policies are key to change this! 👉https://t.co/qxkv16SVxp #MidwivesDay #IDM2021 pic.twitter.com/7aBBwvXFQa
— World Health Organization (WHO) (@WHO) May 5, 2021
Consensus Statement: Post-exercise recovery for the endurance athlete with type 1 diabetes.
6 May, 2021 | 08:42h | UTCPost-exercise recovery for the endurance athlete with type 1 diabetes: a consensus statement – The Lancet Diabetes & Endocrinology (free registration required)
Commentary on Twitter
Post-exercise recovery for the #endurance #athlete with type 1 #diabetes: a consensus statement https://t.co/eCmIeXtGDh #exercise #T1D #FREE to read with registration (also FREE)
— The Lancet Diabetes & Endocrinology (@TheLancetEndo) April 17, 2021
Cohort study: Increased risk in suicide and self-harm in adult survivors of critical illness.
6 May, 2021 | 08:44h | UTCCommentary: ICU admission linked to increased risk of future suicide and self-harm – The BMJ
Commentary on Twitter
Survivors of critical illness have increased risk of suicide and self-harm, and these outcomes were associated with pre-existing psychiatric illness and receipt of invasive life support, concludes new study @shanfernands https://t.co/WOHBAdnBWK
— The BMJ (@bmj_latest) May 5, 2021
COVID has pushed medical research into remote trials, benefiting patients and scientists
5 May, 2021 | 08:38h | UTC
Covax: How will Covid vaccines be shared around the world?
5 May, 2021 | 08:35h | UTCCovax: How will Covid vaccines be shared around the world? – BBC
Related: WHO chief – The world can bring the global COVID-19 pandemic under control in the coming months provided it distributes the necessary resources fairly AND A year in the COVID-19 vaccine scheme COVAX