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CDC website now emphasizes coronavirus spreads in the air.
10 May, 2021 | 01:11h | UTCCDC website now emphasizes coronavirus spreads in the air – CNN
Commentary on Twitter
1/ A radical shift today by @CDCgov, finally aligning itself with science on the modes of transmission, and throwing away the 1910 error of considering "close contact" a mode of transmission!https://t.co/5pP25OTY5d
— Prof. Jose-Luis Jimenez (@jljcolorado) May 8, 2021
Here’s what’s known about the coronavirus variants.
10 May, 2021 | 01:12h | UTCHere’s what’s known about the coronavirus variants – CNN
Viewpoint | Precision Medicine for COVID-19: Phenotype Anarchy or Promise Realized?
10 May, 2021 | 01:09h | UTCPrecision Medicine for COVID-19: Phenotype Anarchy or Promise Realized? – JAMA
Editorial: India’s COVID-19 emergency.
10 May, 2021 | 01:09h | UTCIndia’s COVID-19 emergency – The Lancet
Related: Editorial: ovid-19: India’s crisis is everyone’s crisis – The BMJ AND India’s worsening Covid crisis could spiral into a problem for the world – CNBC AND Is India’s coronavirus death ‘paradox’ vanishing? – Science
M-A: Omega-3 fatty acids supplementation increases the risk of atrial fibrillation in patients with lipid disorders.
10 May, 2021 | 01:00h | UTCCommentaries: Fish oil supplements linked with heart rhythm disorder – European Society of Cardiology AND Could High-Dose Fish Oil Raise Odds for A-Fib in Heart Patients? – HealthDay
Commentary on Twitter
Our latest work showing an increased risk of AFib with O3FA supplementation.
Omega-3 fatty acids supplementation and risk of atrial fibrillation: an updated meta-analysis of randomized controlled trials https://t.co/7Z8CAuDHNr @totocarbone @gbiondizoccai @MarcoDelBuono3 pic.twitter.com/A5m77y5xTE
— Dave Dixon, Professor & Chair @VCUPharmacy (@VCUDPOSChair) April 29, 2021
Perspective | Flu Has Disappeared Worldwide during the COVID Pandemic: “The public health measures that slow the spread of the novel coronavirus work really well on influenza”.
10 May, 2021 | 01:08h | UTCFlu Has Disappeared Worldwide during the COVID Pandemic – Scientific American
A restrictive fluid management strategy shows promise for acute kidney injury in a pilot randomized controlled trial.
10 May, 2021 | 00:57h | UTC
Commentary on Twitter
REVERSE-AKI restrictive fluid management vs usual care among critically ill pts with #AKI (proper initial fluid resus), multicenter feasibility RCT:
restriction? ⬇️cumulative fluid balance#RRT ➡️13% vs 30%
diuretics ↔️
usual care? ⬆️adverse events#FOAMcc https://t.co/JdKDo1XeIf pic.twitter.com/P1sOCHjkCS— Intensive Care Medicine (@yourICM) May 7, 2021
[#ACC21 – not published yet] 1 in 5 adults with high blood pressure also take a medicine that could be elevating their blood pressure.
10 May, 2021 | 00:58h | UTCHave high blood pressure? You may want to check your meds – American College of Cardiology
Commentary: Are You Taking a Med That’s Raising Your Blood Pressure? – HealthDay
Drugs tested in low- and middle-income countries are often not available for use in these countries even after a few years.
10 May, 2021 | 00:54h | UTC
Commentary on Twitter
Sharing benefits and burdens of clinical research? Or not…
Of 70 countries enrolling pts. for new-drug trials, 7% got market access to the drugs they helped test <1 year after FDA approval, 31% did so at 5 years. Lowest access in Africa & Middle East🤨https://t.co/p2uCP43hOG pic.twitter.com/cqsucO1kxP
— Søren M Bentzen (@SorenBentzen) May 6, 2021
Review: Colchicine and the heart.
10 May, 2021 | 00:56h | UTCColchicine and the heart – European Heart Journal
Related meta-analysis: Colchicine administration for percutaneous coronary intervention
Related randomized trials: Colchicine in patients with chronic coronary disease (study and commentaries) AND Low-Dose Colchicine Improves Outcomes after Myocardial Infarction (study and commentaries) AND Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) (study and commentary)
Commentary on Twitter
Colchicine and the heart
🎯 Great review summarizing the evidence of colchicine in CV diseases @ESC_Journals https://t.co/edDw5zID5j pic.twitter.com/NqQGgdDwlX
— Enrique Santas (@SantasEnrique) May 7, 2021
RCT: Inclusion of 18F-fluciclovine-PET/CT imaging to guide postprostatectomy salvage radiotherapy in patients with prostate cancer may improve survival free from biochemical recurrence or persistence.
10 May, 2021 | 00:46h | UTC18F-fluciclovine-PET/CT imaging versus conventional imaging alone to guide postprostatectomy salvage radiotherapy for prostate cancer (EMPIRE-1): a single centre, open-label, phase 2/3 randomised controlled trial – The Lancet (link to abstract – $ for full-text)
RCT: Efficacy and safety of voclosporin for lupus nephritis – voclosporin + MMF + low dose corticosteroids achieved complete renal response at week 52 more often than MMF + low dose corticosteroids alone (41% vs. 23%).
10 May, 2021 | 00:48h | UTCEfficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT: Community pharmacies provision of a progestogen-only pill + invitation to a sexual and reproductive health clinic as a bridging contraception intervention for women receiving emergency contraception is associated with increased subsequent use of long-term effective contraception.
10 May, 2021 | 00:45h | UTC
Case-control study shows an increased risk of colorectal cancer in first degree relatives of patients with colorectal polyps.
10 May, 2021 | 00:50h | UTCCommentaries: Intestinal polyps in close relatives can increase risk of colorectal cancer – Karolinska Institutet AND Relatives’ Colonoscopy Results Could Affect Your Colon Cancer Risk – HealthDay
Commentary on Twitter
After adjusting for family history of colorectal cancer, siblings and children of patients with colorectal polyps were found to be at increased risk of colorectal cancer in this study #BMJResearch https://t.co/E30VDw3PqT
— The BMJ (@bmj_latest) May 9, 2021
Population-based cohort study suggests increased survival after breast conservation surgery + radiotherapy compared to mastectomy with or without radiotherapy in women with breast cancer.
10 May, 2021 | 00:42h | UTC
Commentary on Twitter
Women receiving breast-conserving surgery for #breastcancer fare better than those who take away the whole breast says a new study taking into account comorbidities and socioeconomic background. Superior survival rates support less extensive surgery https://t.co/JEXasP56Di
— JAMA Surgery (@JAMASurgery) May 5, 2021
German National Guideline on the management of pilonidal disease.
10 May, 2021 | 00:40h | UTC
WHO calls for pharma transparency in clinical trial data reporting.
10 May, 2021 | 00:39h | UTCWHO Calls For Pharma Transparency In Clinical Trial Data Reporting – Health Policy Watch
WHO Statement: Joint Statement on transparency and data integrity International Coalition of Medicines Regulatory Authorities (ICMRA) and WHO
Commentary on Twitter
Wide and open access to clinical data for new medicines and vaccines will help build trust and the expand access @WHO @US_FDA @EMA_News @CDSCO_INDIA_INF @MoHFW_INDIA @ICMRDELHI @JeremyFarrar @Chikwe_I @jarottingen @pahowho https://t.co/1OACILbdh6
— Soumya Swaminathan (@doctorsoumya) May 7, 2021
One third of patients hospitalized with COVID-19 have lung changes after a year
7 May, 2021 | 08:37h | UTCCommentaries: One third of patients hospitalized with COVID-19 have lung changes after a year – University of Southampton AND An integrated understanding of long-term sequelae after acute COVID-19 – The Lancet Respiratory Medicine
Cohort study: Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S. 11 excess venous thromboembolic events per 100 000 vaccinations; 2.5 excess cerebral venous thrombosis per 100 000 vaccinations.
7 May, 2021 | 08:33h | UTCEditorial: Thromboembolism and the Oxford-AstraZeneca vaccine – The BMJ
Commentaries: Thrombosis and bleeding after the Oxford-AstraZeneca covid-19 vaccination – The BMJ Opinion AND Putting risks into context: covid-19 vaccines and blood clots – The BMJ Opinion AND Expert reaction to study from Denmark and Norway looking at rare blood clots after the Oxford-AstraZeneca vaccine – Science Media Centre
Commentary on Twitter
NEW research sheds more light on rate of rare blood clots after Oxford-AstraZeneca vaccine
Rate of adverse events low; benefits of the vaccine still outweigh risks in most situations, say researchershttps://t.co/LslgvzWlWi @Pottegard
— The BMJ (@bmj_latest) May 6, 2021
Opinion | Covid-19: Sputnik vaccine rockets, thanks to Lancet boost
7 May, 2021 | 08:31h | UTCCovid-19: Sputnik vaccine rockets, thanks to Lancet boost – The BMJ
Commentary on Twitter
Journals risk being used in place of regulators when they publish studies of novel vaccines that have not yet been authorised by a major regulator @DoctorChrisVT unpicks the story of the Sputnik V vaccine https://t.co/lYf7l0lXcy
— The BMJ (@bmj_latest) May 6, 2021
COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
7 May, 2021 | 08:35h | UTCReport: Estimation of total mortality due to COVID-19 – Institute for Health Metrics and Evaluation
Commentaries: New analysis finds global Covid death toll is double official estimates – STAT AND Global COVID-19 death toll more than double official estimates – IHME – Reuters
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
7 May, 2021 | 08:30h | UTC
Commentary on Twitter
We forget that covid-19 is a new disease, never having been seen until late 2019, w/ different features than any prior illness. A truly outstanding review today on its pathophysiology https://t.co/8gx2w8r1xf @LancetRespirMed @osuchm and colleagues pic.twitter.com/WGIfI2nb9B
— Eric Topol (@EricTopol) May 6, 2021
RCT: Therapeutic drug monitoring during infliximab induction does not improve disease remission in patients with chronic immune-mediated inflammatory diseases
7 May, 2021 | 08:27h | UTCEffect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases – JAMA (free for a limited period)
Commentary: Mixed Results with Refined Treatment Strategies for Rheumatic Diseases – Physician’s Weekly
Commentary on Twitter
Study findings do not support routine use of proactive therapeutic drug monitoring during infliximab induction for improving immune-mediated inflammatory disease remission rates https://t.co/sDslkVm3u9
— JAMA (@JAMA_current) May 5, 2021
CDC Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021
7 May, 2021 | 08:28h | UTC
Commentary on Twitter
New CDC guidelines on botulism, the first botulism clinical guidelines are excellent.
🔑 points:
1) high clinical suspicion needed
2) BAT should be given in first 24 hours but can give later if progression of paralysis
3) Retreatment not recommended https://t.co/AfhrB74G0d— Joseph Marcus (@JosephMarcusID) May 7, 2021
RCT: Among patients with rheumatoid arthritis in remission, tapering conventional DMARDs using half-dose resulted in disease flares in 25% of patients compared with 6% of patients in the stable-dose group.
7 May, 2021 | 08:26h | UTCEffect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases – JAMA (free for a limited period)
Commentary: Mixed Results with Refined Treatment Strategies for Rheumatic Diseases – Physician’s Weekly