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Case report: Thrombosis with Thrombocytopenia After the Messenger RNA–1273 Vaccine.
29 Jun, 2021 | 10:07h | UTCThrombosis With Thrombocytopenia After the Messenger RNA–1273 Vaccine – Annals of Internal Medicine
[Preprint] 3rd AstraZeneca shot gives strong immunity.
29 Jun, 2021 | 10:01h | UTCStudy: 3rd AstraZeneca shot gives strong immunity – Reuters
Original Study (preprint): Tolerability and Immunogenicity After a Late Second Dose or a Third Dose of ChAdOx1 nCoV-19 (AZD1222) – SSRN/The Lancet
Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”.
29 Jun, 2021 | 10:00h | UTC
WHO issues first global report on Artificial Intelligence (AI) in health and six guiding principles for its design and use.
29 Jun, 2021 | 09:56h | UTCGuidance: Ethics and governance of artificial intelligence for health – World Health Organization
Commentary: Artificial Intelligence ‘Very Promising’ for Health, Says WHO – Health Policy Watch
Commentary on Twitter (thread – click for more)
Artificial Intelligence (#AI) holds enormous potential for improving the health of millions of people around 🌎🌍🌏, but only if ethics & human rights are put at the heart of its design, deployment, & use.
More in WHO’s first global report on AI & Health👉https://t.co/fC7SX51YzY pic.twitter.com/1Jp0ASPDY3
— World Health Organization (WHO) (@WHO) June 28, 2021
The COVID pandemic’s lingering impact on clinical trials – “Medical researchers are beginning to shift their focus away from COVID-19 — but the pandemic could continue to affect studies focused on other diseases.”
29 Jun, 2021 | 09:57h | UTCThe COVID pandemic’s lingering impact on clinical trials – Nature
Systematic review: the evidence behind robot-assisted abdominopelvic surgery – “there is currently no clear advantage with existing robotic platforms, which are costly and increase operative duration”.
29 Jun, 2021 | 09:55h | UTCThe Evidence Behind Robot-Assisted Abdominopelvic Surgery: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Robotic Platforms Not Superior for Abdominopelvic Surgery – HealthDay
Podcast | Evaluation and management of hypercalcemia.
29 Jun, 2021 | 09:51h | UTC#281 Hypercalcemia: Calci-fun! with Dr. Carl Pallais – The Curbsiders
EBM Analysis | Does tranexamic acid work for everything? For anything?
29 Jun, 2021 | 09:53h | UTCDoes TXA work for everything? For anything? – First10EM
Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.
28 Jun, 2021 | 10:01h | UTCCommentaries: Heterologous vaccine regimens against COVID-19 – The Lancet AND
Commentary on Twitter (thread – click for more)
NEW #COVID19 research—Phase 2 trial by @borobia_am, @antoniojcarcas
et al. reports BNT162b2 given as a 2nd dose in individuals prime vaccinated with ChAdOx1-S induced a robust immune response, with an acceptable and manageable reactogenicity profile. Read https://t.co/muL0XQxdjG. pic.twitter.com/BxPlXB8EF7— The Lancet (@TheLancet) June 26, 2021
WHO urges fully vaccinated people to continue to wear masks as delta Covid variant spreads.
28 Jun, 2021 | 09:55h | UTCWHO urges fully vaccinated people to continue to wear masks as delta Covid variant spreads – CNBC
Commentary on Twitter (thread – click for more)
⚠️WEAR MASK EVEN IF VACCINATED—Top @WHO leader urges masks against #DeltaVariant even if 2-dose vaxxed. "Vaccine alone won't stop community transmission. People need to use masks consistently, be in ventilated spaces—even if you're vaccinated" #COVID19🧵https://t.co/qPZTmcy9iW pic.twitter.com/j5V6fbHdoi
— Eric Feigl-Ding (@DrEricDing) June 26, 2021
RCT: Similar outcomes with mycophenolate mofetil vs. azathioprine in kidney transplant recipients on steroid-free, low-dose cyclosporine immunosuppression.
29 Jun, 2021 | 09:50h | UTC
Delta “Plus”: Scientists say too early to tell risk of Covid-19 variant.
28 Jun, 2021 | 09:53h | UTCDelta plus India: Scientists say too early to tell risk of Covid-19 variant – BBC
Perspective | Is one vaccine dose enough if you’ve had COVID? What the science says.
28 Jun, 2021 | 09:52h | UTCIs one vaccine dose enough if you’ve had COVID? What the science says – Nature
Commentary on Twitter
One vaccine dose for prior covid: @ElieDolgin reviews the recent data @Nature https://t.co/amJ4RcGtuW
Vaccination cards/proof should be modified here to equate prior covid as the 1st dose and not force people to get an unnecessary 2nd dose— Eric Topol (@EricTopol) June 27, 2021
Study finds 96.1% of patients objectively recovered from anosmia 1 year after COVID-19 diagnosis.
28 Jun, 2021 | 09:49h | UTCClinical Outcomes for Patients With Anosmia 1 Year After COVID-19 Diagnosis – JAMA Network Open
Commentary: Did Covid-19 take your taste and smell? Here’s when they may return – CNN AND Lost Sense of Smell Returns for Almost All COVID Survivors – HealthDay
WHO: Delta variant is ‘most transmissible’ identified so far.
28 Jun, 2021 | 09:58h | UTCWHO: Delta variant is ‘most transmissible’ identified so far – Associated Press
Related: Delta COVID variant fuels global surges, complicates reopenings – CIDRAP AND Delta variant triggers dangerous new phase in the pandemic – Science AND Delta coronavirus variant: scientists brace for impact – Nature AND Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States – medRxiv AND COVID-19: The rise and rise of Delta – Sciblogs AND Increased transmissibility and global spread of SARS-CoV-2 variants of concern – “Estimated transmissibility increases of alpha 29% (95% CI: 24–33), beta 25% (95% CI: 20–30), gamma 38% (95% CI: 29–48) & delta 97% (95% CI: 76–117)”.
Putting people first in managing their health: new WHO guideline on self-care interventions – “Whether it’s for their experience of pregnancy and childbirth; managing fertility intentions, preventing sexually transmitted infections; enjoying better sexual health of themselves or their partner, or self-monitoring their blood pressure, access to quality self-care interventions can help meet people’s many health needs and rights”.
28 Jun, 2021 | 09:40h | UTCNews release: Putting people first in managing their health: new WHO guideline on self-care interventions – World Health Organization
See guidance: WHO consolidated guideline on self-care interventions for health
Commentary on Twitter (thread – click for more)
https://twitter.com/WHO/status/1408350517428953091
IDSA Updated Covid-19 Guidance: Co-Infection and Antimicrobial Stewardship – “bacterial coinfections with SARS-CoV-2 infection are relatively infrequent (likely occurring in less than 10% of hospitalized COVID-19 patients)”.
28 Jun, 2021 | 09:51h | UTCCo-Infection and Antimicrobial Stewardship – Infectious Diseases Society of America
RCT: Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2.
28 Jun, 2021 | 09:46h | UTC
Consensus Recommendations on the Treatment of Opioid Use Disorder in the Emergency Department.
28 Jun, 2021 | 09:43h | UTC
Impact factor abandoned by Dutch university in hiring and promotion decisions – “Faculty and staff members at Utrecht University will be evaluated by their commitment to open science”.
28 Jun, 2021 | 09:37h | UTCImpact factor abandoned by Dutch university in hiring and promotion decisions – Nature
Related: Open-access Science Funders Announce Price Transparency Rules for Publishers (several resources on the subject) AND A new mandate highlights costs, benefits of making all scientific articles free to read – Science AND A guide to Plan S: the open-access initiative shaking up science publishing – Nature
RCT: Tirzepatide yielded greater glycated hemoglobin and body weight reductions compared to Semaglutide 1 mg.
28 Jun, 2021 | 09:45h | UTCTirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Combo GIP/GLP-1 Drug Superior for HbA1c Reduction in T2D – MedPage Today (free registration required)
[Preprint] Long Covid: Third of people infected have long term symptoms.
25 Jun, 2021 | 10:30h | UTCCovid-19: Third of people infected have long term symptoms – The BMJ
Original study (preprint): Persistent symptoms following SARS-CoV-2 infection in a random community sample of 508,707 people – Imperial College London
Guideline | Perimenopause and Postmenopause – Diagnosis and Interventions.
28 Jun, 2021 | 09:32h | UTC
AASLD Guideline: Vascular liver disorders, portal vein thrombosis, and procedural bleeding in patients with liver disease.
28 Jun, 2021 | 09:33h | UTC
Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis.
25 Jun, 2021 | 10:37h | UTC
Commentary on Twitter
#COVID19 Associated Pulmonary Aspergillosis
🍄increasing, associated with excess mortality
🍄complex: colonization + tissue/angio-invasion
🍄diagnose? bronchoscopy/BAL
🍄antifungals recommended
🍄consider discontinuating/tapering steroids in no respondershttps://t.co/HhS6wUfibn pic.twitter.com/CJwE3CEXxn— Intensive Care Medicine (@yourICM) June 23, 2021