All Posts
Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.
16 Jul, 2021 | 11:06h | UTCLong-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – JAMA
Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.
16 Jul, 2021 | 11:02h | UTCHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Related: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. AND Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. AND RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
Health care workers who had received a dose of ChAdOx1 nCoV-19 were offered either ChAdOx1 nCoV-19 or mRNA-1273 9 to 12 weeks later. Levels of S-specific and RBD-specific IgG increased by a factor of 5 after ChAdOx1 nCoV-19 and by a factor of 115 to 125 after mRNA-1273.
— NEJM (@NEJM) July 14, 2021
Short review: The gut in COVID-19.
16 Jul, 2021 | 10:54h | UTCThe gut in COVID-19 – Intensive Care Medicine
Commentary on Twitter
Gut & #COVID19, main findings
➡️clinical GI features
➡️pathophysiology: cytotoxic enterocyte injury, microvascular injury/thromboinfammation, non‑specifc critical illness‑related dysfunction
➡️GI dysfunction in severe #SARSCoV2 vs other critical illnesseshttps://t.co/wzzTNldInN pic.twitter.com/DnHLMsSu6v— Intensive Care Medicine (@yourICM) July 9, 2021
Donuts, drugs, booze, and guns: what governments are offering people to take covid-19 vaccines – “Incentive programs do not target the trust relationship between the public and the providers”.
16 Jul, 2021 | 10:56h | UTC
Deaths from COVID ‘incredibly rare’ among children.
16 Jul, 2021 | 10:58h | UTCDeaths from COVID ‘incredibly rare’ among children – Nature
Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.
16 Jul, 2021 | 11:00h | UTCHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Related: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. AND Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. AND RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
https://twitter.com/EricTopol/status/1415297187718696964
AAFP Guideline: Pharmacologic Management of COPD Exacerbations.
16 Jul, 2021 | 10:51h | UTC
AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia.
16 Jul, 2021 | 10:46h | UTC
Commentary on Twitter
Out now in @AGA_CGH: AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia. Had great time working on this with @AasmaShaukatMD & @seth_crockett. Hope it's a useful reference! @AmerGastroAssn
https://t.co/UB5hFMq6hc pic.twitter.com/KwHeKjU2dk— Peter Liang, MD MPH (@petersliang) February 19, 2021
Pathophysiology of COVID-19-associated acute kidney injury.
16 Jul, 2021 | 10:52h | UTCPathophysiology of COVID-19-associated acute kidney injury – Nature Reviews Nephrology
Joint Opinion from ACC/AHA/ESC/WHF | Clinician Well-Being: Addressing Global Needs for Improvements in the Health Care Field.
16 Jul, 2021 | 10:48h | UTC
Commentary on Twitter
ICYMI: Leading CV orgs #AgainstClinicianBurnout recognize that #ClinicianWellBeing is paramount to providing high-quality patient care and are committed to improving the well-being of the CV workforce. ➡️ https://t.co/ufwAWWakPp @JACCJournals @AHAScience @escardio @worldheartfed pic.twitter.com/iyr3BxNRpr
— American College of Cardiology (@ACCinTouch) July 15, 2021
M-A of randomized trials: In patients with acute respiratory distress syndrome, there was no difference in mortality between higher vs. lower positive end-expiratory pressure strategies.
16 Jul, 2021 | 10:43h | UTC
Assessment and management of peripheral arterial disease: what every cardiologist should know.
16 Jul, 2021 | 10:33h | UTC
Commentary on Twitter
https://twitter.com/Heart_BMJ/status/1400364145980100609
RCT: Ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease.
16 Jul, 2021 | 10:37h | UTC
Review: Sedation in the Intensive Care Unit.
16 Jul, 2021 | 10:31h | UTCSedation in the Intensive Care Unit – Current Anesthesiology Reports
Beyond coronavirus: the virus discoveries transforming biology – “SARS-CoV-2 is just one of nonillions of viruses on our planet, and scientists are rapidly identifying legions of new species”.
16 Jul, 2021 | 10:35h | UTCBeyond coronavirus: the virus discoveries transforming biology – Nature
Commentary on Twitter
.@Nature reports how over the past 10 years, the number of known and named viruses has exploded, owing to advances in the technology for finding them, plus a recent change to the rules for identifying new species. https://t.co/lGqrpOWBsB
— Nature Portfolio (@NaturePortfolio) July 3, 2021
RCT: Effect of neurofeedback facilitation on poststroke gait and balance recovery.
16 Jul, 2021 | 10:30h | UTCCommentary: Neurofeedback Facilitation Improves Gait and Balance in Post-Stroke Patients – BrainPost
M-A: Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis.
16 Jul, 2021 | 10:28h | UTCNon-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and network meta-analysis – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary on Twitter
New research – Akshintala et al – NSAIDs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-ERCP #pancreatitis: a systematic review and network meta-analysishttps://t.co/2Sh8WhqZRD#GITwitter #endoscopy #ERCP pic.twitter.com/nvAKXyPv13
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) June 30, 2021
RCT: Bamlanivimab plus Etesevimab reduce mortality and hospitalization in ambulatory patients with early Covid-19 (within 3 days of a positive test) who are at risk for clinical deterioration (i.e., older people, obese, diabetics, immunocompromised, with CV disease).
15 Jul, 2021 | 09:26h | UTCBamlanivimab plus Etesevimab in Mild or Moderate Covid-19 – New England Journal of Medicine
Severe hearing loss in adults: finding out whether cochlear implants or hearing aids are better.
16 Jul, 2021 | 10:27h | UTC
Commentary on Twitter
Severe hearing loss in adults: finding out whether #CochlearImplants or #HearingAids are better: https://t.co/II0l1G74ny In a new @CochraneUK blog, Dr Adele Horobin from @NottmBRC discusses @COACH_trial, a new clinical trial seeking to find an answer. #LivingWithLTCs #HearingLoss pic.twitter.com/4Tx4jUC1KO
— The Cochrane Library (@CochraneLibrary) July 7, 2021
Long COVID and kids: scientists race to find answers – “Children get long COVID too, but researchers are still working to determine how frequently and how severely”.
15 Jul, 2021 | 09:23h | UTCLong COVID and kids: scientists race to find answers – Nature
Millions of children worldwide missed routine vaccinations during the pandemic, study suggests.
15 Jul, 2021 | 09:24h | UTCMillions of children worldwide missed routine vaccinations during the pandemic, study suggests – CNN
Invited Commentary: Disruptions to childhood immunisation due to the COVID-19 pandemic – The Lancet
COVID and the brain: researchers zero in on how damage occurs.
15 Jul, 2021 | 09:18h | UTCCOVID and the brain: researchers zero in on how damage occurs – Nature
Why aren’t diseases like HIV and malaria, which still kill millions of people a year, called pandemics? – “HIV and AIDS, tuberculosis, and malaria shouldn’t be labeled as “just” epidemics or endemic. They are pandemics that have been beaten in rich countries”.
15 Jul, 2021 | 09:22h | UTC
Commentary on Twitter
"HIV, TB, and malaria shouldn’t be labeled as “just” epidemics or endemic. They are pandemics that have been beaten in rich countries. Allowing them to persist elsewhere is a policy choice and a budgetary decision"https://t.co/MVCS960cN5
— Madhu Pai, MD, PhD (@paimadhu) July 14, 2021
Study shows the viral loads in the Delta infections are ~1000 times higher than those in the earlier strain infections on the day when viruses are firstly detected.
15 Jul, 2021 | 09:20h | UTCCommentary: The Delta Variant Isn’t Just Hyper-Contagious. It Also Grows More Rapidly Inside You – NPR
Related: WHO: Delta variant is ‘most transmissible’ identified so far. AND Increased transmissibility and global spread of SARS-CoV-2 variants of concern – “Estimated transmissibility increases of alpha 29% (95% CI: 24–33), beta 25% (95% CI: 20–30), gamma 38% (95% CI: 29–48) & delta 97% (95% CI: 76–117)”.
Commentary on Twitter
Part of the challenge that Delta presents may be tied to this finding
The variant's viral load ~1,000X higher than previous strains (reflected by low CTs), more infectious in the early stages of the illnesshttps://t.co/09CDQFwCSV pic.twitter.com/mjIfcNTYlO— Eric Topol (@EricTopol) July 9, 2021
[Preprint] Brain imaging before and after COVID-19 in UK Biobank.
15 Jul, 2021 | 09:17h | UTCBrain imaging before and after COVID-19 in UK Biobank – medRxiv
Commentaries: COVID linked to loss of brain tissue: but correlation doesn’t prove causation – The Conversation AND COVID-19 survivors may suffer from a loss of gray matter and other brain tissue over time, a long-term study suggests – Business Insider