All Posts
ALA/ATS Response to Philip Morris International’s (PMI) Purchase of British Producer of Respiratory Treatments – “The announcement that PMI wants to acquire an inhaled medicine company is the latest reprehensible choice from a company that has profited from addicting users to its deadly products”.
20 Jul, 2021 | 10:12h | UTC
RCT: Once weekly semaglutide 2.0 mg vs. 1.0 mg in patients with type 2 diabetes – Mean change in HbA1c from baseline was −2.2 percentage points with 2.0 mg vs. −1.9 percentage points with 1.0 mg; mean change in bodyweight from baseline was −6.9 kg with 2.0 mg vs. −6.0 kg with 1.0 mg.
20 Jul, 2021 | 10:09h | UTCEfficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in patients with type 2 diabetes (SUSTAIN FORTE): a double-blind, randomised, phase 3B trial – The Lancet Endocrinology & Diabetes (link to abstract – $ for full-text)
Brief review: Management of coronary artery disease in high-risk occupations.
20 Jul, 2021 | 10:08h | UTCManagement of Coronary Artery Disease in High-Risk Occupations – American College of Cardiology
Commentary on Twitter
Cardiovascular events can be associated with sudden incapacitation, which in high-risk occupations, could result in catastrophic consequences for the driver or pilot, passengers and bystanders. Read the full story here: https://t.co/VhEa3ZSjMU @rblument1 #cvCAD #HeartDisease
— American College of Cardiology (@ACCinTouch) July 19, 2021
Expert opinion | Bioprosthetic valves and atrial fibrillation: Direct anticoagulants or warfarin – Until conclusive data are available for patients with rheumatic heart disease and those with mechanical valves, DOAC use is not indicated in these patients.
20 Jul, 2021 | 10:06h | UTC
Systematic review: In hospitalized non‐ICU patients, multicomponent non-pharmacological interventions are estimated to reduce the incidence of delirium by 43% compared to usual care.
20 Jul, 2021 | 10:07h | UTC
RCT: more data showing Azithromycin is not better than placebo in patients with Covid-19.
18 Jul, 2021 | 23:54h | UTCRelated: RCT: Another study shows Azithromycin does not improve outcomes in patients with Covid-19. (several articles on the subject)
Commentary on Twitter
Among outpatients with #SARSCoV2 infection, treatment with a single dose of oral #azithromycin compared with placebo did not result in a greater likelihood of being free of symptoms at day 14 https://t.co/dYDcSyGtwd #COVID19
— JAMA (@JAMA_current) July 16, 2021
Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020.
20 Jul, 2021 | 10:04h | UTCRelated: Millions of children worldwide missed routine vaccinations during the pandemic, study suggests.
Review: Symptoms, complications and management of long COVID.
18 Jul, 2021 | 23:46h | UTCCommentary: Long COVID: More likely in patients with 5+ symptoms in first week of infection – SAGE Publications
Commentary on Twitter
Pooled prevalence data in this review showed the 10 most prevalent reported symptoms of long covid were: fatigue, shortness of breath, muscle pain, joint pain, headache, cough, chest pain, altered smell, altered taste and diarrhoea.
https://t.co/ww5HM1s7vm— KK Cheng (@KKCheng4) July 16, 2021
Study: Coffee consumption not linked to increased incidence of tachyarrhythmias.
20 Jul, 2021 | 10:02h | UTCInvited commentary: Another Cup of Coffee Without an Arrhythmia, Please
Author interview: Coffee Consumption and Incident Tachyarrhythmias
Commentary on Twitter
Good news for coffee drinkers ☕️☕️
Debunking the dogma that coffee increases the risk of heart rhythm disturbances, from >386,000 people, 4.5 year follow-up, including putative genomic risk variants@JAMAInternalMed https://t.co/9bBihDfB3A @uk_biobank pic.twitter.com/V6yGeNg7Fp— Eric Topol (@EricTopol) July 19, 2021
Position Paper: Recommendations for the use of topical inhalant budesonide in COVID-19.
18 Jul, 2021 | 23:53h | UTCRecommendations for use of topical inhalant budesonide in COVID-19 – HNO
Related: RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19 AND Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19
Studies elucidate poorly understood long COVID.
18 Jul, 2021 | 23:42h | UTCStudies elucidate poorly understood long COVID – CIDRAP
Long Covid: fatigue, post-exertional malaise, and cognitive dysfunction are the most common symptoms, according to an international survey.
18 Jul, 2021 | 23:44h | UTCCommentaries: Identification of over 200 long COVID symptoms prompts call for UK screening programme – University College London AND A survey of long-haulers found 66 symptoms that lasted more than 6 months. Tiredness and brain fog were most common. – Insider AND Long Covid has more than 200 symptoms, study finds – The Guardian
CDC warns Covid-19 vaccines might not protect people who are immunocompromised – “CDC is looking into ongoing research exploring the possibility that immunocompromised could benefit from an additional dose”.
18 Jul, 2021 | 23:38h | UTCCDC warns Covid-19 vaccines might not protect people who are immunocompromised – CNN
Fauci says natural origins theory of coronavirus is still the most likely.
18 Jul, 2021 | 23:40h | UTCFauci says natural origins theory of coronavirus is still the most likely – CNN
Related article (preprint): The Origins of SARS-CoV-2: A Critical Review – Zenodo
See also: A Group of Scientists Presses a Case Against the Lab Leak Theory of Covid – The New York Times (a few articles per month are free) AND Leading scientists push back against Wuhan lab leak theory – The Age
Related: Opinion | The Covid-19 lab leak theory is a tale of weaponized uncertainty.
WHO publishes new Consolidated HIV guidelines for prevention, treatment, service delivery & monitoring.
18 Jul, 2021 | 23:22h | UTC
Review: Acute kidney injury.
18 Jul, 2021 | 23:18h | UTCAcute kidney injury – Nature Reviews Disease Primers (free for a limited period)
Commentary on Twitter
Get Primed on #AcuteKidneyInjury with our NEW PrimeView, FREE to download this week https://t.co/4RAOOaB8ep pic.twitter.com/d5iHCcqJwY
— Nature Reviews Disease Primers (@DiseasePrimers) July 15, 2021
Review: Parkinson disease-associated cognitive impairment.
18 Jul, 2021 | 23:17h | UTCParkinson disease-associated cognitive impairment – Nature Reviews Disease Primers (free for a limited period)
Infographic: Parkinson disease-associated cognitive impairment
Review: Glucocorticoid induced adrenal insufficiency.
18 Jul, 2021 | 23:15h | UTCGlucocorticoid induced adrenal insufficiency – The BMJ
Commentary on Twitter
◾ What factors affect the risk of Glucocorticoid induced adrenal insufficiency?
◾ What regimen can be used for glucocorticoid taper?
◾ How can adrenal function recovery be best assessed?Read our latest clinical review to find out: https://t.co/m814c1rgIs
— The BMJ (@bmj_latest) July 13, 2021
Study: Pooled saliva analysis is a low-cost and effective strategy for surveillance of Covid-19 in schools and universities and allows to rapidly assess transmission and adjust prevention protocols.
18 Jul, 2021 | 23:37h | UTCRelated: Pooling of Samples for Testing for SARS-CoV-2 in Asymptomatic People AND Implementation of a Pooled Surveillance Testing Program for Asymptomatic SARS-CoV-2 Infections on a College Campus — Duke University, Durham, North Carolina, August 2–October 11, 2020 – CDC Morbidity and Mortality Weekly Report
AHA/ASA Scientific Statement: Primary Care of Adult Patients After Stroke.
18 Jul, 2021 | 23:20h | UTCNews release: Comprehensive primary care is vital to holistic care and optimal recovery after a stroke – American Heart Association
Commentary on Twitter
Primary Care of Adult Patients After Stroke: A Scientific Statement From the American Heart Association/American Stroke Association https://t.co/moIZ1W2cXL @American_Heart @American_Stroke pic.twitter.com/jWOK8Fz0vM
— Stroke AHA/ASA (@StrokeAHA_ASA) July 15, 2021
M-A: benefit-to-harm balance of statins in primary prevention of cardiovascular disease generally favorable.
18 Jul, 2021 | 23:16h | UTCNews release: New study suggests benefit-to-harm balance of statins for healthy adults ‘generally favorable’ – BMJ
Commentary on Twitter
Statins are associated with a small increased risk of side effects in patients without a history of heart disease, but these effects are mild compared with the potential benefits of treatment in preventing major cardiovascular events, say researchers https://t.co/Yvn7Ojtx2F
— The BMJ (@bmj_latest) July 17, 2021
RCT: No benefit from platelet-rich plasma injection for patients with debilitating Achilles tendinopathy.
18 Jul, 2021 | 23:13h | UTCEffect of Platelet-Rich Plasma Injection vs Sham Injection on Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: No benefit from PRP treatment for patients with debilitating Achilles tendon pain – University of Warwick
Commentary on Twitter
A single injection of platelet-rich plasma compared with a sham injection did not significantly reduce #Achillestendon dysfunction https://t.co/K4YKHSbxZY
— JAMA (@JAMA_current) July 13, 2021
Body-mass index and diabetes risk in 57 low-income and middle-income countries – “Optimal BMI thresholds for diabetes screening ranged from 23·8 kg/m2 among men in east, south, and southeast Asia to 28·3 kg/m2 among women in the Middle East and north Africa and in Latin America and the Caribbean”.
18 Jul, 2021 | 23:10h | UTCBody-mass index and diabetes risk in 57 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data in 685 616 adults – The Lancet (link to abstract – $ for full-text)
Related: Study shows BMI cut-offs for obesity and diabetes risk do not work for non-white populations. AND Study: Certain Racial/Ethnic Groups More Likely to Have Diabetes and Prediabetes at Lower Weights
Perspective | Averting Future Vaccine Injustice.
16 Jul, 2021 | 11:04h | UTCAverting Future Vaccine Injustice – New England Journal of Medicine
Commentary on Twitter
As high-income countries have secured much of the #Covid19vaccine supply, many low-income countries have barely begun the immunization process. We need political courage to end vaccine injustice now and political vision to negotiate rules for averting future inequities.
— NEJM (@NEJM) July 15, 2021
Why was a major study on ivermectin for covid-19 just retracted?
16 Jul, 2021 | 11:11h | UTCWhy Was a Major Study on Ivermectin for COVID-19 Just Retracted? – Grifter Analysis and Review
See also: Huge study supporting ivermectin as Covid treatment withdrawn over ethical concerns – The Guardian AND Some problems in the dataset of a large study of Ivermectin for the treatment of Covid-19 – Nick Brown’s Blog AND Is Ivermectin for Covid-19 Based on Fraudulent Research? – Gideon M-K; Health Nerd
Commentary on Twitter (thread – click for more)
So, one of the biggest studies to date on ivermectin for COVID-19 has issues significant enough that, if not fraud, are so serious that it invalidates the study without further explanation
I promised a thread
Here we go 1/n https://t.co/L9QOChmGtA
— Health Nerd (@GidMK) July 16, 2021