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ASCO Guideline Update: Endocrine Treatment and Targeted Therapy for Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer.

30 Jul, 2021 | 11:51h | UTC

Endocrine Treatment and Targeted Therapy for Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer: ASCO Guideline Update – Journal of Clinical Oncology

RCT: Duration of adjuvant aromatase-inhibitor therapy in postmenopausal breast cancer.

30 Jul, 2021 | 11:43h | UTC

Duration of Adjuvant Aromatase-Inhibitor Therapy in Postmenopausal Breast Cancer – New England Journal of Medicine

Commentary on Twitter

In postmenopausal women with hormone-receptor-positive breast cancer who had 5 yrs of AI, extending adjuvant endocrine therapy by 5 years provides no benefit over a 2-year extension but is associated with a greater risk of bone fracturehttps://t.co/YDxeQVu8B9

— K Pavithran (@drkpavithran) July 29, 2021

Management of the Axilla in Early-Stage Breast Cancer: Ontario Health (Cancer Care Ontario) and ASCO Guideline.

30 Jul, 2021 | 11:49h | UTC

Management of the Axilla in Early-Stage Breast Cancer: Ontario Health (Cancer Care Ontario) and ASCO Guideline – Journal of Clinical Oncology

Donor drug use is not associated with worse recipient survival in heart transplantation – “Increasing use of such donors may help alleviate the chronic donor shortage.”

30 Jul, 2021 | 11:39h | UTC

Intoxicated Donors and Heart Transplant Outcomes: Long-Term Safety – Circulation: Heart Failure

Commentary: Donor Drug Use Not Tied to Survival for Heart Transplant Recipients – HealthDay

RCT: Among pregnant women with primary CMV infection diagnosed before 24 weeks’ gestation, monthly infusion of CMV hyperimmune globulin did not prevent congenital cytomegalovirus infection.

30 Jul, 2021 | 11:42h | UTC

A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Hyperimmune Globulin Fails to Prevent Congenital CMV – Physician’s Weekly

Serious complications from youth-onset type 2 diabetes arise by young adulthood.

30 Jul, 2021 | 11:47h | UTC

Commentary: Serious complications from youth-onset type 2 diabetes arise by young adulthood – NIH News Release

Original study: Long-Term Complications in Youth-Onset Type 2 Diabetes – New England Journal of Medicine

Commentary on Twitter

High rates of complications in youth onset T2 diabetes.
Complication occurred in 60% after 13 years

Risk factors for development of complications:
Ethnic minority
Hyperglycaemia
Hypertension
Dyslipidaemia

Importance of risk factor controlhttps://t.co/UcUnuLv0PC pic.twitter.com/TfLEASSQnQ

— Prof Kamlesh Khunti (@kamleshkhunti) July 29, 2021

20-year observational study suggests return to play is manageable for most athletes with Long QT Syndrome or genetic heart diseases.

30 Jul, 2021 | 11:40h | UTC

News release: 20-year study suggests return to play is manageable for athletes with most genetic heart diseases – Mayo Clinic

Original study: Return-to-Play for Athletes With Long QT Syndrome or Genetic Heart Diseases Predisposing to Sudden Death – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries:

Return to Play Seems Safe for Most Athletes With Long QT Syndrome – HealthDay

Return-to-Play for Athletes With LQTS or Genetic Heart Diseases – American College of Cardiology

Commentary on Twitter

SO EXCITED about our 20-year review of every #athlete with #genetic #heart #disease who I have had the privilege to care of @MayoClinic @MayoClinicCV. Hopefully, this experience will spell the end of immediate disqualifications. https://t.co/574xI8aGKh

— Michael J. Ackerman MD,PhD (@MJAckermanMDPhD) July 27, 2021

Review: Changing paradigms in the management of acute uncomplicated diverticulitis.

30 Jul, 2021 | 11:37h | UTC

Changing Paradigms in the Management of Acute Uncomplicated Diverticulitis – Scandinavian Journal of Surgery

RCT: Another study shows that non-antibiotic outpatient treatment in mild acute diverticulitis is safe.

Review: Elective surgical management of diverticulitis

State of the Art Review | Management of colonic diverticulitis

Drains, germs, or steel: Multidisciplinary management of acute colonic diverticulitis

Diverticulitis: Observational study in outpatients suggests amoxicillin-clavulanate is a safe and effective option compared with metronidazole-fluoroquinolone

Randomized trial: Laparoscopic lavage vs. primary resection for perforated purulent diverticulitis; similar long-term results, but recurrence was more common after laparoscopic lavage

Randomized trial: In patients with recurrent, complicated, or persistent painful diverticulitis, sigmoid resection improved quality of life but was associated with a small but significant risk of major complications

Systematic review: Management of colonic diverticulitis

WSES Guidelines for the Management of Acute Colonic Diverticulitis

ASCRS Guidelines for the Treatment of Left-Sided Colonic Diverticulitis

Commentary on Twitter

https://twitter.com/ScandJSurg/status/1420655333815427084

Value-based radiology: what is the ESR doing, and what should we do in the future?

30 Jul, 2021 | 11:33h | UTC

Value-based radiology: what is the ESR doing, and what should we do in the future? – Insights into Imaging

Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.

29 Jul, 2021 | 11:38h | UTC

Ivermectin for preventing and treating COVID‐19 – Cochrane Library

Summary: Ivermectin for preventing and treating COVID-19 – Cochrane Library

Commentary: Ivermectin treatment in humans for COVID-19 – Liverpool School of Tropical Medicine

Why was a major study on ivermectin for covid-19 just retracted?

RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.

Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”.

Ivermectin is the new hydroxychloroquine, take 2 – “Ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial”.

Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials

RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19

What’s new in intensive care: environmental sustainability.

30 Jul, 2021 | 11:32h | UTC

What’s new in intensive care: environmental sustainability – Intensive Care Medicine

Updated WHO SAGE roadmap for prioritizing uses of COVID-19 vaccines in the context of limited supply.

29 Jul, 2021 | 11:34h | UTC

WHO SAGE Roadmap For Prioritizing Uses Of COVID-19 Vaccines In The Context Of Limited Supply – World Health Organization

PRINCIPLE RCT: Doxycycline does not improve outcomes in outpatients with suspected COVID-19 at high risk for adverse outcomes.

29 Jul, 2021 | 11:36h | UTC

Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial – The Lancet Respiratory Medicine

Commentary: PRINCIPLE: a community-based COVID-19 platform trial – The Lancet Respiratory Medicine

Commentary on Twitter

https://twitter.com/LancetRespirMed/status/1420302490864603142

Covid-19 breakthrough infections in vaccinated health care workers.

29 Jul, 2021 | 11:30h | UTC

Covid-19 Breakthrough Infections in Vaccinated Health Care Workers – New England Journal of Medicine

Commentary on Twitter (thread – click for more)

Very important @NEJM paper today on breakthrough infections (BTI) post-vaccination in Israeli health care workers.
5 key points:
1. Of ~1500 people, 0.4% had BIs, sequenced to be Alpha 85% (this was pre-Delta)https://t.co/l69DK5Cbv4 pic.twitter.com/zDSq5e0baN

— Eric Topol (@EricTopol) July 28, 2021

COVID-19 false dichotomies and a comprehensive review of the evidence regarding public health, COVID-19 symptomatology, SARS-CoV-2 transmission, mask wearing, and reinfection.

29 Jul, 2021 | 11:32h | UTC

COVID-19 false dichotomies and a comprehensive review of the evidence regarding public health, COVID-19 symptomatology, SARS-CoV-2 transmission, mask wearing, and reinfection – BMC Infectious Diseases

Commentary on Twitter

A false dichotomy is a logical fallacy that involves presenting only two views or options when other possibilities exist.

Here are 6 COVID-19 false dichotomies:https://t.co/7uYry96l2q by @KevinEscandonMD @angie_rasmussen @BogochIsaac @EpiEllie @SaskiaPopescu @KindrachukJason pic.twitter.com/mHanKxObmt

— Dr. Jonathan N. Stea (@jonathanstea) July 28, 2021

COVID vaccines slash viral spread, but Delta is an unknown – “Studies show that vaccines reduce the spread of SARS-CoV-2 by more than 80%, but the Delta variant is creating fresh uncertainty”.

29 Jul, 2021 | 11:21h | UTC

COVID vaccines slash viral spread – but Delta is an unknown – Nature

What is a breakthrough infection? 6 questions answered about catching COVID-19 after vaccination.

29 Jul, 2021 | 11:28h | UTC

What is a breakthrough infection? 6 questions answered about catching COVID-19 after vaccination – The Conversation

2021 ACC expert consensus decision pathway for cardiovascular risk reduction in patients with persistent hypertriglyceridemia.

29 Jul, 2021 | 11:15h | UTC

2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia: A Report of the American College of Cardiology Solution Set Oversight Committee – Journal of the American College of Cardiology

Key points: ACC Consensus on ASCVD Risk Reduction in Hypertriglyceridemia – American College of Cardiology

Commentary on Twitter

The ACC Expert Consensus Decision Pathway highlights 9️⃣ key points to remember on the management of atherosclerotic #CVD risk reduction in patients with persistent hypertriglyceridemia. Learn more here: https://t.co/zTx4gsIQS2 #ASCVD #cvCAD #Diabetes @virani_md @PamelaBMorris pic.twitter.com/Zjo4wmeZVj

— American College of Cardiology (@ACCinTouch) July 28, 2021

Efficacy of Pfizer/BioNTech Covid vaccine slips to 84% after six months, data show.

29 Jul, 2021 | 11:19h | UTC

Efficacy of Pfizer/BioNTech Covid vaccine slips to 84% after six months, data show – STAT

Original study (preprint): Six Month Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine – medRxiv

Commentary on Twitter (thread – click for more)

https://twitter.com/hildabast/status/1420481872212070404

ESC Position Paper: Cardiac, renal, and metabolic effects of SGLT2 inhibitors.

29 Jul, 2021 | 11:13h | UTC

Cardiac, renal, and metabolic effects of sodium–glucose co-transporter 2 inhibitors: a position paper from the European Society of Cardiology ad-hoc task force on sodium–glucose co-transporter 2 inhibitors – European Journal of Heart Failure

Research aims to stop fuzzy phrasing, medical errors in surgery.

29 Jul, 2021 | 11:09h | UTC

Research aims to stop fuzzy phrasing, medical errors in surgery – University of Kansas

Original study: Semantically Ambiguous Language in the Teaching Operating Room – Journal of Surgical Education (link to abstract – $ for full-text)

Cohort study: Postdiagnosis smoking cessation linked to reduced risk for lung cancer progression and mortality.

29 Jul, 2021 | 11:12h | UTC

Postdiagnosis Smoking Cessation and Reduced Risk for Lung Cancer Progression and Mortality: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Never too late: Cancer centers push patients to quit smoking – STAT

Summary for Patients: Postdiagnosis Smoking Cessation and Reduced Risk for Lung Cancer Progression and Death

Commentary on Twitter

Research led by Paul Brennan, PhD, @mahdi_iarc, et al. of @IARCWHO found that quitting smoking after a #lungcancer diagnosis may extend life without cancer recurrence https://t.co/b0YAqqt7FM. pic.twitter.com/Sjl3ipoXLQ

— Annals of Int Med (@AnnalsofIM) July 26, 2021