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What every intensivist should know about Tocilizumab.

2 Aug, 2021 | 00:25h | UTC

What every intensivist should know about Tocilizumab – Critical Care

Related:

Tocilizumab in COVID-19 therapy: who benefits, and how?

A living WHO guideline on drugs for covid-19 – interleukin-6 receptor blockers are now recommended for patients with severe or critical covid-19.

M-A: Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 – “The 4% absolute risk reduction in mortality from 25% to 21% with IL-6 inhibition added to glucocorticoids may not translate to patients with a lower baseline mortality risk and likely do not justify the additional expense and risk for toxicities for patients hospitalized with modest oxygen requirements and a stable clinical course (from editorial)”.

RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes

Secondary analysis of RCT finds Tocilizumab was beneficial to patients hospitalized with Covid-19 if CRP levels were greater than 15.0 mg/dL, but not if CRP levels were 15.0 mg/dL or less.

M-A: Tocilizumab in COVID-19 – “For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required”.

 


COVID boosters for wealthy nations spark outrage.

2 Aug, 2021 | 00:21h | UTC

COVID boosters for wealthy nations spark outrage – Nature

Related: MSF: No COVID-19 booster shots anywhere before healthcare workers and vulnerable people everywhere have access – Médecins Sans Frontières/Doctors Without Borders

 


Clinical practice guidelines for the management of colonic volvulus and acute colonic pseudo-obstruction.

2 Aug, 2021 | 00:13h | UTC

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colonic Volvulus and Acute Colonic Pseudo-Obstruction – Diseases of the Colon & Rectum

News release: American Society of Colon & Rectal Surgeons Publishes New Guidelines for Colonic Volvulus and Acute Colonic Pseudo-Obstruction

 


Scientists Grapple with Question of COVID-19 Vaccine Booster, as Some Countries Push Ahead.

2 Aug, 2021 | 00:19h | UTC

Scientists Grapple With Question of COVID-19 Vaccine Booster, as Some Countries Push Ahead – Health Policy Watch

 


Ten things to know about ten imaging studies: A preventive cardiology perspective.

2 Aug, 2021 | 00:12h | UTC

Ten things to know about ten imaging studies: A preventive cardiology perspective (“ASPC top ten imaging”) – American Journal of Preventive Cardiology

 


AHA Scientific Statement: Lower extremity peripheral artery disease: contemporary epidemiology, management gaps, and future directions.

2 Aug, 2021 | 00:17h | UTC

Lower Extremity Peripheral Artery Disease: Contemporary Epidemiology, Management Gaps, and Future Directions: A Scientific Statement From the American Heart Association – Circulation

Top Things to Know: Lower Extremity Peripheral Artery Disease: Contemporary Epidemiology, Management Gaps, and Future Directions – American Heart Association

Commentary: The Need for Improved Identification and Treatment of Peripheral Arterial Disease – American Heart Association

 


Assessment and management of peripheral arterial disease: what every cardiologist should know.

2 Aug, 2021 | 00:15h | UTC

Assessment and management of peripheral arterial disease: what every cardiologist should know – Heart

 

Commentary on Twitter

https://twitter.com/Heart_BMJ/status/1417391335246553094

 


Ten things to know about ten cardiovascular disease risk factors.

2 Aug, 2021 | 00:11h | UTC

Ten things to know about ten cardiovascular disease risk factors – American Journal of Preventive Cardiology

 


Study: many patients with small renal masses can be safely managed with active surveillance.

2 Aug, 2021 | 00:07h | UTC

Active Surveillance for Risk Stratification of All Small Renal Masses Lacking Predefined Clinical Criteria for Intervention – The Journal of Urology

Commentary: More Data Support Active Surveillance for Small Renal Masses — Most patients avoided surgery with no metastasis, better focus on aggressive disease – MedPage Today (free registration required)

 


Investigation: FDA allows drugs without proven clinical benefit to languish for years on accelerated pathway.

2 Aug, 2021 | 00:09h | UTC

FDA allows drugs without proven clinical benefit to languish for years on accelerated pathway – The BMJ

News release: Investigation finds nearly half of drugs granted FDA ‘fast track’ approval lack proven clinical benefit – The BMJ

Commentary: Over 100 Drugs Given Speedy Approvals Still Lack Proof of Clinical Efficacy – MedPage Today (free registration required)

 


Guideline summary: A Multidisciplinary collaborative approach to retinal toxic effects screening for patients taking antimalarials.

2 Aug, 2021 | 00:03h | UTC

A Multidisciplinary Collaborative Approach to Retinal Toxic Effects Screening for Dermatology Patients Taking Antimalarials – JAMA Dermatology (free for a limited period)

Original Guidance: Joint Statement: Hydroxychloroquine use with respect to retinal toxicity

 


Does this adult patient have hypertension? the rational clinical examination systematic review.

2 Aug, 2021 | 00:05h | UTC

Does This Adult Patient Have Hypertension? The Rational Clinical Examination Systematic Review – JAMA (free for a limited period)

 


European PanCare Follow Up Recommendations for surveillance of late effects of childhood, adolescent, and young adult cancer.

1 Aug, 2021 | 23:59h | UTC

European PanCare Follow Up Recommendations for surveillance of late effects of childhood, adolescent, and young adult cancer – European Journal of Cancer

 


Viewpoint: The road to addressing Long Covid.

30 Jul, 2021 | 12:09h | UTC

The road to addressing Long Covid – Science (a few articles per month are free)

Related: Review: Long covid—mechanisms, risk factors, and management.

 

Commentary on Twitter

 


Survival outcomes for cancer types with the highest death rates for adolescents and young adults, 1975-2016.

1 Aug, 2021 | 23:58h | UTC

Survival outcomes for cancer types with the highest death rates for adolescents and young adults, 1975-2016 – Cancer

Commentary: Survival Trends for Adolescents and Young Adults With Cancer: 40-Year Analysis – The ASCO Post

 


NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.

30 Jul, 2021 | 12:14h | UTC

COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis – National Institute for Health and Care Excellence

News release: NICE publishes new rapid guideline to diagnose and treat rare blood clotting condition associated with COVID-19 vaccination – National Institute for Health and Care Excellence

Related: Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 


Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

30 Jul, 2021 | 12:12h | UTC

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know – Blood

Related: Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 


Observational study: Positive Fluid balance linked to worse outcomes in critically ill patients with traumatic brain injury.

1 Aug, 2021 | 23:57h | UTC

Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study – The Lancet Neurology (link to abstract – $ for full-text)

Commentary: Traumatic Brain Injury: Fluid Overload Tied to Higher Mortality in ICU Patients – Physician’s Weekly

 

Commentary on Twitter

 


Study: Patients who have recovered from COVID-19 may have persistent cognitive symptoms.

30 Jul, 2021 | 12:03h | UTC

Cognitive deficits in people who have recovered from COVID-19 – EClinicalMedicine

 

Commentary on Twitter (thread – click for more)

 


Risk of acute myocardial infarction and ischemic stroke following COVID-19 in Sweden – “the true risk is increased by between three and eight times for acute myocardial infarction and by between three and seven times for ischaemic stroke following COVID-19.”

30 Jul, 2021 | 12:06h | UTC

Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study – The Lancet

Invited commentary: What is the association of COVID-19 with heart attacks and strokes? – The Lancet

 

Commentary on Twitter

 


Self-reported memory problems 8 months after COVID-19 infection.

30 Jul, 2021 | 12:02h | UTC

Self-reported Memory Problems 8 Months After COVID-19 Infection – JAMA Network Open

Commentary: Post-acute Sequelae of SARS-CoV-2 Infection and Subjective Memory Problems – JAMA Network Open

 

Commentary on Twitter (thread – click for more)

 


Israel to offer 3rd COVID booster shot to older citizens.

30 Jul, 2021 | 11:57h | UTC

Israel to offer 3rd COVID booster shot to older citizens – Associated Press

 


Study: Recommended approaches to minimize aerosol dispersion of SARS-CoV-2 during noninvasive ventilatory support can cause ventilator performance deterioration.

30 Jul, 2021 | 11:59h | UTC

Study Recommended Approaches to Minimize Aerosol Dispersion of SARS-CoV-2 During Noninvasive Ventilatory Support Can Cause Ventilator Performance Deterioration: A Benchmark Comparative Study – CHEST

Editorial: Circuit Set-ups to Reduce Virus Aerosolization During Noninvasive Positive Pressure Ventilation: Dancing in the Dark

 


Telehealth in Oncology: ASCO Standards and Practice Recommendations.

30 Jul, 2021 | 11:52h | UTC

Telehealth in Oncology: ASCO Standards and Practice Recommendations – JCO Oncology Practice

 


Brazilian Guidelines on Unstable Angina and Acute Myocardial Infarction without ST-Segment Elevation – 2021.

30 Jul, 2021 | 11:54h | UTC

Brazilian Society of Cardiology Guidelines on Unstable Angina and Acute Myocardial Infarction without ST-Segment Elevation – 2021 – Arquivos Brasileiros de Cardiologia (PDF)

 


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