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BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.
11 Aug, 2021 | 08:37h | UTCEffect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU? – JAMA (free for a limited period)
Video: Balanced Solution vs. Saline in Intensive Care Study
Opinion | We should not dismiss the possibility of eradicating COVID-19: comparisons with smallpox and polio.
11 Aug, 2021 | 08:42h | UTC
CDC Report: COVID-19 morbidity and mortality far exceed the potential risks of rare side effects caused by vaccines.
11 Aug, 2021 | 08:45h | UTC
USPSTF Statement recommends screening for gestational diabetes in asymptomatic pregnant persons at 24 weeks of gestation or after.
11 Aug, 2021 | 08:35h | UTCEvidence report: Screening for Gestational Diabetes: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA
Editorial: Screening for Gestational Diabetes – JAMA
Author interview: USPSTF Recommendation: Screening for Gestational Diabetes
JAMA Patient Page: Screening for Gestational Diabetes
Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.
11 Aug, 2021 | 08:44h | UTCRelated:
NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Commentary on Twitter
https://twitter.com/JohnGRizk/status/1425126093288353800
BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.
11 Aug, 2021 | 08:39h | UTCEffect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill PatientsThe BaSICS Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU? – JAMA (free for a limited period)
Video: Balanced Solution vs. Saline in Intensive Care Study
Commentary on Twitter
Among critically ill patients requiring fluid challenges, treatment with a balanced solution compared with saline solution did not significantly reduce 90-day mortality https://t.co/LNDtsxxiwB
— JAMA (@JAMA_current) August 10, 2021
Cluster RCT: Vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh conferred 85% total protection.
11 Aug, 2021 | 08:28h | UTCInvited commentary: Salmonella Typhi Vi polysaccharide conjugate vaccine protects infants and children against typhoid fever – The Lancet
New WHO toolkit promotes inclusion of people with dementia in society.
11 Aug, 2021 | 08:31h | UTCNew WHO toolkit promotes inclusion of people with dementia in society – World Health Organization
See Guidance: Towards a dementia inclusive society: WHO toolkit for dementia-friendly initiatives (DFIs) – World Health Organization
Commentary on Twitter (thread – click for more)
🆕 toolkit to promote a #dementia-inclusive society launched. It will helps countries raise public awareness and understanding of dementia to support people living with dementia to remain in, and be a significant part of, their communities.
👉 https://t.co/blpDQHUSWM pic.twitter.com/D5MIM5jdlr
— World Health Organization (WHO) (@WHO) August 10, 2021
Hemodynamics for the Heart Failure Clinician: A State-of-the-Art Review.
11 Aug, 2021 | 08:32h | UTCHemodynamics for the Heart Failure Clinician: A State-of-the-Art Review – Journal of Cardiac Failure
EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumors.
11 Aug, 2021 | 08:29h | UTCCommentary: New guidelines for the diagnosis and treatment of brain metastases – University of Vienna
Commentary on Twitter
Just out📣 @EANOassociation-ESMO Guidelines for the management of patients with #brain metastasis from solid #tumours: find out the latest recommendations, immunohistochemical markers for #carcinoma of unknown primary and treatment algorithms 🔎 https://t.co/CriaZKxFJr #btsm pic.twitter.com/0yQqmJMzT1
— ESMO – Eur. Oncology (@myESMO) August 5, 2021
RCT: Triaging acute pulmonary embolism for home treatment by Hestia vs. simplified PESI criteria – the tools were similarly effective, and more than a third of patients were treated at home with a low incidence of complications.
11 Aug, 2021 | 08:27h | UTC
Commentary on Twitter
Triaging acute pulmonary embolism for home treatment by Hestia or simplified PESI criteria: the HOME-PE randomized trial #EHJ #PE #PERThttps://t.co/gszusChSyU pic.twitter.com/NOyKYsVQHo
— EHJ Editor-in-Chief (@ehj_ed) August 10, 2021
Cystic pancreatic lesions: MR imaging findings and management.
11 Aug, 2021 | 08:21h | UTCCystic pancreatic lesions: MR imaging findings and management – Insights into Imaging
Related:
Recommendations for the management of incidental pancreatic findings in adults.
Pancreatic cystic neoplasms: a review of current recommendations for surveillance and management
Management of Pancreatic Cystic Lesions
Consensus Recommendations: Diagnosis and Surveillance of Incidental Pancreatic Cystic Lesions
Review: Pancreatic Cystic Lesions
Guidelines on pancreatic cystic neoplasms
RCT: Computer-assisted individualized hemodynamic management reduces intraoperative hypotension in intermediate- and high-risk surgery – larger trials with patient-relevant outcomes are required.
11 Aug, 2021 | 08:25h | UTCVideo: Computer-assisted individualized hemodynamic management reduces intraoperative hypotension
Science, Medicine, And The Anesthesiologist | August 2021: Key Papers from the Most Recent Literature Relevant to Anesthesiologists.
11 Aug, 2021 | 08:24h | UTCScience, Medicine, and the Anesthesiologist – Anesthesiology
M-A: Child and youth mental health problems have doubled during COVID-19.
10 Aug, 2021 | 10:03h | UTCCommentary: Child and youth mental health problems have doubled during COVID-19 – The Conversation
Original study: Global Prevalence of Depressive and Anxiety Symptoms in Children and Adolescents During COVID-19: A Meta-analysis – JAMA Pediatrics
Editorial: Addressing the Global Crisis of Child and Adolescent Mental Health – JAMA Pediatrics
Related:
More data on the harmful effects of the COVID-19 pandemic on the mental health of adolescents.
COVID has caused ‘mass trauma,’ worsening mental health globally.
COVID’s mental-health toll: how scientists are tracking a surge in depression
WHO: COVID-19 disrupting mental health services in most countries
Commentary on Twitter (thread – click for more)
Many are rightfully sounding the alarm to a youth #mentalhealth crisis. Our meta-analysis of 29 studies w >80,000 youth worldwide in @JAMAPediatrics, shows 1 in 4 youth had elevated depression or anxiety during #COVID19. A thread 🧵 https://t.co/etIdZTHnme
— Dr. Sheri Madigan (she/her) (@sherimadigan) August 9, 2021
Systematic review: Prescribing practices, patterns, and potential harms in patients receiving palliative care – “many patients receiving palliative care receive multiple medications closer to the time of death”.
11 Aug, 2021 | 08:23h | UTC
Commentary on Twitter
Useful overview of observational research about prescribing in #palliativecare – more work needed to assess appropriateness, potential harms and prescribing trendshttps://t.co/7abM5ANEH0
— deprescribing.org (@deprescribing) August 10, 2021
[Preprint] Phase 1/2 RCT: A booster dose is immunogenic and will be needed for older adults who have completed two doses vaccination with CoronaVac.
10 Aug, 2021 | 09:58h | UTC
Commentary on Twitter
https://twitter.com/hildabast/status/1424644994120372224
Viral load of SARS-CoV-2 in respiratory aerosols emitted by COVID-19 patients while breathing, talking, and singing.
10 Aug, 2021 | 10:02h | UTC
Commentary on Twitter
Our peer-reviewed research is now published in Clinical Infectious Diseases! No matter how you slice it, COVID-19 is an airborne disease. Let's call it like it is and put the appropriate measures in place.https://t.co/R4MeIlwBY6
— Kristen K. Coleman (@drkristenkc) August 7, 2021
A WHO expert explains why she believes the rush for Covid-19 boosters is premature.
10 Aug, 2021 | 09:56h | UTCA WHO expert explains why she believes the rush for Covid-19 boosters is premature – STAT
Commentary on Twitter
Must read interview on rich nations rushing into booster doses
Dr @Kate_L_OBrien by @HelenBranswell @statnews
"We really have huge inequity right now in just getting primary doses to people. Does a third dose need to be given?"https://t.co/pRhYwINuKf pic.twitter.com/YQS6Nj0Hyi
— Madhu Pai, MD, PhD (@paimadhu) August 9, 2021
Covid-19: How effective are vaccines against the delta variant?
10 Aug, 2021 | 10:00h | UTCCovid-19: How effective are vaccines against the delta variant? – The BMJ
A giant trial of COVID-19 treatments organized by the WHO is restarting. Here are the drugs it’s betting on.
10 Aug, 2021 | 09:52h | UTCA giant trial of COVID-19 treatments is restarting. Here are the drugs it’s betting on – Science
Related: WHO Solidarity trial to restart with focus on drugs that act on immune responses caused by Covid-19.
Study ties COVID vaccines to lower transmission rates.
10 Aug, 2021 | 09:51h | UTCStudy ties COVID vaccines to lower transmission rates – CIDRAP
‘Breakthrough’ infections do not mean COVID vaccines are failing.
10 Aug, 2021 | 09:54h | UTC‘Breakthrough’ Infections Do Not Mean COVID Vaccines Are Failing – Scientific American
Commentary on Twitter
https://twitter.com/laurahelmuth/status/1422897892797337609
NICE Guideline | Management of Acne Vulgaris.
10 Aug, 2021 | 09:00h | UTCAcne vulgaris: management – National Institute for Health and Care Excellence
ACOG Guideline: Access to postabortion contraception.
10 Aug, 2021 | 08:57h | UTCAccess to Postabortion Contraception: ACOG Committee Opinion, Number 833 – Obstetrics & Gynecology