All Posts
#ESCCongress – RCT: Initial hypertension treatment with a single pill with 4 drugs at quarter doses (irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) achieved better BP lowering vs. standard monotherapy (irbesartan 150 mg).
29 Aug, 2021 | 18:11h | UTCInitial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Quadruple UltrA-low-dose tReaTment for hypErTension – QUARTET – American College of Cardiology
#ESCCongress – RCT: Among asymptomatic patients with severe carotid stenosis, carotid surgery and stenting carry similar risks, and the long-term risk of stroke was comparable. There was no medically treated arm in this study.
29 Aug, 2021 | 18:06h | UTC
Commentary on Twitter
#ACST-2 stent CAS 🆚surgery CEA
For asymptotic carotid stenosis >= 60%https://t.co/lyLBn8C8cv
🔺No difference in death 30d MI, stroke 5 yr f/u
🔺Slight ⬆️in minor 30d strokes w Stenting but no QOL change at 6 mo
🔺no medical Rx arm
🔺both arms 1% procedural risk #ESCCongress pic.twitter.com/8ptcrstn0D— Ritu Thamman MD (@iamritu) August 29, 2021
#ESCCongress – RCT: Small benefit from systematic screening for atrial fibrillation in older adults – After a median follow-up of 6.9 y there were fewer events (stroke, embolism, bleeding, and death) in the intervention group (31·9%) vs. control group (33·0%).
29 Aug, 2021 | 18:08h | UTCClinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
News release: Screening for atrial fibrillation could reduce risk of stroke – Karolinska Institutet
#ESCCongress – RCT: In patients with heart failure, hemodynamic-guided management was not associated with improved outcomes.
29 Aug, 2021 | 18:03h | UTCHaemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial – The Lancet (free registration required)
Commentary:
Haemodynamic-GUIDEed management of Heart Failure – GUIDE-HF – American College of Cardiology
Commentary on Twitter
The GUIDE-HF trial showed hemodynamic-guided management using remote pulmonary artery pressure monitoring didn't ⬇️ mortality & total #heartfailure events in patients regardless of HF symptom severity compared w/ patients receiving usual care: https://t.co/15Iv1N78sJ #ESCCongress pic.twitter.com/rZSNCfw4kq
— American College of Cardiology (@ACCinTouch) August 27, 2021
#ESCCongress – Pilot study in Sweden showed drones delivered defibrillators faster than ambulances to patients with suspected cardiac arrest.
29 Aug, 2021 | 18:02h | UTCEditorial: Automated external defibrillator delivery by drones: are we ready for prime time?
News releases:
Drones delivered defibrillators to patients with suspected cardiac arrests – Karolinska Institutet
Commentary on Twitter
Just released: #drones are effective in successfully delivering #AEDs to patients with suspected out-of-hospital cardiac arrest #OHCA, with a time benefit compared to emergency medical services https://t.co/D9XOI0Pep4 #EHJ #ESCcongress #ESCYoung @ehj_ed @rladeiraslopes pic.twitter.com/oRSMdQVqAC
— European Society of Cardiology Journals (@ESC_Journals) August 27, 2021
It’s not just SARS-CoV-2: Most respiratory viruses spread by aerosols.
27 Aug, 2021 | 10:18h | UTCOriginal article: Airborne transmission of respiratory viruses – Science
Commentary on Twitter (thread – click for more)
1/ AIRBORNE TRANSMISSION OF RESPIRATORY VIRUSES
A new peer-reviewed paper in @ScienceMagazine, reviewing the scientific literature on this topic. We conclude it is important not just for COVID-19, but also for other respiratory diseases such as the fluhttps://t.co/vik1deBzeB
— Prof. Jose-Luis Jimenez (@jljcolorado) August 26, 2021
#ESCCongress [not published yet] – Systematic FFR has no additional benefit at diagnostic angiography in patients with chest pain.
29 Aug, 2021 | 18:00h | UTCPress release: Systematic pressure wire assessment has no additional benefit at diagnostic angiography – European Society of Cardiology
Commentaries:
FFR During Angiogram Not Beneficial in Chest Pain Patients: RIPCORD 2 – TCTMD
Related:
Randomized Trial: Five-Year Outcomes with PCI Guided by FFR
[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.
27 Aug, 2021 | 10:11h | UTCPress release: Is COVID vaccine protection fading? – ZOE Covid Study
Commentaries:
Covid infection protection waning in double jabbed – BBC
Cohort study: Most COVID-19 hospital survivors had a good physical and functional recovery after 1 year of follow-up, but around half of the patients had at least one sequelae symptom.
27 Aug, 2021 | 10:13h | UTC1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study – The Lancet
Editorial: Understanding long COVID: a modern medical challenge – The Lancet
Related:
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)
New guidelines to help doctors manage long COVID patients published.
[Preprint] Observational data suggests natural immunity after a SARS-CoV-2 infection confers longer lasting and stronger protection compared to vaccine-induced immunity.
27 Aug, 2021 | 10:16h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/andrew_croxford/status/1430799815693250562
Editorial: The Guardian view on global vaccine inequality: unwise as well as unethical.
27 Aug, 2021 | 10:09h | UTCThe Guardian view on global vaccine inequality: unwise as well as unethical
Covid-19 vaccines flirted with perfection at first. Reality is more complicated.
27 Aug, 2021 | 10:05h | UTCCovid-19 vaccines flirted with perfection at first. Reality is more complicated – STAT
Commentary on Twitter
The mixed blessing of the 95% VE: When Pfizer & Moderna reported late last year that their Covid vaccines were highly effective, our expectations for these vaccines soared. It's time for us to get more realistic about what the vaccines can do. https://t.co/BFpje2qRmS
— Helen Branswell 🇨🇦 (@HelenBranswell) August 25, 2021
mRNA vaccines for infectious diseases: principles, delivery and clinical translation.
27 Aug, 2021 | 10:03h | UTC
Commentary on Twitter
It took over 3 decades for mRNA vaccines to be developed. Now their potential against Covid variants and other pathogens is limitless. An outstanding new review @NatRevDrugDisc https://t.co/HETmUVru0Q @WeissmanLab @KWhiteheadLab pic.twitter.com/dN0jgsrEh3
— Eric Topol (@EricTopol) August 27, 2021
COVID-19 associated Mucormycosis: risk factors and mechanisms of disease.
27 Aug, 2021 | 10:07h | UTCRelated: Clinical Picture: Mucormycosis after COVID-19 in a patient with diabetes. (several articles on the subject)
Commentary on Twitter
🆕💥💥Review Article #CID @IDSAInfo @jobadd
COVID-19 associated Mucormycosis (CAM): risk factors and mechanisms of disease #IDTwitter #medtwitter #TwitteRx https://t.co/Ob89SFNoPx pic.twitter.com/tzf7KpGVyG— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) August 22, 2021
Global guideline for the diagnosis and management of rare yeast infections.
27 Aug, 2021 | 09:08h | UTC
Commentary on Twitter
The @eurconfmedmycol did it again!
The 4⃣th One World🌍- One Guideline is published!
This time for the Diagnosis and Management of RARE YEAST Infections
Free access🔗https://t.co/1QSanohMsk @TheLancetInfDis@CornelyOliver @neleshg @ASMicrobiology @ISHAM_Mycology @martinhoenigl pic.twitter.com/DEnS09MnDS— Rosanne Sprute (@RosanneSprute) August 20, 2021
The Lancet Series: Active ingredients for addressing youth anxiety and depression.
27 Aug, 2021 | 09:05h | UTCHomepage: Active ingredients for addressing youth anxiety and depression – The Lancet Psychiatry (free registration required for all articles)
See commentary: The benefits and harms of antidepressants for youth depression and anxiety #ActiveIngredientsMH – The Mental Elf
Identifying and integrating active ingredients for mental health
Commentary on Twitter
https://twitter.com/TheLancetPsych/status/1428692894165225473
M-A: Physical rehabilitation in the ICU improves physical function and reduces ICU and hospital length of stay.
27 Aug, 2021 | 09:02h | UTCPhysical Rehabilitation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)
Review: How to approach a patient with difficult-to-treat IBS.
27 Aug, 2021 | 09:00h | UTCHow to Approach a Patient with Difficult-to-Treat IBS – Gastroenterology (free for a limited period)
Commentary on Twitter
Happy to share 📰 on “How to Approach a Patient with Difficult to Treat IBS” in @AGA_Gastro.
Diagnostic algorithm, practical tips, meds & doses. Based on scientific data & what I've learned caring for #IBS pts for many years.
Free for next 50 days 👉 https://t.co/pHKvJuhZtg
— Lin Chang (@LinChangMD) August 25, 2021
Exposure to antipsychotics in womb not found to increase risk of ADHD, autism in offspring.
27 Aug, 2021 | 09:03h | UTC
A multinational consensus on dysphagia in Parkinson’s disease: screening, diagnosis and prognostic value.
27 Aug, 2021 | 08:51h | UTC
Observational study showed increased risk of postoperative complications with retromuscular mesh placement in emergency incisional hernia repair.
27 Aug, 2021 | 08:58h | UTC
A review of the epidemiology, pathophysiology, and efficacy of anti-diabetic drugs used in the treatment of nonalcoholic fatty liver disease.
27 Aug, 2021 | 08:59h | UTC
Commentary/Podcast: are the AAP guidelines for the evaluation and management of the well-appearing febrile infant the answer to a never ending story?
27 Aug, 2021 | 08:40h | UTCOriginal guideline and commentary: Commentary on the Latest AAP Guidelines for the Febrile Neonate.
Revisiting treatment options for depressed patients with generalized anxiety disorder.
27 Aug, 2021 | 08:52h | UTC
Cohort study: Half of men with low-risk prostate cancer move from surveillance to treatment within a few years.
27 Aug, 2021 | 08:26h | UTC