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Large retrospective matched-cohort study found that #statin use was associated with a higher risk of #diabetes treatment escalation and an increased risk of #hyperglycemic complications https://t.co/lFLz7rVfpd

— JAMA Internal Medicine (@JAMAInternalMed) October 4, 2021

Review: Optimizing care for critically ill older adults.

5 Oct, 2021 | 08:51h | UTC

Optimizing care for critically ill older adults – Canadian Medical Association Journal

Addressing Biased Patient Behavior: A Teachable Moment.

5 Oct, 2021 | 08:54h | UTC

Addressing Biased Patient Behavior: A Teachable Moment – JAMA Internal Medicine

Podcast: Urinary Stone Disease.

5 Oct, 2021 | 08:50h | UTC

#298 Urinary Stone Disease Will Rock Your World – The Curbsiders

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

3 Oct, 2021 | 23:02h | UTC

Merck and Ridgeback’s Investigational Oral Antiviral Molnupiravir Reduced the Risk of Hospitalization or Death by Approximately 50 Percent Compared to Placebo for Patients with Mild or Moderate COVID-19 in Positive Interim Analysis of Phase 3 Study

Commentaries:

Expert reaction to interim analysis of oral antiviral molnupiravir – Science Media Centre

Merck’s antiviral pill reduces hospitalization of Covid patients, a possible game-changer for treatment – STAT

Covid antiviral pill can halve risk of hospitalization – BBC

Why Merck’s Covid-19 pill molnupiravir could be so important – Vox

‘Unquestionably a game changer!’ Antiviral pill cuts COVID-19 hospitalization risk – Researchers excited about Merck drug, but caution data are preliminary and price is high – Science

Commentaries on Twitter

.@DrEricDing convinced many that stopping the #molnupiravir trial early for benefit was a good idea

But it was NOT

Large body of evidence suggests that stopping early for benefit biases the results: overestimates the benefits of the treatment #EBM https://t.co/b3tHEtliO0 https://t.co/LwuCgqcY0C pic.twitter.com/vyPWc0nd37

— Kari Tikkinen (@KariTikkinen) October 2, 2021

(thread – click for more)

💡BREAKING—New oral anti-viral drug *molnupiravir* cuts risk of #COVID19 hospitalization and death **in HALF** in a randomized trial. Results so astounding that the trial is being stopped early, and Merck plans to apply for emergency authorization ASAP. 🧵 https://t.co/g8JGNzvuRg pic.twitter.com/K1SwC3QFXS

— Eric Feigl-Ding (@DrEricDing) October 1, 2021

Evaluating agreement between bodies of evidence from randomized controlled trials and cohort studies in nutrition research: meta-epidemiological study.

5 Oct, 2021 | 08:48h | UTC

Evaluating agreement between bodies of evidence from randomised controlled trials and cohort studies in nutrition research: meta-epidemiological study – The BMJ

Commentary on Twitter

The difference in results between RCTs and cohort studies in nutrition research was small, finds study.

However, with some substantial statistical heterogeneity in cohort studies, differences or potential bias cannot be excluded, say @LSchwingshackl et alhttps://t.co/dyUqhn87V0

— The BMJ (@bmj_latest) September 17, 2021

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.

3 Oct, 2021 | 22:59h | UTC

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance – The BMJ

Original Guidance: NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

RCT: Effects of 30 days of ketogenic diet on body composition, muscle strength, muscle area, metabolism, and performance in semi-professional soccer players.

5 Oct, 2021 | 08:47h | UTC

Effects of 30 days of ketogenic diet on body composition, muscle strength, muscle area, metabolism, and performance in semi-professional soccer players – Journal of the International Society of Sports Nutrition

[Preprint] Assessing the Burden of COVID-19 in Developing Countries: Systematic Review, Meta-Analysis, and Public Policy Implications.

3 Oct, 2021 | 22:56h | UTC

Assessing the Burden of COVID-19 in Developing Countries: Systematic Review, Meta-Analysis, and Public Policy Implications – medRxiv

Commentary on Twitter

https://twitter.com/GidMK/status/1444125087553114113

Will the pandemic fade into an ordinary disease like the flu? The world is watching Denmark for clues.

3 Oct, 2021 | 22:58h | UTC

Will the pandemic fade into an ordinary disease like the flu? The world is watching Denmark for clues – Science

New analysis shows benefits of offering two doses of COVID-19 vaccine to children aged 12-17 clearly outweigh risks.

3 Oct, 2021 | 22:52h | UTC

News release: New analysis shows benefits of offering two doses of COVID-19 vaccine to children aged 12-17 clearly outweigh risks – The Royal Society of Medicine

Original report: Vaccinating adolescents against SARS-CoV-2 in England: a risk-benefit analysis

Editorial | Clinical ethics: consent for vaccination in children.

3 Oct, 2021 | 22:53h | UTC

Clinical ethics: consent for vaccination in children – Archives of Disease in Childhood

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

3 Oct, 2021 | 22:41h | UTC

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 – Intensive Care Medicine

Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.

3 Oct, 2021 | 22:49h | UTC

Covid-19 vaccination: evidence of waning immunity is overstated – The BMJ

COVID vaccine immunity is waning — how much does that matter? – “As debates about booster shots heat up, what’s known about the duration of vaccine-based immunity is still evolving”.

COVID vaccine effects wane over time but still prevent death and severe illness.

Perspective | What we actually know about waning immunity.

Another study shows Pfizer mRNA vaccine immunity is reduced over time.

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

Studies: COVID vaccine protection waning against infection but not hospitalization.

Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.

WHO prioritizes access to diabetes and cancer treatments in new Essential Medicines Lists.

3 Oct, 2021 | 22:46h | UTC

News Release: WHO prioritizes access to diabetes and cancer treatments in new Essential Medicines Lists – World Health Organization

Report: WHO model list of essential medicines – 22nd list, 2021 – World Health Organization

Commentary: For the first time, WHO committee recommends action on high-priced essential medicines – STAT

Commentary on Twitter (thread – click for more)

🆕 WHO 2021 Essential Medicines Lists have 20 new medicines for adults & 17 for children, incl. insulin analogues, new oral medicines for diabetes & medicines for cancer treatment https://t.co/LfWwHEZtuM pic.twitter.com/HMFOP8ioBf

— World Health Organization (WHO) (@WHO) October 1, 2021