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A population-based cohort study in Qatar showed reinfections had 90% lower odds of resulting in hospitalization or death than primary infections.

25 Nov, 2021 | 10:46h | UTC

Severity of SARS-CoV-2 Reinfections as Compared with Primary Infections – New England Journal of Medicine

Related: [Preprint] M-A of 12.011.447 individuals finds individuals previously infected with SARS-CoV-2 had an 81% reduction in odds of a reinfection.

 

ACSM Expert Consensus Statement: Injury prevention and exercise performance during cold-weather exercise.

25 Nov, 2021 | 10:29h | UTC

ACSM Expert Consensus Statement: Injury Prevention and Exercise Performance during Cold-Weather Exercise – Current Sports Medicine Reports

 

WHO releases HIV drug resistance report 2021.

25 Nov, 2021 | 10:36h | UTC

News Release: WHO releases HIV drug resistance report 2021 – World Health Organization

Report: HIV drug resistance report 2021 – World Health Organization

Fact Sheet: HIV Drug Resistance – World Health Organization

 

Commentary on Twitter

 

Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children.

25 Nov, 2021 | 10:31h | UTC

Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children – British Journal of Haematology

 

Global epidemiology of stroke and access to acute ischemic stroke interventions.

25 Nov, 2021 | 10:27h | UTC

Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions – Neurology

Related: Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.

 

Promises and challenges of personalized medicine to guide ARDS therapy.

25 Nov, 2021 | 10:25h | UTC

Promises and challenges of personalized medicine to guide ARDS therapy – Critical Care

 

Systematic Review: Macrolides versus placebo for chronic asthma.

25 Nov, 2021 | 10:14h | UTC

Macrolides versus placebo for chronic asthma – Cochrane Library

 

Commentary on Twitter

 

Clinical practice guideline for the treatment of malignant ascites.

25 Nov, 2021 | 10:28h | UTC

Clinical practice guideline for the treatment of malignant ascites: section summary in Clinical Practice Guideline for peritoneal dissemination (2021) – International Journal of Clinical Oncology

 

Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission – “Published meta-analyses of hypocaloric diets for weight management in people with type 2 diabetes do not support any particular macronutrient profile or style over others”.

25 Nov, 2021 | 10:19h | UTC

Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission – Diabetologia

News Release: Analysis shows low energy diets with formula meal replacements are the most effective methods for weight management and remission in adults with type 2 diabetes – Diabetologia

 

Commentary on Twitter

https://twitter.com/DiabetologiaJnl/status/1461773268231147521

 

Basics of extracorporeal membrane oxygenation.

25 Nov, 2021 | 10:09h | UTC

Basics of Extracorporeal Membrane Oxygenation – Surgical Clinics of North America

 

Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey.

25 Nov, 2021 | 10:23h | UTC

Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey – The Lancet Oncology

Commentaries:

Access to and affordability of cancer medicines: time to focus on the last mile – The Lancet Oncology

Choosing Wisely, Researchers Look at Access to Essential Cancer Drugs on a Global Scale – The ASCO Post

Related: WHO prioritizes access to diabetes and cancer treatments in new Essential Medicines Lists.

 

M-A: Incidence, prevalence and determinants of discomfort in inflammatory bowel disease.

25 Nov, 2021 | 09:54h | UTC

Systematic Review and Meta-analysis on the Incidence, Prevalence and Determinants of Discomfort in Inflammatory Bowel Disease – Journal of the Canadian Association of Gastroenterology

 

Review: The value of systematic reviews and meta-analyses in surgery.

25 Nov, 2021 | 10:11h | UTC

The Value of Systematic Reviews and Meta-Analyses in Surgery – European Surgical Research

 

Review: Noninvasive ventilation and oxygenation strategies.

25 Nov, 2021 | 10:08h | UTC

Noninvasive Ventilation and Oxygenation Strategies – Surgical Clinics of North America

 

WHO issues guidelines on the treatment of children with multisystem inflammatory syndrome associated with COVID-19.

24 Nov, 2021 | 08:51h | UTC

News Release: WHO issues guidelines on the treatment of children with multisystem inflammatory syndrome associated with COVID-19 – World Health Organization

Guideline: Living guidance for clinical management of COVID-19 – World Health Organziation

Related:

An Update on Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2.

Ten Things to Know About Multisystem Inflammatory Syndrome in Children (MIS-C).

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, there was no evidence that recovery differed after primary treatment with intravenous immune globulin (IVIG) alone, IVIG plus glucocorticoids, or glucocorticoids alone.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, initial treatment with intravenous immune globulin (IVIG) plus glucocorticoids was associated with a lower risk of new or persistent cardiovascular dysfunction than IVIG alone.

Cohort study showed that the incidence of Multisystem Inflammatory Syndrome in Children (MIS-C) was 316 persons per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. The incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons.

Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.

Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When

Neurologic involvement in children and adolescents with COVID-19 or Multisystem Inflammatory Syndrome

Clinical Update: Acute covid-19 and multisystem inflammatory syndrome in children

Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19

Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)

SR: Multisystem inflammatory syndrome in children related to COVID-19

Observational study: The combination of Immunoglobulins + Methylprednisolone was associated with a better course of fever compared to Immunoglobulins alone in Multisystem Inflammatory Syndrome in children

ACR Guidance for pediatric patients with multisystem inflammatory syndrome in children associated with SARS‐CoV‐2

New systematic review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 infection summarizes the clinical features, management, and outcomes of the disease, showing favorable outcomes for the majority of children

 

Opinion from thirty two ministers of health: The world must act now to be prepared for future health emergencies.

24 Nov, 2021 | 08:49h | UTC

The world must act now to be prepared for future health emergencies – The BMJ

Related:

Viewpoint | Strengthening global health security and reforming the international health regulations: making the world safer from future pandemics.

Perspective | Learning from crisis: building resilient systems to combat future pandemics.

Systematic review: Border controls, restricted entry, quarantine essential for curbing COVID-19 and future pandemics.

Opinion | The future of pandemic preparedness: agile coordination around clinical trials.

UN Report: Preventing the Next Pandemic – Zoonotic Diseases and How to Break the Chain of Transmission

 

Commentary on Twitter

 

Promoting COVID-19 vaccine acceptance: recommendations from the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA.

24 Nov, 2021 | 08:47h | UTC

Promoting COVID-19 vaccine acceptance: recommendations from the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA – The Lancet

Related: WHO Guidance for improving acceptance and uptake of COVID-19 vaccines

 

Cohort study found the risk of myocardial infarction may be best predicted by the number of apolipoprotein B containing lipoproteins.

24 Nov, 2021 | 08:41h | UTC

Association of Apolipoprotein B–Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis: Distinguishing Between Particle Concentration, Type, and Content – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries:

ApoB Gains Ground as Best Lipid Predictor of MI Risk – TCTMD

Study finds risk of MI best captured by number of apolipoprotein B lipoproteins – MedicalResearch

 

Commentary on Twitter

 

Review: COVID-19-associated Invasive Fungal Infection.

24 Nov, 2021 | 08:48h | UTC

COVID-19-associated Invasive Fungal Infection – Open Forum Infectious Diseases

Related:

Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis.

M-A: Incidence and mortality of COVID‐19‐associated pulmonary aspergillosis – The incidence and mortality in the ICU were estimated to be 10.2% and 54.9%, respectively.

Consensus Guideline: Defining and managing COVID-19-associated pulmonary aspergillosis

Bacterial and fungal superinfections in critically ill patients with COVID-19

Invasive Fungal Disease complicating COVID-19: when it rains it pours

A national strategy to diagnose COVID-19 associated invasive fungal disease in the ICU

Epidemiology of invasive pulmonary aspergillosis among COVID-19 intubated patients

 

Commentary on Twitter

 

AGA Clinical practice update on management of chronic gastrointestinal pain in disorders of gut–brain interaction.

24 Nov, 2021 | 08:42h | UTC

AGA Clinical Practice Update on Management of Chronic Gastrointestinal Pain in Disorders of Gut–Brain Interaction: Expert Review – Clinical Gastroenterology and Hepatology

 

Viewpoint: The growing phenomenon of “virtual-first” primary care.

24 Nov, 2021 | 08:39h | UTC

The Growing Phenomenon of “Virtual-First” Primary Care – JAMA (free for a limited period)

 

We expected people with asthma to fare worse during COVID. Turns out they’ve had a break.

24 Nov, 2021 | 08:44h | UTC

We expected people with asthma to fare worse during COVID. Turns out they’ve had a break – The Conversation

 

Safety analysis of RCTs showed Alzheimer’s drug Aducanumab caused brain swelling in 35% of patients, and 26.0% experienced associated symptoms (e.g., headache, confusion, dizziness, and nausea).

24 Nov, 2021 | 08:35h | UTC

Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease – JAMA Neurology

Commentary: Biogen Alzheimer’s drug shows brain swelling in 35% of patients – MedicalXpress

 

Commentary on Twitter

 

Three Neurologic Societies, Including the AAN, Issue Strong Position Statement on Aducanumab.

24 Nov, 2021 | 08:36h | UTC

Three Neurologic Societies, Including the AAN, Issue Strong Position Statement on Aducanumab – Neurology Today

See statement: Decisions With Patients and Families Regarding Aducanumab in Alzheimer Disease, With Recommendations for Consent: AAN Position Statement – Neurology

Related:

Editorial: Aducanumab for Alzheimer’s disease?

FDA approvement of Alzheimer’s drug sparks controversy among doctors.

 

Commentary on Twitter

 

Systematic Review: Renal denervation may have a modest effect in improving 24h ambulatory blood pressure monitoring (reduction in SBP by 5.29 mmHg and DBP by 3.75 mmHg) but does not improve major cardiovascular outcomes and renal function.

24 Nov, 2021 | 08:33h | UTC

Summary: Renal denervation for improving outcomes in individuals with resistant hypertension – Cochrane Library

Original Review: Renal denervation for resistant hypertension – Cochrane Library

Related: M-A: Renal denervation for hypertension is associated with a modest reduction in ambulatory blood pressure control (3.61 mm Hg reduction in ambulatory systolic BP and 1.85 mm Hg reduction in ambulatory diastolic BP).

 

Commentary on Twitter

https://twitter.com/CochraneHTN/status/1462979551558995971

 

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