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Another randomized trial showed convalescent plasma does not benefit patients hospitalized with Covid-19.

1 Dec, 2021 | 09:49h | UTC

Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia: A Randomized Clinical Trial – JAMA Network Open

Related:

M-A: Convalescent plasma does not reduce mortality in COVID-19.

RCT: Another study shows convalescent plasma does not improve outcomes in critically ill patients with Covid-19.

RCT: Convalescent plasma does not improve outcomes and may be harmful to hospitalized patients with COVID-19.

NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms.

M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.

RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.

 

Commentary on Twitter

 


Guidelines developed under pressure. The case of the COVID-19 low-quality “rapid” guidelines and potential solutions.

1 Dec, 2021 | 08:54h | UTC

Guidelines developed under pressure. The case of the COVID-19 low-quality “rapid” guidelines and potential solutions – Journal of Clinical Epidemiology

 


Cohort study: Allergic conditions linked to lower COVID-19 infection risk.

1 Dec, 2021 | 08:52h | UTC

News Release: Allergic conditions linked to lower COVID-19 infection risk – BMJ

Original Study: Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK) – Thorax

 


NICE Guideline | Tobacco: preventing uptake, promoting quitting, and treating dependence.

1 Dec, 2021 | 08:50h | UTC

Tobacco: preventing uptake, promoting quitting and treating dependence – National Institute for Health and Care Excellence

 


RCT: Intravenous or intraosseous calcium does not improve the return of spontaneous circulation in adults with out-of-hospital cardiac arrest.

1 Dec, 2021 | 08:46h | UTC

Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA

 

Commentary on Twitter

https://twitter.com/expensivecare/status/1465778134632972290

 


AAP Clinical Report: Promoting the participation of children and adolescents with disabilities in sports, recreation, and physical activity.

1 Dec, 2021 | 08:48h | UTC

Promoting the Participation of Children and Adolescents With Disabilities in Sports, Recreation, and Physical Activity – Pediatrics

 

Commentary on Twitter

 


M-A: Efficacy of non-invasive and invasive respiratory management strategies in adult patients with acute hypoxemic respiratory failure.

1 Dec, 2021 | 08:44h | UTC

Efficacy of non-invasive and invasive respiratory management strategies in adult patients with acute hypoxaemic respiratory failure: a systematic review and network meta-analysis – Critical Care

 


Global estimates of viral suppression in 31 countries shows too many people with HIV fail to achieve durable viral suppression.

1 Dec, 2021 | 08:41h | UTC

News Release: Too many people with HIV fail to achieve durable viral suppression – NIH News Releases

Original Study: Global estimates of viral suppression in children and adolescents and adults on antiretroviral therapy adjusted for missing viral load measurements: a multiregional, retrospective cohort study in 31 countries – The Lancet HIV (link to abstract – $ for full-text)

 


Review: Ethical advice in pediatric care.

1 Dec, 2021 | 08:42h | UTC

Ethical advice in paediatric care – Archives of Disease in Childhood

 


Integrative oncology: Addressing the global challenges of cancer prevention and treatment.

1 Dec, 2021 | 08:34h | UTC

Integrative oncology: Addressing the global challenges of cancer prevention and treatment – Ca: A Cancer Journal for Clinicians

Commentary: Addressing the Global Challenges of Cancer Prevention and Treatment – The ASCO Post

 


Review: Current treatment and future directions in the management of anal cancer.

1 Dec, 2021 | 08:38h | UTC

Current treatment and future directions in the management of anal cancer – CA: A Cancer Journal for Clinicians

 


Systematic Review: Late (after 6 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.

1 Dec, 2021 | 08:32h | UTC

Late (≥ 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants – Cochrane Library

 


CT imaging of peritoneal carcinomatosis with surgical correlation: a pictorial review.

1 Dec, 2021 | 08:30h | UTC

CT imaging of peritoneal carcinomatosis with surgical correlation: a pictorial review – Insights into Imaging

 


Systematic Review: Early (started within six days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants.

1 Dec, 2021 | 08:33h | UTC

Summary: Early (started within six days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants – Cochrane Library

Original Study: Early (< 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants – Cochrane Library

 

Commentary on Twitter

 


RCT: Small caliber 14-Fr percutaneous catheters (pigtail) were as effective as 28- to 32-Fr chest tubes in their ability to drain traumatic hemothorax with no difference in complications.

30 Nov, 2021 | 10:11h | UTC

The small (14 Fr) percutaneous catheter (P-CAT) versus large (28–32 Fr) open chest tube for traumatic hemothorax: A multicenter randomized clinical trial – Trauma and Acute Care Surgery (link to abstract – $ for full-text)

 


193 countries adopt first-ever global agreement on the Ethics of Artificial Intelligence.

30 Nov, 2021 | 10:16h | UTC

News Release: 193 countries adopt first-ever global agreement on the Ethics of Artificial Intelligence – United Nations

See Guidance: Outcome document: first draft of the Recommendation on the Ethics of Artificial Intelligence – United Nations

 


M-A: Minimally invasive treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia.

30 Nov, 2021 | 10:06h | UTC

Minimally invasive treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia: a network meta‐analysis – Cochrane Library

 


Systematic Review: Are there ways to improve stop-smoking treatment in primary care to help more people quit smoking?

30 Nov, 2021 | 10:03h | UTC

Summary: Are there ways to improve stop-smoking treatment in primary care to help more people to quit smoking? – Cochrane Library

Original Study: Strategies to improve smoking cessation rates in primary care – Cochrane Library

 


Guideline Interventions for the management of acute and chronic low back pain.

30 Nov, 2021 | 10:15h | UTC

Interventions for the Management of Acute and Chronic Low Back Pain: Revision 2021 – Journal of Orthopaedic & Sports Physical Therapy

 

Commentary on Twitter

 


M-A (mostly observational studies): Comparison of gastrojejunostomy to endoscopic stenting for gastric outlet obstruction.

30 Nov, 2021 | 10:08h | UTC

Comparison of gastrojejunostomy to endoscopic stenting for gastric outlet obstruction: An updated Systematic Review and Meta‐analysis – The American Journal of Surgery

 


Systematic Review: Anticoagulants for acute ischemic stroke.

30 Nov, 2021 | 10:01h | UTC

Summary: Early treatment with blood-thinning drugs for people who have had a stroke – Cochrane Library

Original Study: Anticoagulants for acute ischaemic stroke – Cochrane Library

 


Advances in Breast Cancer Radiotherapy: Implications for Current and Future Practice.

30 Nov, 2021 | 09:55h | UTC

Advances in Breast Cancer Radiotherapy: Implications for Current and Future Practice – JCO Oncology Practice

 

Commentary on Twitter

 


WHO Technical Brief and Priority Actions: Enhancing Readiness for Omicron.

30 Nov, 2021 | 08:46h | UTC

Enhancing Readiness for Omicron (B.1.1.529): Technical Brief and Priority Actions for Member States – World Health Organization

Commentaries:

The World Health Organization warns of very high risk posed by the omicron variant – NPR

Omicron Covid variant poses very high global risk, says WHO – The Guardian

See also the latest articles on the subject:

Statement On Omicron Variant – Infectious Diseases Society of America

Covid-19: Omicron may be more transmissible than other variants and partly resistant to existing vaccines, scientists fear – The BMJ

Helen Salisbury: Omicron—panic mongering or appropriate caution? – The BMJ

The Omicron variant underscores the global stakes of Covid-19 vaccine inequity – STAT

EXPLAINER: What we know and don’t know about omicron variant – Associated Press

Omicron: How do you detect it? – BBC

Are new COVID variants like Omicron linked to low vaccine coverage? Here’s what the science says – The Conversation

Omicron: why the WHO designated it a variant of concern – The Conversation

It looks like Omicron causes milder illness – is this how COVID becomes endemic? – The Conversation

As Omicron spreads, studies suggest that travel bans alone don’t do much good – NPR

 


Benzodiazepines: Uses, dangers, and clinical considerations.

30 Nov, 2021 | 09:59h | UTC

Benzodiazepines: Uses, Dangers, and Clinical Considerations – Neurology International

 


Transient Ischemic Attack: Emergency Department Evaluation and Disposition.

30 Nov, 2021 | 09:56h | UTC

TIA: Emergency Department Evaluation and Disposition – emDocs

Related:

AHA/ASA Guideline: Prevention of stroke in patients with previous stroke and transient ischemic attack – prevention efforts should be based on the cause of the first ischemic event.

Stroke and transient ischaemic attack in over 16s: diagnosis and initial management – National Institute for Health and Care Excellence

Canadian Stroke Best Practice Recommendations for Acute Stroke Management

Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ

2 recent meta-analysis highlight the benefits of short term (30 days) dual antiplatelet therapy with aspirin + clopidogrel in patients within 24 hours of high-risk transient ischemic attack or mild-moderate ischemic stroke.

Prospective validation of Canadian TIA Score for subsequent stroke risk after transient ischemic attack

Systematic review: Multiple vs. fewer antiplatelet agents for preventing early recurrence after ischemic stroke or transient ischemic attack

 


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