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M-A: Vasopressin and glucocorticoids for in-hospital cardiac arrest.

1 Feb, 2022 | 08:43h | UTC

Vasopressin and glucocorticoids for in-hospital cardiac arrest: A systematic review and meta-analysis of individual participant data – Resuscitation

Related: RCT: Vasopressin + Methylprednisolone increase the likelihood of return of spontaneous circulation compared to placebo in patients with in-hospital cardiac arrest.

 

Commentary on Twitter

 

The extraordinary success of Covid-19 vaccines, in two charts.

1 Feb, 2022 | 08:48h | UTC

The extraordinary success of Covid-19 vaccines, in two charts – Vox

 

Systematic Review: Change in resting heart rate and risk for all-cause mortality.

1 Feb, 2022 | 08:40h | UTC

Change in resting heart rate and risk for all-cause mortality – European Journal of Preventive Cardiology

 

Commentary on Twitter

 

Observational Study: Same-day mastectomy and axillary lymph node dissection seems safe for most patients with breast cancer.

1 Feb, 2022 | 08:38h | UTC

Same-day mastectomy and axillary lymph node dissection is safe for most patients with breast cancer – Journal of Surgical Oncology

 

Recommendations on the everyday management of patients with spondyloarthritis, including psoriatic arthritis.

1 Feb, 2022 | 08:44h | UTC

2022 French Society for Rheumatology (SFR) recommendations on the everyday management of patients with spondyloarthritis, including psoriatic arthritis – Joint Bone Spine

 

Research methods & reporting: Incorporating dose effects in network meta-analysis.

1 Feb, 2022 | 08:39h | UTC

Incorporating dose effects in network meta-analysis – The BMJ

See also: thread from the author on Twitter summarizing the article

 

RCT: In patients with rheumatoid arthritis, treatment with oral drug Tofacitinib increases cardiovascular and cancer risk compared to treatment with subcutaneous TNF inhibitors.

1 Feb, 2022 | 08:35h | UTC

Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)

Video: CV and Cancer Risk with Tofacitinib in RA – New England Journal of Medicine

Commentary: CV, Cancer Risk Up With Tofacitinib for Rheumatoid Arthritis – HealthDay

 

RCT: A comprehensive geriatric assessment hospital at home may be a cost-effective alternative to hospital admission.

1 Feb, 2022 | 08:32h | UTC

Is comprehensive geriatric assessment hospital at home a cost-effective alternative to hospital admission for older people? – Age and Aging

 

Review | Hepatic encephalopathy: thinking beyond ammonia.

1 Feb, 2022 | 08:36h | UTC

Hepatic Encephalopathy: Thinking Beyond Ammonia – Clinical Liver Disease

 

Concussion management is changing as more research suggests exercise is the best approach.

1 Feb, 2022 | 08:27h | UTC

Concussion management is changing as more research suggests exercise is best approach – The Conversation

Related:

Guideline: Nonpharmacological treatment of persistent postconcussion symptoms in adults.

RCT: Early treatment with mild aerobic exercise safely speeds recovery from sport-related concussion in adolescents.

Randomized Trial: Early Aerobic Exercise for Sport-Related Concussion

RCT: Limiting screen time for young adults after concussion results in shorter duration of symptoms.

Selected issues in sport-related concussion for the team physician: a consensus statement – “Current evidence suggests strict rest after SRC slows recovery and increases the probability of prolonged symptoms”.

RCT: Prescribed light exercise vs. standard management for emergency department patients with acute mild traumatic brain injury

 

RCT: Early drain removal is safe in patients with low or intermediate risk of pancreatic fistula after pancreaticoduodenectomy.

1 Feb, 2022 | 08:33h | UTC

Early Drain Removal is Safe in Patients With Low or Intermediate Risk of Pancreatic Fistula After Pancreaticoduodenectomy: A Multicenter, Randomized Controlled Trial – Annals of Surgery (link to abstract – $ for full-text)

 

Review: Primary care-based cardiovascular disease risk management after adverse pregnancy outcomes.

1 Feb, 2022 | 08:29h | UTC

Primary Care–Based Cardiovascular Disease Risk Management After Adverse Pregnancy Outcomes: a Narrative Review – Journal of General Internal Medicine (if the link is paywalled, try this one)

Commentary: Better management of long-term heart disease risk needed following complicated pregnancies – Boston Medical Center

See also: thread from the author on Twitter summarizing the article

Related:

A national cohort study in Sweden showed pregnancy complications (preeclampsia or eclampsia, gestational hypertension, gestational diabetes, preterm birth, small for gestational age, and stillbirth) are associated with increased risk of cardiovascular disease later in life.

AHA Scientific Statement | Adverse Pregnancy Outcomes and Cardiovascular Disease Risk

Consensus statement: Cardiovascular health after menopause transition, pregnancy disorders, and other gynecologic conditions

Cohort Study: Preeclampsia and Cardiovascular Disease

Cohort Study: Cardiovascular Disease After Hypertensive Disorders of Pregnancy Largely Explained by Conventional Cardiovascular Risk Factors (recent studies on the subject)

 

Systematic Review: Value of imaging to guide interventional procedures in rheumatic and musculoskeletal diseases.

1 Feb, 2022 | 08:20h | UTC

Value of imaging to guide interventional procedures in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider – RMD Open

 

Commentary on Twitter

 

RCT: Sugemalimab improves progression-free survival vs. placebo in patients with metastatic non-small-cell lung cancer.

1 Feb, 2022 | 08:25h | UTC

Sugemalimab versus placebo, in combination with platinum-based chemotherapy, as first-line treatment of metastatic non-small-cell lung cancer (GEMSTONE-302): interim and final analyses of a double-blind, randomised, phase 3 clinical trial – The Lancet Oncology (link to abstract – $ for full-text)

Related study: Sugemalimab versus placebo after concurrent or sequential chemoradiotherapy in patients with locally advanced, unresectable, stage III non-small-cell lung cancer in China (GEMSTONE-301): interim results of a randomised, double-blind, multicentre, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentaries:

Sugemalimab shows promise for locally advanced, metastatic NSCLC – Medicine Matters

Sugemalimab Boosts Outcomes in NSCLC – MedPage Today (free registration required)

 

Commentary on Twitter

https://twitter.com/NatRevClinOncol/status/1483839169839255554

 

Meta-analysis: Androgen deprivation therapy, in addition to radiotherapy, is associated with improved metastasis-free survival in men with localized prostate cancer.

1 Feb, 2022 | 08:24h | UTC

Androgen deprivation therapy use and duration with definitive radiotherapy for localised prostate cancer: an individual patient data meta-analysis – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Effect of ADT Use and Duration in Combination With Definitive Radiotherapy for Localized Prostate Cancer – The ASCO Post

 

M-A: The diagnostic accuracy of syndromic management for genital ulcer disease.

1 Feb, 2022 | 08:12h | UTC

The Diagnostic Accuracy of Syndromic Management for Genital Ulcer Disease: A Systematic Review and Meta-Analysis – Frontiers in Medicine

 

Systematic Review: Self‐management interventions for people with chronic obstructive pulmonary disease.

1 Feb, 2022 | 08:21h | UTC

Self‐management interventions for people with chronic obstructive pulmonary disease – Cochrane Library

Summary: Self-management for people with chronic obstructive pulmonary disease – Cochrane Library

 

Commentary on Twitter

 

Registry study in Denmark found an increased bleeding risk with the association of systemic Fluconazole and Apixaban (OR 3.5; 95% CI, 1.4-10.6).

1 Feb, 2022 | 08:13h | UTC

Bleeding Risk Following Systemic Fluconazole or Topical Azoles in Patients with Atrial Fibrillation on Apixaban, Rivaroxaban, or Dabigatran – American Journal of Medicine

 

Review: Multidisciplinary management of tracheobronchial injury.

1 Feb, 2022 | 08:17h | UTC

Multidisciplinary management of tracheobronchial injury – European Respiratory Review

 

Position Paper: Preventing heart failure.

30 Jan, 2022 | 14:53h | UTC

Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology

 

Studies show parental vaccination provided indirect protection of children from SARS-CoV-2 infection during the Delta wave.

30 Jan, 2022 | 14:52h | UTC

Indirect protection of children from SARS-CoV-2 infection through parental vaccination – Science

See also: Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel – Science

Commentary: COVID vaccine markedly cuts household transmission, studies show – CIDRAP

 

Commentary on Twitter

 

M-A: Association of antenatal diet and physical activity–based interventions with gestational weight gain and pregnancy.

1 Feb, 2022 | 08:10h | UTC

Association of Antenatal Diet and Physical Activity–Based Interventions With Gestational Weight Gain and Pregnancy Outcomes: A Systematic Review and Meta-analysis – JAMA Internal Medicine

News Release: New evidence shows the importance of healthy lifestyle programs in pregnancy – University of Monash

 

Commentary on Twitter

 

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

30 Jan, 2022 | 14:40h | UTC

Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study – European Journal of Pediatrics

Related:

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

 

Commentary on Twitter

 

Observational analysis in Lombardy, Italy, showed a gradual decrease in protection against SARS-CoV-2 clinical outcomes after the second dose of vaccine.

30 Jan, 2022 | 14:51h | UTC

Persistence of protection against SARS-CoV-2 clinical outcomes up to 9 months since vaccine completion: a retrospective observational analysis in Lombardy, Italy – The Lancet Infectious Diseases

Commentary: COVID-19 vaccine: what are we doing and what should we do? – The Lancet Infectious Diseases

 

FDA halts use of antibody drugs that don’t work vs. Omicron.

30 Jan, 2022 | 14:35h | UTC

FDA halts use of antibody drugs that don’t work vs. omicron – Associated Press

Related: Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

 

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