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Development and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalized adults with bloodstream infections: a multicenter, prospective, cohort study.

3 Feb, 2022 | 08:28h | UTC

Development and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalised adults with bloodstream infections: a multicentre, prospective, cohort study – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

M-A: Timing of carotid intervention in symptomatic carotid artery stenosis.

3 Feb, 2022 | 08:33h | UTC

Editor’s Choice – Timing of Carotid Intervention in Symptomatic Carotid Artery Stenosis: A Systematic Review and Meta-Analysis – European Journal of Vascular & Endovascular Surgery

 

Increasing financial payments from industry to medical oncologists in the U.S., 2014-2017.

3 Feb, 2022 | 08:26h | UTC

Increasing Financial Payments from Industry to Medical Oncologists in the United States, 2014-2017 – Journal of the National Comprehensive Cancer Network

Invited Commentary: Physician Interactions With Industry: Striking the Right Balance – Journal of the National Comprehensive Cancer Network

 

M-A: Laparoscopic versus open distal gastrectomy for gastric cancer.

3 Feb, 2022 | 08:30h | UTC

Laparoscopic versus open distal gastrectomy for gastric cancer: A systematic review and meta-analysis – Surgery

 

Study finds there is probably a high rate of underdiagnosed Fragile X Syndrome in the general population.

3 Feb, 2022 | 08:23h | UTC

Prevalence of Underdiagnosed Fragile X Syndrome in 2 Health Systems – JAMA Network Open

 

RCT: In patients with complex regional pain syndrome, lumbar sympathetic ganglion block with botulinum toxin type A may reduce pain intensity.

3 Feb, 2022 | 08:25h | UTC

Botulinum Toxin Type A for Lumbar Sympathetic Ganglion Block in Complex Regional Pain Syndrome: A Randomized Trial – Anesthesiology

 

M-A of 26 observational studies found hearing loss and dual sensory loss are linked to excess all-cause and cardiovascular mortality.

3 Feb, 2022 | 08:22h | UTC

Associations of Hearing Loss and Dual Sensory Loss With Mortality: A Systematic Review, Meta-analysis, and Meta-regression of 26 Observational Studies With 1 213 756 Participants – JAMA Otolaryngology—Head & Neck Surgery (link to abstract – $ for full-text)

Author Interview: Associations of Hearing Loss and Dual Sensory Loss With Mortality

 

In mechanically ventilated pediatric patients, an observational study showed hospitals varied widely in their use of endotracheal aspirates cultures, and higher rates were correlated with increased antibiotic use.

3 Feb, 2022 | 08:19h | UTC

Association of Endotracheal Aspirate Culture Variability and Antibiotic Use in Mechanically Ventilated Pediatric Patients – JAMA Network Open

 

Commentary from the author on Twitter (thread – click for more)

https://twitter.com/andreaprinzi/status/1476627285490864128

 

M-A: factors for Mesh infection following abdominal wall hernia repair surgery.

3 Feb, 2022 | 08:18h | UTC

Systematic review and meta-analysis of risk factors for Mesh infection following Abdominal Wall Hernia Repair Surgery – The American Journal of Surgery (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Outpatient Therapies for COVID-19: How do we choose?

2 Feb, 2022 | 08:53h | UTC

Outpatient Therapies for COVID-19: How do we choose? – Open Forum Infectious Diseases

 

WHO Report: Global analysis of health care waste in the context of COVID-19.

2 Feb, 2022 | 08:54h | UTC

Global analysis of health care waste in the context of COVID-19 – World Health Organization

News Release: Tonnes of COVID-19 health care waste expose urgent need to improve waste management systems – World Health Organization

Commentaries:

Covid-19: Pandemic waste threatens human and environmental health, says WHO – The BMJ

Amid Mountains of COVID Waste, WHO Urges Sustainable Solutions – Health Policy Watch

 

Commentary on Twitter (thread – click for more)

 

A pragmatic RCT found low adherence and no additional benefit of prescribing a very low-protein diet in patients with advanced chronic kidney disease.

3 Feb, 2022 | 08:21h | UTC

No additional benefit of prescribing a very low-protein diet in patients with advanced Chronic Kidney Disease under regular nephrology care: a pragmatic, randomized, controlled trial – American Journal of Clinical Nutrition (link to abstract – $ for full-text)

 

Updated NIH COVID-19 Treatment Guidelines: Therapeutic management of nonhospitalized adults with COVID-19.

2 Feb, 2022 | 08:50h | UTC

Therapeutic Management of Nonhospitalized Adults With COVID-19 – NIH COVID-19 Treatment Guidelines

 

Commentary on Twitter

 

Editorial: Menstruation and Covid-19 vaccination.

2 Feb, 2022 | 08:46h | UTC

Menstruation and covid-19 vaccination – The BMJ

News Release: New studies provide reassuring data on menstrual changes after covid-19 vaccination – BMJ

 

Commentary on Twitter

 

Ten billion COVID vaccinations: world hits new milestone.

2 Feb, 2022 | 08:48h | UTC

Ten billion COVID vaccinations: world hits new milestone – Nature

 

Commentary on Twitter

 

As Denmark scraps COVID restrictions, WHO urges caution.

2 Feb, 2022 | 08:47h | UTC

As Denmark Scraps COVID Restrictions, WHO Urges Caution – Health Policy Watch

Related: Despite the ongoing spread of Omicron, some European countries have decided to lift Covid-19 restrictions.

 

M-A: Impact of Ketamine on analgosedative consumption in critically ill patients.

2 Feb, 2022 | 08:44h | UTC

Impact of Ketamine on Analgosedative Consumption in Critically Ill Patients: A Systematic Review and Meta-Analysis – Annals of Pharmacotherapy

Related:

RCT: Fentanyl vs. placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department.

RCT: In patients undergoing emergency endotracheal intubation, 7-day survival was significantly lower with etomidate vs. ketamine (77.3% versus 85.1%), but 28 survival rates were not significantly different (etomidate 64.1% vs. ketamine 66.8%, p = 0.294).

 

Perspective: Avoidance of β-blockers in patients who use stimulants is not supported by good evidence.

2 Feb, 2022 | 08:39h | UTC

Avoidance of β-blockers in patients who use stimulants is not supported by good evidence – Canadian Medical Association Journal

 

Perspective: The ongoing saga of normal saline vs. balanced fluids.

2 Feb, 2022 | 08:43h | UTC

The ongoing saga of normal saline versus balanced fluids – First10EM

Original studies:

RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis – NEJM Evidence

Related:

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

 

Using melatonin for sleep is on the rise, study says, despite potential health harms.

2 Feb, 2022 | 08:41h | UTC

Using melatonin for sleep is on the rise, study says, despite potential health harms – CNN

Original Study: Trends in Use of Melatonin Supplements Among US Adults, 1999-2018 – JAMA (free for a limited period)

 

Cohort Study: Association of posttraumatic epilepsy with 1-year outcomes after traumatic brain injury.

2 Feb, 2022 | 08:36h | UTC

Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury – JAMA Network Open

 

Commentary on Twitter

 

Cluster Randomized Trial: In older patients undergoing elective surgical procedures, a multimodal nonpharmacological prevention program reduced postoperative delirium occurrence and days with delirium.

2 Feb, 2022 | 08:38h | UTC

Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery: A Stepped-Wedge Cluster Randomized Clinical Trial – JAMA Surgery

Author Interview: Effective Delirium Prevention in Older Persons After Elective Surgery

 

Commentary on Twitter

 

RCT: Safety and efficacy of agomelatine in children and adolescents with major depressive disorder receiving psychosocial counselling.

2 Feb, 2022 | 08:34h | UTC

Safety and efficacy of agomelatine in children and adolescents with major depressive disorder receiving psychosocial counselling: a double-blind, randomised, controlled, phase 3 trial in nine countries – The Lancet Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter

 

NCCN Guideline: Kidney Cancer.

2 Feb, 2022 | 08:30h | UTC

Kidney Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

 

Review: Primary and metastatic peritoneal surface malignancies.

2 Feb, 2022 | 08:33h | UTC

Primary and metastatic peritoneal surface malignancies – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Primary and metastatic peritoneal surface malignancies – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 

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