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The Paxlovid pill (Nirmatrelvir) randomized, placebo-controlled trial published @NEJM:
89% efficacy vs Covid hospitalizations or deaths, and quick reduction of viral load.
The active pills had less serious adverse events or discontinuations than placebohttps://t.co/HBMRZt4wBo pic.twitter.com/LDQv41O56c

— Eric Topol (@EricTopol) February 16, 2022

Retrospective cohort study: Pfizer vaccine reduces the risk of reinfection after recovery from Covid-19.

17 Feb, 2022 | 10:13h | UTC

Effectiveness of the BNT162b2 Vaccine after Recovery from Covid-19 – New England Journal of Medicine

Commentary on Twitter

Among patients who had recovered from Covid-19, the receipt of at least one dose of the BNT162b2 vaccine was associated with a significantly lower risk of recurrent infection. https://t.co/AAlsY9sFlv pic.twitter.com/Nkj1lP77ZW

— NEJM (@NEJM) February 16, 2022

Meta-analysis finds the overall prevalence of statin intolerance is around 9% and identifies the most common risk factors.

17 Feb, 2022 | 10:07h | UTC

Prevalence of statin intolerance: a meta-analysis – European Heart Journal

Commentaries:

Study shows the true prevalence of statin intolerance worldwide is between 6 to 10% – News Medical / European Society of Cardiology

Expert reaction to study looking at statin intolerance – Science Media Centre

Side effect patterns in a crossover trial of statin, placebo, and no treatment – This N-of-1 trial, now published in full, suggests the nocebo effect causes most of statins muscle adverse effects.

#AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo

Commentary on Twitter

Statin intolerance is “over-estimated and over-diagnosed”. World’s largest study shows less than 10% suffer side-effects caused by statins https://t.co/pcVk8YI3I3 @escardio #EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes #CVD #Riskfactors pic.twitter.com/b3nFWsc74d

— European Society of Cardiology Journals (@ESC_Journals) February 16, 2022

England to offer Covid jab to five to 11-year-olds.

17 Feb, 2022 | 10:09h | UTC

England to offer Covid jab to five to 11-year-olds – BBC

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year.

17 Feb, 2022 | 09:58h | UTC

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year – Nature Medicine

Commentary: Studies detail risk of severe COVID-19, GI problems in kids – CIDRAP

Commentary on Twitter

The risk of intensive care unit admission among children with COVID-19 is affected by age, ethnicity and comorbidities, according to a @NatureMedicine paper. Understanding these modifiers might help identify at-risk children and guide interventions. https://t.co/MIkLecyNI6 pic.twitter.com/JtN3Ab4Lu7

— Nature Portfolio (@NaturePortfolio) December 20, 2021

Review: Diagnosis and treatment of acute coronary syndromes.

17 Feb, 2022 | 10:04h | UTC

Diagnosis and Treatment of Acute Coronary Syndromes: A Review – JAMA (free for a limited period)

Audio clinical review: Diagnosis and Treatment of Acute Coronary Syndromes – JAMA

How COVID-19 transformed genomics and changed the handling of disease outbreaks forever.

17 Feb, 2022 | 09:56h | UTC

How COVID-19 transformed genomics and changed the handling of disease outbreaks forever – The Conversation

Review | Wastewater network infrastructure in public health: Applications and learnings from the COVID-19 pandemic.

17 Feb, 2022 | 09:54h | UTC

Wastewater network infrastructure in public health: Applications and learnings from the COVID-19 pandemic – PLOS Global Public Health

Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly.

CDC unveils its latest weapon in Covid-19 detection: wastewater.

CDC Report: Using Wastewater Surveillance Data to Support the COVID-19 Response — United States, 2020–2021.

Rapid, large-scale wastewater surveillance and automated reporting system enabled early detection of nearly 85% of COVID-19 cases on a University campus.

[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.

Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME

Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT

Sewage sleuths helped an Arizona town beat back Covid-19. For wastewater epidemiology, that’s just the start – STAT

The myriad ways sewage surveillance is helping fight COVID around the world – Nature

Testing sewage can give school districts, campuses and businesses a heads-up on the spread of COVID-19 – The Conversation

It’s time to begin a national wastewater testing program for Covid-19 – STAT

Coronavirus: Testing sewage an ‘easy win’ – BBC

Development of wastewater pooled surveillance of SARS-CoV-2 from congregate living settings – high sensitivity, but unable to distinguish new infectious cases from persistent convalescent shedding.

German Guidelines for the diagnosis, therapy and follow-up of cervical cancer – Part 1 with recommendations on epidemiology, screening, diagnostics and therapy.

17 Feb, 2022 | 08:47h | UTC

Diagnosis, Therapy and Follow-up of Cervical Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry No. 032/033OL, May 2021) – Part 1 with Recommendations on Epidemiology, Screening, Diagnostics and Therapy – Geburtshilfe und Frauenheilkunde

SIMEU position paper on non-invasive respiratory support in COVID-19 pneumonia.

17 Feb, 2022 | 10:01h | UTC

SIMEU position paper on non-invasive respiratory support in COVID-19 pneumonia – Internal and Emergency Medicine

RCT: CPAP improved outcomes in patients with acute hypoxemic respiratory failure due to COVID-19, but high-flow nasal oxygen was not better than conventional oxygen therapy.

RCT: In patients with severe Covid-19, high-flow oxygen therapy reduced the likelihood of invasive mechanical ventilation and decreased the time to clinical recovery compared to conventional oxygen therapy.

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research – “The two randomized controlled trials indicate superiority of non-invasive ventilation over high-flow nasal oxygen in reducing the need for intubation”.

ASCRS Guidelines for the management of colon cancer.

17 Feb, 2022 | 08:49h | UTC

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colon Cancer – Diseases of the Colon & Rectum

Commentary on Twitter

This #DCRJournal highlights CPG: Colon Cancer – see all in these visual abstracts: https://t.co/qGE9lqZiIc @JonVogel7 @a_bham18 @alexhawkinsmd @seanlangenfeld @ajthorsenL @ColonCancerDoc @AmyLightnerMD @ianmpaquette @KyleCologne @SamAtallahMD @debby_keller @SeanLangenfeld pic.twitter.com/xqLeCF0lGz

— DCRjournal (@DCRjournal) February 7, 2022

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