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RCT: Methenamine Hippurate (a non-antibiotic preventive treatment) is noninferior to prophylactic antibiotics for treating recurrent urinary tract infections in women.

11 Mar, 2022 | 10:21h | UTC

Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial – The BMJ

News Release: Antiseptic drug as good as antibiotics for preventing recurrent urinary tract infections – BMJ Newsroom

Editorial: Methenamine hippurate for recurrent urinary tract infections – The BMJ

Commentaries:

Trial supports antibiotic alternative for recurrent urinary infections – CIDRAP

Nonantibiotic Prophylaxis Noninferior for Recurrent UTI – HealthDay

 

Commentary on Twitter

https://twitter.com/bmj_latest/status/1501800030608494596

 

Systematic Review: Inhaled corticosteroids for the treatment of COVID‐19.

11 Mar, 2022 | 10:18h | UTC

Inhaled corticosteroids for the treatment of COVID‐19 – Cochrane Library

Related:

[Preprint] M-A: Inhaled corticosteroids in COVID-19 outpatients.

PRINCIPLE RCT: Inhaled budesonide improves time to recovery from COVID-19 in people at high risk of complications in the community.

Position Paper: Recommendations for the use of topical inhalant budesonide in COVID-19.

RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19

Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19

 

Commentary on Twitter (thread – click for more)

https://twitter.com/CochraneLibrary/status/1501615982208507912

 

WHO Guidance: Use of SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing.

11 Mar, 2022 | 10:20h | UTC

Use of SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing – World Health Organization

 

Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21.

11 Mar, 2022 | 10:16h | UTC

Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 – The Lancet

News Release: Global death toll of COVID-19 pandemic may be more than three times higher than official records, estimates of excess deaths indicate – The Lancet

Commentaries:

COVID’s true death toll: far higher than official records – Nature

Covid deaths probably three times higher than records say – BBC

Related:

Editorial: “Excess deaths” is the best metric for tracking the pandemic.

The pandemic’s true death toll: millions more than official counts.

We can be confident there have been far more than 5 million global Covid deaths – “Estimating ‘excess’ fatalities, a more robust analysis method, puts the pandemic’s grim toll between 10m and 19m people”.

Global Covid-19 deaths surpass five million.

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Commentary on Twitter

https://twitter.com/EricTopol/status/1502064507597860872

 

COVID pandemic 2nd anniversary: 3 things we got wrong, and 3 things to watch out for.

11 Mar, 2022 | 10:07h | UTC

COVID pandemic 2nd anniversary: 3 things we got wrong, and 3 things to watch out for – The Conversation

 

Misinformation: susceptibility, spread, and interventions to immunize the public.

11 Mar, 2022 | 10:03h | UTC

Misinformation: susceptibility, spread, and interventions to immunize the public – Nature Medicine

See also: An epidemic of uncertainty: rumors, conspiracy theories and vaccine hesitancy – Nature Medicine

 

Another study suggests that a third vaccine dose is necessary to protect populations against the omicron variant.

11 Mar, 2022 | 10:14h | UTC

Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study – The BMJ

News Release: Third vaccine dose critical for protecting populations against omicron variant – BMJ Newsroom

 

Commentary on Twitter

 

Retrospective Cohort Study: Frequency and outcomes of MRI-detected axillary adenopathy following COVID-19 vaccination.

11 Mar, 2022 | 10:05h | UTC

Frequency and outcomes of MRI-detected axillary adenopathy following COVID-19 vaccination – European Radiology

Related:

Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care.

2 Case Series and Guidance | Lymphadenopathy in COVID-19 Vaccine Recipients

Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging.

Covid-19: Schedule breast screening before vaccine or 4 to 6 weeks after to avoid false positives, says guidance

 

RCT: Effect of offering care management or online dialectical behavior therapy skills training vs. usual care on self-harm among adult outpatients with suicidal ideation (important negative study).

11 Mar, 2022 | 10:01h | UTC

Effect of Offering Care Management or Online Dialectical Behavior Therapy Skills Training vs Usual Care on Self-harm Among Adult Outpatients With Suicidal Ideation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Low-Intensity Care Options Flop for Self-Harm Prevention— In randomized trial, two therapeutic interventions failed to help people with suicidal thoughts – MedPage Today (free registration required)

See also: Visual Abstract

 

Commentary on Twitter

https://twitter.com/JonathanShedler/status/1493846504238321664

 

Optimizing hospital electronic prescribing systems: a systematic scoping review.

11 Mar, 2022 | 10:02h | UTC

Optimizing Hospital Electronic Prescribing Systems: A Systematic Scoping Review – Journal of Patient Safety

 

SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches for preventing central line-associated bloodstream infections.

11 Mar, 2022 | 09:53h | UTC

SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches for the prevention of central line-associated bloodstream infections – Infection Control and Hospital Epidemiology

News Release: Practical approaches for the prevention of central line-associated bloodstream infections in NICU – Society for Healthcare Epidemiology of America

 

Report: Measuring sex, gender identity, and sexual orientation.

11 Mar, 2022 | 09:55h | UTC

Report: Measuring Sex, Gender Identity, and Sexual Orientation – National Academies of Sciences, Engineering, and Medicine

News Release: NIH Should Standardize Questions Used to Collect Sex, Gender, and Sexual Orientation Data in Studies and Surveys, Says New Report – National Academies of Sciences, Engineering, and Medicine

Commentary: NIH-funded study offers recommendations for measuring gender, sexual orientation – Healthcare IT News

 

WHO issues new guidelines on abortion to help countries deliver lifesaving care.

11 Mar, 2022 | 09:56h | UTC

News Release: WHO issues new guidelines on abortion to help countries deliver lifesaving care – World Health Organization

See Guidance: Abortion care guideline – World Health Organization

Commentary: New WHO Abortion Guidelines Include Telemedicine for First Time – Health Policy Watch

 

Commentary on Twitter (thread – click for more)

 

RCT: Safety and efficacy of three enteral feeding strategies in patients with severe stroke.

11 Mar, 2022 | 09:51h | UTC

Safety and efficacy of three enteral feeding strategies in patients with severe stroke in China (OPENS): a multicentre, prospective, randomised, open-label, blinded-endpoint trial – The Lancet Neurology (link to abstract – $ for full-text)

 

Methods primer: Data linkage in medical research.

11 Mar, 2022 | 09:44h | UTC

Data linkage in medical research – BMJ Medicine

 

Commentary on Twitter

 

Efficacy and safety of non-operative management of uncomplicated acute appendicitis compared to appendectomy: an umbrella review of systematic reviews and meta-analyses.

11 Mar, 2022 | 09:49h | UTC

Efficacy and Safety of Non-Operative Management of Uncomplicated Acute Appendicitis Compared to Appendectomy: An Umbrella Review of Systematic Reviews and Meta-Analyses – World Journal of Surgery

Related:

Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.

Review: Diagnosis of uncomplicated and complicated appendicitis in adults.

Another RCT evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis.

A Randomized trial comparing antibiotics with appendectomy for appendicitis

Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin

Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis

Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis

Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children

Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International

 

RCT: Overall survival with Ribociclib plus Letrozole in advanced breast cancer.

11 Mar, 2022 | 09:47h | UTC

Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Ribociclib plus endocrine therapy offers survival benefit for postmenopausal patients with metastatic breast cancer – University of Texas MD Anderson Cancer Center / News Medical

Adding Ribociclib to Letrozole Prolongs Survival in Advanced Breast Cancer – HealthDay

 

Review: Hypertensive eye disease.

11 Mar, 2022 | 09:42h | UTC

Hypertensive eye disease – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Hypertensive eye disease (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Association between statin use and daptomycin-related musculoskeletal adverse events: A mixed approach combining a meta-analysis and a disproportionality analysis.

11 Mar, 2022 | 09:39h | UTC

Association between statin use and daptomycin-related musculoskeletal adverse events: A mixed approach combining a meta-analysis and a disproportionality analysis – Clinical Infectious Diseases

 

Systematic Review: Antiplatelet agents for chronic kidney disease.

11 Mar, 2022 | 09:35h | UTC

Antiplatelet agents for chronic kidney disease – Cochrane Library

 

Review: Acute cholecystitis.

11 Mar, 2022 | 09:40h | UTC

Acute Cholecystitis: A Review – JAMA (free for a limited period)

Author Interview: Acute Cholecystitis

 

RCT: In pediatric ICUs, a bundled intervention that emphasized a physiologically focused cardiopulmonary resuscitation training did not improve outcomes in cardiac arrest.

11 Mar, 2022 | 09:37h | UTC

Effect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: CPR Intervention Failed to Improve Survival in Kids With Cardiac Arrest — Physiologically focused CPR training did not lead to difference in survival to discharge – MedPage Today (free registration required)

 

Commentary on Twitter

 

Nationwide analysis of persistent type II endoleak and late outcomes of endovascular abdominal aortic aneurysm repair in Japan: a propensity-matched analysis.

11 Mar, 2022 | 09:32h | UTC

Nationwide Analysis of Persistent Type II Endoleak and Late Outcomes of Endovascular Abdominal Aortic Aneurysm Repair in Japan: a Propensity-matched Analysis – Circulation

Commentary: Type II Endoleak and EVAR Outcomes for Abdominal Aortic Aneurysm – American College of Cardiology

 

Expert Analysis: Clinical practice algorithm for the follow-up of unrepaired and repaired secundum atrial septal defects.

11 Mar, 2022 | 09:31h | UTC

Clinical Practice Algorithm For the Follow-up of Unrepaired and Repaired Secundum Atrial Septal Defects – American College of Cardiology

 

Comparing bowel lengthening procedures: which, when, and why?

11 Mar, 2022 | 09:33h | UTC

Comparing bowel lengthening procedures: which, when, and why? – Current Opinion in Organ Transplantation

 

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