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‘We suppressed our scientific imagination’: four experts examine the big successes and failures of the COVID response so far.

15 Mar, 2022 | 08:47h | UTC

‘We suppressed our scientific imagination’: four experts examine the big successes and failures of the COVID response so far – The Conversation

 


Open Label RCT: Azithromycin for poorly controlled asthma in children.

15 Mar, 2022 | 08:39h | UTC

Azithromycin for Poorly Controlled Asthma in Children: A randomized controlled trial – CHEST (link to abstract – $ for full-text)

Commentary: Adding azithromycin to standard care improves asthma control, exacerbations in children – Healio

Related: Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma

 


NCCN Guideline: T-Cell Lymphomas.

15 Mar, 2022 | 08:41h | UTC

T-Cell Lymphomas, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

 


RCT: A preconception lifestyle intervention for weight loss did not improve fertility rates among women with obesity and infertility.

15 Mar, 2022 | 08:34h | UTC

Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial – PLOS Medicine

Commentary: Weight loss doesn’t help pregnancy chances, study finds – University of Virginia Health System

 


Guideline: The use of antenatal corticosteroids for fetal maturation.

15 Mar, 2022 | 08:43h | UTC

The use of antenatal corticosteroids for fetal maturation: clinical practice guideline by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine foundation – Journal of Perinatal Medicine

 


Guide to statistics and methods: collider bias.

15 Mar, 2022 | 08:30h | UTC

Collider Bias – JAMA (free for a limited period)

 


Single-center RCT: Accessible Hepatitis C care for people who inject drugs.

15 Mar, 2022 | 08:36h | UTC

Accessible Hepatitis C Care for People Who Inject Drugs: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

 

Commentary on Twitter

 


Cohort Study: Evaluating rates of recurrent ischemic stroke among young adults with embolic stroke of undetermined source.

15 Mar, 2022 | 08:33h | UTC

Evaluating Rates of Recurrent Ischemic Stroke Among Young Adults With Embolic Stroke of Undetermined Source: The Young ESUS Longitudinal Cohort Study – JAMA Neurology (free for a limited period)

Commentary: Embolic Stroke of Undetermined Source in the Young: Low Recurrence, but Few Answers — Growing evidence that role of atrial fibrillation is less important than originally believed – MedPage Today (free registration required)

 

Commentary on Twitter

 


Review: Diagnosis and management of postural orthostatic tachycardia syndrome.

15 Mar, 2022 | 08:26h | UTC

Diagnosis and management of postural orthostatic tachycardia syndrome – Canadian Medical Association Journal

 


Cohort studies show an independent association of Lipoprotein(a) and coronary artery calcification with atherosclerotic cardiovascular risk.

15 Mar, 2022 | 08:28h | UTC

Independent Association of Lipoprotein(a) and Coronary Artery Calcification With Atherosclerotic Cardiovascular Risk – Journal of the American College of Cardiology (link to abstract – $ for full-text)

 


M-A: Similar outcomes with Beta-lactam monotherapy vs. combination therapy for bloodstream infections or pneumonia due to Pseudomonas aeruginosa.

15 Mar, 2022 | 08:29h | UTC

Beta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to Pseudomonas aeruginosa: a meta-analysis – International Journal of Antimicrobial Agents (link to abstract – $ for full-text)

 


Patient-centered care in thoracic surgery: a holistic approach—A review of the subjects of enhanced recovery after surgery, rehabilitation, pain management and patient-reported outcome measures in thoracic surgery.

15 Mar, 2022 | 08:16h | UTC

Patient-centred care in thoracic surgery: a holistic approach—A review of the subjects of enhanced recovery after surgery, rehabilitation, pain management and patient-reported outcome measures in thoracic surgery – Journal of Thoracic Disease

 


Podcast: Cardiorenal Syndrome Pearls.

15 Mar, 2022 | 08:23h | UTC

#326 NephMadness 2022: Cardiorenal Syndrome – The Curbsiders

 


Case Report: “Popeye deformity” associated with proximal biceps tendon rupture.

15 Mar, 2022 | 08:25h | UTC

“Popeye deformity” associated with proximal biceps tendon rupture – Canadian Medical Association Journal

 


Systematic Review: De-implementing low-value care in cancer care delivery.

15 Mar, 2022 | 08:22h | UTC

De-implementing low-value care in cancer care delivery: a systematic review – Implementation Science

 


Opinion: Open science, done wrong, will compound inequities.

15 Mar, 2022 | 08:14h | UTC

Open science, done wrong, will compound inequities – Nature

Related:

Open-access publishing fees deter researchers in the global south.

Impact factor abandoned by Dutch university in hiring and promotion decisions – “Faculty and staff members at Utrecht University will be evaluated by their commitment to open science”.

Open-access Science Funders Announce Price Transparency Rules for Publishers (several resources on the subject)

A new mandate highlights costs, benefits of making all scientific articles free to read – Science

A guide to Plan S: the open-access initiative shaking up science publishing – Nature

 


Cohort Study: History of neurological or psychiatric conditions increases the likelihood of developing more.

15 Mar, 2022 | 08:08h | UTC

News Release: History of neurological or psychiatric conditions increases the likelihood of developing more – University of Waterloo

Original Study: Incidence of neurological and psychiatric comorbidity over time: a population-based cohort study in Ontario, Canada – Age and Ageing (link to abstract – $ for full-text)

 


Systematic Review: Long-term outcomes among patients with advanced kidney disease who forgo maintenance dialysis.

15 Mar, 2022 | 08:11h | UTC

Long-term Outcomes Among Patients With Advanced Kidney Disease Who Forgo Maintenance Dialysis: A Systematic Review – JAMA Network Open

Commentaries:

Conservative Care for Kidney Failure—The Other Side of the Coin – JAMA Network Open

Study: Advanced kidney disease patients can survive, with quality life, without dialysis – UPI

 


M-A: Reassessment of the efficacy of carboplatin for metastatic urothelial carcinoma in the era of immunotherapy.

15 Mar, 2022 | 08:05h | UTC

Reassessment of the Efficacy of Carboplatin for Metastatic Urothelial Carcinoma in the Era of Immunotherapy: A Systematic Review and Meta-analysis – European Urology Focus

 


Systematic review and non-inferiority meta-analysis of randomized phase II/III trials on S-1-based therapy vs. 5-fluorouracil- or capecitabine-based therapy in the treatment of patients with metastatic colorectal cancer.

15 Mar, 2022 | 08:06h | UTC

Systematic review and non-inferiority meta-analysis of randomised phase II/III trials on S-1-based therapy versus 5-fluorouracil- or capecitabine-based therapy in the treatment of patients with metastatic colorectal cancer – European Journal of Cancer

 


Effectiveness of contact tracing in the control of infectious diseases: a systematic review.

14 Mar, 2022 | 01:45h | UTC

Effectiveness of contact tracing in the control of infectious diseases: a systematic review – The Lancet Public Health

 


Meta-analysis of randomized controlled trials comparing intraoperative red blood cell transfusion strategies.

14 Mar, 2022 | 01:47h | UTC

A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell Transfusion Strategies – Annals of Surgery

Related:

Systematic Review: Restrictive transfusion thresholds can safely decrease transfusions by 41% across a broad range of clinical contexts.

RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

Randomized trial: Liberal vs. restrictive transfusion thresholds in extremely low-birth-weight infants

Meta-Analysis: Effects of Restrictive vs. Liberal Transfusion Strategies on Longer-term Outcomes After Cardiac Surgery

Randomized Trial: In Patients Undergoing Cardiac Surgery, A Restrictive Transfusion Approach Does Not Increase the Risk of Acute Kidney Injury

Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials – Critical Care

Research: Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA

 


The changing epidemiology of SARS-CoV-2.

14 Mar, 2022 | 01:37h | UTC

The changing epidemiology of SARS-CoV-2 – Science

 


Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression.

14 Mar, 2022 | 01:44h | UTC

Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression – The Lancet

Commentaries:

Review of pre-Omicron data finds COVID-19 vaccine protection from severe disease remains strong at six months – Johns Hopkins University Bloomberg School of Public Health

Waning of COVID-19 vaccine effectiveness: individual and public health risk – The Lancet

Related: [Preprint] Systematic Review: Duration of Effectiveness of Vaccines Against SARS-CoV-2 Infection and COVID-19 Disease – “effectiveness against COVID-19 severe disease remained high (>70%) in most studies in the six months after full vaccination, although it did decrease some (on average, 8-10 percentage points) between one and six months after full vaccination”.

 


Stopping pandemics before they start: Lessons learned from SARS-CoV-2.

14 Mar, 2022 | 01:38h | UTC

Stopping pandemics before they start: Lessons learned from SARS-CoV-2 – Science

 


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