All Posts
Researchers generate the first complete, gapless sequence of a human genome.
4 Apr, 2022 | 01:30h | UTCNews Release: Researchers generate the first complete, gapless sequence of a human genome – NIH News Releases
Original Study: The complete sequence of a human genome – Science
Commentaries:
Scientists sequence the complete human genome for the first time – CNN
First complete gap-free human genome sequence published – The Guardian
Scientists finally finish decoding entire human genome – Associated Press
#ACC22 – RCT: Among ambulatory patients with heart failure, a dietary intervention to reduce sodium intake did not reduce clinical events.
4 Apr, 2022 | 01:32h | UTCReduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial – The Lancet (free registration required)
Commentaries:
SODIUM-HF: No Impact of Dietary Salt Restriction on Death or Hospitalization – TCTMD
Commentary on Twitter
Nutritional counseling/strictly limiting sodium intake didn’t significantly reduce MACE in #HeartFailure patients in 6️⃣ countries, but did modestly improve QOL according to results of SODIUM-HF trial presented at #ACC22. https://t.co/ESjiy6g8a7 #ACCIntl #cvPrev #CardioNutrition pic.twitter.com/CjK6CfWNXg
— American College of Cardiology (@ACCinTouch) April 2, 2022
Randomized, comparative effectiveness study: 3 at-home visual acuity tests validated through comparison with in-office visual acuity measurements, supporting their potential use in teleophthalmology care.
4 Apr, 2022 | 01:17h | UTCValidation of Home Visual Acuity Tests for Telehealth in the COVID-19 Era – JAMA Ophthalmology (free for a limited period)
Commentaries:
Valid but Undervalued – JAMA Ophthalmology (free for a limited period)
At-Home Visual Acuity Tests Valid Versus In-Office Testing – HealthDay
RCT: Higher dose primaquine more effective for preventing relapse of Plasmodium vivax Malaria compared to standard dose.
4 Apr, 2022 | 01:25h | UTC
Commentaries on Twitter
To prevent relapse of Plasmodium vivax malaria, primaquine at a total dose of 7.0 mg per kilogram had higher efficacy than a total dose of 3.5 mg per kilogram. https://t.co/qIu27ruhKP pic.twitter.com/HdTNhqB0J1
— NEJM (@NEJM) April 1, 2022
In most of the Americas, recommended primaquine-based therapy for P. vivax malaria has moderate efficacy for preventing relapse. Whether higher-dose primaquine might reduce recurrence is unknown. New research findings are summarized in a short video. https://t.co/aFt9gNGg0m pic.twitter.com/oiAkLMgPIJ
— NEJM (@NEJM) April 2, 2022
Two new studies show vaccination provides additional protection after Covid-19 infection.
4 Apr, 2022 | 01:16h | UTCCommentaries:
Vaccines offer substantial extra protection after COVID-19 infection – CIDRAP
Had COVID? Getting Vaccine Boosts Resilience Even More, Studies Show – HealthDay
Related:
Commentary on Twitter (thread – click for more)
THREAD | New studies in @TheLancetInfDis confirm #COVID19 vaccines provide extra protection for those with immunity from previous infection, especially against severe disease ⤵️
(Cases of reinfection from omicron variants not included)
— The Lancet (@TheLancet) April 1, 2022
#ACC22 [Not published yet] – RCT: Mavacamten reduces the need for surgical intervention in patients with obstructive hypertrophic cardiomyopathy.
4 Apr, 2022 | 01:13h | UTCCommentaries:
Mavacamten Slashes Need for Septal Reduction in Obstructive HCM: VALOR-HCM – TCTMD
Commentary on Twitter
ICYMI: The VALOR-HCM trial at #ACC22 showed that mavacamten improved symptoms & significantly reduced eligibility for needing septal reduction therapy (SRT) among symptomatic patients with obstructive #cvHCM. Check out the Trial Summary here: https://t.co/fXVp8H0bw5 @DLBHATTMD pic.twitter.com/f0gPp9dNX8
— American College of Cardiology (@ACCinTouch) April 2, 2022
Single-arm cohort study: percutaneous intramyocardial septal radiofrequency ablation in patients with drug-refractory hypertrophic obstructive cardiomyopathy.
4 Apr, 2022 | 01:10h | UTCPercutaneous Intramyocardial Septal Radiofrequency Ablation in Patients With Drug-Refractory Hypertrophic Obstructive Cardiomyopathy – JAMA Cardiology (free for a limited period)
Invited Commentary: Septal Reduction Strategies in Hypertrophic Cardiomyopathy—The Scalpel, Catheter, or Wire? – JAMA Cardiology (free for a limited period)
Video: Percutaneous Intramyocardial Septal Radiofrequency Ablation
Commentary on Twitter
In this cohort study, percutaneous intramyocardial septal radiofrequency ablation was associated with a durable reduction in peak left ventricular outflow tract gradients. Medium-term follow-up saw improvement in symptoms with low morbidity and mortality. https://t.co/DiyLHPR0Bw
— JAMA Cardiology (@JAMACardio) April 1, 2022
#ACC22 – RCT: Diltiazem did not significantly improve coronary vasomotor dysfunction in angina and nonobstructive coronary arteries.
4 Apr, 2022 | 01:09h | UTCEfficacy of Diltiazem to improve coronary vasomotor dysfunction in angina and nonobstructive coronary arteries (ANOCA): Results of the EDIT-CMD randomized clinical trial – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)
Commentaries:
In ANOCA, Diltiazem Fails to Improve Vasomotor Function: EDIT-CMD – TCTMD
Commentary on Twitter
#ACC22 #JACCIMG SimPub: In this first performed RCT in pts w/ ANOCA, authors show that 6 weeks therapy w/ #diltiazem didn't substantially improve CVDys, symptoms or #QoL when compared w/ placebo, but did ⬇️ prevalence of epicardial spasm. https://t.co/An8v4JHkl4 #CardioTwitter pic.twitter.com/D0fRG0PewG
— JACC Journals (@JACCJournals) April 2, 2022
ACG Guideline: Diagnosis and management of Barrett’s esophagus.
4 Apr, 2022 | 01:07h | UTC
ESPEN micronutrient guideline.
4 Apr, 2022 | 01:00h | UTCESPEN micronutrient guideline – Clinical Nutrition
BSR guideline on management of pediatric, adolescent and adult patients with idiopathic inflammatory myopathy.
4 Apr, 2022 | 01:05h | UTC
WHO launches global initiative to tackle deadly insect-borne ‘arboviruses’.
4 Apr, 2022 | 00:57h | UTCWHO launches Global Initiative to Tackle Deadly Insect-Borne ‘Arboviruses’ – Health Policy Watch
WHO’s training for caregivers of children with autism goes online.
4 Apr, 2022 | 00:59h | UTCNews Release: WHO’s training for caregivers of children with autism goes online – World Health Organization
Online Course: WHO eLearning Caregiver Skills Training for Families of Children with Developmental Delays or Disabilities – OpenWHO
RCT: Pembrolizumab vs. placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma.
4 Apr, 2022 | 00:56h | UTCPembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Building an evidence standards framework for artificial intelligence-enabled digital health technologies.
4 Apr, 2022 | 00:52h | UTC
Registry-based cohort study | recurrent mitral regurgitation after MitraClip: predictive factors, morphology, and clinical implication.
4 Apr, 2022 | 00:55h | UTC
Commentary on Twitter
Residual MR is a predictive factor for recurrent MR in both primary and secondary MR treated with #MitraClip. What predictive factors are different for the two? #AHAJournals #Cardiotwitter #ACCFIT #structuralheart #mitravalvehttps://t.co/gTkiOytNeu pic.twitter.com/HafPkyxNQ6
— CircInterventions (@CircIntv) March 25, 2022
Before-and-after study: Antimicrobial stewardship in high-risk febrile neutropenia patients reduced carbapenem and glycopeptide use and was associated with improved clinical outcomes.
4 Apr, 2022 | 00:49h | UTCRelated:
Management of febrile neutropaenia: ESMO Clinical Practice Guidelines – Annals of Oncology
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/AdrienContejean/status/1508792991917432838
Guidelines for diagnosing incidental solitary bone lesions on CT and MRI in adults: bone reporting and data system (Bone-RADS).
4 Apr, 2022 | 00:45h | UTC
Commentary on Twitter (article and images under a http://creativecommons.org/licenses/by-nc/4.0/)
https://twitter.com/AdamSingerMD/status/1509949481969668098
Systematic review: there is insufficient evidence that therapeutic drug monitoring improves outcomes during treatment with penicillins.
4 Apr, 2022 | 00:47h | UTC
M-A: Global estimates of diabetic retinopathy prevalence and progression in pregnant women with preexisting diabetes.
4 Apr, 2022 | 00:42h | UTCGlobal Estimates of Diabetic Retinopathy Prevalence and Progression in Pregnant Women With Preexisting Diabetes: A Systematic Review and Meta-analysis – JAMA Ophthalmology (free for a limited period)
Invited Commentary: Diabetic Retinopathy in Pregnancy – JAMA Ophthalmology (free for a limited period)
Commentary on Twitter
In this study, higher #diabeticretinopathy (DR) prevalences were found in pregnant women with pre-existing #diabetes compared w non-pregnant women. Women with T2D compared w T1D were not noted to have a different risk of DR progression during pregnancy. https://t.co/lfTi9kIBTj
— JAMA Ophthalmology (@JAMAOphth) April 1, 2022
Systematic Review: There is insufficient evidence to support or refute the use of antibiotics for preventing infection following surgery to treat stress urinary incontinence in women.
4 Apr, 2022 | 00:26h | UTC
Commentary on Twitter
https://twitter.com/C_Incontinence/status/1509106659842564098
RCT: Spectacle lenses with aspherical lenslets for myopia control vs. single-vision spectacle lenses.
4 Apr, 2022 | 00:41h | UTCInvited Commentary: Clinical Relevance of Myopia Control With Specialized Spectacles – JAMA Ophthalmology (free for a limited period)
Commentary on Twitter
Study found that a higher asphericity of lenslets may be associated with more effective myopia control in children with #myopia. https://t.co/lEOIXj9qYG
— JAMA Ophthalmology (@JAMAOphth) March 31, 2022
Systematic Review | Guidewire or contrast: which works better to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis?
4 Apr, 2022 | 00:28h | UTC
Network M-A: Prophylactic cyclo‐oxygenase inhibitor drugs to prevent morbidity and mortality in preterm infants.
4 Apr, 2022 | 00:24h | UTC
Systematic Review: Occupational therapy for cognitive impairment in stroke patients.
4 Apr, 2022 | 00:25h | UTCOccupational therapy for cognitive impairment in stroke patients – Cochrane Library
Summary: Occupational therapy for cognitive impairment in people who have had a stroke – Cochrane Library