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Pre-hospital and emergency department treatment of convulsive status epilepticus in adults: an evidence synthesis.

13 Apr, 2022 | 10:15h | UTC

Pre-hospital and emergency department treatment of convulsive status epilepticus in adults: an evidence synthesis – Health Technology Assessment

 

M-A: Adverse perinatal outcomes associated with protease inhibitor-based antiretroviral therapy in pregnant women living with HIV.

13 Apr, 2022 | 10:18h | UTC

Adverse perinatal outcomes associated with protease inhibitor-based antiretroviral therapy in pregnant women living with HIV: A systematic review and meta-analysis – EClinicalMedicine

News Release: Protease inhibitors safer than thought for pregnant women with HIV – University of Oxford

 

Brief review | Infective endocarditis: words of caution for management.

13 Apr, 2022 | 10:12h | UTC

Infective Endocarditis: Words of Caution For Management – American College of Cardiology

Related:

Randomized Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis

Cohort Study: Socio-economic variations determine the clinical presentation, etiology and outcome of infective endocarditis.

Podcast: Infective Endocarditis Pearls.

AHA Statement: Prevention of Viridans Group Streptococcal Infective Endocarditis – Antibiotic prophylaxis for invasive dental procedures is suggested only for high-risk patients with the following conditions: 1) cardiac prosthetic valve; 2) previous infective endocarditis; 3) congenital heart disease; or 4) previous heart transplant

New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis

Review: Infective endocarditis after surgical and transcatheter aortic valve replacement

Infective Endocarditis: A Contemporary Review

Summary: Current AATS Guidelines on Surgical Treatment of Infective Endocarditis

Review: Current Evidence on Oral Antibiotics for Infective Endocarditis

[Abstract Only] Prevalence of Infective Endocarditis in Patients with Positive Blood Cultures According to the Organism

Observational Study Suggests Early Surgery is Associated with Reduced Mortality in Patients with Infective Endocarditis and Large Vegetation

Research: Invasive Procedures Associated With the Development of Infective Endocarditis

Meta-Analysis: Association of Vegetation Size With Embolic Risk in Patients With Infective Endocarditis

Prosthetic Valve Endocarditis After Surgical Aortic Valve Replacement

 

Interplay of mineralocorticoid receptor antagonists and Empagliflozin in heart failure: Secondary analysis of the EMPEROR-Reduced trial.

13 Apr, 2022 | 10:14h | UTC

Interplay of Mineralocorticoid Receptor Antagonists and Empagliflozin in Heart Failure: EMPEROR-Reduced – Journal of the American College of Cardiology

Editorial: Quadruple Medical Therapy for Heart Failure: Medications Working Together to Provide the Best Care

 

RCT: Prophylactic Rivaroxaban for 30 days to prevent left ventricular thrombus after anterior ST-Segment Elevation Myocardial Infarction.

13 Apr, 2022 | 09:56h | UTC

Prophylactic Rivaroxaban Therapy for Left Ventricular Thrombus After Anterior ST-Segment Elevation Myocardial Infarction – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)

 

Drug resistant TB – latest developments in epidemiology, diagnostics and management.

13 Apr, 2022 | 10:09h | UTC

Drug resistant TB – latest developments in epidemiology, diagnostics and management – International Journal of Infectious Diseases

Related:

Summary | WHO recommendations on the treatment of drug-resistant tuberculosis, 2020 update.

WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment

Randomized Trial: 9-month Treatment for Multi-drug Resistant TB is as Effective as 24-month Treatment

Canadian Tuberculosis Standards – 8th Edition.

Guideline: Treatment of Drug-Resistant Tuberculosis

NICE Guideline: Tuberculosis

The Lancet Commission: Management of Multidrug-resistant and Incurable Tuberculosis

Regimens to Treat Multidrug-resistant Tuberculosis: Past, Present and Future Perspectives

 

New WHO online course: Monkeypox epidemiology, preparedness and response.

13 Apr, 2022 | 10:03h | UTC

Monkeypox epidemiology, preparedness and response – OpenWHO

 

Commentary on Twitter

 

M-A: Three-port vs. four-port technique for laparoscopic cholecystectomy.

13 Apr, 2022 | 10:02h | UTC

Three-port versus four-port technique for laparoscopic cholecystectomy: systematic review and meta-analysis – BJS Open

 

Commentary on Twitter

 

Study identifies which treatments are associated with an increased risk of heart disease among women with breast cancer.

13 Apr, 2022 | 10:00h | UTC

Risk of Cardiovascular Disease in Women With and Without Breast Cancer: The Pathways Heart Study – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentary: Major study links breast cancer treatment with increased risk of cardiovascular disease – Fred Hutch

 

Commentary on Twitter

 

Seminar: Cholera.

13 Apr, 2022 | 09:55h | UTC

Cholera – The Lancet (free registration required)

 

Review | PCI in patients with heart failure: current evidence, impact of complete revascularization, and contemporary techniques to improve outcomes.

13 Apr, 2022 | 09:57h | UTC

PCI in Patients With Heart Failure: Current Evidence, Impact of Complete Revascularization, and Contemporary Techniques to Improve Outcomes – JSCAI

 

Commentary on Twitter

(Images and article under a CC BY 4.0 Licence)

 

M-A: Assessment of frequency of rosacea subtypes in patients with rosacea.

13 Apr, 2022 | 09:54h | UTC

Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)

Commentary: Study Evaluates Prevalence of 4 Major Rosacea Subtypes – HCPLive

 

Commentary on Twitter

 

Systematic Review: Control interventions in randomized trials among people with mental health disorders.

13 Apr, 2022 | 09:38h | UTC

Control interventions in randomised trials among people with mental health disorders – Cochrane Library

Summary: Control interventions in randomised trials for people with a mental health disorder – Cochrane Library

Featured review: Control interventions in randomized trials among people with mental health disorders

 

Systematic Review: Tacrolimus for induction of remission in corticosteroid‐refractory ulcerative colitis.

13 Apr, 2022 | 09:37h | UTC

Tacrolimus (FK506) for induction of remission in corticosteroid‐refractory ulcerative colitis – Cochrane Library

Summary: A review about a drug called tacrolimus for the treatment of difficult-to-treat ulcerative colitis – Cochrane Library

 

Systematic Review: Narrow band imaging vs. white light cystoscopy alone for transurethral resection of non‐muscle invasive bladder cancer.

13 Apr, 2022 | 09:36h | UTC

Narrow band imaging versus white light cystoscopy alone for transurethral resection of non‐muscle invasive bladder cancer – Cochrane Library

Summary: Comparing narrow band imaging to regular cystoscopy for treatment of bladder cancer – Cochrane Library

 

Cohort Study: Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of the Pfizer vaccine in adolescents.

12 Apr, 2022 | 10:07h | UTC

Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of BNT162b2 in adolescents: cohort study – The BMJ

 

RCT: Single-dose HPV vaccination found effective among young African women.

12 Apr, 2022 | 10:08h | UTC

Efficacy of Single-Dose Human Papillomavirus Vaccination among Young African Women – NEJM Evidence

News Releases:

Study boosts support for single-dose HPV vaccine regimen – University of Washington

One-dose Human Papillomavirus (HPV) vaccine offers solid protection against cervical cancer – World Health Organization

Related:

Three-year follow-up of 2-dose versus 3-dose HPV vaccine

 

Commentary on Twitter (thread – click for more)

 

M-A: SGLT2 inhibitors reduce hospitalizations in patients with heart failure regardless of the presence of diabetes.

12 Apr, 2022 | 10:05h | UTC

Sodium–Glucose Cotransporter-2 Inhibitors in Patients With Heart Failure: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: SGLT2 inhibitors reduces hospitalization for heart failure regardless of presence of diabetes – American College of Physicians

 

Evidence- and consensus-based guidelines for drug-drug interactions with anticancer drugs; A practical and universal tool for management.

12 Apr, 2022 | 10:02h | UTC

Evidence- and consensus-based guidelines for drug-drug interactions with anticancer drugs; A practical and universal tool for management – Seminars in Oncology

 

AHA Scientific Statement: SARS-CoV-2 infection and associated cardiovascular manifestations and complications in children and young adults.

12 Apr, 2022 | 09:59h | UTC

SARS-CoV-2 Infection and Associated Cardiovascular Manifestations and Complications in Children and Young Adults: A Scientific Statement From the American Heart Association – Circulation

News Release: Heart issues after COVID-19 uncommon in children and young adults, more research needed – American Heart Association

Commentary: COVID-19 CV Complications in Children Are Rare, Treatable: AHA Statement – TCTMD

 

Opinion | Aligning incentives for improving diagnostic excellence.

12 Apr, 2022 | 09:54h | UTC

Aligning Incentives for Improving Diagnostic Excellence – JAMA (free for a limited period)

 

Cohort Study: Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection.

12 Apr, 2022 | 09:57h | UTC

Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study – Canadian Medical Association Journal

News Release: Children older than 5 at higher risk of COVID-19-related multisystem inflammatory syndrome – Canadian Medical Association Journal

Commentary: Older Kids More Vulnerable to MIS-C: Study – HealthDay

 

More data suggests the Omicron variant causes milder disease compared to the Delta variant.

12 Apr, 2022 | 09:49h | UTC

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study – The Lancet

Commentary: Covid-19: Symptomatic infection with omicron variant is milder and shorter than with delta, study reports – The BMJ

Related:

Another study suggests a lower risk of hospitalization and death from infection with SARS-CoV-2 Omicron variant vs. Delta.

Perspective: Challenges in inferring intrinsic severity of the SARS-CoV-2 Omicron variant.

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa.

Cohort Study: Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.

[Preprint] SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.

[Preprint] Study showed reduced clinical severity of Covid-19 patients admitted to hospitals in Gauteng, South Africa, during the Omicron-dominant fourth wave – “any combination of a less-virulent virus, comorbidities, high immunity from prior infection(s) or vaccination may be important contributors to this clinical presentation”.

Early data from South Africa hints Omicron variant may cause less severe Covid, but more research is needed.

Too early to tell, but preliminary information from doctors in South Africa suggests the new Covid variant Omicron may be associated with less severe disease.

 

RCT: Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer.

12 Apr, 2022 | 08:54h | UTC

Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer – New England Journal of Medicine

News Release: Immunotherapy Plus Chemotherapy Before Surgery Improves Outcomes for Patients with Lung Cancer – Johns Hopkins Medicine

 

Commentary on Twitter

 

COVID-19 disease severity in children infected with the Omicron variant.

12 Apr, 2022 | 09:47h | UTC

COVID-19 Disease Severity in Children Infected with the Omicron Variant – Clinical Infectious Diseases

Related: Cohort Study: Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.

 

Commentary on Twitter

 

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