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RCT: Long-term efficacy and safety of up to 108 weeks of Ixekizumab in pediatric patients with moderate to severe plaque psoriasis.

18 Apr, 2022 | 09:49h | UTC

Long-term Efficacy and Safety of Up to 108 Weeks of Ixekizumab in Pediatric Patients With Moderate to Severe Plaque Psoriasis: The IXORA-PEDS Randomized Clinical Trial – JAMA Dermatology

Original Study: Efficacy and safety of ixekizumab in a phase III, randomized, double-blind, placebo-controlled study in paediatric patients with moderate-to-severe plaque psoriasis (IXORA-PEDS) – British Journal of Dermatology

 

Commentary on Twitter

 

Cross-sectional study: evaluating prediction models of sleep apnea from smartphone-recorded sleep breathing sounds.

18 Apr, 2022 | 09:44h | UTC

Evaluating Prediction Models of Sleep Apnea From Smartphone-Recorded Sleep Breathing Sounds – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – for full-text)

 

Commentary on Twitter

 

Risk for asymptomatic household transmission of Clostridioides difficile infection associated with recently hospitalized family members.

18 Apr, 2022 | 09:41h | UTC

Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members – Emerging Infectious Diseases

Commentary: Recently Discharged Patients Pose Risk for Spreading C. Difficile Infection – HealthDay

 

Incidental discovery of interstitial lung disease: diagnostic approach, surveillance and perspectives.

18 Apr, 2022 | 09:36h | UTC

Incidental discovery of interstitial lung disease: diagnostic approach, surveillance and perspectives – European Respiratory Review

 

Systematic Review: The effect of conditional cash transfers on the control of neglected tropical disease.

18 Apr, 2022 | 09:38h | UTC

The effect of conditional cash transfers on the control of neglected tropical disease: a systematic review – The Lancet Global Health

Invited Commentary: The potential of conditional cash transfers for the control of neglected tropical diseases – The Lancet Global Health

Related: Does giving money to people, in low- and middle-income countries, without conditions attached lead to better health and other life improvements? – Cochrane Library

 

Commentary from the author on Twitter (thread – click for more)

 

Phase 2 RCT: De-escalated neoadjuvant pertuzumab plus trastuzumab therapy with or without weekly paclitaxel in HER2-positive, hormone receptor-negative, early breast cancer.

18 Apr, 2022 | 09:31h | UTC

De-escalated neoadjuvant pertuzumab plus trastuzumab therapy with or without weekly paclitaxel in HER2-positive, hormone receptor-negative, early breast cancer (WSG-ADAPT-HER2+/HR–): survival outcomes from a multicentre, open-label, randomised, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)

 

Advanced testing for human papillomavirus infection improves prognostic evaluation in cervical cancer.

18 Apr, 2022 | 09:33h | UTC

Human Papillomavirus Infection Determines Prognosis in Cervical Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)

Editorial: Testing for High-Risk Human Papillomavirus in Lower Genital Tract Tumors: If Knowledge Does Not Translate to an Action That Helps Patients—Why Do It? – Journal of Clinical Oncology

Commentary: Study Confirms Favorable Prognosis for HPV-Positive Cervical Cancer— RNA sequencing identified more HPV+ tumors, showed 43% mortality disparity for HPV- tumors – MedPage Today (free registration required)

 

A nationwide observational analysis in Israel showed a fourth dose of the Pfizer vaccine may reduce the short-term risk of Covid-19–related outcomes.

14 Apr, 2022 | 08:51h | UTC

Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting – New England Journal of Medicine

Editorial: Covid-19 Boosters — Where from Here?

Related:

COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines.

Observational study suggests a fourth dose of the Pfizer vaccine provided additional protection against severe disease in patients 60 years of age or older during the Omicron wave in Israel.

Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

Covid-19: Fourth vaccine doses—who needs them and why?

[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

 

Commentary on Twitter

 

Covid-19: What is the evidence for the antiviral molnupiravir?

14 Apr, 2022 | 08:47h | UTC

Covid-19: What is the evidence for the antiviral molnupiravir? – The BMJ

 

Study showed low rates of severe COVID-19 in children hospitalized with confirmed SARS-CoV-2 infection.

14 Apr, 2022 | 08:49h | UTC

Very low rates of severe COVID-19 in children hospitalised with confirmed SARS-CoV-2 infection in London, England – Journal of Infection

Commentary: Severe COVID-19 extremely rare among children – News Medical

Related:

[Preprint] Risk of Hospitalization, severe disease, and mortality due to COVID-19 in children with SARS-CoV-2 infection in Germany – “overall hospitalization rate associated with SARS-CoV-2 infection was 35.9 per 10,000 children, ICU admission rate was 1.7 per 10,000 and case fatality was 0.09 per 10,000”.

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.

Editorial: COVID-19 vaccines for children – “Although it is true that most children experience asymptomatic or mild disease, some will get quite sick, and a small number will die. It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis”.

COVID-19 disease severity in children infected with the Omicron variant.

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year.

Study identifies risk factors for severe CoviD-19 in children.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

International study identifies predictors of severe outcomes in children with COVID-19.

 

The Lancet Series: Origins of chronic obstructive pulmonary disease.

14 Apr, 2022 | 08:38h | UTC

Homepage: Origins of chronic obstructive pulmonary disease – The Lancet Respiratory Medicine (free registration required for all articles)

Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder

Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment

Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan

GETting to know the many causes and faces of COPD

COPD, smoking, and social justice

 

Commentary on Twitter (thread – click for more)

 

RCT: Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children.

14 Apr, 2022 | 08:43h | UTC

Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

Expert Analysis: The role of the posterior left pericardiotomy in reducing pericardial effusion and postoperative atrial fibrillation after cardiac surgery.

14 Apr, 2022 | 08:45h | UTC

The Role of the Posterior Left Pericardiotomy in Reducing Pericardial Effusion and Postoperative Atrial Fibrillation After Cardiac Surgery – American College of Cardiology

Related study from the same authors: #AHA21 – RCT: Among patients undergoing cardiac surgery, routine posterior left pericardiotomy can prevent postoperative atrial fibrillation.

 

Commentary on Twitter

 

Opinion | The big idea: should we get rid of the scientific paper? – “As a format it’s slow, encourages hype, and is difficult to correct. A radical overhaul of publishing could make science better”.

14 Apr, 2022 | 08:37h | UTC

The big idea: should we get rid of the scientific paper? – The Guardian

 

M-A: Association between physical activity and risk of depression.

14 Apr, 2022 | 08:35h | UTC

Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis – JAMA Psychiatry

Commentary: Exercise Is Powerful Medicine for Depression – HealthDay

 

Commentary on Twitter

 

Cross-sectional study: The use of Selective Serotonin Reuptake Inhibitors is associated with a reduction in measured movements.

14 Apr, 2022 | 08:32h | UTC

Association of Selective Serotonin Reuptake Inhibitor Use With Abnormal Physical Movement Patterns as Detected Using a Piezoelectric Accelerometer and Deep Learning in a Nationally Representative Sample of Noninstitutionalized Persons in the US – JAMA Network Open

 

Commentary on Twitter

 

Population based cohort study: Healthy lifestyle and life expectancy with and without Alzheimer’s dementia.

14 Apr, 2022 | 08:27h | UTC

Healthy lifestyle and life expectancy with and without Alzheimer’s dementia: population based cohort study – The BMJ

Editorial: Healthy lifestyles and more life years without dementia – The BMJ

 

Commentary on Twitter

 

Cohort Study: Non-O blood type is associated with increased risk of venous thromboembolism in patients with cancer.

14 Apr, 2022 | 08:29h | UTC

ABO blood group type and risk of venous thromboembolism in patients with cancer – Blood Advances (link to abstract – $ for full-text)

 

RCT: Comparison of intranasal vs. intramuscular naloxone in opioid overdoses managed by ambulance staff.

14 Apr, 2022 | 08:23h | UTC

Comparison of intranasal and intramuscular naloxone in opioid overdoses managed by ambulance staff: a double-dummy, randomised, controlled trial – Addiction

Commentary: Breathing restored within 10 minutes for 80% of overdose patients using nasal spray – Norwegian University of Science and Technology

 

Review: Cutaneous manifestations of monoclonal gammopathy.

14 Apr, 2022 | 08:21h | UTC

Cutaneous manifestations of monoclonal gammopathy – Blood Cancer Journal

 

M-A: Symptom burden and health-related quality of life in chronic kidney disease.

14 Apr, 2022 | 08:22h | UTC

Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis – PLOS Medicine

 

M-A: Abdominal vs. perineal approach for external rectal prolapse.

14 Apr, 2022 | 08:11h | UTC

Abdominal versus perineal approach for external rectal prolapse: systematic review with meta-analysis – BJS Open

 

Review: Ethical considerations for Phase I trials in oncology.

14 Apr, 2022 | 08:14h | UTC

Ethical Considerations for Phase I Trials in Oncology – Journal of Clinical Oncology

 

Commentary on Twitter

 

Systematic review of the incidence of and risk factors for urothelial cancers and renal cell carcinoma among patients with hematuria.

14 Apr, 2022 | 08:16h | UTC

Systematic Review of the Incidence of and Risk Factors for Urothelial Cancers and Renal Cell Carcinoma Among Patients with Haematuria – European Urology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Discharge preparation and readiness after birth: a scoping review of global policies, guidelines and literature.

14 Apr, 2022 | 08:07h | UTC

Discharge preparation and readiness after birth: a scoping review of global policies, guidelines and literature – BMC Pregnancy & Childbirth

Related:

WHO recommendations on maternal and newborn care for a positive postnatal experience.

Putting positive experiences at the center of postnatal care.

 

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