All Posts
Brief Review | In search of the Holy Grail: identifying the best PEEP in ventilated patients.
9 May, 2022 | 01:50h | UTC
Commentary on Twitter
Best PEEP on MV?? Individual-specific providing oxygenation (SpO2 >90%/no excessive FiO2 + acceptable PaCO2 (<50/55 mmHg) & minimal need for fluids/cardioactives. Start at 10-12 but stay alert to hemodynamic impact & as set, serially asses need/adequacy.
🖇https://t.co/wdK92bs8B9 pic.twitter.com/NlTzoxfwa5— Intensive Care Medicine (@yourICM) May 5, 2022
Brief Review | Oxygen targets.
9 May, 2022 | 01:48h | UTCOxygen targets – Intensive Care Medicine (if the link is paywalled, try this one)
Related:
Commentary on Twitter
Oxygen targets in #ICU?? Supplemental O2 often required in critically ill, but balancing opposing risks hypo/hyperxaemia required to choose right amount to give. Hyperoxaemia associated with negative cellular/physiological effects: O2 can harm!#FOAMcc
🫧 https://t.co/F4r3Qg7hXg pic.twitter.com/EizwMNjjnc— Intensive Care Medicine (@yourICM) May 7, 2022
Systematic Review: Comprehensive Geriatric Assessment for community‐dwelling, high‐risk, frail, older people.
9 May, 2022 | 01:43h | UTC
Systematic Review: Outpatient versus inpatient treatment for acute pulmonary embolism.
9 May, 2022 | 01:47h | UTCOutpatient versus inpatient treatment for acute pulmonary embolism – Cochrane Library
Commentary: Is home or hospital treatment better for people with blood clots in the lungs? – Cochrane Library
Commentary on Twitter
#CochraneEvidence updated – Is home or hospital treatment better for people with blood clots in the lungs? #VTE #PE #CLOT https://t.co/6tubeADzUY @CochraneLibrary @CochraneUK @NIHRresearch @VSGBI @PERTConsortium @isth @APPTGThrombosis @accpchest @EuropeanTHA @ThrombosisCan pic.twitter.com/JDTio2KC1N
— Vascular Evidence (@Vasc_Evidence) May 6, 2022
Systematic Review: Negative pressure wound therapy for managing the open abdomen in non‐trauma patients.
9 May, 2022 | 01:41h | UTC
Retrospective Cohort Study: Identification of patients with branch-duct intraductal papillary mucinous neoplasm and very low risk of cancer.
9 May, 2022 | 01:40h | UTC
Commentary on Twitter
BD-IPMN 🍇 at very low risk of cancer 🔎 how to identify patients for surveillance
🌐 Multicentre Pancreas 2000 study of @EurPancClub
⚠️ 20% develop WF/HRS at FU
🏁 80% with WF/HRS still surveilled safely👉 MOST BD IPMN will never need surgery 👈https://t.co/YPHaQd98u1 pic.twitter.com/ypglRlNR2q
— Giovanni Marchegiani (@Gio_Marchegiani) May 7, 2022
Clinical challenges treating Stenotrophomonas maltophilia infections: an update.
9 May, 2022 | 01:32h | UTCRelated:
Phase 2 RCT: Anti-tumor necrosis factor therapy for early-stage Dupuytren’s disease.
9 May, 2022 | 01:38h | UTCNews Release: Breakthrough in treatment for Dupuytren’s disease – University of Oxford
Commentary: Treatment for finger-bending disease may be ‘gamechanger’ – The Guardian
Commentary on Twitter
NEW RESEARCH—Intranodular injections of anti-tumour necrosis factor therapy (adalimumab) for early-stage Dupuytren's disease: a phase 2b, randomised, double-blind, placebo-controlled trial https://t.co/Jz9QUJEzS8 #LancetRheumatology #OpenAccess pic.twitter.com/mcZj9GK4l4
— The Lancet Rheumatology (@TheLancetRheum) May 4, 2022
RCT: Reloxaliase vs. placebo in enteric hyperoxaluria.
9 May, 2022 | 01:30h | UTCRandomized Placebo-Controlled Trial of Reloxaliase in Enteric Hyperoxaluria – NEJM Evidence
Commentary on Twitter
Patients with enteric hyperoxaluria received reloxaliase, an enzyme that degrades oxalate in the GI tract, or placebo with food for 4 weeks. There was a greater reduction in urinary oxalate excretion with reloxaliase. https://t.co/x7m12QHyWX#NephTwitter #UroSoMe #ClinicalTrials pic.twitter.com/rzCpd6YfLM
— NEJM Evidence (@NEJMEvidence) May 6, 2022
RCT: Terminal complement inhibitor Ravulizumab in generalized myasthenia gravis.
9 May, 2022 | 01:27h | UTCTerminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis – NEJM Evidence
Commentary on Twitter
In this RCT, Ravulizumab provided rapid and efficacious treatment of adult patients with anti-AChR antibody-positive generalized myasthenia gravis (gMG), as determined by both patient- and clinician-rated outcomes, with few adverse events. https://t.co/9mlCOULiJR#NeuroTwitter pic.twitter.com/ZljrTs282f
— NEJM Evidence (@NEJMEvidence) May 3, 2022
Diagnostic stewardship tied to fewer blood cultures, antibiotics in sick kids.
9 May, 2022 | 01:23h | UTCCommentary: Diagnostic stewardship tied to fewer blood cultures, antibiotics in sick kids – CIDRAP
Commentary on Twitter
Results from the Bright STAR collaborative: Multi-center diagnostic stewardship found blood cultures in the PICU safely reduced overtesting and broad-spectrum antibiotic use. https://t.co/523QlbOLL2 @BrightSTAR_QI @HopkinsKids @ChildrensPhila #PICUtwitter
— JAMA Pediatrics (@JAMAPediatrics) May 2, 2022
Derivation and validation of a score for predicting poor neurocognitive outcomes in acute carbon monoxide poisoning.
9 May, 2022 | 01:20h | UTC
RCT: Efficacy and safety of Difelikefalin in patients with moderate to severe pruritus receiving hemodialysis.
9 May, 2022 | 01:21h | UTC
Commentary on Twitter
This RCT found difelikefalin, a κ-opioid receptor agonist, improved moderate to severe pruritus in Japanese hemodialysis patients. Difelikefalin is expected to be a new option for the treatment of uremic pruritus in patients with end stage kidney disease. https://t.co/cXqNx4QIaS pic.twitter.com/7QdA9GoLwN
— JAMA Network Open (@JAMANetworkOpen) May 5, 2022
Cohort Study: Anal incontinence after a prolonged second stage of labor in primiparous women.
9 May, 2022 | 01:25h | UTCAnal incontinence after a prolonged second stage of labor in primiparous women – Scientific Reports
Cohort Study: Rotating night shift work and healthy aging after 24 years of follow-up in the Nurses’ Health Study.
9 May, 2022 | 02:29h | UTCCommentary: Rotating Night Shifts May Hamper Healthy Aging – HealthDay
Commentary on Twitter
This cohort study of 24 years of follow-up from Nurses' Health Study found that long periods of rotating night shift work were associated with modestly decreased odds of healthy aging in women. https://t.co/HY3p136gkC
— JAMA Network Open (@JAMANetworkOpen) May 4, 2022
Artificial intelligence for screening of multiple retinal and optic nerve diseases.
9 May, 2022 | 01:18h | UTC
Commentary on Twitter
This diagnostic study developed and prospectively validated a #DeepLearning algorithm to recognize multiple retinal diseases, with better accuracy vs retinal specialists, and may help to overcome the lack of ophthalmologists in underdeveloped areas. https://t.co/9fvwOTVV8N
— JAMA Network Open (@JAMANetworkOpen) May 3, 2022
Podcast: Appendicitis Pearls.
9 May, 2022 | 01:15h | UTC#49: Appendicitis – Tips and Tricks For When It’s the Appendix – The Cribsiders
Systematic Review: Interventions to promote physical activity and healthy digital media use in children and adolescents.
9 May, 2022 | 01:10h | UTC
Systematic Review: Preventing unintentional injuries in school-aged children.
9 May, 2022 | 01:13h | UTCPreventing Unintentional Injuries in School-Aged Children: A Systematic Review – Pediatrics
M-A: Interventions for high-burden infectious diseases in children and adolescents.
9 May, 2022 | 01:12h | UTC
Systematic Review: Delivery strategies supporting school-age child health.
9 May, 2022 | 01:07h | UTCDelivery Strategies Supporting School-Age Child Health: A Systematic Review – Pediatrics
Interventions for health and well-being in school-aged children and adolescents: a way forward.
9 May, 2022 | 01:09h | UTC
RCT: Effect of early vs. standard approach to tracheostomy on functional outcome at 6 months among patients with severe stroke receiving mechanical ventilation.
6 May, 2022 | 11:13h | UTCEffect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
In this study, among patients with severe stroke receiving mechanical ventilation, a strategy of early tracheostomy, compared with a standard approach to tracheostomy, did not significantly improve functional outcome at 6 months. https://t.co/bLZ4b6hBxr
— JAMA (@JAMA_current) May 4, 2022
Review: SARS-CoV-2 pathogenesis.
6 May, 2022 | 11:01h | UTCSARS-CoV-2 pathogenesis – Nature Reviews Microbiology
Commentary on Twitter
A Review published in @NatureRevMicro explores recent clinical and experimental advances in understanding SARS-CoV-2 pathogenesis, interactions with host cells and the involvement of the immune system in the development of severe disease. https://t.co/GTm0BZ3ikH pic.twitter.com/jPXFU05Pwm
— Nature Portfolio (@NaturePortfolio) April 23, 2022
RCT: Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet.
6 May, 2022 | 11:05h | UTCLong-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)