All Posts | Links Medicus - Free Medical News & Perspective

RCT | Efficacy and safety of ciprofloxacin plus fluocinolone acetonide among patients with acute otitis externa.

15 Jul, 2022 | 12:43h | UTC

Efficacy and Safety of Ciprofloxacin Plus Fluocinolone Acetonide Among Patients With Acute Otitis Externa: A Randomized Clinical Trial – JAMA Network Open

Commentary on Twitter

In this randomized clinical trial, ciprofloxacin 0.3% plus fluocinolone acetonide 0.025% otic solution was efficacious and safe in treating acute otitis externa. https://t.co/VRf1vEojY1

— JAMA Network Open (@JAMANetworkOpen) July 14, 2022

M-A (mostly of observational studies) | Catheter-directed thrombolysis vs. systemic anticoagulation alone for submassive pulmonary embolism.

15 Jul, 2022 | 12:39h | UTC

Meta-Analysis Comparing Catheter-Directed Thrombolysis Versus Systemic Anticoagulation Alone for Submassive Pulmonary Embolism – American Journal of Cardiology

M-A of RCTs | Effectiveness of home-based cardiac rehabilitation, using wearable sensors, as a multicomponent, cutting-edge intervention.

15 Jul, 2022 | 12:35h | UTC

Effectiveness of Home-Based Cardiac Rehabilitation, Using Wearable Sensors, as a Multicomponent, Cutting-Edge Intervention: A Systematic Review and Meta-Analysis – Journal of Clinical Medicine

Review | Regional anesthesia and acute perioperative pain management in thoracic surgery.

15 Jul, 2022 | 12:33h | UTC

Regional anesthesia and acute perioperative pain management in thoracic surgery: a narrative review – Journal of Thoracic Disease

Registry-based cohort study | Modifiable and non-modifiable risk factors in hip fracture mortality in Norway, 2014 to 2018.

15 Jul, 2022 | 12:31h | UTC

Modifiable and non-modifiable risk factors in hip fracture mortality in Norway, 2014 to 2018 – The Bone & Joint Journal

RCT | Deucravacitinib vs. placebo vs. apremilast in moderate to severe plaque psoriasis.

15 Jul, 2022 | 12:26h | UTC

Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial – Journal of the American Academy of Dermatology (link to abstract – $ for full-text)

Phase 2 RCT | Efficacy of preoperative mFOLFIRINOX vs. mFOLFIRINOX plus hypofractionated radiotherapy for borderline resectable adenocarcinoma of the pancreas.

15 Jul, 2022 | 12:29h | UTC

Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the PancreasThe A021501 Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)

Editorial: The Continued Struggle for Defining a Role for Radiotherapy in Pancreas Cancer – JAMA (free for a limited period)

News Release: Preoperative combination chemotherapy improved survival in patients with pancreatic cancer – The University of Texas MD Anderson Cancer Center

Commentary on Twitter

Ph 2 trial of 126 pts w/borderline resectable pancreatic ductal adenoCa shows 18 mo OS after neoadjuvant mFOLFIRINOX of 66.7%, favorable vs. historical data; 18m OS if mFOLFORINOX then hypofract RT is 47.3%, if chemo then pancreatectomy is 87.5%. https://t.co/wOMNrTOAzm

— JAMA Oncology (@JAMAOnc) July 14, 2022

One-year safety and efficacy of Tapinarof cream for the treatment of plaque psoriasis.

15 Jul, 2022 | 12:28h | UTC

One-Year Safety and Efficacy of Tapinarof Cream for the Treatment of Plaque Psoriasis: Results from the PSOARING 3 Trial – Journal of the American Academy of Dermatology

News Release: Tapinarof Effective for Longer-Term Treatment of Plaque Psoriasis – HealthDay

Pediatric intestinal pseudo-obstruction: progress and challenges.

15 Jul, 2022 | 12:24h | UTC

Pediatric Intestinal Pseudo-Obstruction: Progress and Challenges – Frontiers in Pediatrics

Review | Strongyloides stercoralis.

15 Jul, 2022 | 12:23h | UTC

Strongyloides stercoralis – Lung (if the link is paywalled, try this one)

Randomized trials in maternal and perinatal health in low and middle-income countries from 2010 to 2019: a systematic scoping review.

15 Jul, 2022 | 12:22h | UTC

Randomised trials in maternal and perinatal health in low and middle-income countries from 2010 to 2019: a systematic scoping review – BMJ Open

Cohort Study | Comparison of diagnostic criteria for acute kidney injury in critically ill children.

15 Jul, 2022 | 12:17h | UTC

Comparison of diagnostic criteria for acute kidney injury in critically ill children: a multicenter cohort study – Critical Care

Pressure ulcers (pressure injuries) | Cochrane Library evidence and resources.

14 Jul, 2022 | 13:03h | UTC

Pressure ulcers (pressure injuries): evidence and resources – Evidently Cochrane

M-A | Vortioxetine for the treatment of major depressive disorder in adults.

15 Jul, 2022 | 12:15h | UTC

Systematic Review and Meta-Analysis of Vortioxetine for the Treatment of Major Depressive Disorder in Adults – Frontiers in Psychiatry

RCT | Pharmacogenomic testing for drug-gene interactions provides little benefit for the remission of symptoms in major depressive disorder.

14 Jul, 2022 | 13:05h | UTC

Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Pharmacogenomic Testing for Next-Step Antidepressant Selection: Still a Work in Progress – JAMA (free for a limited period)

Commentary: Does Pharmacogenomic Testing Improve Outcomes in Major Depressive Disorder? — The evidence is unclear – MedPage Today (free registration required)

Commentary on Twitter

In this randomized clinical trial, pharmacogenomic testing for drug-gene interactions in major depressive disorder reduced prescription of medications with predicted drug-gene interactions but had small and nonpersistent effects on symptom remission. https://t.co/Z2OIK3h1Bo pic.twitter.com/8eKSipfBFN

— JAMA (@JAMA_current) July 12, 2022

FDA authorizes emergency use of Novavax COVID-19 vaccine.

14 Jul, 2022 | 13:01h | UTC

Coronavirus (COVID-19) Update: FDA Authorizes Emergency Use of Novavax COVID-19 Vaccine, Adjuvanted – U.S. Food & Drug Administration

Commentaries:

FDA authorizes Novavax Covid vaccine, in hopes the traditional shot will convince holdouts – STAT

US regulators OK new COVID-19 shot option from Novavax – Associated Press

How to bounce back from a PhD-project failure.

14 Jul, 2022 | 12:59h | UTC

How to bounce back from a PhD-project failure – Nature

WHO Updated Report | Severe acute hepatitis of unknown etiology in children.

14 Jul, 2022 | 12:54h | UTC

Severe acute hepatitis of unknown aetiology in children – Multi-country – World Health Organization

Indeterminate pediatric acute liver failure: Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022 – UEG Journal

Sudden onset hepatitis in children – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one)

Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)

Investigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology

What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 3 – UK Health Security Agency

Case numbers of acute hepatitis of unknown aetiology among children in 24 countries up to 18 April 2022 compared to the previous 5 years – Eurosurveillance

Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022 – Eurosurveillance

Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens – The Lancet Gastroenterology & Hepatology

Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT

Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC

Hepatitis outbreak in children: What do we know so far? – Imperial College London

Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases

Epidemiological update: Hepatitis of unknown aetiology in children – European Centre for Disease Prevention and Control

Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 2 – UK Health Security Agency

With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids – STAT

Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022 – Morbidity and Mortality Weekly Report

The CDC and WHO Have Reported an Unusual Cluster of Severe Pediatric Hepatitis Cases – Science-Based Medicine

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing – UK Health Security Agency

Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization

WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT

CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

A case series of children with acute hepatitis and human Adenovirus infection.

14 Jul, 2022 | 12:56h | UTC

A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Related Study: Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Unexplained Acute Hepatitis in Children: More Evidence for Adenovirus 41 — Two studies point to a suspiciously high prevalence – MedPage Today (free registration required)

Commentaries on Twitter

A majority of children admitted to a single hospital in late 2021–early 2022 with acute hepatitis of unknown cause tested positive for adenovirus. This report describes the children’s illnesses and outcomes. https://t.co/QYvi6U1jUN pic.twitter.com/auPRq1duQm

— NEJM (@NEJM) July 13, 2022

From January–April 2022, 44 children with acute hepatitis of unknown cause were referred to a liver-transplantation center in the U.K. Six underwent liver transplantation. https://t.co/CMI4KCqdxM pic.twitter.com/og72u58L5R

— NEJM (@NEJM) July 13, 2022