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Systemic hormone therapy (HT) before and during menopause is associated with higher risk of depression, especially in the years immediately after initiation; locally administered HT is associated with lower risk of depression for women ≥54 years. https://t.co/8k44K8SVtp

— JAMA Network Open (@JAMANetworkOpen) November 1, 2022

RCT | Chronic remote ischemic conditioning is not beneficial for patients with symptomatic intracranial atherosclerotic stenosis.

9 Nov, 2022 | 12:18h | UTC

Chronic remote ischaemic conditioning in patients with symptomatic intracranial atherosclerotic stenosis (the RICA trial): a multicentre, randomised, double-blind sham-controlled trial in China – The Lancet Neurology (link to abstract – $ for full-text)

Defining the optimum strategy for identifying adults and children with celiac disease: systematic review and economic modeling.

9 Nov, 2022 | 12:16h | UTC

Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling – Health Technology Assessment

Cohort Study | Associations between childhood trauma and childhood psychiatric disorders in Brazil.

9 Nov, 2022 | 12:15h | UTC

Associations between childhood trauma and childhood psychiatric disorders in Brazil: a population-based, prospective birth cohort study – The Lancet Psychiatry

Commentary: Birth cohort study reveals the mental health burden of trauma in childhood – University of Bath

Review | Direct oral anticoagulants for the prevention and acute treatment of cancer-associated thrombosis.

9 Nov, 2022 | 12:13h | UTC

Direct Oral Anticoagulants for the Prevention and Acute Treatment of Cancer-Associated Thrombosis – Vascular Health and Risk Management

M-A | Point-of-care ultrasound evaluation for patients with acute onset dyspnea.

9 Nov, 2022 | 12:14h | UTC

Point-of-care ultrasound improves clinical outcomes in patients with acute onset dyspnea: a systematic review and meta-analysis – Internal and Emergency Medicine

RCT | Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma.

9 Nov, 2022 | 12:12h | UTC

Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)

RCT | Efficacy of 9 months of delamanid, linezolid, levofloxacin, and pyrazinamide for treatment of fluoroquinolone-sensitive MDR-TB.

9 Nov, 2022 | 12:11h | UTC

9 months of delamanid, linezolid, levofloxacin, and pyrazinamide versus conventional therapy for treatment of fluoroquinolone-sensitive multidrug-resistant tuberculosis (MDR-END): a multicentre, randomised, open-label phase 2/3 non-inferiority trial in South Korea – The Lancet (link to abstract – $ for full-text)

RCT | Moxidectin and albendazole vs. ivermectin and albendazole in adolescents infected with Trichuris trichiura.

9 Nov, 2022 | 12:10h | UTC

Efficacy and safety of moxidectin and albendazole compared with ivermectin and albendazole coadministration in adolescents infected with Trichuris trichiura in Tanzania: an open-label, non-inferiority, randomised, controlled, phase 2/3 trial – The Lancet Infectious Diseases

Invited Commentary: Alternative treatment strategies for trichuriasis – The Lancet Infectious Diseases

RCT | Efficacy and safety of methylphenidate and behavioral parent training for children aged 3–5 years with ADHD.

9 Nov, 2022 | 12:09h | UTC

Efficacy and safety of methylphenidate and behavioural parent training for children aged 3–5 years with attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled, and sham behavioural parent training-controlled trial – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentary on Twitter (thread – click for more)

Methylphenidate was effective in reducing #ADHD symptoms and improving functionality, and behavioural parent training was effective in improving functionality for preschool children with ADHD after 8 weeks of treatment.

New RCT by @gvpolanczyk & team: https://t.co/iDUhRMTno4

— The Lancet Child & Adolescent Health (@LancetChildAdol) October 26, 2022

Canadian guideline for the prevention and management of cardiovascular disease in primary care.

8 Nov, 2022 | 12:37h | UTC

Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2022 update – Canadian Medical Association Journal

News Release: New one-stop guideline for cardiovascular health in Canada – Canadian Medical Association Journal

Cross-sectional Study | Factors associated with lesion detection in colonoscopy among different indications.

9 Nov, 2022 | 12:08h | UTC

Factors associated with lesion detection in colonoscopy among different indications – UEG Journal

NICE Guideline | Obesity: identification, assessment and management.

8 Nov, 2022 | 12:35h | UTC

Obesity: identification, assessment and management – National Institute for Health and Care Excellence

Keep the size of your waist to less than half of your height, updated NICE draft guideline recommends.

ASMBS Guidelines | Indications for metabolic and bariatric surgery.

AGA clinical practice guideline on pharmacological interventions for adults with obesity.

Guideline | Preventing obesity in midlife women.

ADA Guideline Summary | Obesity and weight management for prevention and treatment of Type 2 Diabetes.

Follow-up of the ISCHEMIA trial | Similar survival after invasive vs. conservative management of stable coronary disease.

8 Nov, 2022 | 12:32h | UTC

Survival After Invasive or Conservative Management of Stable Coronary Disease – Circulation (free for a limited period)

Original Articles:

ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease

ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease

ISCHEMIA Trial: Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease

ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease

RCT | In patients with paroxysmal, untreated AF, cryoballoon ablation reduced recurrence compared to drug therapy.

8 Nov, 2022 | 12:29h | UTC

Progression of Atrial Fibrillation after Cryoablation or Drug Therapy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary on Twitter

Initial treatment of paroxysmal atrial fibrillation with cryoballoon ablation was associated with a lower incidence of persistent atrial tachyarrhythmias over 3 years than rhythm-control medications. #AHA22 https://t.co/ZjLkt9L2xr pic.twitter.com/tzRiDPBSdx

— NEJM (@NEJM) November 7, 2022

RCT | Surgery reduced major adverse limb events vs. endovascular therapy in patients with chronic limb-threatening ischemia.

8 Nov, 2022 | 12:34h | UTC

Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Bypass surgery favorable for initial treatment of chronic limb-threatening ischemia – National Institutes of Health

Commentary on Twitter

https://twitter.com/NEJM/status/1589621195632439296

Phase 2 RCT | Small interfering RNA to reduce Lipoprotein(a) in cardiovascular disease.

8 Nov, 2022 | 12:30h | UTC

Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Clinical trial finds novel therapy markedly reduced lipoprotein(a) levels in people with cardiovascular disease – Brigham and Women’s Hospital

Commentary on Twitter

Lipoprotein(a) is similar to LDL cholesterol but contains apolipoprotein(a). A trial tested the effects of an oligonucleotide drug targeting apo(a) mRNA on lipoprotein(a) concentrations in patients with CVD. #AHA22 https://t.co/eLgnrnTm5D pic.twitter.com/QmNUcxeJwX

— NEJM (@NEJM) November 6, 2022

RCT | New defibrillation strategies increased the rates of survival to hospital discharge in patients with refractory ventricular fibrillation.

8 Nov, 2022 | 12:27h | UTC

Defibrillation Strategies for Refractory Ventricular Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: “Double shock” from two defibrillators could save more lives – Heart & Stroke

Commentary on Twitter

In a trial involving patients with refractory ventricular fibrillation, double sequential external defibrillation or vector-change defibrillation improved survival as compared with standard defibrillation. #AHA22 https://t.co/2l2t9iGnwq pic.twitter.com/SzVU93OsrX

— NEJM (@NEJM) November 6, 2022