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Practice: I am your trans patient
2 Jul, 2017 | 21:06h | UTCPractice: I am your trans patient – The BMJ (free)
Related infographic: Managing disclosure of gender dysphoria – The BMJ (free PDF)
“Five transgender authors share their experiences of healthcare & the important messages they’d like doctors to know” (RT @bmj_latest see Tweet)
Complications of Proton Pump Inhibitor Therapy
30 Jun, 2017 | 15:20h | UTCComplications of Proton Pump Inhibitor Therapy – Gastroenterology (free)
Commentary: Complications of Proton Pump Inhibitor Therapy – PracticeUpdate (free registration required)
Related: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD – Journal of the American Society of Nephrology (link to abstract – registration required for full text) AND Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis – Jama Neurology (link to abstract – subscription required for full text)
The authors of this review argue that the observational studies that brought up the safety issues associated with PPIs (above studies, for example) are insufficient to establish causation and suggest a more balanced approach to PPI prescribing.
Living Systematic Reviews are going live
2 Jul, 2017 | 21:04h | UTCLiving Systematic Reviews are going live – Cochrane UK (free) (RT @CochraneUK see Tweet)
Related: Living Systematic Reviews – Cochrane Community (free)
“Living Systematic Review is a “systematic review which is continually updated, incorporating relevant new evidence as it becomes available”.
Diagnosis and management of myocardial involvement in systemic immune-mediated diseases
2 Jul, 2017 | 20:59h | UTCDiagnosis and management of myocardial involvement in systemic immune-mediated diseases: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Disease – European Heart Journal (free) (RT @rafavidalperez see Tweet)
Judging the benefits and harms of medicines
30 Jun, 2017 | 15:15h | UTCEditorial: Judging the benefits and harms of medicines – The BMJ (free for 15 days)
“Please read/comment on our editorial @bmj_latest about @acmedsci report on judging benefits and harms of medicines” (RT @fgodlee see Tweet)
Review: Subclinical Hypothyroidism
2 Jul, 2017 | 21:00h | UTCSubclinical Hypothyroidism – NEJM Resident 360 (free)
Short and practical review with algorithm on the management of subclinical hypothyroidism.
Common practice is not always evidence-based
30 Jun, 2017 | 15:14h | UTCCommon practice is not always evidence-based – Students 4 Best Evidence (free)
This is the fourth in a series of 34 blogs based on a list of ‘Key Concepts’ developed by an Informed Health Choices project team.
Delirium Prevention Strategies for Elderly Adults with Hip Fracture
30 Jun, 2017 | 15:18h | UTCSource: PracticalReviews ($)
See related article on the effect of multicomponent nonpharmacologic interventions to prevent delirium in abdominal surgery in our May 25th issue (see #5)
Delirium-friendly preprinted postoperative orders executed by regular nursing staff resulted in a significant reduction in postoperative delirium.
Patients’ Discomfort and Students’ Moral Distress When Learning Procedures
30 Jun, 2017 | 15:17h | UTC“Medical institutions should support a culture of “speaking up” to promote the safety of patients AND learners” (RT @JournalofEthics see Tweet)
You’ll mess up but save the day: advice to new doctors as they start work as interns
30 Jun, 2017 | 15:14h | UTCYou’ll mess up but save the day: advice to new doctors as they start work as interns – STAT News (free)
Association is not the same as causation
30 Jun, 2017 | 15:13h | UTCAssociation is not the same as causation – Students 4 Best Evidence (free)
This is the third in a series of 34 blogs based on a list of ‘Key Concepts’ developed by an Informed Health Choices project team.
Air pollution: outdoor air quality and health
30 Jun, 2017 | 15:16h | UTCAir pollution: outdoor air quality and health – NICE Guideline (free)
News release: ‘No idling’ zones can help to protect vulnerable people from air pollution, says NICE (free)
Last Month in Oncology with Dr. Bishal Gyawali
30 Jun, 2017 | 15:08h | UTCLast Month in Oncology with Dr. Bishal Gyawali: June 2017 – ecancer News (free)
“New edition of my blogs @ecancer is out focusing on studies presented at #ASCO17 (RT @oncology_bg see Tweet)
Websites offering pirated papers are shaking up science
30 Jun, 2017 | 15:10h | UTCWebsites offering pirated papers are shaking up science – The Economist (a few articles per month are free)
When Anxiety or Depression Masks a Medical Problem
30 Jun, 2017 | 15:09h | UTCWhen Anxiety or Depression Masks a Medical Problem – New York Times (10 articles month are free)
Related: Managing Anxiety in the Medically Ill – Psychiatric Times (free)
“Very 1st differential before making a psych diagnosis should be – is this due to medical problem? 2nd question – medication/substance/alcohol? (RT @AllenFrancesMD see Tweet)
New Natural Selection: How Scientists are Altering DNA to Genetically Engineer New Forms of Life
30 Jun, 2017 | 15:12h | UTC“What happens when you can write and edit genomes? Life 2.0? (RT @EricTopol see Tweet)
C. Diff Infections Are Falling, Thanks To Better Cleaning And Fewer Antibiotics
30 Jun, 2017 | 15:11h | UTCC. Diff Infections Are Falling, Thanks To Better Cleaning And Fewer Antibiotics – NPR (free)
Child marriage will cost the world $4tn by 2030
29 Jun, 2017 | 16:25h | UTCChild marriage will cost the world $4tn by 2030, researchers warn – The Guardian (free)
Original report and other resources: The economic impacts of child marriage (all resources are free)
Source: Global Health NOW Newsletter
Interventions for preventing high altitude illness
29 Jun, 2017 | 20:24h | UTCInterventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs – Cochrane Library (link to summary – $ for full-text) (RT @CochraneUK see Tweet)
Acetazolamide seems to be effective to prevent acute high altitude illness in dosages of 250 to 750 mg/day.
Fri, June 30 – 10 Stories of The Day!
30 Jun, 2017 | 00:34h | UTC
1 – Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs – Cochrane Library (link to summary – $ for full-text) (RT @CochraneUK see Tweet)
Acetazolamide seems to be effective to prevent acute high-altitude illness in dosages of 250 to 750 mg/day.
2 – Comparison of Outcome of Coronary Artery Bypass Grafting Versus Drug-Eluting Stent Implantation for Non–ST-Elevation Acute Coronary Syndrome – The American Journal of Cardiology (link to abstract – $ for full-text)
Source: EvidenceAlerts
In patients with Non–ST-Elevation Acute Coronary Syndrome and left main or multivessel CAD, CABG significantly reduced the risk of death from any causes, myocardial infarction, or stroke compared with PCI with drug-eluting stents.
3 – A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Adding Antibiotics to Incision-and-Drainage of Small Skin Abscesses Helps – Physician’s First Watch (free) AND Antibiotics Improve Short-Term Outcomes for Simple Abscesses – Medscape (free registration required) AND Study finds benefit for antibiotic treatment of simple skin wounds – CIDRAP (free)
4 – Air Pollution and Mortality in the Medicare Population – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Air Pollution and Mortality (free)
Editorial: Air Pollution Still Kills (link to abstract – $ for full-text)
Commentary: Study of US seniors strengthens link between air pollution and premature death – Harvard T.H. Chan School of Public Health, via Science Daily (free)
Related: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)
5 – Childhood intelligence in relation to major causes of death in 68 year follow-up: prospective population study – The BMJ (free)
Editorial: Higher IQ in childhood is linked to a longer life (free)
Why do those with higher IQs live longer? A new study points to answers – STAT News (free) Higher childhood IQ associated with lower adult mortality – OnMedica (free) AND People with higher IQs are more likely to live to their 80s – New Scientist (free)
6 – Is the staggeringly profitable business of scientific publishing bad for science? – The Guardian (free)
“Interesting long read” (RT @CochraneUK see Tweet)
7 – Precision Medicine: the Promise vs. the Reality – Michigan University Health Lab (free) (RT @pash22)
“Scientists find great potential in using genetic sequencing to help direct targeted cancer therapy, but practicing oncologists see some important limitations”.
8 – Clinical Review: Update on anti-tumor necrosis factor agents and other new drugs for inflammatory bowel disease – The BMJ (free)
9 – Editorial: Clinical effects of antivirals for hepatitis C: context is critical – The Lancet Gastroenterology & Hepatology (free)
Original Cochrane review: Direct-acting antivirals for chronic hepatitis C – Cochrane Library (link to summary – $ for full-text)
Commentary in The Guardian: ‘Miracle’ hepatitis C drugs costing £30k per patient ‘may have no clinical effect’ (free)
“Presence of nucleated RBCs is a robust predictor of post-discharge mortality and unplanned hospital readmission” (RT @Crit_Care see Tweet)
‘Exaggerations’ threaten public trust in science, says leading statistician
29 Jun, 2017 | 15:47h | UTC‘Exaggerations’ threaten public trust in science, says leading statistician – The Guardian (free)
Implantable Cardioverter-Defibrillators for Primary Prevention in Patients With Ischemic or Nonischemic Cardiomyopathy
29 Jun, 2017 | 15:38h | UTCImplantable Cardioverter-Defibrillators for Primary Prevention in Patients With Ischemic or Nonischemic Cardiomyopathy: A Systematic Review and Meta-analysis – Annals of Internal Medicine (free registration required)
Commentary: Meta-Analysis: ICDs Improve Survival in Ischemic and Nonischemic Cardiomyopathy – Physician’s First Watch (free) AND ICD Primary Prevention Benefit Affirmed in Meta-Analysis – MedPage Today (free registration required) AND ICD therapy significantly reduces death risk in patients with ischemic or nonischemic cardiomyopathy – 2 minute medicine (free)
Colorectal polypectomy and endoscopic mucosal resection
29 Jun, 2017 | 15:38h | UTC
CABG vs DES for Non–ST-Elevation Acute Coronary Syndrome and left main or multivessel CAD
29 Jun, 2017 | 16:12h | UTCComparison of Outcome of Coronary Artery Bypass Grafting Versus Drug-Eluting Stent Implantation for Non–ST-Elevation Acute Coronary Syndrome – The American Journal of Cardiology (link to abstract – $ for full-text)
Source: EvidenceAlerts
In patients with Non–ST-Elevation Acute Coronary Syndrome and left main or multivessel CAD, CABG significantly reduced the risk of death from any causes, myocardial infarction, or stroke compared with PCI with drug-eluting stents
Precision Medicine: the Promise vs. the Reality
29 Jun, 2017 | 15:36h | UTCPrecision Medicine: the Promise vs. the Reality – Michigan University Health Lab (free) (RT @pash22 see Tweet)
“Scientists find great potential in using genetic sequencing to help direct targeted cancer therapy, but practicing oncologists see some important limitations”.