All Posts
M-A | Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia
14 Feb, 2023 | 10:43h | UTC
Commentary on Twitter
Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia: A systematic review and meta-analysis
✅ Just Accepted
🆓 Freely Available
🔗 https://t.co/a8SYDUM8UH pic.twitter.com/L5niNTVIUd— Clinical Infectious Diseases (@CIDJournal) February 9, 2023
Design, power, and alpha levels in randomized phase II oncology trials
14 Feb, 2023 | 10:40h | UTCSummary: This study examined the methodology, reporting, and bias in the interpretation of outcomes in randomized phase II oncology trials. It found that many trials failed to report essential data for determining sample size calculations, did not use a comparator to determine efficacy, and had positive conclusions even though the results were indeterminate or the primary endpoint was not met. The study concluded that phase II trials need to adhere to the same reporting standards and be interpreted in the context of their primary endpoint and endpoints important for the patient.
(By ChatGPT, reviewed and edited)
Article: Design, power, and alpha levels in randomized phase II oncology trials – ESMO Open
Review | Anisocoria in the ED: pathophysiology, evaluation, and management
14 Feb, 2023 | 10:41h | UTCAnisocoria in the ED: Pathophysiology, Evaluation, and Management – emDocs
Takayasu Arteritis | JACC Focus Seminar
14 Feb, 2023 | 10:39h | UTCTakayasu Arteritis: JACC Focus Seminar 3/4 – Journal of the American College of Cardiology
Related:
Retrospective Study | Outcomes of percutaneous intervention in patients with Takayasu arteritis
14 Feb, 2023 | 10:38h | UTCRelated:
Takayasu Arteritis: JACC Focus Seminar 3/4 – Journal of the American College of Cardiology
Phase 2 RCT | Aficamten in patients with obstructive hypertrophic cardiomyopathy
14 Feb, 2023 | 10:37h | UTC
Retrospective Cohort | Phenotypes of overdiagnosed Long QT syndrome
14 Feb, 2023 | 10:35h | UTCPhenotypes of Overdiagnosed Long QT Syndrome – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries:
Phenotypes of Overdiagnosed Long QT Syndrome – American College of Cardiology
Long QT syndrome overdiagnosis persists – MDedge
Commentary on Twitter
Increased physician & public awareness of LQTS-assoc. warning signs & an increase in #ECG screening programs may contribute to an overdiagnosis of #LQTS.
Authors discuss the top 5 causes of LQTS misdiagnosis & provide guidance to reduce this burden. https://t.co/CDUoiUhihY #JACC pic.twitter.com/BNTXMWQzGP
— JACC Journals (@JACCJournals) February 3, 2023
Development of a model to estimate the optimal number of oocytes to attempt to fertilize in IVF
14 Feb, 2023 | 10:36h | UTC
Commentary on Twitter
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799935
M-A | Predictors of survival to immunotherapy and chemoimmunotherapy in non-small cell lung cancer
14 Feb, 2023 | 10:34h | UTC
Podcast | Intravenous fluids in pediatrics
14 Feb, 2023 | 10:32h | UTC#76: IV Fluids – Salty and Sweet – The Cribsiders
Stillbirth after adolescent and young adult cancer: a population-based study
14 Feb, 2023 | 10:33h | UTCCommentary: Previous Cancer Treatment Not Tied to Higher Stillbirth Rate – HealthDay
RCT | Testing equivalence of two doses of intravenous iron to treat iron deficiency in pregnancy
14 Feb, 2023 | 10:31h | UTC
Recommended adult immunization schedule, United States, 2023
13 Feb, 2023 | 13:06h | UTCRecommended Adult Immunization Schedule, United States, 2023 – Annals of Internal Medicine
Commentary: Recommended 2023 Adult Immunization Schedule Published – HealthDay
Commentary on Twitter
The 2023 #ACIP schedule is out now with important changes to #COVID19 and pneumococcal vaccines, including recommendations for adults who have previously received PCV13 and PPSV23: https://t.co/QeErLZJFuZ pic.twitter.com/BR6aa1kNKi
— Annals of Int Med (@AnnalsofIM) February 10, 2023
Development of a machine learning model for sonographic assessment of gestational age
14 Feb, 2023 | 10:30h | UTCCommentary: AI Models Have Higher Accuracy for Estimating Gestational Age – HealthDay
RCT | Azithromycin reduces the risk of maternal sepsis or death in women planning a vaginal birth
13 Feb, 2023 | 13:02h | UTCAzithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Single-dose antibiotic prevents maternal sepsis and death – NIH News
Commentaries:
In large study, a single antibiotic dose slashed rate of sepsis in childbirth – STAT
Dose of azithromycin found to cut risk of maternal death, sepsis in childbirth – CIDRAP
RCT | Tenecteplase noninferior to alteplase in acute ischemic cerebrovascular events
13 Feb, 2023 | 12:59h | UTCTenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Updated child and adolescent immunization schedule, United States, 2023
13 Feb, 2023 | 13:05h | UTCChild and Adolescent Immunization Schedule by Age – Centers for Diseases Control and Prevention
See also: Recommended Childhood and Adolescent Immunization Schedule: United States, 2023 – Pediatrics
Commentary: Immunization Schedule for Children, Teens Updated for 2023 – HealthDay
RCTs | Endovascular therapy improves functional outcomes in large ischemic strokes, but increases bleeding and vascular complications
13 Feb, 2023 | 13:00h | UTCStudy 1: Trial of Endovascular Thrombectomy for Large Ischemic Strokes – New England Journal of Medicine (link to abstract – $ for full-text)
Study 2: Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct – New England Journal of Medicine (link to abstract – $ for full-text)
M-A | Tenecteplase vs. alteplase for treatment of acute ischemic stroke
13 Feb, 2023 | 12:57h | UTCRelated: Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Perspective | Five new realities in critical care for patients with cancer
13 Feb, 2023 | 12:53h | UTCFive new realities in critical care for patients with cancer – Intensive Care Medicine
Related:
Consensus Conference: Critically ill cancer patient’s resuscitation.
Raising awareness for time-limited trial discussion upon ICU triage and admission.
Commentary on Twitter
New realities in critical care for pts with cancer
1️⃣ serious illness no longer means end of life
2️⃣ novel cancer therapies: changing outcomes but creating new diseases
3️⃣ take fresh look at ARF
4️⃣ goals of care & time‑limited trial
5️⃣ look beyond #ICU
📖 https://t.co/ZRNQD6AMIw pic.twitter.com/5QoYVSq5Br— Intensive Care Medicine (@yourICM) February 10, 2023
Video | ChatGPT: will it transform the world of health care?
13 Feb, 2023 | 12:55h | UTCChatGPT: Will It Transform the World of Health Care? – UCSF Department of Medicine
Related:
ChatGPT and the future of medical writing (ChatGPT itself wrote this paper)
ChatGPT: five priorities for research – Nature
The path forward for ChatGPT in academia – Lumo’s Newsletter
ChatGPT is fun, but not an author – Science
Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature
ChatGPT listed as author on research papers: many scientists disapprove – Nature
Abstracts written by ChatGPT fool scientists
RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care
13 Feb, 2023 | 12:50h | UTCDeprescribing Medications Among Older Adults From End of Hospitalization Through Postacute Care: A Shed-MEDS Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Related:
Deprescribing proton pump inhibitors – Australian Journal of General Practice
Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports
Deprescribing in Palliative Cancer Care – Life
Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international
Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety
Commentary on Twitter
A randomized trial of patient-centered #deprescribing in the acute care setting reduced medication burden by 14% among older hospitalized patients that needed ongoing post-acute care. https://t.co/FJf53O00Cv #ShedMEDS #polypharmacy #LessIsMore #Geriatrics
— JAMA Internal Medicine (@JAMAInternalMed) February 9, 2023
The Lancet Series | Breastfeeding 2023
13 Feb, 2023 | 12:52h | UTCHomepage: Breastfeeding 2023 – The Lancet
Editorial: Unveiling the predatory tactics of the formula milk industry
Breastfeeding: crucially important, but increasingly challenged in a market-driven world
Marketing of commercial milk formula: a system to capture parents, communities, science, and policy
Commentaries:
Expert reaction to review of formula baby milk – Science Media Centre
Guideline | Barrett’s esophagus and stage 1 esophageal adenocarcinoma: monitoring and management
13 Feb, 2023 | 12:49h | UTC
Updated Guideline | Cardiovascular disease risk assessment and reduction, including lipid modification
13 Feb, 2023 | 12:47h | UTCRelated Guidelines:
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease – Circulation
#ESCCongress – 2019 ESC/EAS Guidelines for the Management of Dyslipidaemias
#ESCCongress – 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.