All Posts
Cohort Study | Female hormone therapy and risk of intracranial hemorrhage from cerebral cavernous malformations
2 Mar, 2023 | 13:03h | UTCSummary: The study aimed to investigate the association between female hormone therapy (oral contraception or menopausal hormone therapy) and intracranial hemorrhage in female patients with cerebral cavernous malformations (CCM) using data from 2 large prospective cohort studies. The researchers analyzed data from 722 female patients with CCM and found that female hormone therapy use was associated with an increased risk of subsequent intracranial hemorrhage. The risk was more significant among female patients aged 10-44 years using oral contraceptives (adjusted hazard ratio 2·00, 95% CI 1·26-3·17; p=0·003). These findings raise questions about the safety of female hormone therapy in patients with cerebral cavernous malformation.
Article: Female Hormone Therapy and Risk of Intracranial Hemorrhage From Cerebral Cavernous Malformations: A Multicenter Observational Cohort Study – Neurology (link to abstract – $ for full-text – you can try this link for full-text)
Youth-onset type 2 diabetes: the epidemiology of an awakening epidemic
2 Mar, 2023 | 13:01h | UTCYouth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic – Diabetes Care
M-A | Thromboprophylaxis in patients with Fontan circulation
2 Mar, 2023 | 12:57h | UTCThromboprophylaxis in Patients With Fontan Circulation – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: Thromboprophylaxis in Patients With Fontan Circulation – American College of Cardiology
Commentary from the author on Twitter (thread – click for more)
🔥Hot off the press🔥Read our new paper about #Thromboprophylaxis in patients with #Fontan #circulation just published in @JACCJournals@ACCinTouch.
Article link: https://t.co/eeu6kT7PDH— Jef Van den Eynde (@JefVandenEynde) January 23, 2023
RCT | Empagliflozin (SGLT2i) is more effective for reducing HbA1c than linagliptin (DPP-4i) in young people with Type 2 DM
2 Mar, 2023 | 13:00h | UTCEfficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries:
DINAMO: Empagliflozin shows promise for young people with type 2 diabetes – medwire News
M-A | Prevalence and odds of depressive and anxiety disorders and symptoms in children and adults with alopecia areata
2 Mar, 2023 | 12:59h | UTCPrevalence and Odds of Depressive and Anxiety Disorders and Symptoms in Children and Adults With Alopecia Areata: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)
Commentary: Anxiety, Depressive Disorder Prevalence Greater Among Alopecia Areata Patients – HCP Live
Cohort Study | Risk of endometrial polyps, hyperplasia, carcinoma, and uterine cancer after tamoxifen treatment in premenopausal women with breast cancer
2 Mar, 2023 | 12:56h | UTCCommentary: Risk of Uterine Diseases, Cancers Up With Tamoxifen Treatment – HealthDay
Commentary on Twitter
Use of tamoxifen as an adjuvant hormone therapy for breast cancer was associated with an increased risk of endometrial polyps, hyperplasia, carcinoma, and other uterine cancers in Korean premenopausal women. https://t.co/JqnKjemjoW
— JAMA Network Open (@JAMANetworkOpen) November 29, 2022
M-A | Incidence, indications, risk factors, and outcomes of emergency peripartum hysterectomy worldwide
2 Mar, 2023 | 12:54h | UTC
Cohort Study | IVF-conceived children have similar school-age educational outcomes as spontaneously conceived children
2 Mar, 2023 | 12:53h | UTCSchool-age outcomes among IVF-conceived children: A population-wide cohort study – PLOS Medicine
News Release: No link between IVF-assisted conception and school-age childhood development outcomes, study says – University of Melborn
Commentary: IVF Not Tied to Worse Developmental, Educational Outcomes – HealthDay
Cohort Study | Risk factors for serious infections in ANCA-associated vasculitis
2 Mar, 2023 | 12:52h | UTCRisk factors for serious infections in ANCA-associated vasculitis – Annals of the Rheumatic Diseases
Commentary from the author on Twitter
Just published in @ARD_BMJ (https://t.co/mZVZ7HZaLC) – risk of severe infections in #AAV. The prophylactic use of low-dose TMP/SMX may reduce this risk. A work I am really proud of. Many thanks to all my co-authors, especially to my friend @AKronbichler for his endless support!
— Balazs Odler (@odlerb) January 26, 2023
RCT | Effects of a respiratory distress symptom intervention for lung cancer breathlessness–cough–fatigue symptom cluster
2 Mar, 2023 | 12:51h | UTC
RCT | Impact of supplementation with milk–cereal mix during 6–12 months of age on growth at 12 months in Delhi, India
2 Mar, 2023 | 12:50h | UTCCommentary: High-protein supplementation improves linear growth in infants – 2 Minute Medicine
RCT | Electrostimulation with the Alpha-Stim AID device is not better than sham treatment in major depression
2 Mar, 2023 | 12:49h | UTCCommentary: Active AID Device Not More Effective Than Sham at Improving Depressive Symptoms – Neurology Advisor
Mean systolic blood pressure above the control threshold in people with treated uncontrolled hypertension in 55 countries
2 Mar, 2023 | 12:48h | UTC
SR | Trifocal intraocular lenses vs. bifocal intraocular lenses after cataract extraction among participants with presbyopia
2 Mar, 2023 | 12:46h | UTCSummary: Trifocal versus bifocal lenses implantation after cataract surgery – Cochrane Library
RCT | Addition of preoperative transversus abdominis plane block to multimodal analgesia in open gynecological surgery
2 Mar, 2023 | 12:43h | UTC
Cohort Study | Association between marked fetal heart rate variability and neonatal acidosis
2 Mar, 2023 | 12:44h | UTCCommentary: Marked variability associated with twofold increased risk of neonatal acidosis: BJOG
Cohort Study | Lifetime traumatic brain injury and cognitive domain deficits in late life
2 Mar, 2023 | 12:45h | UTCLifetime Traumatic Brain Injury and Cognitive Domain Deficits in Late Life: The PROTECT-TBI Cohort Study – Journal of Neurotrauma (link to abstract – you can try this link for full-text)
News Release: Three or more concussions linked with worse brain function in later life – University of Exeter
RCT | Application of opioid-free general anesthesia for gynecological laparoscopic surgery under ERAS protocol
2 Mar, 2023 | 12:42h | UTC
Brief Review | Acute rheumatic fever: recent advances
2 Mar, 2023 | 12:41h | UTCAcute Rheumatic Fever: Recent Advances – The Pediatric Infectious Disease Journal (free for a limited period)
M-A | Eccentric exercise vs. other exercises in the treatment of mid-portion Achilles tendinopathy
2 Mar, 2023 | 12:40h | UTC
RCT | Endovascular ultrasound renal denervation is modestly effective in the treatment of hypertension
1 Mar, 2023 | 14:11h | UTCSummary: The RADIANCE II randomized clinical trial investigated the efficacy and safety of endovascular ultrasound renal denervation in patients with hypertension without the influence of antihypertensive medications. The trial enrolled 224 patients who were withdrawn from such medications and randomly assigned to receive either ultrasound renal denervation or a sham procedure. Results showed that ultrasound renal denervation reduced ambulatory systolic blood pressure by 6.3 mmHg on average at 2 months, compared to the sham procedure, without any reported adverse events. While these findings suggest that ultrasound renal denervation may be modestly effective in the treatment of hypertension, the short-term follow-up period limits the generalizability of these results to daily practice. Additionally, the clinical relevance of a procedure that reduces blood pressure only after withdrawing blood pressure medications should be considered.
Article: Endovascular Ultrasound Renal Denervation to Treat Hypertension: The RADIANCE II Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Is There a Role for Renal Denervation in the Treatment of Hypertension? – JAMA Cardiology (free for a limited period)
RCT | Long-term effects of early antiretroviral therapy initiation in HIV infection highlight the importance of early treatment
1 Mar, 2023 | 14:12h | UTCSummary: The article discusses the long-term results of the Strategic Timing of AntiRetroviral Treatment (START) trial, which aimed to determine the effects of early initiation of antiretroviral therapy (ART) for individuals with HIV and CD4+ counts above 500 cells/mm3 compared to those who deferred treatment until their CD4+ count was below 350 cells/mm3. The trial found that immediate ART initiation reduced the risk of AIDS and serious non-AIDS (SNA) conditions compared to deferred treatment. The study’s long-term results also found that a persistent excess risk of AIDS and SNA conditions remained even after ART was initiated in those who initially deferred treatment. The study highlights the importance of early diagnosis and prompt initiation of ART for individuals with HIV.
Article: Long-Term Benefits from Early Antiretroviral Therapy Initiation in HIV Infection – NEJM Evidence
Original Study: Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection – New England Journal of Medicine
Pooled analysis of 3 sham-controlled trials on ultrasound renal denervation for patients with hypertension
1 Mar, 2023 | 14:10h | UTCSummary: The article reports a patient-level pooled analysis of 3 randomized clinical trials that aimed to determine the effectiveness and safety of ultrasound renal denervation (uRDN) in reducing blood pressure (BP) compared to a sham procedure. The analysis included 506 patients with varying severities of hypertension and found that uRDN was modestly effective in reducing daytime ambulatory systolic BP at 2 months compared to the sham procedure, with a mean difference of 5.9 mmHg. One of the limitations of this analysis is that its findings are restricted to a 2-month follow-up. Additional follow-up from the included trials will be required to examine the durability of the effect and safety data.
Editorial: Is There a Role for Renal Denervation in the Treatment of Hypertension? – JAMA Cardiology (free for a limited period)
Artificial sweetener erythritol possibly implicated in increased cardiovascular risk
1 Mar, 2023 | 14:08h | UTCSummary: A recent study published in Nature Medicine found that erythritol, a popular artificial sweetener, is possibly implicated with an increased risk of major adverse cardiovascular events (MACE) such as heart attack and stroke. Analyzing data from over 4,000 people in the US and Europe, the researchers found that those with higher blood erythritol levels were at a greater risk of MACE. The researchers also examined the effects of adding erythritol to whole blood or isolated platelets and found that it made platelets easier to activate and form clots. In addition, a pilot intervention study with healthy volunteers showed that erythritol ingestion led to a marked and sustained increase in plasma erythritol levels above those associated with heightened platelet reactivity and thrombosis potential. The authors note that further studies are needed to confirm their findings and assess the long-term safety of erythritol.
Article: The artificial sweetener erythritol and cardiovascular event risk – Nature Medicine (free for a limited period)
News Release: Cleveland Clinic study finds common artificial sweetener linked to higher rates of heart attack and stroke
Commentaries:
Zero-calorie sweetener linked to heart attack and stroke, study finds – CNN
Could a Common Sweetener Raise Heart Risks? – HealthDay
Commentary on Twitter
A study in @NatureMedicine suggests that a commonly used artificial sweetener—erythritol—may be linked to cardiovascular disease events. https://t.co/QrbtvCFDJ4 pic.twitter.com/WpM9cLnXh7
— Nature Portfolio (@NaturePortfolio) February 27, 2023
M-A | Combination of multiple low-risk lifestyle behaviors and incident type 2 diabetes
1 Mar, 2023 | 14:06h | UTCSummary: This systematic review and meta-analysis assessed the association between multiple low-risk lifestyle behaviors (LRLBs) and the incidence of type 2 diabetes. The study examined 30 cohort comparisons involving 1,693,753 participants and 75,669 cases of type 2 diabetes. The LRLBs evaluated in the study were maintaining a healthy body weight, healthy diet, regular exercise, smoking abstinence or cessation, and light alcohol consumption. Results showed that the highest adherence to these LRLBs was associated with an 80% lower risk of type 2 diabetes compared to the lowest adherence group. Thus, targeting these LRLBs could be an effective strategy for the primary prevention of type 2 diabetes. However, the authors recommend promoting only four LRLBs, excluding alcohol intake, due to its association with increased harm. The potential benefits of small alcohol intake remain a controversial issue since most studies on the subject are observational and subject to residual confounding.
Article: Combination of Multiple Low-Risk Lifestyle Behaviors and Incident Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies – Diabetes Care (free for a limited period)
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/tauseefkhan/status/1628510003853131776