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Prevalence and Economic Burden of Medication Errors in The NHS in England. Rapid evidence synthesis and economic analysis of the prevalence and burden of medication error in the UK – Policy Research Unit in Economic Evaluation of Health & Care Interventions (EEPRU) (free PDF)

Commentaries: More than 200 million medication errors occur in NHS per year, say researchers – The University of Sheffield News (free) AND Drug errors cause appalling harm and deaths, says Hunt – BBC (free)

Decreasing the Cost of Care by Avoiding Illness

27 Feb, 2018 | 15:51h | UTC

Decreasing the Cost of Care by Avoiding Illness – NEJM Catalyst (free)

Meta-Analysis: Neurocognitive and Educational Outcomes in Children and Adolescents with CKD

27 Feb, 2018 | 15:47h | UTC

Neurocognitive and Educational Outcomes in Children and Adolescents with CKD: A Systematic Review and Meta-Analysis – Clinical Journal of the American Society of Nephrology (free)

Commentaries: Analysis finds lower IQ in children with chronic kidney disease – American Society of Nephrology, via ScienceDaily (free) AND CKD Linked to Cognitive Impairment in Kids – MedPage Today (free registration required)

Research: Surprising Rate of Cardiac Amyloidosis in TAVR Patients

27 Feb, 2018 | 15:45h | UTC

Surprising Rate of Cardiac Amyloidosis in TAVR Patients Poses Tough Questions for Diagnosis, Decision-Making – TCTMD (free)

Research: Bedtime Low Dose Amitriptyline in Chronic Neck Pain

27 Feb, 2018 | 15:44h | UTC

Randomized double-blind controlled study of bedtime low dose amitriptyline in chronic neck pain – European Journal of Pain (link to abstract – $ for full-text)

Commentary: Low-dose amitriptyline reduces idiopathic chronic neck pain – Univadis (free registration required)

Opinion: How Value-Based Medicare Payments Exacerbate Health Care Disparities

27 Feb, 2018 | 15:50h | UTC

Medical News & Perspectives: How Value-Based Medicare Payments Exacerbate Health Care Disparities – JAMA (free for a limited period)

Oman will raise taxes on tobacco, alcohol, soft drinks and energy drinks by 100%

27 Feb, 2018 | 15:45h | UTC

100% excise tax on tobacco, energy drinks from June – MuscatDaily (free) (via @DrFrieden see Tweet)

Oman will raise taxes on tobacco, alcohol, soft drinks and energy drinks by 100%.

Review: Immunotherapy-Induced Colitis

27 Feb, 2018 | 15:42h | UTC

Immunotherapy-Induced Colitis: An Emerging Problem for the Hospitalist – Journal of Hospital Medicine (free PDF)

Source: Hospital Medicine Virtual Journal Club

Research: The Effects of Fluoride in the Drinking Water

27 Feb, 2018 | 15:41h | UTC

The Effects of Fluoride in the Drinking Water – The Institute for Evaluation of Labour Market and Education Policy (free PDF)

Commentary: Fluoride does not have negative effect on intelligence – News Medical (free)

Mon, February 26 – 10 Stories of The Day!

26 Feb, 2018 | 01:12h | UTC

1 – Latent TB Infection: Updated and consolidated guidelines for programmatic management – World Health Organization (free)

News release: WHO issues new recommendations calling for accelerated uptake of testing and treatment for TB prevention (free)

2 – ACG Clinical Guideline: Alcoholic Liver Disease – The American Journal of Gastroenterology (free)

Commentary and summary: New Guideline for Management of Alcoholic Liver Disease – NEJM Journal Watch (free for a limited period)

3 – Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning – Nature Biomedical Engineering (link to abstract – $ for full-text) (via @EricTopol see Very interesting Tweet)

Commentaries: Assessing Cardiovascular Risk Factors with Computer Vision – Google Research Blog (free) AND Google’s new AI algorithm predicts heart disease by looking at your eyes – TheVerge (free) AND Combination of AI, eye images could predict cardiovascular disease – Cardiovascular Business (free) AND It’s All in the Eyes: Google AI Calculates Cardiovascular Risk From Retinal Images – Medium (free)

4 – Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

5 – Opinion: Doctors, Revolt! – The New York Times (free)

“Healing is replaced with treating, caring is supplanted by managing, and the art of listening is taken over by technological procedures. Bernard Lown” (via @lucadf see Tweet)

6 – The global crackdown on parents who refuse vaccines for their kids has begun – VOX (free)

“Countries like Italy and Australia are tired of measles outbreaks — so they’re moving to fine anti-vaccine parents”.

7 – Scientists Aim to Pull Peer Review Out Of The 17th Century – NPR (free)

8 – Antifibrinolytic drugs for treating primary postpartum haemorrhage – Cochrane Library (free)

Related: Updated WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage (free PDF) AND Early use of tranexamic acid reduces bleeding more effectively – NIHR Signal (free) AND Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free)

9 – Spironolactone Versus Clonidine as a Fourth-Drug Therapy for Resistant Hypertension: The ReHOT Randomized Study (Resistant Hypertension Optimal Treatment) – Hypertension (free)

Commentary: Spironolactone bests clonidine as fourth drug for resistant hypertension – Univadis (free registration required)

10 – Infant Hospitalizations and Mortality After Maternal Vaccination – Pediatrics (free)

Commentaries: Maternal vaccination during pregnancy not associated with infant hospitalization, mortality – 2 Minute Medicine (free) AND Getting Recommended Vaccines During Pregnancy Doesn’t Lead to Harm in Infants – Physician’s First Watch (free)

Impact of Implementing Antibiotic Stewardship Programs in 15 Small Hospitals

27 Feb, 2018 | 15:40h | UTC

Impact of Implementing Antibiotic Stewardship Programs in 15 Small Hospitals: A Cluster-Randomized Intervention – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentary: Intensive, well-resourced antibiotic stewardship found best in small hospitals – CIDRAP (free)

Tue, February 27 – 10 Stories of The Day!

27 Feb, 2018 | 00:56h | UTC

1 – 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free)

2 – Guidelines for Adolescent Depression in Primary Care – American Academy of Pediatrics

Part I. Practice Preparation, Identification, Assessment, and Initial Management (free)

Part II. Treatment and Ongoing Management (free)

Commentary: Pediatricians Call For Universal Depression Screening For Teens – NPR (free)

3 – Guidelines for Burn Care Under Austere Conditions: Surgical and Nonsurgical Wound Management – Journal of Burn Care & Research (free)

Source: Critical Care Reviews Newsletter

4 – “Is there a doctor on board?”: Practical recommendations for managing in-flight medical emergencies – Canadian Medical Association Journal (free)

News release: Responding to inflight medical emergencies can be stressful for doctors – CMAJ News (free)

5 – Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial – European Heart Journal (free)

Commentaries: 3% rise in deaths for every 10 min delay in restoring blood flow after heart attack – OnMedica (free) AND Treatment Delay and Mortality in STEMI With Shock – American College of Cardiology, Latest in Cardiology (free)

6 – Interventions for paracetamol (acetaminophen) overdose – Cochrane Library (free)

Original article: Interventions for paracetamol (acetaminophen) overdose – Cochrane Library (link to abstract – $ for full-text)

7 – Richard Lehman’s journal review, 26 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

8 – FDA Safety Alert: Clarithromycin (Biaxin): Drug Safety Communication – Potential Increased Risk of Heart Problems or Death in Patients With Heart Disease (free)

Commentaries: FDA: Antibiotic Linked to Increased Risk of Death in Heart Disease Patients – MPR (free) AND FDA: Clarithromycin Risks Persist in Patients With CAD – TCTMD (free) FDA Alert: Clarithromycin Risky in Patients With Heart Disease – Medscape (free registration required)

9 – Idiopathic pulmonary fibrosis: pathogenesis and management – Respiratory Research (free)

10 – Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Pulmonary Embolism Rule-out Criteria non-inferior to usual care for patients at low-risk for pulmonary embolism – 2 Minute Medicine (free) AND EM Nerd-The Case of the Diagnostic Absurdity (free) AND Using PERC & Sending Home Pulmonary Emboli For Fun and Profit – Emergency Literature of Note (free)

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