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“Are we turning sudden cardiac death into a longer, winding path? Defibrillators can prevent sudden death but they also can take away the sudden-death option.” (via @RasoiniR see Tweet)

Meta-Analysis: Pharmacological Treatment of Arterial Hypertension in Children and Adolescents

3 Aug, 2018 | 02:54h | UTC

Pharmacological Treatment of Arterial Hypertension in Children and Adolescents: A Network Meta-Analysis – Hypertension (free)

Commentary: Pediatric hypertension: ACEi/ARBs look like the best choice – Univadis (free)

“According to the present analysis, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers could represent the best choice as antihypertensive treatment for pediatric hypertension. However, because of the paucity of available data for the other classes of antihypertensive drugs, definitive conclusions are not allowed and further randomized controlled trials are warranted.”

Study: Prevalence of Depression Among New Fathers

3 Aug, 2018 | 02:55h | UTC

Prevalence of Depression Among Fathers at the Pediatric Well-Child Care Visit – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: New dads need depression screening, too – Reuters (free) AND New Dads as Likely to Suffer From Depression as Moms, Study Suggests – Medscape (free registration required)

Fri, August 3 – 10 Stories of The Day!

3 Aug, 2018 | 00:22h | UTC

1 – National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the management of heart failure 2018 – The Medical Journal of Australia (free for 10 days)

2 – National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the diagnosis and management of atrial fibrillation 2018 – The Medical Journal of Australia (free for 10 days)

3 – Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics – Italian Journal of Pediatrics (free)

4 – The Top 10 Pulmonary Pearls for Primary Care Physicians – Mayo Clinic Proceedings (free for a limited period)

5 – Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence – Mayo Clinic Proceedings (free for a limited period)

Commentaries: Regular sauna users may have fewer chronic diseases – Reuters (free) AND Saunas Linked to Numerous Health Benefits – Medscape (free registration required) AND Frequent sauna bathing has many health benefits – Elsevier, via ScienceDaily (free)

6 – No proof that moderate drinking prevents dementia – NHS Choices (free)

See original study: Alcohol consumption and risk of dementia (free text, editorial and commentaries)

“”Middle aged drinking may reduce dementia risk, new study finds,” is the misleading and irresponsible headline in The Daily Telegraph.”

7 – Viewpoint: Lyme Disease in 2018: What Is New (and What Is Not) – JAMA (free for a limited period)

8 – ACG Clinical Guideline: Management of Crohn’s Disease in Adults – The American Journal of Gastroenterology (free)

Commentary: New Crohn Disease Management Guidelines: Top Five Takeaways – Medscape (free registration required)

9 – Obesity Increases the Duration of Influenza A Virus Shedding in Adults – The Journal of Infectious Diseases (free)

Commentaries: Study suggests obesity may increase flu spread – CIDRAP (free) AND Beyond Disease Severity: The Impact of Obesity on Influenza A Virus Shedding – The Journal of Infectious Diseases (free) AND Study suggests obesity may also impact flu transmission, not just severity of illness – Infectious Diseases Society of America, via EurekAlert (free) AND Obesity extends duration of influenza A virus shedding – NIH News (free)

10 – Increasing tolerance of hospital Enterococcus faecium to handwash alcohols – Science Translational Medicine (link to abstract – $ for full-text)

Commentaries: Study finds increased alcohol tolerance in common hospital pathogen – CIDRAP (free) AND Superbugs now also becoming resistant to alcohol disinfectants – Reuters (free) AND Some Bacteria Are Becoming ‘More Tolerant’ Of Hand Sanitizers, Study Finds – NPR (free)

“Researchers found that E faecium isolates collected in 2 Australian hospitals after 2009 were 10x more tolerant to alcohol than those collected before 2004, and that the date of isolation was a much better predictor of survival than the genotype” (via @CIDRAP_ASP see Tweet)

Wed, August 1 – 10 Stories of The Day!

1 Aug, 2018 | 00:01h | UTC

1 – Report: Capture the moment – Early initiation of breastfeeding: the best start for every newborn – World Health Organization (free)

News Release: 3 in 5 babies not breastfed in the first hour of life (free)

Commentaries: When it comes to breastfeeding, ‘timing is everything’ in saving newborn lives – UNICEF chief – UN News (free) AND 60% of babies ‘at risk due to breastfeeding delay after birth’ – The Guardian (free)

2 – Evidence Synopsis: Aspirin Plus Clopidogrel vs Aspirin Alone for Preventing Cardiovascular Events Among Patients at High Risk for Cardiovascular Events – JAMA (free for a limited period)

“Clopidogrel+ASA: Reduced risk for MI and ischemic stroke – Increased risk for major bleeding compared with aspirin alone. Combined therapy is NOT associated with lower mortality.” (via @ehlJAMA see Tweet)

3 – Risk factors associated with revision for prosthetic joint infection after hip replacement: a prospective observational cohort study – The Lancet Infectious Diseases (free)

Commentaries: Risk factors in septic revisions following total hip arthroplasty – The Lancet Infectious Diseases (free) AND Several factors associated with hip replacement revision due to prosthetic joint infection – ACP Internist Weekly (free)

4 – Choosing Wisely: Society for the Advancement of Blood Management: Five Things Physicians and Patients Should Question (free)

Commentary: Choosing Wisely: Five Anemia, Transfusion Practices to Avoid – Physician’s First Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

5 – Perspective: Europe Expanded the “No Elsevier Deal” Zone & This Could Change Everything – Hilda Bastian, in Absolutely Maybe Blog (free)

6 – Perspective: Assisted suicide is controversial, but palliative sedation is legal and offers peace – The Washington Post (free)

7 – Perspective: A Fear of Lawsuits Really Does Seem to Result in Extra Medical Tests – The New York Times (10 articles per month are free)

“Doctors are known for complaining about how the malpractice system adds costs. But it has been hard to prove, until now.”

8 – Review: Differential diagnosis, investigation and therapy of bilateral adrenal incidentalomas – European Journal of Endocrinology (free)

9 – Antithrombotic Therapy in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Undergoing Percutaneous Coronary Intervention – Circulation (free)

Commentary: New Consensus Statement: NOAC and Clopidogrel for Most A-fib Patients Treated With PCI – TCTMD (free)

10 – Association of Statin Exposure With Histologically Confirmed Idiopathic Inflammatory Myositis in an Australian Population – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Rare Inflammatory Muscle Inflammation Increased With Statin Exposure – MedicalResearch.com (free) AND Statin Associated with an Increase in Inflammatory Myopathy – RheumNow (free) AND Statin use may increase risk for idiopathic inflammatory myositis – Healio (free registration required)

Cohort Study: Alcohol Consumption and Risk of Dementia

3 Aug, 2018 | 00:18h | UTC

Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study – The BMJ (free)

Editorial: Relation between alcohol consumption in midlife and dementia in late life (free)

Commentaries: Expert reaction to long term abstinence and heavy drinking associated with dementia – Science Media Centre (free) AND Middle-aged non-drinkers may have ‘higher risk’ of dementia – The Guardian (free)

Study: Medications that Reduce Emergency Hospital Admissions

27 Jul, 2018 | 01:15h | UTC

Medications that reduce emergency hospital admissions: an overview of systematic reviews and prioritisation of treatments – BMC Medicine (free) (via @OxPrimaryCare)

Commentary: The eleven best medications for reducing pressure on emergency care services – University of Oxford (free)

Thu, August 2 – 10 Stories of The Day!

2 Aug, 2018 | 03:15h | UTC

1 – Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults – New England Journal of Medicine (free)

Quick Take Video Summary: Rifampin or Isoniazid for Latent Tuberculosis (free)

Commentaries: New tuberculosis treatment could help tackle global epidemic – The Guardian (free) AND Rifampin Promising for Latent TB in Phase 3 Trials – Medscape (free registration required)

2 – Clinical Report: Physician’s Role in Coordinating Care of Hospitalized Children – American Academy of Pediatrics (free)

News Release: Report guides pediatricians in improving care coordination of hospitalized children – AAP News (free)

3 – Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Validation of ESC 0/1-h Algorithm for MI – American College of Cardiology (free) AND ESC Algorithm Safely Rules Out NSTEMI, But Caution May Be Warranted in the US – TCTMD (free)

4 – Prospective Randomized Evaluation of Preoperative Angiotensin-Converting Enzyme Inhibition (PREOP-ACEI) – Journal of Hospital Medicine (free)

Commentary: Omitting ACE inhibitor before surgery reduced intraoperative hypotension, study finds – ACP Hospitalist (free)

5 – Cluster of presumptive Ebola cases in North Kivu in the Democratic Republic of the Congo – World Health Organization (free)

Commentaries: New Ebola outbreak declared in DRC a week after earlier one declared over – STAT (free) AND DRC confirms new Ebola cluster days after outbreak declared over – CIDRAP (free) AND Congo declares new Ebola outbreak in eastern province – Reuters (free) AND Deadly Ebola Strikes Anew, a Week After Previous Outbreak Was Extinguished – The New York Times (10 articles per month are free)

6 – Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline – Neurology (link to abstract – $ for full-text)

Commentary: People who frequently feel dizzy on standing ‘at future risk of dementia’ – NHS Choices (free)

7 – A Consensus Statement on acromegaly therapeutic outcomes – Nature Reviews Endocrinology (free)

Commentary: Consensus statement: optimizing acromegaly management – Univadis (free registration required)

8 – Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study – The BMJ (free)

Editorial: Relation between alcohol consumption in midlife and dementia in late life (free)

Commentaries: Expert reaction to long term abstinence and heavy drinking associated with dementia – Science Media Centre (free) AND Middle-aged non-drinkers may have ‘higher risk’ of dementia – The Guardian (free)

9 – Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels: A Meta-analysis – JAMA Cardiology (free for a limited period)

Author Interview: Efficacy and Safety of Further Lowering of LDL Cholesterol in Patients Starting With Very Low Levels (free)

10 – MRI-defined White Matter Microstructural Alteration Associated with Soccer Heading Is More Extensive in Women than Men – Radiology (free for a limited period)

Commentaries: Soccer Heading May Be Riskier for Female Players – RSNA (free) AND Heading May Be Riskier For Female Soccer Players Than Males – NPR (free)

Mon, July 30 – 10 Stories of The Day!

30 Jul, 2018 | 00:05h | UTC

1 – Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection – World Health Organization (free)

See also: World Hepatitis Day (28 July 2018) – World Health Organization (free manuals, guidelines and campaign resources)

2 – Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

3 – Analysis of clinical benefit, harms, and cost-effectiveness of screening women for abdominal aortic aneurysm – The Lancet (free)

Invited Commentary: Should we screen women for abdominal aortic aneurysm? – The Lancet (free)

4 – Esomeprazole and aspirin in Barrett’s oesophagus (AspECT): a randomised factorial trial – The Lancet (free)

Invited Commentary: Should aspirin and PPIs be recommended for patients with Barrett’s oesophagus? – The Lancet (free)

5 – Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Treating Depression May Improve Cardiac Outcomes, Research Finds – AJMC (free) AND Treating depression may prevent repeat heart attack, study says – UPI (free)

6 – Opinion: How Do You Want to Die? – The New York Times (10 articles per month are free)

“Are we turning sudden cardiac death into a longer, winding path? Defibrillators can prevent sudden death but they also can take away the sudden-death option.” (via @RasoiniR see Tweet)

7 – Treatment for HIV-associated cryptococcal meningitis – Cochrane Library (free)

Summary: Treatment for HIV-associated cryptococcal meningitis – Cochrane Library (free)

8 – Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Protease inhibitors may increase risk of death in people with HIV and heart failure – OnMedica (free) AND Protease inhibitors may increase risk of death in people with HIV and heart failure – Massachusetts General Hospital, via EurekAlert (free)

9 – Prevalence of Depression Among Fathers at the Pediatric Well-Child Care Visit – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: New dads need depression screening, too – Reuters (free) AND New Dads as Likely to Suffer From Depression as Moms, Study Suggests – Medscape (free registration required)

10 – Pharmacological Treatment of Arterial Hypertension in Children and Adolescents: A Network Meta-Analysis – Hypertension (free)

Commentary: Pediatric hypertension: ACEi/ARBs look like the best choice – Univadis (free)

Tue, July 31 – 10 Stories of The Day!

31 Jul, 2018 | 00:01h | UTC

1 – Low-Calorie Sweetened Beverages and Cardiometabolic Health: A Science Advisory From the American Heart Association – Circulation (free PDF)

News Release: Limit low-calorie sodas and drinks, and stick to water instead, researchers advise (free)

2 – Health Collection: Strategic review of child health – The BMJ (free articles)

“About 5.6m children died before their 5th birthday in 2016. The new global child health collection launching today explores how we can work together to safeguard the health and wellbeing of children across the world.”

3 – Guideline: PSA-Based Prostate Cancer Screening in Men Aged 55-69 – American Academy of Family Physicians (free)

News Release: AAFP Updates Its PSA Screening Recommendation (free)

Related Guidelines with conflicting viewpoints: American Cancer Society Guideline for the Early Detection of Prostate Cancer (free) AND USPSTF Recommendation Statement: Screening for Prostate Cancer (free guideline, editorial and commentaries)

4 – The association between suicide deaths and putatively harmful and protective factors in media reports – Canadian Medical Association Journal (free) (via @IrfanDhalla)

Invited Commentary: Responsible reporting to prevent suicide contagion (free for one week)

5 – Richard Lehman’s journal reviews, 30 July 2018 – The BMJ Opinion (free)

Richard Lehman’s final review of the latest research in the top medical journals.

6 – Viewpoint: Gaps in the Clinical Management of Influenza: A Century Since the 1918 Pandemic – JAMA (free)

7 – Counseling in Pediatric Populations at Risk for Infertility and/or Sexual Function Concerns – Pediatrics (free)

News Release: How and when to counsel at-risk patients about fertility preservation, sexual function – AAP News (free)

8 – Drinking or Smoking While Breastfeeding and Later Cognition in Children – Pediatrics (free)

Commentaries: Study: Drinking while breastfeeding linked with children’s reasoning deficits – AAP News (free) AND Alcohol in breast milk may lead to lower cognition in kids, study finds – CNN (free) AND Fuel For Mommy Shaming: Breastfeeding And Alcohol Study Deeply Misleading – Forbes (free)