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Study: Clinical Chemistry Score to Identify Patients at Low or High Risk for Myocardial Infarction or Death

23 Aug, 2018 | 22:36h | UTC

Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department – Canadian Medical Association Journal (free)

Commentaries: Simple score to diagnose heart attacks is safer, faster than current methods – McMaster University (free) AND Clinical Chemistry Score Helps Rule Out Diagnosis of Heart Attack – MedicalResearch.com (free)

 


Randomized Trial: Oral Steroids for Resolution of Otitis Media with Effusion in Children

23 Aug, 2018 | 22:36h | UTC

Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial – The Lancet (free)

Invited commentary: Helping children with hearing loss from otitis media with effusion – The Lancet (free)

“Short-course oral prednisolone is not an effective treatment for most children aged 2–8 years with persistent otitis media with effusion but is well tolerated—findings from OSTRICH, the first placebo-controlled trial” (via @TheLancet see Tweet)

 


Report: E-Cigarettes

23 Aug, 2018 | 22:33h | UTC

Report: E-Cigarettes – House of Commons Science and Technology Committee (free PDF)

Commentaries: Stop treating e-cigs like conventional cigarettes, MPs tell NHS – OnMedica (free) AND E-cigarettes can be key weapon against smoking, say MPs – BBC (free)

See also: related guidelines, reports and commentaries on e-cigarettes (all free)

 


Study: Association Between Electronic Cigarette Use and Myocardial Infarction

23 Aug, 2018 | 22:35h | UTC

Association Between Electronic Cigarette Use and Myocardial Infarction – American Journal of Preventive Medicine (free for a limited period)

Commentary: Risk of heart attacks is double for daily e-cigarette users – University of California – San Francisco, via ScienceDaily (free)

“New analysis shows five-fold risk for people who use both cigarettes and e-cigarettes daily” (from ScienceDaily)

 


Perspective: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It

23 Aug, 2018 | 22:32h | UTC

Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It – The New York Times (10 articles per month are free) (via @CarlosdelRio7 see Tweet)

Related commentaries: Vitamin D Screening and Supplementation in Primary Care: Time to Curb Our Enthusiasm – American Family Physician (free) AND Your vitamin D tests and supplements are probably a waste of money – VOX (free) AND Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)

Related Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (free)

“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk” (from NICE Guideline)

 


Meta-Analysis: Corticosteroids in Sepsis

23 Aug, 2018 | 22:32h | UTC

Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis – Critical Care Medicine (free)

Related: Corticosteroid therapy for sepsis: a clinical practice guideline – The BMJ (free)

 


Review: Intravenous Fluid Therapy in Critically ill Adults

23 Aug, 2018 | 22:30h | UTC

Intravenous fluid therapy in critically ill adults – Nature Reviews Nephrology (free for a limited period) (via @CritCareReviews)

 


Too Much Medicine: A Small Medical Conference with a Big Impact

23 Aug, 2018 | 22:31h | UTC

Too Much Medicine: A small medical conference with a big impact – HealthNewsReview (free)

 


Cohort Study: Dietary Carbohydrate Intake and Mortality

23 Aug, 2018 | 22:25h | UTC

Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis – The Lancet Public Health (free)

Commentaries: Evolving evidence about diet and health – The Lancet Public Health (free) AND Expert reaction to study looking at carbohydrate intake and health – Science Media Centre (free) AND Moderate carbohydrate intake may be best for health, study suggests – The Lancet, via ScienceDaily (free) AND Low-carb diets could shorten life, study suggests – BBC (free)

 


Review: Airway and Ventilation Management During CPR and After Successful Resuscitation

23 Aug, 2018 | 22:27h | UTC

Airway and ventilation management during cardiopulmonary resuscitation and after successful resuscitation – Critical Care (free)

 


WHO: Situation of the Ebola Outbreak in the Democratic Republic of the Congo

23 Aug, 2018 | 22:27h | UTC

Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentaries: WHO Expects Ebola To Spread In Congo In Areas Too Dangerous To Send Workers – NPR (free) AND Health worker among 5 new cases in DRC Ebola outbreak – CIDRAP (free) AND Militia threat hampers Ebola fight in Congo as disease kills 47 – Reuters (free)

 


Study: Association of Body Mass Index With Blood Pressure

23 Aug, 2018 | 22:26h | UTC

Association of Body Mass Index With Blood Pressure Among 1.7 Million Chinese Adults – JAMA Network Open (free)

Commentary: As body mass index increases, blood pressure may as well – Yale University (free)

 


Wed, August 22 – 10 Stories of The Day!

22 Aug, 2018 | 00:01h | UTC

 

1 – Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Related articles: Screening for Cervical Cancer With High-Risk Human Papillomavirus Testing: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA (free) AND Screening for Cervical Cancer in Primary Care: A Decision Analysis for the US Preventive Services Task Force – JAMA (free)

Editorials: Screening for Cervical Cancer: New Tools and New Opportunities (free for a limited period) AND Cervical Cancer Screening—Moving From the Value of Evidence to the Evidence of Value (free for a limited period)

Author Interview: USPSTF Recommendation: Screening for Cervical Cancer (free)

Final Update Summary: Cervical Cancer: Screening – US Preventive Service Task Force (free)

Commentaries: Cervical cancer screening without Pap test OK for some women – Reuters (free) AND For Cervical Cancer Screening, Women Over 30 Can Now Choose The HPV Test Only – NPR (free) AND Annual Pap Test a ‘Thing of the Past?’ – Florida Atlantic University (free)

 

2 – Joint Consensus Document: Management of antithrombotic therapy in AF patients presenting with ACS and/or undergoing PCI – European Heart Journal (free)

 

3 – CSI position statement on management of heart failure in India – Indian Heart Journal (free)

 

4 – 2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation – World Journal of Emergency Surgery (free)

 

5 – The Japanese Clinical Practice Guideline for acute kidney injury 2016 – Journal of Intensive Care (free)

 

6 – Our first year together – World Health Organization (free)

“Delighted to share my first annual letter as WHO Director-General. It outlines our major achievements over the past year and what I believe are the keys to achieving #HealthForAll. I’m proud of everything we’ve achieved – but we’re just getting started!” (via @DrTedros see Tweet)

 

7 – How smartphones are becoming a weapon in the global fight against tuberculosis – STAT (free)

 

8 – Long-Term Association of Low-Density Lipoprotein Cholesterol With Cardiovascular Mortality in Individuals at Low 10-Year Risk of Atherosclerotic Cardiovascular Disease – Circulation (free)

Commentaries: ‘Bad’ cholesterol can be deadly in otherwise healthy people – AHA News (free) AND LDL >160 Tied to Increased Mortality in Low-Risk Patients – Physician’s First Watch (free) AND Study: Elevated LDL, non-HDL increase CVD mortality risk in young, healthy individuals – Cardiovascular Business (free) AND Moderate ‘bad cholesterol’ levels tied to early death for healthy people – Reuters (free)

 

9 – Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials – Critical Care (free)

Commentary: Procalcitonin guidance linked to improved sepsis survival – Univadis (free registration required)

 

10 – Pregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Pregabalin may increase the risk of death when coprescribed with opioids – 2 Minute Medicine (free) AND Pregabalin Linked To Increased Risk for Opioid-Related Deaths – MedicalResearch.com (free) AND Anticonvulsant With Opioids Tied To Higher Mortality – MedPage Today (free registration required)

 


Tue, August 21 – 10 Stories of The Day!

21 Aug, 2018 | 01:55h | UTC

 

1 – Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association – Circulation (free PDF)

AHA News Release: Chagas disease, caused by a parasite, has spread outside of Latin America and carries a high risk of heart disease (free)

Top Ten Things to Know: Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management (free PDF)

 

2 – Clinical Report: The Power of Play: A Pediatric Role in Enhancing Development in Young Children – Pediatrics (free)

News Release: Want Creative, Curious, Healthier Children with 21st Century Skills? Let Them Play – American Academy of Pediatrics (free)

Commentary: It’s come to this: A checkup with the pediatrician may soon include a prescription for play – Los Angeles Times (free) AND Let Kids Play – The New York Times (10 articles per month are free) AND AAP Report Highlights Importance of Children’s Play for Development – Journal Watch (free)

 

3 – Rapid Communication: Key changes to treatment of multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) – World Health Organization (free PDF)

News Release: WHO announces landmark changes in MDR-TB treatment regimens (free)

Commentary: WHO revises MDR-TB treatment with focus on oral drugs – CIDRAP (free)

 

4 – Measles cases hit record high in the European Region – World Health Organization (free)

Commentaries: Measles cases hit record high in Europe – BBC (free) AND Expert reaction to measles cases in Europe – Science Media Centre (free) AND Low MMR uptake blamed for surge in measles cases across Europe – The Guardian (free) AND Measles cases reach record high in Europe – CNN (free)

 

5 – Assessment of the Safety of Discharging Select Patients Directly Home From the Intensive Care Unit: A Multicenter Population-Based Cohort Study – JAMA Internal Medicine (free for a limited period)

Invited Commentary: The Complexity and Challenges of Intensive Care Unit Admissions and Discharges: Similarities With All Hospitalized Patients – JAMA Internal Medicine (free for a limited period)

 

6 – Clinical Update: Management of Groin Hernias in Adults—2018 – JAMA (free for a limited period)

 

7 – Perspective: This Drug Is Safe and Effective. Wait. Compared With What? – The New York Times (10 articles per month are free)

 

8 – Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years – JAMA Pediatrics (free)

“Rotavirus-associated mortality has decreased by 48.2% in children under 5 between 1990 and 2016” (via @IHME_UW see Tweet with infographics)

 

9 – Optimising first- and second-line treatment strategies for untreated major depressive disorder — the SUND study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial – BMC Medicine (free)

 

10 – Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department – Canadian Medical Association Journal (free)

Commentaries: Simple score to diagnose heart attacks is safer, faster than current methods – McMaster University (free) AND Clinical Chemistry Score Helps Rule Out Diagnosis of Heart Attack – MedicalResearch.com (free)

 


Mon, August 20 – 10 Stories of The Day!

20 Aug, 2018 | 00:01h | UTC

 

1 – Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial – The Lancet (free)

Invited commentary: Helping children with hearing loss from otitis media with effusion – The Lancet (free)

“Short-course oral prednisolone is not an effective treatment for most children aged 2–8 years with persistent otitis media with effusion but is well tolerated—findings from OSTRICH, the first placebo-controlled trial” (via @TheLancet see Tweet)

 

2 – Report: E-Cigarettes – House of Commons Science and Technology Committee (free PDF)

Commentaries: Stop treating e-cigs like conventional cigarettes, MPs tell NHS – OnMedica (free) AND E-cigarettes can be key weapon against smoking, say MPs – BBC (free)

See also: related guidelines, reports and commentaries on e-cigarettes (all free)

 

3 – Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis – Critical Care Medicine (free)

Related: Corticosteroid therapy for sepsis: a clinical practice guideline – The BMJ (free)

 

4 – Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It – The New York Times (10 articles per month are free) (via @CarlosdelRio7 see Tweet)

Related commentaries: Vitamin D Screening and Supplementation in Primary Care: Time to Curb Our Enthusiasm – American Family Physician (free) AND Your vitamin D tests and supplements are probably a waste of money – VOX (free) AND Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)

Related Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (free)

“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk” (from NICE Guideline)

 

5 – Too Much Medicine: A small medical conference with a big impact – HealthNewsReview (free)

 

6 – Review: Intravenous fluid therapy in critically ill adults – Nature Reviews Nephrology (free for a limited period) (via @CritCareReviews)

 

7 – Review: Airway and ventilation management during cardiopulmonary resuscitation and after successful resuscitation – Critical Care (free)

 

8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentaries: WHO Expects Ebola To Spread In Congo In Areas Too Dangerous To Send Workers – NPR (free) AND Health worker among 5 new cases in DRC Ebola outbreak – CIDRAP (free) AND Militia threat hampers Ebola fight in Congo as disease kills 47 – Reuters (free)

 

9 – Association of Body Mass Index With Blood Pressure Among 1.7 Million Chinese Adults – JAMA Network Open (free)

Commentary: As body mass index increases, blood pressure may as well – Yale University (free)

 

10 – Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis – The Lancet Public Health (free)

Commentaries: Evolving evidence about diet and health – The Lancet Public Health (free) AND Expert reaction to study looking at carbohydrate intake and health – Science Media Centre (free) AND Moderate carbohydrate intake may be best for health, study suggests – The Lancet, via ScienceDaily (free) AND Low-carb diets could shorten life, study suggests – BBC (free)

 


AHA/ACC Guideline: Management of Adults with Congenital Heart Disease

17 Aug, 2018 | 02:37h | UTC

2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease (free PDF)

News Release: Societies Release Updated Guideline for Treating Adult Congenital Heart Disease Patients (free)

Key Points to Remember: 2018 AHA/ACC Guideline for Adults With Congenital Heart Disease – American College of Cardiology (free)

 


Thu, August 23 – 10 Stories of The Day!

23 Aug, 2018 | 00:12h | UTC

 

1 – Podcast: #109: Things We Do For No Reason: A High Value Episode – The Curbsiders (free audio and summary)

Related Series: Choosing Wisely: Things We Do For No Reason – Journal of Hospital Medicine (some free articles)

 

2 – Perspective: Outbreaks in a Rapidly Changing Central Africa — Lessons from Ebola – New England Journal of Medicine (free)

Related: Experimental Ebola treatments OK’d in DRC as cases top 100 – CIDRAP (free) AND Congo approves more experimental Ebola treatments as cases rise – Reuters (free)

 

3 – Sport Specialization and Risk of Overuse Injuries: A Systematic Review With Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentary: Sport specialization tied to injuries in kids and teens – Reuters (free)

 

4 – Asthma and COPD Overlap in Women: Incidence and Risk Factors – Annals of the American Thoracic Society (link to abstract – $ for full-text)

Commentaries: More than 40 percent of women with asthma may develop COPD, but risk may be reduced – Annals of Thoracic Society (free) AND Four in 10 women with asthma may develop COPD – Reuters (free) AND Four in 10 women with asthma may develop COPD – OnMedica (free)

 

5 – Perspective: Exploring the Relationship Between Depression and Dementia – JAMA (free for a limited period)

 

6 – Association Between Electronic Cigarette Use and Myocardial Infarction – American Journal of Preventive Medicine (free for a limited period)

Commentary: Risk of heart attacks is double for daily e-cigarette users – University of California – San Francisco, via ScienceDaily (free)

“New analysis shows five-fold risk for people who use both cigarettes and e-cigarettes daily”

 

7 – Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) – Cochrane Library (free for a limited period)

Summary: Phosphate binders to prevent complications of chronic kidney disease – Cochrane Library (free)

 

8 – Extended antibiotic infusions could save lives: Here’s how to do it – PulmCCM (free)

Related Research: Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams (free)

“The simplest (and cheapest) technique is simply to reduce the time between doses.”

 

9 – Seven days of antibiotics were as good as 14 for gram-negative bacteremia – PulmCCM (free)

Related Commentary: Seven-day antibiotic course delivers similar outcomes to 14-days for Gram-negative bacteraemia – European Society of Clinical Microbiology and Infectious Diseases, via EurekAlert (free)

“It’s important to note that source control was believed to be achieved in all enrolled patients. If source control cannot be achieved (e.g., an abscess, or an infected heart valve or indwelling catheter that cannot safely be removed), prolonged antibiotic courses are often advisable.”

 

10 – Breastfeeding History and Risk of Stroke Among Parous Postmenopausal Women in the Women’s Health Initiative – Journal of the American Heart Association (free)

Commentaries: Breastfeeding linked to lower stroke risk – Reuters (free) AND Breastfeeding may help protect mothers against stroke – AHA News (free)

“…ultimately, the study is observational, which means that it can only prove that breastfeeding is associated with lower risk of stroke as opposed to being the cause of the lowered risk.” (from Reuters)

 


Systematic Review: Endovascular Coiling vs. Neurosurgical Clipping for Aneurysmal Subarachnoid Hemorrhage

17 Aug, 2018 | 02:36h | UTC

Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage – Cochrane Library (free for a limited period)

Summary: Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage – Cochrane Library (free)

 


Cohort Studies: Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality

17 Aug, 2018 | 02:35h | UTC

Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality – The New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Weight gain after smoking cessation linked with increased short-term diabetes risk – Harvard T.H. Chan School of Public Health (free) AND Weight gain temporarily hikes diabetes risk when smokers quit – Reuters (free) AND Smokers Are Better Off After They Quit Even if They Gain Weight – Physician’s First Watch (free)

 


Randomized Trial: Letters with Peer Comparison May Reduce Overprescribing

17 Aug, 2018 | 02:34h | UTC

Effect of Peer Comparison Letters for High-Volume Primary Care Prescribers of Quetiapine in Older and Disabled Adults: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Behavioral nudges lead to striking drop in prescriptions of potent antipsychotic – Columbia University’s Mailman School of Public Health, via ScienceDaily (free) AND Study Reduces Over-prescription of Antipsychotics in Older Adults – Mad in America (free) AND ‘Dear Doctor’ Letters Use Peer Pressure, Government Warning To Stop Overprescribing – NPR (free) AND Peer Pressure Tactic Successfully Curbs Overprescribing – Medscape (free registration required)

 


Guideline: Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in the ICU

17 Aug, 2018 | 02:32h | UTC

Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU – Critical Care Medicine (free) (via @Abraham_RMI)

 


Study: Association of Compensation to Physicians From Industry and Self-declared Conflict of Interest

17 Aug, 2018 | 02:30h | UTC

Association of Compensation From the Surgical and Medical Device Industry to Physicians and Self-declared Conflict of Interest – JAMA Surgery (free for a limited period)

Author Interview: Association of Compensation to Physicians From Industry and Self-declared Conflict of Interest (free)

Commentaries: Safeguarding Against Conflicts of Interest in the Surgical Literature – JAMA Surgery (free for a limited period) AND Financial Ties That Bind: Studies Often Fall Short On Conflict-Of-Interest Disclosures – Kaiser Health News (free)

 


Study: Changes in Midlife Death Rates Across Racial and Ethnic Groups in the United States

17 Aug, 2018 | 02:29h | UTC

Changes in midlife death rates across racial and ethnic groups in the United States: systematic analysis of vital statistics – The BMJ (free)

Infographic:  Why is US Life Expectancy Falling Behind? (free PDF)

Commentary: Life expectancy drops in the US and the UK, rises in Australia, a new study finds – CNN (free)

 


Study: Trends in Life Expectancy Across High Income Countries

17 Aug, 2018 | 02:29h | UTC

Recent trends in life expectancy across high income countries: retrospective observational study – The BMJ (free)

Editorial: Reversals in life expectancy in high income countries? (free for a limited period)

Commentaries: Life Expectancy Declining Across High Income Countries – Eurasia Review (free) AND Australians living longer but life expectancy dips in US and UK – The Guardian (free) AND UK life expectancy drops while other western countries improve – NHS Choices (free)

 


Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere

17 Aug, 2018 | 02:28h | UTC

Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD (free)

Related: Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free) AND Rise of the Tweetorial – Precious Bodily Fluids (free) AND Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free) AND University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

 


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