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Guideline Summary: 2018 IDSA Guidelines for Clostridium Difficile Infection

5 Oct, 2018 | 01:24h | UTC

2018 IDSA Guidelines for Clostridium Difficile Infection: fecal transplant gets its moment in the sun – PulmCCM (free)

Study: Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

5 Oct, 2018 | 01:25h | UTC

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing – New England Journal of Medicine (free)

Editorial: The Coming of Age of Drug-Susceptibility Testing for Tuberculosis (free)

Commentaries: Study heralds genetic era of TB drug susceptibility testing – CIDRAP (free) AND UK-led study marks shift towards genetic era in tackling TB – NIHR Oxford Biomedical Research Centre (free)

Fri, October 5 – 10 Stories of The Day!

5 Oct, 2018 | 00:01h | UTC

1 – Acceleration of BMI in Early Childhood and Risk of Sustained Obesity – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Childhood BMI Acceleration and Sustained Obesity (free)

Commentary: BMI in Early Childhood and Sustained Obesity – American College of Cardiology (free)

2 – Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: The Lancet Diabetes & Endocrinology: Vitamin D supplementation in adults does not prevent fractures, falls or improve bone mineral density – The Lancet (free) AND Vitamin D supplements don’t help bone health, major study concludes – The Guardian (free) AND Millions of Americans take vitamin D. Most should just stop – VOX (free)

Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline) AND Vitamin D Not Linked to Fracture Risk (free study and commentaries)

3 – Clinical Update: Immune Checkpoint Inhibitor Toxicity in 2018 – JAMA (free for a limited period)

4 – Perspective: Given Their Potential for Harm, It’s Time to Focus on the Safety of Supplements – JAMA (free) (via @NUNESDOC)

“About 23 000 visits to emergency departments each year can be attributed to adverse events from dietary supplements.”

5 – Perspective: When Conventional Wisdom Is Put on Trial – UNDark (free) (via @EricTopol)

“The author of “Randomistas” shows how randomized trials have overturned many popular findings, from hormone therapy to the benefits of multivitamins.”

6 – Report: The future of healthcare – The Economist (free PDF)

7 – Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Weight loss drug shows positive effect on diabetes – Brigham and Women’s Hospital (free) AND Weight Loss Drug Helped Prevent Diabetes in Overweight People – MedPage Today (free registration required)

Related Article: Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients (link to abstract and commentaries)

8 – Collaboration between academics and industry in clinical trials: cross sectional study of publications and survey of lead academic authors – The BMJ (free)

Commentaries: Shining a light on industry collaboration – The BMJ Opinion (free) AND Industry funders involved in most aspects of funded trials – OnMedica (free)

9 – Perspective: New Tools in the Ebola Arsenal – New England Journal of Medicine (free)

10 – Prescribed Exercise With Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)

Commentaries: Adding Exercise to Compression Improves Outcomes in Venous Leg Ulcers – Physcian’s First Watch (free) AND Compressions May Remedy Venous Leg Ulcers – MedPage Today (free)

Wed, October 3 – 10 Stories of The Day!

3 Oct, 2018 | 00:35h | UTC

1 – Ten Principles for More Conservative, Care-Full Diagnosis – Annals of Internal Medicine (free) (via @EricTopol)

2 – Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine (free)

3 – Effect of Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears: The ESCAPE Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: PT an Alternative to Surgery for Some Meniscal Tears – Physician’s First Watch (free)

Related: Adverse Outcomes After Arthroscopic Partial Meniscectomy (free study, commentary and guideline on the subject)

“Our Dutch multi center RCT demonstrates noninferiority of physical therapy compared with early surgery with arthroscopic partial meniscectomy for improving self-reported knee function in patients with nonobstructive meniscal tears.” (via @RudolfPoolman see Tweet)

4 – Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Most Patients With Subclinical Hypothyroidism May Not Require Thyroid Medication – MedicalResearch.com (free) AND Hormone Tx May Not Benefit Subclinical Hypothyroidism – MedPage Today (free registration required) AND Treating Subclinical Hypothyroidism Is of Little Benefit – Medscape (free registration required)

5 – A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? – Addictive Behaviours (free PDF)

Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)

Related: Antidepressant Withdrawal Syndrome (free review and NYT article)

6 – Association is not causation: treatment effects cannot be estimated from observational data in heart failure – European Heart Journal (free)

7 – Fracture Prevention with Zoledronate in Older Women with Osteopenia – New England Journal of Medicine (free)

Editorial: A Not-So-New Treatment for Old Bones (free)

Commentary: Study Suggests More Older Women May Benefit From Bone Drugs – The Associated Press (free)

8 – Review: Neuro-Ophthalmology at the bedside: A clinical guide – Journal of Neurosciences in Rural Practice (free)

9 – Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Low-dose antidepressants ease back pain – Australian Hospital + Healthcare Bulletin (free) AND Antidepressant Amitriptyline Might Help Ease Low Back Pain – Physician’s First Watch (free)

10 – Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction (DAPT-STEMI): randomised, multicentre, non-inferiority trial – The BMJ (free)

Related Research: 6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (link to abstract and commentaries)

In this study, DAPT for 6 months was non-inferior to DAPT for 12 months after drug-eluting stent implantation in ST-elevation myocardial infarction.

Thu, October 4 – 10 Stories of The Day!

4 Oct, 2018 | 00:01h | UTC

1 – NICE Guideline: Renal replacement therapy and conservative management – National Institute for Health and Care Excellence (free)

2 – The projected timeframe until cervical cancer elimination in Australia: a modelling study – The Lancet Public Health (free)

Commentaries: Modelling cervical cancer elimination – The Lancet Public Health (free) AND Australia on track to wipe out cervical cancer within 20 years – The Guardian (free) AND In Australia, Cervical Cancer Could Soon Be Eliminated – The New York Times (10 articles per month are free)

3 – Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Invited Commentary: The burden of Parkinson’s disease: a worldwide perspective (free)

“In 2016, 6·1 million people worldwide had Parkinson’s disease, 2·9 million (48%) women & 3·2 million (52%) men; the increase in burden since 1990 was not exclusively explained by an increasing number of older people” (via @TheLancet see Tweet)

4 – Guidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS^®) Society Recommendations – World Journal of Surgery (free for a limited period)

5 – Recommendations for the use of Electrophysiological Study: Update 2018 – Helenic Journal of Cardiology (free)

6 – Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline – Journal of Clinical Endocrinology and Metabolism (free PDF)

News Release: Managing congenital adrenal hyperplasia requires shared decisions among patients, families, and heal – The Endocrine Society (free)

7 – Evaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology: A Systematic Review and Quantitative Analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Health-related quality of life overlooked in cancer drug studies – McMaster University (free) AND Investigators Question the Use of PFS as a Surrogate End Point – Cancer Therapy Advisor (free) AND Preventing tumor spread may not improve quality of life – Reuters (free) AND Research: Consider quality of life when evaluating cancer drug studies – UPI (free)

8 – Committee Opinion: Well-Woman Visit – American College of Obstetrics and Gynecology (free)

News Release: ACOG and WPSI Release Materials to Support Women’s Preventive Care at Every Life Stage (free)

Commentary: ACOG Stresses Role of Ob/Gyns in Preventive Care For Women – Medscape (free registration required)

9 – Two antiplatelet drugs may prevent further strokes but increase major bleeds – NIHR Signal (free)

Original Article: Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (link to abstract – $ for full-text)

10 – A Population-Based Analysis of the Relationship Between Substance Use and Adolescent Cognitive Development – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Teen cannabis use is not without risk to cognitive development – Université de Montréal (free) AND Cannabis ‘more harmful than alcohol’ for teen brains – BBC (free)

Mon, October 1 – 10 Stories of The Day!

1 Oct, 2018 | 00:01h | UTC

1 – WHO launches SAFER alcohol control initiative to prevent and reduce alcohol-related death and disability – World Health Organization (free)

See also: SAFER High Impact Strategies (free)

Related: WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries)

2 – Guideline: Placenta Praevia and Placenta Accreta: Diagnosis and Management – British Journal of Obstetrics and Gynaecology (free)

3 – Guideline: Vasa Praevia: Diagnosis and Management – British Journal of Obstetrics and Gynaecology (free)

4 – Video: KHN Conversation on Overtreatment – Kaiser Health News (free)

Commentary: Changing Healthcare’s Culture of Overtreatment a Challenge – MedPage Today (free registration required)

Related KHN Series: Treatment Overkill (free articles)

5 – WCLC 2018: NELSON Study: CT Screening for Early Lung Cancer Reduces Lung Cancer Mortality – The ASCO Post (free)

6 – Perspective: More Evidence That Nutrition Studies Don’t Always Add Up – The New York Times (10 articles per month are free)

7 – Podcast: #116 Geriatric Psychiatry: Sleep, Dementia, and Behavioral Disturbances – Curbsiders Internal Medicine Podcast (free)

Related Podcast: #115 Geriatric Depression – The Curbsiders Internal Medicine Podcast (free)

8 – Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials – Journal of the American Heart Association (free)

Commentary: Coenzyme Q10 reduces statin-induced myopathy symptoms – Univadis (free registration required)

9 – Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing – New England Journal of Medicine (free)

Editorial: The Coming of Age of Drug-Susceptibility Testing for Tuberculosis (free)

Commentaries: Study heralds genetic era of TB drug susceptibility testing – CIDRAP (free) AND UK-led study marks shift towards genetic era in tackling TB – NIHR Oxford Biomedical Research Centre (free)

10 – 2018 IDSA Guidelines for Clostridium Difficile Infection: fecal transplant gets its moment in the sun – PulmCCM (free)

Tue, October 2 – 10 Stories of The Day!

2 Oct, 2018 | 00:01h | UTC

1 – Press Release: The Nobel Prize in Physiology or Medicine 2018 – The Nobel Prize (free)

Commentaries: Cancer immunologists scoop medicine Nobel prize – Nature (free) AND Nobel Prize in medicine awarded to two cancer researchers for immune system breakthrough – STAT (free) AND 2018 Nobel Prize in Medicine Awarded to 2 Cancer Immunotherapy Researchers – The New York Times (10 articles per month are free)

2 – Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Editorial: Drinking More Water for Prevention of Recurrent Cystitis (free)

Commentaries: Drinking more water reduces bladder infections in women – UT Southwestern Medical Center (free) AND Drinking more water linked to fewer bladder infections in women – UPI (free)

3 – Report: Taking action on childhood obesity report – World Health Organization (free PDF) (via @equitylist)

4 – Supplement: Practical guide for allergy and immunology in Canada 2018 – Allergy, Asthma & Clinical Immunology (free reviews)

– Homepage

– Introduction from the Editors

– An introduction to immunology and immunopathology

– Asthma

– Allergic rhinitis

– Atopic dermatitis

– Allergen-specific immunotherapy

– Anaphylaxis

– IgE-mediated food allergy

– Non-IgE-mediated food hypersensitivity

– Early introduction of foods to prevent food allergy

– Eosinophilic esophagitis

– Urticaria and angioedema

– Drug allergy

– Primary immunodeficiency

5 – Perspective: Failing the Public Health — Rofecoxib, Merck, and the FDA – New England Journal of Medicine (free)

6 – Zackary Berger’s journal reviews, 1 October 2018 – The BMJ Opinion (free)

7 – Standards for Neurologic Critical Care Units: A Statement for Healthcare Professionals from The Neurocritical Care Society – Neurocritical Care (free)

Source: Critical Care Reviews Newsletter

8 – Review: Pulmonary vasculitis – Journal of Thoracic Disease (free)

Source: Critical Care Reviews Newsletter

9 – Over 80,000 Americans Died of Flu Last Winter, Highest Toll in Years – The New York Times (10 articles per month are free)

10 – Language Experience in the Second Year of Life and Language Outcomes in Late Childhood – Pediatrics (free)

Commentaries: Early Language Exposure and Middle School Language and IQ: Implications for Primary Prevention – Pediatrics (free) AND Conversations Between Parents and Toddlers Help Build Intelligence and Vocabulary – Journal Watch (free)

NYT Editorial: We Know How to Conquer Tuberculosis

28 Sep, 2018 | 01:16h | UTC

We Know How to Conquer Tuberculosis – The New York Times (10 articles per month are free)

Study: Potential Effect of Household Contact Management on Childhood Tuberculosis

28 Sep, 2018 | 01:15h | UTC

Potential effect of household contact management on childhood tuberculosis: a mathematical modelling study – The Lancet Global Health (free)

Invited Commentary: Preventing tuberculosis in household contacts crucial to protect children and contain epidemic spread (free)

Fri, September 28 – 10 Stories of The Day!

28 Sep, 2018 | 01:20h | UTC

1 – Editorial: We Know How to Conquer Tuberculosis – The New York Times (10 articles per month are free)

2 – Potential effect of household contact management on childhood tuberculosis: a mathematical modelling study – The Lancet Global Health (free)

Invited Commentary: Preventing tuberculosis in household contacts crucial to protect children and contain epidemic spread (free)

3 – Doctor Referral of Overweight People to Low Energy total diet replacement Treatment (DROPLET): pragmatic randomised controlled trial – The BMJ (free)

Commentaries: Susan Jebb: Interventions to treat obesity work—so why am I not celebrating? – The BMJ Opinion (free) AND Expert reaction to study looking at total diet replacement programmes and obesity – Science Media Centre (free) AND Crash diets are highly effective – new evidence – The Conversation (free)

4 – Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentaries: Limiting children’s recreational screen time to less than 2 hours a day linked to better cognition – The Lancet (free) AND Limiting children’s screen time linked to better cognition, study says – CNN (free) AND Limiting children’s screen time linked to better cognition – BBC (free)

“Researchers said more work was now needed to better understand the effects of different types of screen use. However, they acknowledge that their observational study shows only an association between screen time and cognition and cannot prove a causal link.” (from BBC)

5 – Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes – JAMA Network Open (free)

“Same day discharge after elective PCI used infrequently (3.5%), while safe + associated w/ reduced costs” (via @krychtiukmd see Tweet)

6 – Video: Understanding How Machine Learning Works – JAMA (free)

7 – Deprescribing recommendations: An essential consideration for clinical guideline developers – Research in Social and Administrative Pharmacy (free)

Related: Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)

““Clinical guidelines often do not accommodate frailty or patients with multiple comorbid conditions. This can give rise to complex medication regimens and risk of medication harm. “Paper discusses the need to include deprescribing in clinical guidelines” (via @Deprescribing see Tweet)

8 – Opinion: No more first authors, no more last authors – Nature (free)

“The controversial suggestion that we “blow up” authorship conventions to foster team, collaborative science” (via @EricTopol see Tweet)

9 – Perspective: No One Knows Exactly What Would Happen If Mosquitoes Were to Disappear – The Atlantic (free)

10 – Ethanol lock is effective on reducing the incidence of tunneled catheter-related bloodstream infections in hemodialysis patients: a systematic review and meta-analysis – International Urology and Nephrology (link to abstract – $ for full-text)

Commentary: Ethanol locks in catheters for dialysis may prevent sepsis – NIHR Signal (free)

Randomized Trial: Total Diet Replacement Programme to Treat Obesity

28 Sep, 2018 | 01:14h | UTC

Doctor Referral of Overweight People to Low Energy total diet replacement Treatment (DROPLET): pragmatic randomised controlled trial – The BMJ (free)

Commentaries: Susan Jebb: Interventions to treat obesity work—so why am I not celebrating? – The BMJ Opinion (free) AND Expert reaction to study looking at total diet replacement programmes and obesity – Science Media Centre (free) AND Crash diets are highly effective – new evidence – The Conversation (free)

Study: Limiting Children’s Screen Time Linked to Better Cognition

28 Sep, 2018 | 01:13h | UTC

Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentaries: Limiting children’s recreational screen time to less than 2 hours a day linked to better cognition – The Lancet (free) AND Limiting children’s screen time linked to better cognition, study says – CNN (free) AND Limiting children’s screen time linked to better cognition – BBC (free)

“Researchers said more work was now needed to better understand the effects of different types of screen use. However, they acknowledge that their observational study shows only an association between screen time and cognition and cannot prove a causal link.” (from BBC)

Video: Understanding How Machine Learning Works

28 Sep, 2018 | 01:12h | UTC

Understanding How Machine Learning Works – JAMA (free)

Study: Same-Day Discharge After Elective PCI Seems Safe and Reduce Costs

28 Sep, 2018 | 01:13h | UTC

Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes – JAMA Network Open (free)

“Same day discharge after elective PCI used infrequently (3.5%), while safe + associated w/ reduced costs” (via @krychtiukmd see Tweet)

Deprescribing Recommendations: An Essential Consideration for Clinical Guideline Developers

28 Sep, 2018 | 01:11h | UTC

Deprescribing recommendations: An essential consideration for clinical guideline developers – Research in Social and Administrative Pharmacy (free)

Related: Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)

““Clinical guidelines often do not accommodate frailty or patients with multiple comorbid conditions. This can give rise to complex medication regimens and risk of medication harm.” Paper discusses the need to include deprescribing in clinical guidelines” (via @Deprescribing see Tweet)