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Tue August 6 – 10 Stories of The Day!

6 Aug, 2019 | 08:17h | UTC

 

1 – AGA Guideline on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D) – Gastroenterology (free)

 

2 – Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant – JAMA Internal Medicine (free for a limited period)

Commentary: Study Sheds Light on Stopping and Resuming DOACs in Afib Patients Undergoing Surgery – NEJM Journal Watch (free)

“The DOAC regimens were omitted for 1 day before a low–bleeding-risk procedure and 2 days before a high–bleeding-risk procedure. The DOAC regimens were resumed 1 day after a low–bleeding-risk procedure and 2 to 3 days after a high–bleeding-risk procedure.”

 

3 – Potential Medicare Savings From Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers – JAMA Internal Medicine (free for a limited period)

“By maximizing generic substitution and therapeutic interchange, Medicare could have saved approximately $676 million (89.6%) in 2016 and 2017 of the total $754 million spent on these brand-name ACEIs and ARBs during those 2 years”.

 

4 – #164 Stroke and TIA Deconstructed – The Curbsiders Internal Medicine Podcast (free audio)

 

5 – Evaluation of spin in abstracts of papers in psychiatry and psychology journals – BMJ Evidence-Based Medicine (free)

Commentaries: Expert reaction to study reporting ‘spin’ in abstracts of psychiatry and psychology journals – Science Media Centre (free) AND ‘Spin’ found in over half of clinical trial abstracts published in top psychiatry journals – The British Medical Journal (free)

Related: Systematic Review: Spin in Published Cardiovascular Randomized Trials with Statistically Nonsignificant Primary Outcomes (free study and editorial) AND ‘Spin’ in published biomedical literature: A methodological systematic review – PLOS Biology (free)

 

6 – Alex Nowbar’s journal review, 5 August 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 

7 – Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis – Mayo Clinic Proceedings: Innovations, Quality & Outcomes (free)

 

8 – The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017 – The Lancet Oncology (free)

Commentaries: Global burden of childhood cancer: growing, but controllable – The Lancet Oncology (free) AND Globally, more than 11 million years of healthy life lost due to childhood cancer in 2017 – The Lancet (free)

 

9 – Financial conflicts of interest in systematic reviews: associations with results, conclusions, and methodological quality – Cochrane Library (free)

Summary: Financial conflicts of interests and results, conclusions, and quality of systematic reviews – Cochrane Library (free)

 

10 – Renin-Angiotensin System Inhibition Following Transcatheter Aortic Valve Replacement – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: RAS Inhibition After TAVR Gains More Support, but RCT Still Needed – TCTMD (free) AND Renin-angiotensin system inhibition following transcatheter aortic valve replacement linked with lower cardiac mortality – 2 Minute Medicine (free)

 

Cohort Study: Perioperative Management of Patients with Atrial Fibrillation Receiving a Direct Oral Anticoagulant

6 Aug, 2019 | 08:10h | UTC

Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant – JAMA Internal Medicine (free for a limited period)

Commentary: Study Sheds Light on Stopping and Resuming DOACs in Afib Patients Undergoing Surgery – NEJM Journal Watch (free)

“The DOAC regimens were omitted for 1 day before a low–bleeding-risk procedure and 2 days before a high–bleeding-risk procedure. The DOAC regimens were resumed 1 day after a low–bleeding-risk procedure and 2 to 3 days after a high–bleeding-risk procedure.”

 

Related Commentary on Twitter

 

AGA Guideline on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults

6 Aug, 2019 | 08:15h | UTC

AGA Guideline on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D) – Gastroenterology (free)

 

Potential Savings from Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers

6 Aug, 2019 | 08:06h | UTC

Potential Medicare Savings From Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers – JAMA Internal Medicine (free for a limited period)

“By maximizing generic substitution and therapeutic interchange, Medicare could have saved approximately $676 million (89.6%) in 2016 and 2017 of the total $754 million spent on these brand-name ACEIs and ARBs during those 2 years”.

 

Study: Evaluation of “Spin” in Abstracts of Papers in Psychiatry and Psychology Journals

6 Aug, 2019 | 08:02h | UTC

Evaluation of spin in abstracts of papers in psychiatry and psychology journals – BMJ Evidence-Based Medicine (free)

Commentaries: Expert reaction to study reporting ‘spin’ in abstracts of psychiatry and psychology journals – Science Media Centre (free) AND ‘Spin’ found in over half of clinical trial abstracts published in top psychiatry journals – The British Medical Journal (free)

Related: Systematic Review: Spin in Published Cardiovascular Randomized Trials with Statistically Nonsignificant Primary Outcomes (free study and editorial) AND ‘Spin’ in published biomedical literature: A methodological systematic review – PLOS Biology (free)

 

Podcast: Stroke and TIA Deconstructed

6 Aug, 2019 | 08:04h | UTC

#164 Stroke and TIA Deconstructed – The Curbsiders Internal Medicine Podcast (free audio)

 

The Global Burden of Childhood and Adolescent Cancer

6 Aug, 2019 | 07:57h | UTC

The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017 – The Lancet Oncology (free)

Commentaries: Global burden of childhood cancer: growing, but controllable – The Lancet Oncology (free) AND Globally, more than 11 million years of healthy life lost due to childhood cancer in 2017 – The Lancet (free)

 

Related Commentary on Twitter

 

Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis

6 Aug, 2019 | 07:58h | UTC

Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis – Mayo Clinic Proceedings: Innovations, Quality & Outcomes (free)

 

Alex Nowbar’s journal review—5 August 2019

6 Aug, 2019 | 08:00h | UTC

Alex Nowbar’s journal review, 5 August 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 

Financial Conflicts of Interest in Systematic Reviews: Associations with Results, Conclusions, and Methodological Quality

6 Aug, 2019 | 07:55h | UTC

Financial conflicts of interest in systematic reviews: associations with results, conclusions, and methodological quality – Cochrane Library (free)

Summary: Financial conflicts of interests and results, conclusions, and quality of systematic reviews – Cochrane Library (free)

 

[Abstract Only] Observational Study: Renin-Angiotensin System Inhibition May Improve Prognosis Following Transcatheter Aortic Valve Replacement

6 Aug, 2019 | 07:53h | UTC

Renin-Angiotensin System Inhibition Following Transcatheter Aortic Valve Replacement – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: RAS Inhibition After TAVR Gains More Support, but RCT Still Needed – TCTMD (free) AND Renin-angiotensin system inhibition following transcatheter aortic valve replacement linked with lower cardiac mortality – 2 Minute Medicine (free)

 

Related Commentary on Twitter

 

Mon August 5 – 10 Stories of The Day!

5 Aug, 2019 | 02:38h | UTC

 

1 – Preterm labour and birth – National Institute for Health and Care Excellence (free)

Related Guideline: Practice Bulletin: Management of Preterm Labor – Obstetrics & Gynecology (free)

Related Review: Preterm Labor: One Syndrome, Many Causes – Science (free)

 

2 – Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial – The Lancet (free)

Commentary: Oral regimen management of acute hypertension in pregnancy – The Lancet (free)

 

3 – Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial – The Lancet (free)

Commentary: Ursodeoxycholic acid for intrahepatic cholestasis in pregnancy – The Lancet (free)

 

4 – An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction – The Lancet (link to abstract – $ for full-text)

Commentaries: Deep learning AI may identify atrial fibrillation from a normal rhythm ECG – The Lancet (free) AND AI may help detect atrial fibrillation from a normal rhythm ECG – OnMedica (free) AND Expert reaction to a study looking at an AI algorithm to identify atrial fibrillation – Science Media Centre (free) AND AI-Trained EKG Can Detect New or Impending Atrial Fibrillation – MedicalResearch.com (free) AND AI could enable accurate screening for atrial fibrillation – Mayo Clinic (free)

 

5 – Meta-Analysis of Oral Anticoagulant Monotherapy as an Antithrombotic Strategy in Patients With Stable Coronary Artery Disease and Nonvalvular Atrial Fibrillation – The American Journal of Cardiology (link to abstract – $ for full-text)

Source: EvidenceAlerts

 

6 – High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis – Neurology (link to abstract – $ for full-text)

Commentaries: Blood test may accurately identify people with early Alzheimer’s brain changes – Washington University School of Medicine in St. Louis (free) AND The new blood test for Alzheimer’s disease: developed in a study without patients – Medium (free)

 

7 – A Brain Scan May Predict Alzheimer’s. Should You Get One? – The New York Times (10 articles per month are free)

 

8 – Breastfeeding: A round up of Cochrane evidence – Evidently Cochrane (free)

 

9 – Celiac disease: a comprehensive current review – BMC Medicine (free)

Related Guidelines: European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders (free) AND ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease (free) AND Coeliac Disease: Recognition, Assessment and Management – NICE Guideline (free)

 

10 – If You Smoke Pot, Your Anesthesiologist Needs To Know – Kaiser Health News (free)

Related: Perioperative care of cannabis users: A comprehensive review of pharmacological and anesthetic considerations – Journal of Clinical Anesthesia (free)

“One small study of Colorado patients published in May found marijuana users required more than triple the amount of one common sedation medicine, propofol, as did nonusers.”

 

Randomized Trial: Antihypertensive Regimens Compared for the Management of Severe Hypertension in Pregnancy

5 Aug, 2019 | 02:27h | UTC

Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial – The Lancet (free)

Commentary: Oral regimen management of acute hypertension in pregnancy – The Lancet (free)

 

Related Commentary on Twitter

 

NICE Guideline: Preterm Labor and Birth

5 Aug, 2019 | 02:29h | UTC

Preterm labour and birth – National Institute for Health and Care Excellence (free)

Related Guideline: Practice Bulletin: Management of Preterm Labor – Obstetrics & Gynecology (free)

Related Review: Preterm Labor: One Syndrome, Many Causes – Science (free)

 

Randomized Trial: Ursodeoxycholic Acid Not Effective for Women with Intrahepatic Cholestasis of Pregnancy

5 Aug, 2019 | 02:24h | UTC

Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial – The Lancet (free)

Commentary: Ursodeoxycholic acid for intrahepatic cholestasis in pregnancy – The Lancet (free)

 

[Abstract Only] Artificial Intelligence Algorithm Can Detect Patients with Atrial Fibrillation from a Sinus Rhythm ECG

5 Aug, 2019 | 02:22h | UTC

An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction – The Lancet (link to abstract – $ for full-text)

Commentaries: Deep learning AI may identify atrial fibrillation from a normal rhythm ECG – The Lancet (free) AND AI may help detect atrial fibrillation from a normal rhythm ECG – OnMedica (free) AND Expert reaction to a study looking at an AI algorithm to identify atrial fibrillation – Science Media Centre (free) AND AI-Trained EKG Can Detect New or Impending Atrial Fibrillation – MedicalResearch.com (free) AND AI could enable accurate screening for atrial fibrillation – Mayo Clinic (free)

 

Related Commentary on Twitter

https://twitter.com/EricTopol/status/1157077561064615936?s=03

 

[Abstract Only] Meta-Analysis: Oral Anticoagulant Monotherapy vs. Oral Anticoagulant Plus Antiplatelet therapy in Patients with Stable Coronary Artery Disease and Nonvalvular Atrial Fibrillation

5 Aug, 2019 | 02:15h | UTC

Meta-Analysis of Oral Anticoagulant Monotherapy as an Antithrombotic Strategy in Patients With Stable Coronary Artery Disease and Nonvalvular Atrial Fibrillation – The American Journal of Cardiology (link to abstract – $ for full-text)

Source: EvidenceAlerts

 

Related Commentary on Twitter

 

[Abstract Only] Study: Blood Test Can Identify Pre-Clinical Brain Changes Linked to Alzheimer’s Disease

5 Aug, 2019 | 02:14h | UTC

High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis – Neurology (link to abstract – $ for full-text)

Commentaries: Blood test may accurately identify people with early Alzheimer’s brain changes – Washington University School of Medicine in St. Louis (free) AND The new blood test for Alzheimer’s disease: developed in a study without patients – Medium (free)

 

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

5 Aug, 2019 | 02:07h | UTC

If You Smoke Pot, Your Anesthesiologist Needs To Know – Kaiser Health News (free)

Related: Perioperative care of cannabis users: A comprehensive review of pharmacological and anesthetic considerations – Journal of Clinical Anesthesia (free)

“One small study of Colorado patients published in May found marijuana users required more than triple the amount of one common sedation medicine, propofol, as did nonusers.”

 

Perspective: A Brain Scan May Predict Alzheimer’s. Should You Get One?

5 Aug, 2019 | 02:13h | UTC

A Brain Scan May Predict Alzheimer’s. Should You Get One? – The New York Times (10 articles per month are free)

 

Celiac Disease: A Comprehensive Current Review

5 Aug, 2019 | 02:09h | UTC

Celiac disease: a comprehensive current review – BMC Medicine (free)

Related Guidelines: European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders (free) AND ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease (free) AND Coeliac Disease: Recognition, Assessment and Management – NICE Guideline (free)

 

Breastfeeding: A Round Up of Cochrane Evidence

5 Aug, 2019 | 02:12h | UTC

Breastfeeding: A round up of Cochrane evidence – Evidently Cochrane (free)

 

Study: Cancer Patients with HIV Infection Have Worse Outcomes

5 Aug, 2019 | 01:59h | UTC

HIV Infection, Cancer Treatment Regimens, and Cancer Outcomes Among Elderly Adults in the United States – JAMA Oncology (free for a limited period)

Commentaries: Despite Treatment, Elderly Cancer Patients Have Worse Outcomes if HIV-Positive – Moffitt Cancer Center (free) AND Among Elderly Patients With Cancer, Those With HIV Fare Worse Even After Adjusting for Treatment Variation – AJMC (free)

 

Mitral Regurgitation in Heart Failure: Time for a Rethink

5 Aug, 2019 | 01:58h | UTC

Mitral regurgitation in heart failure: time for a rethink – European Heart Journal (free)

Commentary with Key Points: Mitral Regurgitation in Heart Failure – American College of Cardiology (free)

 

Artificial Intelligence in Intensive Care: Are We There Yet?

5 Aug, 2019 | 01:53h | UTC

Artificial intelligence in intensive care: are we there yet? – Intensive Care Medicine (free PDF)

 

Related Commentary on Twitter

 

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