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Randomized trial of intermittent hormone therapy +/- radiation to oligometastatic sites of #prostatecancer shows significantly improved PFS & assoc time off hormone therapy & w/normal testosterone from combination. https://t.co/ZnmkQuqHZm #RadOnc #PCSM #GUCSM

— JAMA Oncology (@JAMAOnc) April 6, 2023

M-A | High-flow nasal cannula vs. noninvasive positive pressure ventilation in acute hypoxic respiratory failure

10 Apr, 2023 | 13:37h | UTC

High-Flow Nasal Cannula Compared With Noninvasive Positive Pressure Ventilation in Acute Hypoxic Respiratory Failure: A Systematic Review and Meta-Analysis – Critical Care Explorations

Cohort Study | Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care

10 Apr, 2023 | 13:38h | UTC

Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study – Intensive Care Medicine (free for a limited period)

Commentary on Twitter

🧠 Meningoencephalitis in adults requiring #ICU, EURECA study
➡️ poor outcomes at 3 months (moderate-to-severe disability or death) in ½ pts
➡️ older age, immunodepression, neurologic presentation nonmodifiable factors associated w poor outcome.#FOAMcc
🖇️ https://t.co/AR3w8x0Hiy pic.twitter.com/ChoucOnP8B

— Intensive Care Medicine (@yourICM) April 7, 2023

M-A | Retinopathy of prematurity and neurodevelopmental outcomes in preterm infants

10 Apr, 2023 | 13:36h | UTC

Retinopathy of prematurity and neurodevelopmental outcomes in preterm infants: A systematic review and meta-analysis – Frontiers in Pediatrics

Cohort Study | Impact of complications after resection of pancreatic cancer on disease recurrence and survival

10 Apr, 2023 | 13:34h | UTC

Impact of complications after resection of pancreatic cancer on disease recurrence and survival, and mediation effect of adjuvant chemotherapy: nationwide, observational cohort study – BJS Open

Commentary on Twitter

Major complications after🦀surgery are known to impair DF- and OS ➡️📜of all 🇳🇱 pat undergoing panc surgery 2014–2017 (n=1071) confirms via causal mediation 📈that this is mediated due to omission of adjuvant CTX!https://t.co/8kjr9MpRt4 #some4surgery #some4hpb @BJSAcademy pic.twitter.com/EZd7Yvi4z2

— BJS Open (@BjsOpen) April 1, 2023

SR | Anti‐vascular endothelial growth factor for neovascular glaucoma

10 Apr, 2023 | 13:33h | UTC

Anti‐vascular endothelial growth factor for neovascular glaucoma – Cochrane Database of Systematic Reviews

SR | Chest physiotherapy for acute bronchiolitis in pediatric patients between 0 and 24 months old

10 Apr, 2023 | 13:32h | UTC

Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old – Cochrane Database of Systematic Reviews

Sodium intake linked to both coronary & carotid atherosclerosis in the Swedish population

10 Apr, 2023 | 13:30h | UTC

The association between sodium intake and coronary and carotid atherosclerosis in the general Swedish population – European Heart Journal Open

Commentary on Twitter

Association between salt intake and both carotid and coronary atherosclerosis in a contemporary community-based cohort 👉https://t.co/sHTCEdu4Uw #EHJOpen @ehjopen @SaDeRosa78 #cardiotwitter

— European Society of Cardiology Journals (@ESC_Journals) April 3, 2023

Review | Refeeding Syndrome: diagnostic challenges and the potential of clinical decision support systems

10 Apr, 2023 | 13:28h | UTC

Refeeding Syndrome: Diagnostic challenges and the potential of clinical decision support systems – Deutsches Ärzteblatt International – Deutsches Ärzteblatt International

Guidelines on diagnosis and management of chronic neutropenia in adults and children

10 Apr, 2023 | 13:25h | UTC

The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children: A Consensus Between the European Hematology Association and the EuNet-INNOCHRON COST Action – HemaSphere

Commentary on Twitter

Neutropenia diagnosis & management were previously based on physicians' experience or local practices. To harmonize #hematology treatment, #EHA & @eunet_innochron have published a new #EHAGuideline on #neutropenia in adults & children in @Hemasphere_EHA: https://t.co/ifYEtzNlAv pic.twitter.com/CnKuqG03Up

— European Hematology Association (@EHA_Hematology) April 3, 2023

Review | Urinary incontinence and pelvic organ prolapse in women

10 Apr, 2023 | 13:27h | UTC

Urinary Incontinence and Pelvic Organ Prolapse in Women: Prevention and Treatment – Deutsches Ärzteblatt International

Consensus Paper | Best management of patients with an acute sore throat

6 Apr, 2023 | 13:32h | UTC

Best management of patients with an acute sore throat – a critical analysis of current evidence and a consensus of experts from different countries and traditions – Infectious Diseases

Review | Assessing the risk of surgery in patients with cirrhosis

10 Apr, 2023 | 13:20h | UTC

Assessing the risk of surgery in patients with cirrhosis – Hepatology Communications

Blood pressure targets in adults with hypertension | A clinical practice guideline from the AAFP

6 Apr, 2023 | 13:30h | UTC

Blood Pressure Targets in Adults With Hypertension: A Clinical Practice Guideline From the AAFP – American Academy of Family Physicians (PDF)

Commentary: AAFP Issues New Clinical Practice Guideline on Hypertension – Annals of Family Medicine

Consensus Paper | An approach to deprescribe antidepressants for depression in older adults

6 Apr, 2023 | 13:25h | UTC

An Approach to Deprescribe Antidepressants for Depression in Older Adults: Consensus, Multidisciplinary Practice – The Permanente Journal

Discontinuing antidepressants: Pearls and pitfalls.

Review | Newer generation antidepressants and withdrawal effects: reconsidering the role of antidepressants and helping patients to stop.

RCT: Maintenance vs. discontinuation of antidepressants in patients who felt well enough to discontinue antidepressant therapy.

A method for tapering antipsychotic treatment that may minimize the risk of relapse

Systematic Review: Managing Antidepressant Discontinuation

Randomized controlled trial: preventive cognitive therapy for prevention of depressive recurrence

M-A: Continuation of antidepressants vs. sequential psychological interventions to prevent relapse in depression.

Global epidemiology of cirrhosis — Etiology, trends and predictions

6 Apr, 2023 | 13:27h | UTC

Global epidemiology of cirrhosis — aetiology, trends and predictions – Nature Reviews Gastroenterology & Hepatology

Commentary on Twitter

New content online: Global epidemiology of cirrhosis — aetiology, trends and predictions https://t.co/EbgDWTjOyI pic.twitter.com/Cj7KFoWtLi

— Nature Reviews Gastroenterology & Hepatology (@NatRevGastroHep) March 28, 2023

RCT | Routine invasive approach fails to benefit frail older adults with non–ST-segment elevation acute myocardial infarction

6 Apr, 2023 | 13:23h | UTC

Effect of Routine Invasive vs Conservative Strategy in Older Adults With Frailty and Non–ST-Segment Elevation Acute Myocardial Infarction: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Routine invasive strategy not associated with improved outcomes in older adults with frailty and non-ST segment elevation acute myocardial infarction – Physician’s Weekly

Commentary on Twitter

A routine invasive strategy did not improve clinical outcomes in frail patients with NSTEMI. Future trials should confirm whether a policy of watchful observation rather than routine invasive management may be effective for these patients. https://t.co/N4hAXg5fid

— JAMA Internal Medicine (@JAMAInternalMed) March 6, 2023