Archives
Mon September 16 – 10 Stories of The Day!
16 Sep, 2019 | 02:58h | UTC
Key Points to Remember: ACC Consensus Decision Pathway for Heart Failure Hospitalizations – American College of Cardiology (free)
2 – Head injury: assessment and early management – National Institute for Health and Care Excellence (free)
Related Guidelines: Management of severe traumatic brain injury (first 24 hours) – Anaesthesia Critical Care & Pain Medicine (free) AND New Guidelines for the Management of Pediatric Severe Traumatic Brain Injury (free) AND CDC Guideline: Diagnosis and Management of Mild Traumatic Brain Injury Among Children (free) AND Italian guidelines on the assessment and management of pediatric head injury in the emergency department – Italian Journal of Pediatrics (free) AND Scandinavian guidelines for initial management of minor and moderate head trauma in children – BMC Medicine (free)
Commentaries: Comparing antibiotic, silver, and standard ventriculoperitoneal shunts – The Lancet (free)
AND Antibiotic-impregnated shunt could prevent hydrocephalus infections, save millions – News Medical (free) AND Innovative treatment to prevent common brain infection could save NHS 7 million pounds per year – University of Liverpool (free)
5 – Prevalence, Characteristics and Association of Obstructive Sleep Apnea with Blood Pressure Control in Patients with Resistant Hypertension – Annals of the American Thoracic Society (link to abstract – $ for full-text)
Commentaries: Most patients with resistant hypertension have sleep apnoea – OnMedica (free) AND More Severe OSA Leads to Higher Blood Pressure in Patients with Resistant Hypertension – American Thoracic Society (free) AND Obstructive Sleep Apnea Common in Patients with Resistant Hypertension – MedicalResearch.com (free)
Original Guideline: Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society (free)
See also: AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease (free guideline and commentary)
Editorial: ACE inhibitor and ARB therapy: Practical recommendations (free)
Commentary: First-in-Human Telerobotic Coronary Intervention Procedures Published in EClinicalMedicine – Diagnostic and Interventional Cardiology (free)
9 – Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer – JAMA Oncology (free for a limited period)
Author Interview: Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer (free audio)
Commentaries: Antibiotics reduce survival rates in cancer patients taking immunotherapy – Imperial College London (free) AND Antibiotics prior to immunotherapy lower survival rate for cancer patients, study says – UPI (free)
10 – Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma: A Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Commentary: Metformin Repurposed: Boosts Survival in TKI-Treated Lung Cancer – MedPage Today (free registration required)
Randomized Trial: Antibiotic Impregnated Ventriculoperitoneal Shunts Reduce Infection Risk
16 Sep, 2019 | 02:21h | UTCCommentaries: Comparing antibiotic, silver, and standard ventriculoperitoneal shunts – The Lancet (free)
AND Antibiotic-impregnated shunt could prevent hydrocephalus infections, save millions – News Medical (free) AND Innovative treatment to prevent common brain infection could save NHS 7 million pounds per year – University of Liverpool (free)
NICE Guideline: Assessment and Early Management of Head Injury
16 Sep, 2019 | 02:23h | UTCHead injury: assessment and early management – National Institute for Health and Care Excellence (free)
Related Guidelines: Management of severe traumatic brain injury (first 24 hours) – Anaesthesia Critical Care & Pain Medicine (free) AND New Guidelines for the Management of Pediatric Severe Traumatic Brain Injury (free) AND CDC Guideline: Diagnosis and Management of Mild Traumatic Brain Injury Among Children (free) AND Italian guidelines on the assessment and management of pediatric head injury in the emergency department – Italian Journal of Pediatrics (free) AND Scandinavian guidelines for initial management of minor and moderate head trauma in children – BMC Medicine (free)
[Abstract Only] Study: High Prevalence of Obstructive Sleep Apnea in Patients with Resistant Hypertension
16 Sep, 2019 | 02:18h | UTCPrevalence, Characteristics and Association of Obstructive Sleep Apnea with Blood Pressure Control in Patients with Resistant Hypertension – Annals of the American Thoracic Society (link to abstract – $ for full-text)
Commentaries: Most patients with resistant hypertension have sleep apnoea – OnMedica (free) AND More Severe OSA Leads to Higher Blood Pressure in Patients with Resistant Hypertension – American Thoracic Society (free) AND Obstructive Sleep Apnea Common in Patients with Resistant Hypertension – MedicalResearch.com (free)
Randomized Trial: Surgical Treatments for Uterine Prolapse Compared
16 Sep, 2019 | 02:20h | UTC
Related Commentary on Twitter
https://twitter.com/bmj_latest/status/1172888061694402560
Small Randomized Trial Suggests a Benefit from Metformin as Adjunctive Therapy in Patients with Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma
16 Sep, 2019 | 00:46h | UTCEffect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma: A Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Commentary: Metformin Repurposed: Boosts Survival in TKI-Treated Lung Cancer – MedPage Today (free registration required)
Short Review: Food Allergy Prevention with Early Food Introduction
16 Sep, 2019 | 02:16h | UTCOriginal Guideline: Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society (free)
See also: AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease (free guideline and commentary)
ACE inhibitors and ARBs: Managing Potassium and Renal Function
16 Sep, 2019 | 02:14h | UTCEditorial: ACE inhibitor and ARB therapy: Practical recommendations (free)
Meta-Analysis: Parenteral Methotrexate Better Than Oral MTX for Achieving Reduction in Disease Activity in Patients with Rheumatoid Arthritis
15 Sep, 2019 | 23:59h | UTCCommentary: Rheumatoid arthritis: parenteral MTX tops pills for efficacy – Univadis (free registration required)
Long Distance Tele-Robotic-Assisted Percutaneous Coronary Intervention: A Report of First-in-Human Experience
16 Sep, 2019 | 02:13h | UTCCommentary: First-in-Human Telerobotic Coronary Intervention Procedures Published in EClinicalMedicine – Diagnostic and Interventional Cardiology (free)
Observational Study Suggests Antibiotics Can Greatly Impair the Response to Immune Checkpoint Inhibitors in Patients with Cancer
16 Sep, 2019 | 00:48h | UTCAssociation of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer – JAMA Oncology (free for a limited period)
Author Interview: Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer (free audio)
Commentaries: Antibiotics reduce survival rates in cancer patients taking immunotherapy – Imperial College London (free) AND Antibiotics prior to immunotherapy lower survival rate for cancer patients, study says – UPI (free)
Related Commentary on Twitter
https://twitter.com/EricTopol/status/1172514038330212357
Viewpoint: Redefining Heart Failure with a Reduced Ejection Fraction
15 Sep, 2019 | 23:46h | UTCRedefining Heart Failure With a Reduced Ejection Fraction – JAMA (free for a limited period)
European Guidelines on Endoscopic Management of Polyposis Syndromes
15 Sep, 2019 | 23:58h | UTC
Systematic Review: Strategies to Reduce Diagnostic Errors
15 Sep, 2019 | 23:44h | UTCRelated: Discover and defeat your diagnostic errors – ACP Internist (free)
[Abstract Only] Study: Liquid vs. Tissue Biopsy for Detecting Acquired Resistance and Tumor Heterogeneity in Gastrointestinal Cancers
15 Sep, 2019 | 23:41h | UTCLiquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers – Nature Medicine (link to abstract – $ for full-text)
Commentary: Liquid biopsies reveal genetic alterations linked to cancer drug resistance – Broad Institute of MIT and Harvard (free)
Related Commentary on Twitter
6 words not often seen in top tier journals: "These findings have profound therapeutic implications …and highlight the potential advantages of cfDNA [liquid biopsy] over tissue biopsy in the setting of acquired [#cancer] resistance.https://t.co/92gF4OX10H @NatureMedicine pic.twitter.com/mj0NQC17SP
— Eric Topol (@EricTopol) September 10, 2019
Evaluation and Management of Angioedema in the Emergency Department
15 Sep, 2019 | 23:43h | UTCSource: Medscape
Study: Progress in Cancer Survival, Mortality, and Incidence in Seven High-income Countries 1995–2014
15 Sep, 2019 | 23:35h | UTCCommentaries: Cancer Patients in Rich Countries Are Gaining Years, Study Shows – Bloomberg (free) AND Cancer survival in high income countries is improving but international disparities persist – eCancer News (free)
Related Commentary on Twitter
1-yr & 5-yr survival of seven #cancers (oesophagus, stomach, colon, rectum, pancreas, lung & ovary) improved in Australia, Canada, Denmark, Ireland, New Zealand, Norway & UK: SURVMARK-2 study of 3.9m cancer cases 1995-2014 @IARCWHO https://t.co/NqWmKl5T6R pic.twitter.com/xhmIpCwflq
— The Lancet Oncology (@TheLancetOncol) September 11, 2019
[Abstract Only] What’s the Right Pediatric ETT Size?
15 Sep, 2019 | 23:37h | UTCWhat’s the Right Pediatric ETT Size? – Journal Feed (free)
Original Article: Tracheal Size and Morphology on the Reconstructed CT Imaging – Pediatric Critical Care Medicine (link to abstract – $ for full-text)
Updates in Pathophysiology, Definition and Classification of Hepatorenal Syndrome
15 Sep, 2019 | 23:34h | UTCNews in pathophysiology, definition and classification of hepatorenal syndrome: A step beyond the International Club of Ascites (ICA) consensus document – Journal of Hepatology (free for a limited period)
Related Article: Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites – Gut (free PDF)
Related Guidelines: Cirrhosis in Over 16s: Assessment and Management – National Institute for Health and Care Excellence (free) AND 2018 KASL clinical practice guidelines for liver cirrhosis: Ascites and related complications – Clinical and Molecular Hepatology (free) AND 2018 Recommendations of the Brazilian Society of Hepatology for the management of acute kidney injury in patients with cirrhosis (free PDF) AND Evidence-based clinical practice guidelines for liver cirrhosis 2015 – Journal of Gastroenterology (free) AND Chinese guidelines on the management of ascites and its related complications in cirrhosis – Hepatology International (free)
Randomized Trial: Laparoscopic Supracervical Hysterectomy vs. Endometrial Ablation for Women with Heavy Menstrual Bleeding
13 Sep, 2019 | 08:21h | UTCCommentaries: HEALTH for heavy menstrual bleeding: real-world implications – The Lancet (free) AND Heavy menstrual bleeding: Keyhole hysterectomy technique ‘more effective’ – BBC (free)
[Abstract Only] Study: Few People with Peanut Allergy Tolerate Peanut After Stopping Oral Immunotherapy
15 Sep, 2019 | 23:32h | UTCFew people with peanut allergy tolerate peanut after stopping oral immunotherapy – NIH News Releases (free)
Original Study: Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study – The Lancet (link to abstract – $ for full-text)
Related: Meta-Analysis: Oral Immunotherapy for Peanut Allergy INCREASES Allergic and Anaphylactic Reactions (link to abstract and commentaries)
NICE Guideline: Tuberculosis
13 Sep, 2019 | 08:27h | UTCTuberculosis – National Institute for Health and Care Excellence (free)
Related: WHO Guidelines on Tuberculosis Infection Prevention and Control (free guidelines)
Fri September 13 – 10 Stories of The Day!
13 Sep, 2019 | 08:41h | UTC
1 – Tuberculosis – National Institute for Health and Care Excellence (free)
Related: WHO Guidelines on Tuberculosis Infection Prevention and Control (free guidelines)
2 – The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis – The Lancet (free registration required)
Related Articles: Management of drug-resistant tuberculosis – The Lancet (free registration required) AND Challenges and controversies in childhood tuberculosis – The Lancet (free)
Editorial: Tuberculosis needs accelerated and continued attention (free)
Related: WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment (free) AND Randomized Trial: 9-month Treatment for Multi-drug Resistant TB is as Effective as 24-month Treatment (free)
Commentaries: HEALTH for heavy menstrual bleeding: real-world implications – The Lancet (free) AND Heavy menstrual bleeding: Keyhole hysterectomy technique ‘more effective’ – BBC (free)
4 – Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials – Science Translational Medicine (free for a limited period)
Commentaries: Cancer drugs don’t always work as intended, researchers warn – Cold Spring Harbor Laboratory (free) AND Why Aren’t Cancer Drugs Better? The Targets Might Be Wrong – The New York Times (10 articles per month are free)
5 – Supercooling Extends Preservation Time of Human Livers – Nature Biotechnology (free)
Commentaries: Scientists triple storage time of human donor livers – NIH News Releases (free) AND ‘Supercool’ method triples organ survival – BBC (free) AND A Human Liver Can Be Cooled to –4 Degrees Celsius and Survive – The Atlantic (free)
Commentary: Diabetes Risk Plummets by 75% When Multiple Risk Factors Tackled – Medscape (free registration required)
7 – Chest Radiograph Signs Suggestive of Pericardial Disease – American College of Cardiology (free)
8 – Vaccines for Health Care Personnel – Mayo Clinic Proceedings (free)
Related: Immunization of Health-Care Personnel: Recommendations of the Advisory Committee on Immunization Practices (ACIP) – Centers for Disease Control and Prevention (free) AND Vaccination of healthcare workers: A review – Human Vaccines & Immunotherapeutics (free)
Related: Pneumococcal infection in adults: burden of disease – Clinical Microbiology and Infection (free) AND The remaining challenges of pneumococcal disease in adults – European Respiratory Review (free)
Commentary: Sleeping on back may not lead to worse pregnancy outcomes – Reuters (free)
The Lancet Commission: Management of Multidrug-resistant and Incurable Tuberculosis
13 Sep, 2019 | 08:22h | UTCThe Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis – The Lancet (free registration required)
Related Articles: Management of drug-resistant tuberculosis – The Lancet (free registration required) AND Challenges and controversies in childhood tuberculosis – The Lancet (free)
Editorial: Tuberculosis needs accelerated and continued attention (free)
Related: WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment (free) AND Randomized Trial: 9-month Treatment for Multi-drug Resistant TB is as Effective as 24-month Treatment (free)
Study: Supercooling Extends Preservation Time of Human Livers
13 Sep, 2019 | 08:17h | UTCSupercooling Extends Preservation Time of Human Livers – Nature Biotechnology (free)
Commentaries: Scientists triple storage time of human donor livers – NIH News Releases (free) AND ‘Supercool’ method triples organ survival – BBC (free) AND A Human Liver Can Be Cooled to –4 Degrees Celsius and Survive – The Atlantic (free)