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Predicting Conversion to Wet Age-related Macular Degeneration Using Deep Learning

19 May, 2020 | 04:11h | UTC

Predicting conversion to wet age-related macular degeneration using deep learning – Nature Medicine (link to abstract – $ for full-text)

Commentary: Using AI to predict retinal disease progression – Deep Mind

 

Tue May 19 – 10 Stories of The Day!

19 May, 2020 | 04:42h | UTC

 

1 – Management of acute kidney injury in patients with COVID-19 – The Lancet Respiratory Medicine

Related: Acute Kidney Injury In Patients Hospitalized With Covid-19 – Kidney International

 

2 – Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic – The Lancet Psychiatry

 

3 – Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic – Circulation

Related Case Report: Cardiac dysfunction and thrombocytopenia-associated multiple organ failure inflammation phenotype in a severe paediatric case of COVID-19 – The Lancet Child & Adolescent Health

 

4 – Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody – Nature

Commentary: Cross-neutralization of SARS and COVID-19 coronaviruses by a monoclonal antibody – News Medical

 

5 – Seroprevalence of SARS-CoV-2–Specific Antibodies Among Adults in Los Angeles County, California, on April 10-11, 2020 – JAMA

“the prevalence of antibodies to SARS-CoV-2 was 4.65%. The estimate implies that approximately 367 000 adults had SARS-CoV-2 antibodies, which is substantially greater than the 8430 cumulative number of confirmed infections in the county on April 10”

 

6 – Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV): An Unprecedented Partnership for Unprecedented Times – JAMA

Commentary: NIH Director: Defeating COVID-19 requires unprecedented action and collaboration – National Institutes of Health

Related Viewpoint: Planning for a COVID-19 Vaccination Program – JAMA

 

7 – Coronavirus: hamster research shows effectiveness of masks ‘huge’ in Covid-19 battle, Hong Kong scientists say – South China Morning Post

 

8 – Early data show Moderna Covid-19 vaccine generates immune response – STAT

See also: Moderna Coronavirus Vaccine Trial Shows Promising Early Results – The New York Times AND Expert reaction to Moderna announcement about their phase 1 trial data on their mRNA vaccine (mRNA-1273) candidate against COVID-19 – Science Media Centre

 

9 – Decline in Child Vaccination Coverage During the COVID-19 Pandemic — Michigan Care Improvement Registry, May 2016–May 2020 – CDC Morbidity and Mortality Weekly Report

Commentaries: More evidence US childhood vaccinations are dropping amid coronavirus pandemic – CNN AND Michigan reports a sharp drop in child vaccinations after the CDC warned missed shots could lead to a measles resurgence across the US – Business Insider

 

10 –COVID-19 Updates / 19 May 2020 Edition

19 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

New NICE Covid-19 Rapid Guidelines: Chronic Kidney Disease & Interstitial Lung Disease

18 May, 2020 | 02:15h | UTC

COVID-19 rapid guideline: chronic kidney disease – National Institute for Health and Care Excellence

COVID-19 rapid guideline: interstitial lung disease – National Institute for Health and Care Excellence

See also: Complete Collection of Covid-19 Rapid Guidelines

 

WHO Scientific Brief: Multisystem Inflammatory Syndrome in Children and Adolescents with COVID-19

18 May, 2020 | 02:18h | UTC

Multisystem inflammatory syndrome in children and adolescents with COVID-19 – World Health Organization

News Release: Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19

Related: Covid-19: Cases of inflammatory syndrome in children surge after urgent alert – The BMJ AND Description of an Outbreak of Severe Kawasaki-like Disease at the Italian Epicenter of the SARS-CoV-2 Epidemic

 

WHO Policy Brief: COVID-19 and the Need for Action on Mental Health

18 May, 2020 | 02:17h | UTC

Policy Brief: COVID-19 and the Need for Action on Mental Health – World Health Organization

News Release: Substantial investment needed to avert mental health crisis – World Health Organization

Commentary: “Mental health services are an essential part of all government responses to COVID-19” – United Nations

 

Randomized Trial: No Benefit from Hydroxychloroquine in Patients with Mild to Moderate Covid-19

18 May, 2020 | 02:11h | UTC

Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial – The BMJ

Commentary: Further evidence does not support hydroxychloroquine for patients with COVID-19 – BMJ

 

Clinical Practice: Severe Covid-19

18 May, 2020 | 02:09h | UTC

Severe Covid-19 – New England Journal of Medicine

 

More Harm Than Good? The Net Impact of COVID-19 Policies Is What Matters for Health

18 May, 2020 | 02:01h | UTC

More Harm Than Good? The Net Impact of COVID-19 Policies Is What Matters for Health – Center for Global Development

Related: Indirect Effects of the COVID-19 Pandemic on Maternal and Child Mortality in Low-income and Middle-income Countries

 

Hemostasis Disorders in Critically Ill Patients with COVID-19

18 May, 2020 | 02:08h | UTC

Understanding pathophysiology of hemostasis disorders in critically ill patients with COVID-19 – Intensive Care Medicine

 

Related Commentary on Twitter

 

LDH, Lymphocyte Count, and C-reactive protein can Predict Mortality in Covid-19

18 May, 2020 | 01:58h | UTC

An interpretable mortality prediction model for COVID-19 patients – Nature Machine Learning

 

Related Commentary on Twitter

 

Guidance for Tracheostomy in the COVID-19 Era

18 May, 2020 | 02:05h | UTC

Tracheostomy in the COVID-19 era: global and multidisciplinary guidance – The Lancet Respiratory Medicine

Commentary: Walking the line between benefit and harm from tracheostomy in COVID-19 – The Lancet Respiratory Medicine

 

Clinical and Chest Radiography Features Determine Patient Outcomes In COVID-19

18 May, 2020 | 01:59h | UTC

Clinical and Chest Radiography Features Determine Patient Outcomes In Young and Middle Age Adults with COVID-19 – Radiology

 

Resumption of Sport and Exercise After COVID-19 Infection

18 May, 2020 | 01:54h | UTC

A Game Plan for the Resumption of Sport and Exercise After Coronavirus Disease 2019 (COVID-19) Infection – JAMA

 

Risk Factors for SARS-CoV-2 in Patients with Symptoms

18 May, 2020 | 01:55h | UTC

Assessing risk factors for SARS-CoV-2 infection in patients presenting with symptoms in Shanghai, China: a multicentre, observational cohort study – Lancet Digital Health

 

Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure

18 May, 2020 | 01:52h | UTC

Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure – JAMA

Related Study: Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit – JAMA

Editorial: Is the Prone Position Helpful During Spontaneous Breathing in Patients With COVID-19?

 

Risk factors for SARS-CoV-2 in a Primary Care Network

18 May, 2020 | 01:56h | UTC

Risk factors for SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study – The Lancet Infectious Diseases

Commentaries: Who is most likely to be infected with SARS-CoV-2? – The Lancet Infectious Diseases AND Sociodemographic factors associated with a positive test for COVID-19 in primary care – The Lancet AND COVID-19 discriminates along racial, socioeconomic lines, study finds – UPI

 

Quantifying the Impact of Interventions in COVID-19 Pandemic

18 May, 2020 | 01:50h | UTC

Quantifying the impact of interventions in COVID-19 pandemic – Max Planck Institute for Dynamics and Self-Organization

Original Study: Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions – Science

 

Systematic Review: Risks and Impact of ACE Inhibitors or ARBs on SARS-CoV-2 Infection in Adults

18 May, 2020 | 01:47h | UTC

Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults: A Living Systematic Review – Annals of Internal Medicine

Editorial: COVID-19 and Angiotensin-Converting Enzyme Inhibitor/Angiotensin-Receptor Blocker Therapy – Annals of Internal Medicine

 

Randomized Trial: Graduated Compression Stockings in Elective Surgical Patients

18 May, 2020 | 01:41h | UTC

Graduated compression stockings as adjuvant to pharmaco-thromboprophylaxis in elective surgical patients (GAPS study): randomised controlled trial – The BMJ

Commentaries: Graduated compression stockings on trial – The BMJ Opinion AND Compression stockings might not be needed to prevent blood clots after surgery – The British Medical Journal

 

Wrong but Useful — What Covid-19 Epidemiologic Models Can and Cannot Tell Us

18 May, 2020 | 01:48h | UTC

Wrong but Useful — What Covid-19 Epidemiologic Models Can and Cannot Tell Us – New England Journal of Medicine

Related: Modelling the pandemic – The BMJ AND Predictive Mathematical Models of the COVID-19 Pandemic (several commentaries on the subject)

 

Study: Use of Renin–angiotensin–aldosterone System Inhibitors Does Not Increase the Risk of COVID-19 Requiring Admission to Hospital

18 May, 2020 | 01:45h | UTC

Use of renin–angiotensin–aldosterone system inhibitors and risk of COVID-19 requiring admission to hospital: a case-population study – The Lancet

Commentary: Hypertension, renin–angiotensin–aldosterone system inhibition, and COVID-19 – The Lancet

 

Mon May 18 – 10 Stories of The Day!

18 May, 2020 | 02:22h | UTC

 

1 – Multisystem inflammatory syndrome in children and adolescents with COVID-19 – World Health Organization

News Release: Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19

Related: Covid-19: Cases of inflammatory syndrome in children surge after urgent alert – The BMJ AND Description of an Outbreak of Severe Kawasaki-like Disease at the Italian Epicenter of the SARS-CoV-2 Epidemic

 

2 – Policy Brief: COVID-19 and the Need for Action on Mental Health – World Health Organization

News Release: Substantial investment needed to avert mental health crisis – World Health Organization

Commentary: “Mental health services are an essential part of all government responses to COVID-19” – United Nations

 

3 – New NICE Covid-19 Rapid Guidelines: Chronic Kidney Disease & Interstitial Lung Disease

COVID-19 rapid guideline: chronic kidney disease – National Institute for Health and Care Excellence

COVID-19 rapid guideline: interstitial lung disease – National Institute for Health and Care Excellence

See also: Complete Collection of Covid-19 Rapid Guidelines

 

4 – Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial – The BMJ

Commentary: Further evidence does not support hydroxychloroquine for patients with COVID-19 – BMJ

 

5 – Severe Covid-19 – New England Journal of Medicine

 

6 – Understanding pathophysiology of hemostasis disorders in critically ill patients with COVID-19 – Intensive Care Medicine

 

7 – Tracheostomy in the COVID-19 era: global and multidisciplinary guidance – The Lancet Respiratory Medicine

Commentary: Walking the line between benefit and harm from tracheostomy in COVID-19 – The Lancet Respiratory Medicine

 

8 – More Harm Than Good? The Net Impact of COVID-19 Policies Is What Matters for Health – Center for Global Development

Related: Indirect Effects of the COVID-19 Pandemic on Maternal and Child Mortality in Low-income and Middle-income Countries

 

9 – Clinical and Chest Radiography Features Determine Patient Outcomes In Young and Middle Age Adults with COVID-19 – Radiology

 

10 –COVID-19 Updates / 18 May 2020 Edition

18 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

[Preprint] Early Safety Indicators of COVID-19 Convalescent Plasma in 5,000 Patients

15 May, 2020 | 03:50h | UTC

Early Safety Indicators of COVID-19 Convalescent Plasma in 5,000 Patients – medRxiv

Commentary: Convalescent plasma is safe to treat COVID-19: nationwide study – NBC News

 

Description of an Outbreak of Severe Kawasaki-like Disease at the Italian Epicenter of the SARS-CoV-2 Epidemic

15 May, 2020 | 03:53h | UTC

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study – The Lancet

Commentaries: Kawasaki-like disease: emerging complication during the COVID-19 pandemic – The Lancet AND Kawasaki-like COVID-19 complication found in Italian kids – CIDRAP AND What we know about the new Covid-19-linked illness in children – Vox AND Coronavirus: Children affected by rare Kawasaki-like disease – BBC

Related: Case Series: Hyperinflammatory Shock in Children During COVID-19 Pandemic

 

Cochrane Library Review of Guidelines for Key Questions Relating to the Care of Pregnant Women and Their Babies

15 May, 2020 | 03:46h | UTC

COVID-19 review of national clinical practice guidelines for key questions relating to the care of pregnant women and their babies – Cochrane Pregnancy and Childbirth

 

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