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Cohort Study: Prognostic Factors Associated with Adverse Outcomes Among Patients with Covid-19

25 May, 2020 | 01:35h | UTC

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study – The BMJ

Related Study: Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study – The BMJ

Editorial: Covid-19 care before, during, and beyond the hospital

Commentary: Age, male sex, obesity, and underlying illness risk factors for severe COVID-19 or death – The BMJ

 


Cohort Study: Fluconazole Use in the First Trimester of Pregnancy Linked to Increased Risk of Musculoskeletal Malformations

25 May, 2020 | 01:31h | UTC

Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study – The BMJ

Commentary: Musculoskeletal Malformations Up With Fluconazole in Pregnancy – Physician’s Weekly

 


Mon May 25 – 10 Stories of The Day!

25 May, 2020 | 02:08h | UTC

 

1 – Remdesivir for the Treatment of Covid-19 — Preliminary Report – New England Journal of Medicine

Commentaries: Preliminary report on NIAID trial of remdesivir – PulmCrit AND Peer-reviewed data shows remdesivir for COVID-19 improves time to recovery – National Institutes of Health AND Covid-19 study details benefits of treatment with remdesivir, and also its limitations – STAT

 

2 – Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis – The Lancet

Commentaries: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous? – The Lancet AND What a big new study on malaria drugs as Covid-19 treatments tells us — and what it doesn’t – STAT AND Hydroxychloroquine May Cause More Harm Than Benefit To COVID-19 Patients, Says New Lancet Study – Health Policy Watch

 

3 – Why countries should stop using anti-malarial drugs for COVID-19 – The Conversation

 

4 – Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial – The Lancet

Commentaries: First human trial of COVID-19 vaccine finds it is safe and induces rapid immune response – The Lancet AND Early Study Of Covid-19 Vaccine Developed In China Sees Mixed Results – Forbes AND Coronavirus Vaccine Shows Promising Early Results in China – The New York Times AND A Chinese biotech just published the first human data for its coronavirus vaccine candidate, supporting further trials – Business Insider AND Experts skeptical after researchers report positive vaccine results – CNN AND Two COVID-19 Vaccine Candidates Induce Immune Response In Healthy Volunteers – Health Policy Watch

 

5 – The world needs Covid-19 vaccines. It may also be overestimating their power – STAT

 

6 – SARS-CoV2 vaccines: Slow is fast – Science

 

7 – Susceptibility to and transmission of COVID-19 amongst children and adolescents compared with adults: a systematic review and meta-analysis – medRxiv

Commentaries: Children appear half as likely to catch COVID-19 as adults – London School of Hygiene & Tropical Medicine AND Expert reaction to systematic review preprint looking at susceptibility to SARS-CoV-2 infection in children and adolescents compared with adults – Science Media Centre

 

8 – Coronavirus Disease 2019 Test Results After Clinical Recovery and Hospital Discharge Among Patients in China – JAMA Network Open

Commentaries: Expert reaction to study on PCR testing results from 60 people after clinical recovery from COVID-19 – Science Media Centre AND 16% of recovered patients test positive for COVID-19 weeks after discharge: study – UPI

 

9 – SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area – Water Research

Related: New Research Examines Wastewater to Detect Community Spread of Covid-19

 

10 –COVID-19 Updates / 25 May 2020 Edition

25 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 


SARS2-CoV-2 and Stroke in a New York Healthcare System

22 May, 2020 | 04:56h | UTC

SARS2-CoV-2 and Stroke in a New York Healthcare System – Stroke

News Release: Stroke rates among COVID-19 patients are low, but cases are more severe; overall stroke hospital admissions are down globally – American Heart Association

Commentary: COVID-19 patients may have lower stroke rates than previously suggested – NYU Grossman School of Medicine

 


Choosing Wisely in the COVID-19 Era: Preventing Harm to Healthcare Workers

22 May, 2020 | 04:58h | UTC

Choosing Wisely in the COVID-19 Era: Preventing Harm to Healthcare Workers – Journal of Hospital Medicine

 


Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

22 May, 2020 | 04:59h | UTC

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 – New England Journal of Medicine

Commentary: Lungs of deceased COVID-19 patients show distinctive features – Brigham and Women’s Hospital

Related: Postmortem Examination of Patients With COVID-19 – JAMA AND Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series – Annals of Internal Medicine AND Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19 – Journal of Thrombosis and Haemostasis

 


Opinion: Ten Reasons why Immunity Passports are a Bad Idea

22 May, 2020 | 04:54h | UTC

Ten reasons why immunity passports are a bad idea – Nature

Related: Ethical and Legal Challenges of COVID-19 Immunity Certificates (articles and commentaries on the subject) AND Privileges and Immunity Certification During the COVID-19 Pandemic – JAMA AND The Ethics of COVID-19 Immunity-Based Licenses (“Immunity Passports”) – JAMA

 


Which Interventions Work Best in a Pandemic?

22 May, 2020 | 04:50h | UTC

Which interventions work best in a pandemic? – Science

 


How Coronavirus Lockdowns Stopped Flu in its Tracks

22 May, 2020 | 04:53h | UTC

How coronavirus lockdowns stopped flu in its tracks – Nature

“Reported rates of influenza and other infections have fallen sharply, but some communicable diseases may see a rise.”

 


15 Drugs Being Tested to Treat COVID-19 and How They Would Work

22 May, 2020 | 04:52h | UTC

15 drugs being tested to treat COVID-19 and how they would work – Nature

 


Open Access: How COVID-19 will Change the Way Research Findings are Shared

22 May, 2020 | 04:48h | UTC

Open access: how COVID-19 will change the way research findings are shared – Wellcome

Related: Plan S: Making Full and Immediate Open Access a Reality AND UC Terminates Subscriptions with World’s Largest Scientific Publisher in Push for Open Access (several resources on the subject) AND PLOS and the University of California announce open access publishing agreement – PLOS Blogs AND The war to free science – Vox (free) AND WHO Joins Coalition for Free Digital Access to Health Research

 


[Preprint] IL6 Inhibition in Critically Ill COVID-19 Patients is Associated with Increased Secondary Infections

22 May, 2020 | 04:44h | UTC

IL6 inhibition in critically ill COVID-19 patients is associated with increased secondary infections – medRxiv

 


Ethics of Controlled Human Infection to Address COVID-19

22 May, 2020 | 04:49h | UTC

Ethics of controlled human infection to address COVID-19 – Science

 


Opinion: Revisiting the No Visitors Policy

22 May, 2020 | 04:43h | UTC

Revisiting the No Visitors Policy – CMAJ Blogs

“I follow the policy, as I must, but neither my heart nor my mind believe that the harm we aim to prevent with current no visitors edicts outweighs the harm we are causing.”

 


[Preprint] Estimating the Number of Deaths that Could Have Been Prevented with Earlier Lockdown Measures

22 May, 2020 | 04:45h | UTC

Differential Effects of Intervention Timing on COVID-19 Spread in the United States – medRxiv

Commentaries: At Least 54,000 U.S. Deaths Could Have Been Avoided If Lockdown Had Come Two Weeks Earlier – Forbes AND Lockdown Delays Cost at Least 36,000 Lives, Data Show – The New York Times AND Latest Columbia COVID-19 Projections: Delayed Response to Rebound Would Cost Lives – Columbia University, Mailman School of Public Health AND Delayed Social Restrictions Led to 36,000 Deaths – U.S. News AND About 83% of US coronavirus deaths could have been avoided if lockdowns were imposed March 1, researchers estimate – Business Insider

 


Opinion: Calling Health Care Workers ‘Heroes’ Harms all of Us

22 May, 2020 | 04:41h | UTC

Calling health care workers ‘heroes’ harms all of us – STAT

 


Study: Lower Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children May Help Explain why COVID-19 is Less Prevalent in Children

22 May, 2020 | 04:39h | UTC

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults – JAMA

Editorial: Nasal ACE2 Levels and COVID-19 in Children

 


Attacks Against Health-care Personnel Must Stop, Especially as the World Fights COVID-19

22 May, 2020 | 04:40h | UTC

Attacks against health-care personnel must stop, especially as the world fights COVID-19 – The Lancet

 


Review: Optimization of the Organ Donor and Effects on Transplanted Organs

22 May, 2020 | 04:37h | UTC

Optimisation of the organ donor and effects on transplanted organs: a narrative review on current practice and future directions – Anaesthesia

Related Guideline: Management of the neurologically deceased organ donor: A Canadian clinical practice guideline – Canadian Medical Association Journal

 


Wide Complex Tachycardia Differentiation: A Reappraisal of the State‐of‐the‐Art

22 May, 2020 | 04:38h | UTC

Wide Complex Tachycardia Differentiation: A Reappraisal of the State‐of‐the‐Art – Journal of the American Heart Association

 


Systematic Review: Early Warning Scores for Detecting Deterioration in Adult Hospital Patients

22 May, 2020 | 04:34h | UTC

Early warning scores for detecting deterioration in adult hospital patients: systematic review and critical appraisal of methodology – The BMJ

 


Meta-Analysis: Complete vs. Culprit-Lesion-Only Revascularization for ST-Segment Elevation Myocardial Infarction

22 May, 2020 | 04:36h | UTC

Complete vs Culprit-Lesion-Only Revascularization for ST-Segment Elevation Myocardial Infarction: A Systematic Review and Meta-analysis – JAMA Cardiology (free for a limited period)

 


SARS-CoV-2 Infection Protects Against Rechallenge in Rhesus Macaques

21 May, 2020 | 09:27h | UTC

SARS-CoV-2 infection protects against rechallenge in rhesus macaques – Science

Related Study: DNA vaccine protection against SARS-CoV-2 in rhesus macaques – Science

Commentaries: Infection With SARS-CoV-2 Protects Against Re-infection – At Least in Rhesus Macaques – Technology Networks AND Prototype Vaccine Protects Monkeys From Coronavirus – The New York Times

 


Fri May 22 – 10 Stories of The Day!

22 May, 2020 | 05:01h | UTC

 

1 – Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 – New England Journal of Medicine

Commentary: Lungs of deceased COVID-19 patients show distinctive features – Brigham and Women’s Hospital

Related: Postmortem Examination of Patients With COVID-19 – JAMA AND Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series – Annals of Internal Medicine AND Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19 – Journal of Thrombosis and Haemostasis

 

2 – Choosing Wisely in the COVID-19 Era: Preventing Harm to Healthcare Workers – Journal of Hospital Medicine

 

3 – SARS2-CoV-2 and Stroke in a New York Healthcare System – Stroke

News Release: Stroke rates among COVID-19 patients are low, but cases are more severe; overall stroke hospital admissions are down globally – American Heart Association

Commentary: COVID-19 patients may have lower stroke rates than previously suggested – NYU Grossman School of Medicine

 

4 – Ten reasons why immunity passports are a bad idea – Nature

Related: Ethical and Legal Challenges of COVID-19 Immunity Certificates (articles and commentaries on the subject) AND Privileges and Immunity Certification During the COVID-19 Pandemic – JAMA AND The Ethics of COVID-19 Immunity-Based Licenses (“Immunity Passports”) – JAMA

 

5 – How coronavirus lockdowns stopped flu in its tracks – Nature

“Reported rates of influenza and other infections have fallen sharply, but some communicable diseases may see a rise.”

 

6 – 15 drugs being tested to treat COVID-19 and how they would work – Nature

 

7 – Which interventions work best in a pandemic? – Science

 

8 – Ethics of controlled human infection to address COVID-19 – Science

 

9 – Open access: how COVID-19 will change the way research findings are shared – Wellcome

Related: Plan S: Making Full and Immediate Open Access a Reality AND UC Terminates Subscriptions with World’s Largest Scientific Publisher in Push for Open Access (several resources on the subject) AND PLOS and the University of California announce open access publishing agreement – PLOS Blogs AND The war to free science – Vox (free) AND WHO Joins Coalition for Free Digital Access to Health Research

 

10 –COVID-19 Updates / 22 May 2020 Edition

22 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 


Audio Interview: Capitalizing on Immune Responses to Covid-19

21 May, 2020 | 09:26h | UTC

Audio Interview: Capitalizing on Immune Responses to Covid-19 – New England Journal of Medicine

 


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