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Less is more? Our new trial suggests #deprescribing #bloodpressure lowering medications is safe in the short-term in older people with frailty and multimorbidity – see thread for details https://t.co/fLf2Vv42hB #hypertension #RCT @richardjmcmanus @jenniaburt @HomeUrs29 @prof_mant pic.twitter.com/HfScHju6HS

— James Sheppard (@jamessheppard48) May 26, 2020

Meta-Analysis: Vasopressin or Its Analogs are Not Associated with Reduced Mortality Compared to Catecholamines Alone in Patients with Septic Shock

27 May, 2020 | 02:13h | UTC

Clinical Efficiency of Vasopressin or Its Analogs in Comparison with Catecholamines Alone on Patients With Septic Shock: A Systematic Review and Meta-Analysis – Frontiers in Pharmacology

The Challenge of Implementing “Less is More” Medicine: A European Perspective

27 May, 2020 | 02:14h | UTC

The challenge of implementing Less is More medicine: A European perspective – European Journal of Internal Medicine

[Abstract Only] Study: Estimating the Lifetime Benefits of a Multi-drug Regimen for Heart Failure

27 May, 2020 | 02:41h | UTC

Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomised controlled trials – The Lancet (link to abstract – $ for full-text)

Commentary: Multi-drug regimen for heart failure could meaningfully extend patients’ lives – Brigham and Women’s Hospital

Related Commentary on Twitter

NEW Research—Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomised controlled trialshttps://t.co/XjRPvdU7tK pic.twitter.com/ZAjynxPdAK

— The Lancet (@TheLancet) May 22, 2020

Wed May 27 – 10 Stories of The Day!

27 May, 2020 | 02:50h | UTC

1 – Revealing the toll of COVID-19: A technical package for rapid mortality surveillance and epidemic response – World Health Organization

2 – WHO Manifesto for a healthy recovery from COVID-19 – World Health Organization

3 – “Is It Safe for Me to Go to Work?” Risk Stratification for Workers during the Covid-19 Pandemic – New England Journal of Medicine

4 – When You Can be Around Others After You Had or Likely Had COVID-19 – Centers for Disease Control and Prevention

“I think or know I had COVID-19, and I had symptoms”.

You can be with others after:

3 days with no fever AND
Symptoms improved AND
10 days since symptoms first appeared”

5 – Loss of Smell and Taste in 2013 European Patients With Mild to Moderate COVID-19 – Annals of Internal Medicine

6 – Just the Facts: What drugs are safe and effective for COVID-19? – Canadian Journal of Emergency Medicine

“Apart from supportive care, there are no current effective therapeutics for COVID-19”

7 – The Totality of the Evidence – Boston Review

See other interesting perspectives from the Boston Review: Models v. Evidence AND Good Science Is Good Science

“Given what we know now, it is reasonable to consider alternatives to population-wide lockdown, even as we focus on protecting those most at risk and support health care systems to care for patients who are sick.”

8 – Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—a Living Working Document – Circulation: Heart Failure

9 – Efficacy and safety of convalescent plasma for severe COVID-19 based on evidence in other severe respiratory viral infections: a systematic review and meta-analysis – Canadian Medical Association Journal

10 –COVID-19 Updates / 27 May 2020 Edition

27 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)